Electric Sheep: Analyzing American Societal Anxieties Towards Artificial Intelligence Through Popular Media, 1921-2014

While scientists continue to test the boundaries and the ethical limitations of artificial intelligence (A.I.), they create an omnipresent trend of distrust and, more importantly, fear. From 1921 to 2014, A.I. functioned as an undeniable threat in film, literature, and television, commenting on societal perceptions, subconscious fears, and unexplored anxieties. This thesis aims to observe and contextualize the growing struggle between human and machine using popular media and their reviews to conceptualize societal anxieties. It also casts light on two broader concerns: the growing role of artificial intelligence in our daily lives and what we can learn from popular media over the last two centuries. Themes like gender, oppression, the definition of humanity, and fear of control frame this analysis, with these themes appearing throughout the twentieth and twenty-first centuries. By contextualizing these cultural objects within the history of artificial intelligence – from the Cold War to the digital revolution – we can better understand our anxieties towards artificial intelligence and the implications of accepting it into our lives

The Status of Women at the University of Dayton: 2020-2021 Report Card

In this third iteration, the Status of Women at the University of Dayton: 2020-2021 Report Card\u27\u27 continues the effort of the inaugural report card in measuring the representation of women across the university’s workforce and in leadership roles, with a focus on highlighting changes from year to year. Our goal in generating this report card is to annually evaluate progress toward increasing institutional diversity and promoting equity for women-identified staff and faculty. In doing so, the report identifies areas where progress is being made and areas where more work is needed. The report card is also a space to share progress on gender equity initiatives led by the Women\u27s Center and other units across campus. Data presented in this report card was provided by the university’s Institutional Research Office and represents data collected in Fall 2020; all gender and racial categories are self-reported. As with the previous iteration of the report card, we disaggregated the data to more clearly show the differences between and among women (and men) by examining both gender and race. This year\u27s report card has some changes from the previous academic year, including: revised definitions of \u27Senior Academic Leadership\u27 and \u27Senior Administrators\u27; and revised categories among exempt and non-exempt staff due, in part, to changes at the federal level. We believe our reporting categories continue to add to our understanding of the gendered division of labor within the institution and its connection to pay, job security, and advancement

Roots to Reasons: A Podcast Series - Emotional, Intellectual, & Substantive Environmental Conversations

As six students of the Resources and Sustainability Global Theme of the Franke GLI program our capstone project addresses the need for emotional, intellectual and substantive environmental conversations, a lack thereof we all have observed in our studies and daily lives. We conducted research of scholarly sources that found experience, upbringing, biases, and emotions are influencers of a person’s attitude and behavior toward the environment and climate change. Attitude is expressed through a person’s morals that inform behavior. The topics of environment and climate change are largely interpreted and expressed through pathos, which is easily manipulated by social media, marketing, and news sources. The second half of our research focused on conversation and interview techniques that would help us discuss these influences with others and learn how they manifest themselves in individuals\u27 lives. Finding agreement, listening intently, providing a safe atmosphere, creating rapport, being cognisant of pacing, tone, and emotions are crucial to conducting an emotionally, politically, or personally challenging conversation. We compiled our sources into a literature review that identifies what shapes a person’s relationship with the environment and climate change and how to hold conversations about these topics. The culmination of work is a podcast series, “Roots to Reason,” that models these environmental conversations. We conducted nine conversations with individuals such as ranchers, professors, small business owners and tribal members about their upbringing and relationship with the environment and climate change. These conversations were analyzed and synthesized into a podcast format to deliver conversation models to scholars and laymen. Not considering the background that shapes an individual’s morals, attitudes, and behaviors impedes productivity and collaboration that is critical to solving environmental challenges. This project models how differing backgrounds can cooperate from a place of mutual understanding and acceptance

The spin and charge gaps of the half-filled N-leg Kondo ladders

In this work, we study N-leg Kondo ladders at half-filling through the density matrix renormalization group. We found non-zero spin and charge gaps for any finite number of legs and Kondo coupling $J>0$. We also show evidence of the existence of a quantum critical point in the two dimensional Kondo lattice model, in agreement with previous works. Based on the binding energy of two holes, we did not find evidence of superconductivity in the 2D Kondo lattice model close to half-filling.Comment: 4 pages, 1 table, 3 fig

Neurovisceral phenotypes in the expression of psychiatric symptoms

This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Research is revealing how brainbody mechanisms underlie individual differences in psychophysiological reactivity that can be important for predicting, stratifying and treating individuals with anxiety disorders and related conditions. One common constitutional difference is Joint Hypermobility, in which there is an increased range of joint movement as a result of a variant of collagen. Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-sensitive medical conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. Structural differences in 'emotional' brain regions are reported in hypermobile individuals, and many people with joint hypermobility manifest autonomic abnormalities, typically Postural Tachycardia Syndrome. Enhanced heart rate reactivity during postural change and as recently recognised factors causing vasodilatation (as noted post prandially, post exertion and with heat) is characteristic of Postural Tachycardia Syndrome, and there is a phenomenological overlap with anxiety disorders, which may be partially accounted for by exaggerated neural reactivity within ventromedial prefrontal cortex. People who experience Vasovagal Syncope, a heritable tendency to fainting induced by emotional challenges (and needle/blood phobia), are also more vulnerable to anxiety disorders. Neuroimaging implicates brainstem differences in vulnerability to faints, yet the structural integrity of the caudate nucleus appears important for the control of fainting frequency in relation to parasympathetic tone and anxiety. Together there is clinical and neuroanatomical evidence to show that common constitutional differences affecting autonomic responsivity are linked to psychiatric symptoms, notably anxiety

Toxic Effects of Domoic Acid in the Seabream Sparus aurata

Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (66.67 ± 16.67%) was only observed in dose of 9.0 mg kg−1 bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg−1 bw. Furthermore, the mean concentrations (±SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg−1 bw were 0.61 ± 0.01, 0.96 ± 0.00, and 0.36 ± 0.01 mg DA kg−1 tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

Helicobacter pylori infection causes gastric cancer, the third leading cause of cancer death worldwide. More than half of the world’s population is infected, making universal eradication impractical. Clinical trials suggest that antibiotic treatment only reduces gastric cancer risk in patients with non-atrophic gastritis (NAG), and is ineffective once preneoplastic lesions of multifocal atrophic gastritis (MAG) and intestinal metaplasia (IM) have occurred. Therefore, additional strategies for risk stratification and chemoprevention of gastric cancer are needed. We have implicated polyamines, generated by the rate-limiting enzyme ornithine decarboxylase (ODC), in gastric carcinogenesis. During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine. Herein, we assessed the role of SMOX in the increased gastric cancer risk in Colombia associated with the Andean mountain region when compared with the low-risk region on the Pacific coast. When cocultured with gastric epithelial cells, clinical strains of H. pylori from the high-risk region induced more SMOX expression and oxidative DNA damage, and less apoptosis than low-risk strains. These findings were not attributable to differences in the cytotoxin-associated gene A oncoprotein. Gastric tissues from subjects from the high-risk region exhibited greater levels of SMOX and oxidative DNA damage by immunohistochemistry and flow cytometry, and this occurred in NAG, MAG and IM. In Mongolian gerbils, a prototype colonizing strain from the high-risk region induced more SMOX, DNA damage, dysplasia and adenocarcinoma than a colonizing strain from the low-risk region. Treatment of gerbils with either α-difluoromethylornithine, an inhibitor of ODC, or MDL 72527 (N[superscript 1,]N[superscript 4]-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride), an inhibitor of SMOX, reduced gastric dysplasia and carcinoma, as well as apoptosis-resistant cells with DNA damage. These data indicate that aberrant activation of polyamine-driven oxidative stress is a marker of gastric cancer risk and a target for chemoprevention.National Institutes of Health (U.S.) (Grant P01CA028842)Vanderbilt Digestive Disease Center (Grant P30DK058404

Jet Substructure at the Tevatron and LHC: New results, new tools, new benchmarks

In this report we review recent theoretical progress and the latest experimental results in jet substructure from the Tevatron and the LHC. We review the status of and outlook for calculation and simulation tools for studying jet substructure. Following up on the report of the Boost 2010 workshop, we present a new set of benchmark comparisons of substructure techniques, focusing on the set of variables and grooming methods that are collectively known as "top taggers". To facilitate further exploration, we have attempted to collect, harmonise, and publish software implementations of these techniques.Comment: 53 pages, 17 figures. L. Asquith, S. Rappoccio, C. K. Vermilion, editors; v2: minor edits from journal revision

Computational fluid dynamics modelling in cardiovascular medicine

This paper reviews the methods, benefits and challenges associated with the adoption and translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine. CFD, a specialist area of mathematics and a branch of fluid mechanics, is used routinely in a diverse range of safety-critical engineering systems, which increasingly is being applied to the cardiovascular system. By facilitating rapid, economical, low-risk prototyping, CFD modelling has already revolutionised research and development of devices such as stents, valve prostheses, and ventricular assist devices. Combined with cardiovascular imaging, CFD simulation enables detailed characterisation of complex physiological pressure and flow fields and the computation of metrics which cannot be directly measured, for example, wall shear stress. CFD models are now being translated into clinical tools for physicians to use across the spectrum of coronary, valvular, congenital, myocardial and peripheral vascular diseases. CFD modelling is apposite for minimally-invasive patient assessment. Patient-specific (incorporating data unique to the individual) and multi-scale (combining models of different length-And time-scales) modelling enables individualised risk prediction and virtual treatment planning. This represents a significant departure from traditional dependence upon registry-based, populationaveraged data. Model integration is progressively moving towards 'digital patient' or 'virtual physiological human' representations. When combined with population-scale numerical models, these models have the potential to reduce the cost, time and risk associated with clinical trials. The adoption of CFD modelling signals a new era in cardiovascular medicine. While potentially highly beneficial, a number of academic and commercial groups are addressing the associated methodological, regulatory, education-And service-related challenges

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a ‘putative β-lactamase-like protein’ from Brucella melitensis

The structure of a β-lactamase-like protein from B. melitensis was solved independently using two data sets with anomalous signal. Anomalous Fourier maps could confirm the identity of two metal ions in the active site. AMP-bound and GMP-bound structures provide hints to the possible function of the protein