The Ringdown of GW190521: Hints of Multiple Quasinormal Modes with a Precessional Interpretation

GW190521 is a short-duration, low-frequency gravitational-wave signal in the LIGO-Virgo catalogue. The signal is consistent with the ringdown and possibly some of the inspiral-merger of an intermediate-mass binary black-hole coalescence. We find that previous models of the quasinormal mode spectrum in the ringdown of GW190521 give remnant mass and spin estimates which are not fully consistent with those of many inspiral-merger-ringdown waveforms. In our own analysis, we find that ringdown models which include both the angular ${l=2}$, ${m=1}$ and ${l=m=2}$ fundamental quasinormal modes are in full agreement with most inspiral-merger-ringdown waveforms, and in particular with the numerical relativity surrogate NRSur7dq4. We also find some support for including the ${l=3}$, ${m=2}$ fundamental quasinormal mode in our fits, building on Capano et al.'s findings regarding a higher-frequency subdominant mode. We propose an interpretation of our GW190521 ringdown model that links precession to the excitation of ${l\neq m}$ quasinormal modes, but we do not rule out eccentricity or other interpretations.Comment: Data Release: https://doi.org/10.5281/zenodo.816977

PORTAL VENOUS CATECHOL AMINES IN PORTAL HYPERTENSION

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32177/1/0000233.pd

The seed magnetic field generated during recombination

Nonlinear dynamics creates vortical currents when the tight-coupling approximation between photons and baryons breaks down around the time of recombination. This generates a magnetic field at second order in cosmological perturbations, whose power spectrum is fixed by standard physics, without the need for any ad hoc assumptions. We present the fully relativistic calculation of the magnetic power spectrum, including the effects of metric perturbations, second-order velocity and the photon anisotropic stress, thus generalizing and correcting previous results. We also show that significant magnetogenesis continues to occur after recombination. The power spectrum $\sqrt{k^3 P_B}$ behaves as $\propto k^4$ on large scales, and $\propto k^{0.5}$ on small scales, down to $\sim 1\,$Mpc. On cluster scales, the created field has strength $\sim 3\times 10^{-29}$ Gauss.Comment: references added, version accepted by MNRA

Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection

Pseudomonas aeruginosa causes problematic chronic lung infections in those suffering from cystic fibrosis. This is due to its antimicrobial resistance mechanisms and its ability to form robust biofilm communities with increased antimicrobial tolerances. Using novel antimicrobials or repurposing current ones is required in order to overcome these problems. Manuka honey is a natural antimicrobial agent that has been used for many decades in the treatment of chronic surface wounds with great success, particularly those infected with P. aeruginosa. Here we aim to determine whether the antimicrobial activity of manuka honey could potentially be repurposed to inhibit pulmonary P. aeruginosa infections using two ex vivo models. P. aeruginosa isolates (n = 28) from an international panel were tested for their susceptibility to manuka honey and clinically relevant antibiotics (ciprofloxacin, ceftazidime, and tobramycin), alone and in combination, using conventional antimicrobial susceptibility testing (AST). To increase clinical applicability, two ex vivo porcine lung (EVPL) models (using alveolar and bronchiolar tissue) were used to determine the anti-biofilm effects of manuka honey alone and in combination with antibiotics. All P. aeruginosa isolates were susceptible to manuka honey, however, varying incidences of resistance were seen against antibiotics. The combination of sub-inhibitory manuka honey and antibiotics using conventional AST had no effect on activity against the majority of isolates tested. Using the two ex vivo models, 64% (w/v) manuka honey inhibited many of the isolates where abnormally high concentrations of antibiotics could not. Typically, combinations of both manuka honey and antibiotics had increased antimicrobial activity. These results highlight the potential of manuka honey as a future antimicrobial for the treatment of pulmonary P. aeruginosa isolates, clearing potential infection reservoirs within the upper airway

Internal and external cooling methods and their effect on body temperature, thermal perception and dexterity

© 2018 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0191416© 2018 Maley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective The present study aimed to compare a range of cooling methods possibly utilised by occupational workers, focusing on their effect on body temperature, perception and manual dexterity. Methods Ten male participants completed eight trials involving 30 min of seated rest followed by 30 min of cooling or control of no cooling (CON) (34C, 58% relative humidity). The cooling methods utilised were: ice cooling vest (CV0), phase change cooling vest melting at 14C (CV14), evaporative cooling vest (CVEV), arm immersion in 10C water (AI), portable water-perfused suit (WPS), heliox inhalation (HE) and ice slushy ingestion (SL). Immediately before and after cooling, participants were assessed for fine (Purdue pegboard task) and gross (grip and pinch strength) manual dexterity. Rectal and skin temperature, as well as thermal sensation and comfort, were monitored throughout. Results Compared with CON, SL was the only method to reduce rectal temperature (P = 0.012). All externally applied cooling methods reduced skin temperature (P0.05). Conclusion The present study observed that ice ingestion or ice applied to the skin produced the greatest effect on rectal and skin temperature, respectively. AI should not be utilised if workers require subsequent fine manual dexterity. These results will help inform future studies investigating appropriate pre-cooling methods for the occupational worker.This project is financially supported by the US Government through the Technical Support Working Group within the Combating Terrorism Technical Support Office.Published versio

No straight lines – young women’s perceptions of their mental health and wellbeing during and after pregnancy: a systematic review and meta-ethnography

Background: Young mothers face mental health challenges during and after pregnancy including increased rates of depression compared to older mothers. While the prevention of teenage pregnancy in countries such as the United States and the United Kingdom has been a focus for policy and research in recent decades, the need to understand young women’s own experiences has been highlighted. The aim of this meta-ethnography was to examine young women’s perceptions of their mental health and wellbeing during and after pregnancy to provide new understandings of those experiences. Methods: A systematic review and meta-ethnographic synthesis of qualitative research was conducted. Seven databases were systematically searched and forward and backward searching conducted. Papers were included if they were from Organisation for Economic Co-operation and Development countries and explored mental health and wellbeing experiences of young mothers (age under 20 in pregnancy; under 25 at time of research) as a primary research question – or where evidence about mental health and wellbeing from participants was foregrounded. Nineteen papers were identified and the Critical Appraisal Skills Programme checklist for qualitative research used to appraise the evidence. Following the seven-step process of meta-ethnography, key constructs were examined within each study and then translated into one another. Results: Seven translated themes were identified forming a new line of argument wherein mental health and wellbeing was analysed as relating to individual bodily experiences; tied into past and present relationships; underpinned by economic insecurity and entangled with feelings of societal surveillance. There were ‘no straight lines’ in young women’s experiences, which were more complex than dominant narratives around overcoming adversity suggest. Conclusions: The synthesis concludes that health and social care professionals need to reflect on the operation of power and stigma in young women’s lives and its impact on wellbeing. It adds to understanding of young women’s mental health and wellbeing during and after pregnancy as located in physical and structural factors rather than individual capacities alone

On dynamically consistent eddy fluxes

Author Posting. © The Author, 2004. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Dynamics of Atmospheres and Oceans 38 (2005): 123-146, doi:10.1016/j.dynatmoce.2004.11.003.The role of mesoscale oceanic eddies in driving the large-scale currents is studied in an eddy-resolving, double-gyre ocean model. The new diagnostic method is proposed, which is based on dynamical decomposition of the flow into the large-scale and eddy components. The method yields the time history of the eddy forcing, which can be used as additional, external forcing in the corresponding non-eddy-resolving model of the gyres. The main strength of this approach is in its dynamical consistency: the non-eddy-resolving solution driven by the eddy forcing history correctly approximates the original large-scale flow component. It is shown that statistical decompositions, which are based on space-time filtering diagnostics, are dynamically inconsistent. The diagnostics algorithm is formulated and tested, and the diagnosed eddies are analysed, both statistically and dynamically. It is argued that the main dynamic role of the eddies is to maintain the eastward-jet extension of the subtropical western boundary current (WBC). This is done largely by both the time–mean isopycnal-thickness flux and the relative-vorticity eddy flux fluctuations. The fluctuations drive large-scale flow through the nonlinear rectification mechanism. The relative-vorticity flux contributes mostly to the eastward jet meandering. Finally, eddy fluxes driven by both the eddies and the large-scale flow are found to be important. The latter is typically neglected in the analysis, but here it corresponds to important large-scale feedback on the eddies.Funding for this research was provided by NSF grant OCE 00–91836, by the Royal Society Fellowship, and by WHOI grants 27100056 and 52990035

Assessing personality in San Joaquin kit fox in situ: efficacy of field-based experimental methods and implications for conservation management

Utilisation of animal personality has potential benefit for conservation management. Due to logistics of robust behavioural evaluation in situ, the majority of studies on wild animals involve taking animals into captivity for testing, potentially compromising results. Three in situ tests for evaluation of boldness in San Joaquin kit fox (Vulpes macrotis mutica) were developed (ENOT: extended novel object test; RNOT: rapid novel object test; TH: trap/handling test). Each test successfully identified variation in boldness within its target age class(es). The TH test was suitable for use across all age classes. Tests were assessed for in situ suitability and for quantity/quality of data yielded. ENOT was rated as requiring high levels of time, cost and labour with greater likelihood of failure. However, it was rated highly for data quantity/quality. The TH test was rated as requiring little time, labour and cost, but yielding lower quality data. RNOT was rated in the middle. Each test had merit and could be adapted to suit project or species constraints. We recommend field-based evaluation of personality, reducing removal of animals from the wild and facilitating routine incorporation of personality assessment into conservation projects