Spatial and Temporal Risk Assessment for Water Resources Decision Making

Water resources systems are vulnerable to natural disasters such as floods, wind storms, earthquakes, and various meteorological events. Flooding is the most frequent natural hazard that can cause damage to human life and property. A new methodology presented in this thesis is capable of flood risk management by: (a) addressing various uncertainties caused by variability and ambiguity; (b) integrating objective and subjective flood risk; and (c) assisting the flood risk management based on better understanding of spatial and temporal variability of risk. The new methodology is based on the use of fuzzy reliability theory. A new definition of risk is used and described using three performance indices (i) a combined fuzzy reliability-vulnerability, (ii) fuzzy robustness and (iii) fuzzy resiliency. The traditional flood risk management relies on either temporal or spatial variability, but not both. However, there is a need to understand the dynamic characteristics of flood risk and its spatial variability. The two-dimensional (2-D) fuzzy set that relates the universe of discourse and its membership degree, is not sufficient to address both, spatial and temporal, variations of flood risk. The theoretical contribution of this study is based on the development of a three dimensional (3-D) fuzzy set. The spatial and temporal variability of fuzzy performance indices – (i) combined reliability-vulnerability, (ii) robustness, and (iii) resiliency – have been implemented to (i) river flood risk analysis and (ii) urban flood risk analysis. The river flood risk analysis is illustrated using the Red River flood of 1997 (Manitoba, Canada) as a case study. The urban flood risk analysis is illustrated using the residential community of Cedar Hollow (London, Ontario, Canada) as a case study. The final results of the fuzzy flood reliability analysis are presented using maps that show the spatial and temporal variation of reliability-vulnerability, robustness and resiliency indices. Maps of fuzzy reliability indices provide additional decision support for (a) land use planning, (b) selection of appropriate flood mitigation strategies, (c) planning emergency management measures, (d) selecting an appropriate construction technology for flood prone areas, and (e) flood insurance

Th9 Cells: Probable players in ulcerative colitis pathogenesis

T lymphocytes represent an important part of adaptive immune system undertaking different functions to regulate immune responses. CD4+ T cells are the most important activator cells in inflammatory conditions. Depending on the type of induced cells and inflamed sites, expression and activity of different subtypes of helper T cells are changed. Recent studies have confirmed the existence of a new subset of helper T lymphocytes called Th9. Naive T cells can differentiate into Th9 subtypes if they are exposed simultaneously by interleukin (IL) 4 and transforming growth factor β and also secondary activation of a complicated network of transcription factors such as interferon regulatory factor 4 (IRF4) and Smads which are essential for adequate induction of this phenotype. Th9 cells specifically produce interleukin 9 and their probable roles in promoting intestinal inflammation are being investigated in human subjects and experimental models of ulcerative colitis (UC). Recently, infiltration of Th9 cells, overexpression of IL-9, and certain genes associated with Th9 differentiation have been demonstrated in inflammatory microenvironment of UC. Intestinal oversecretion of IL-9 protein is likely to break down epithelial barriers and compromise tolerance to certain commensal microorganisms which leads to inflammation. Th9 pathogenicity has not yet been adequately explored in UC and they are far from being considered as inflammatory cells in this milieu, therefore precise understanding the role of these newly identified cells in particular their potential role in gut pathogenesis may enable us to develop novel therapeutic approaches for inflammatory bowel disease. So, this article tries to discuss the latest knowledge on the above-mentioned fiel

BIM-driven energy simulation and optimization for net-zero tall buildings: sustainable construction management

The growing demand for sustainable and energy-efficient buildings, particularly in the context of tall structures, has prompted increased attention to innovative solutions. Despite advancements in Building Information Modelling (BIM) technology, there exists a critical gap in understanding its comprehensive application for achieving net-zero energy consumption in tall buildings, particularly in the Malaysian construction industry. This research addresses this gap by presenting a novel strategy that integrates BIM technology with energy analysis tools for net-zero tall buildings in Malaysia. The aim of the study is to contribute valuable insights to the construction industry, policymakers, and researchers by conducting empirical research, utilizing case studies, validating the proposed framework, advancing sustainable design practices, and supporting the transition towards net-zero energy tall buildings in Malaysia. The methodology involves a three-phase approach, including qualitative analysis, a pilot survey, and a main questionnaire. Exploratory factor analysis (EFA) validates the categorization derived from qualitative interviews, while Partial Least Squares Structural Equation Modelling (PLS-SEM) assesses the convergent and discriminant validity of the measurement model. Hypotheses testing using bootstrapping establishes the significance of correlations between BIM deployment and key factors such as early design integration, enhanced energy efficiency, optimized system integration, predictive performance analysis, and validation of sustainable design. The research findings support the positive associations between BIM deployment and the mentioned factors, providing statistical significance through T-statistics and p-values. The implications of this research extend beyond the Malaysian context, offering valuable insights for architects, engineers, and stakeholders involved in designing and managing sustainable tall buildings. By addressing the identified gaps and leveraging BIM technology effectively, stakeholders can contribute to the construction of net-zero energy structures, aligning with global efforts towards sustainable and energy-efficient building practices

EUREC⁴A

The science guiding the EUREC⁴A campaign and its measurements is presented. EUREC⁴A comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic – eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC⁴A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200 km) and larger (500 km) scales, roughly 400 h of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10 000 profiles), lower atmosphere (continuous profiling), and along the air–sea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC⁴A explored – from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview of EUREC⁴A's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement

EUREC⁴A

The science guiding the EUREC⁴A campaign and its measurements is presented. EUREC⁴A comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic – eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC⁴A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200 km) and larger (500 km) scales, roughly 400 h of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10 000 profiles), lower atmosphere (continuous profiling), and along the air–sea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC⁴A explored – from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview of EUREC⁴A's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement

A methodology for spatial fuzzy reliability analysis

Natural hazard risk assessment requires quantification of uncertainty that is spatially and temporally variable. Spatial variability of risk has been rarely considered in the past research. This paper presents a new methodology to capture the spatial uncertainty as well as the subjectivity associated with the natural hazard risk analysis. The fuzzy set theory has been integrated with the geographic information system (GIS) in the development of the methodology for spatial reliability analysis. Paper explores the spatial extension of three fuzzy reliability indices i.e. (1) combined reliability-vulnerability, (2) robustness, and (3) resiliency. Fuzzy risk and reliability are quantified within a GIS framework and maps showing spatial variability of three fuzzy indices are developed. The proposed methodology has been applied to flood hazard management. It has been found that the application of spatial fuzzy reliability analysis provides additional information to flood managers regarding the spatial variability of flood risk and aids in the development of a sustainable flood management options

A methodology for spatial fuzzy reliability analysis

Natural hazard risk assessment requires quantification of uncertainty that is spatially and temporally variable. Spatial variability of risk has been rarely considered in the past research. This paper presents a new methodology to capture the spatial uncertainty as well as the subjectivity associated with the natural hazard risk analysis. The fuzzy set theory has been integrated with the geographic information system (GIS) in the development of the methodology for spatial reliability analysis. Paper explores the spatial extension of three fuzzy reliability indices i.e. (1) combined reliability-vulnerability, (2) robustness, and (3) resiliency. Fuzzy risk and reliability are quantified within a GIS framework and maps showing spatial variability of three fuzzy indices are developed. The proposed methodology has been applied to flood hazard management. It has been found that the application of spatial fuzzy reliability analysis provides additional information to flood managers regarding the spatial variability of flood risk and aids in the development of a sustainable flood management options