Оказание медицинской помощи пациентам с акне. Результаты экспертизы качества медицинской помощи

Goal. To obtain information on typical errors in medical aid rendered to acne patients in dermatovenerology dispensaries in St. Petersburg in order to develop measures to improve the quality of medical aid rendered to this group of patients. Materials and methods. The authors conducted a special expert examination of 55 patients with acne who received treatment at St. Petersburg dermatovenerology dispensaries in 2013. The quality of medical aid was assessed using the Automated Expert Examination Technique (hereinafter referred to as AEET). Major results. The percentage of cases when medical aid of due quality was rendered to acne patients was 49%. Treatment and diagnostics errors prevailed in the structure of errors in medical aid. Errors in treatment were mainly a wrong combination of drugs, simultaneous administration of external and systemic antibacterial drugs, delayed comedolytic therapy and pathogenically infeasible therapy. Errors in diagnostics included absence of indications of the form and/or severity of acne. The most important error in the collection of information was absence of gynecology examinations for women to determine whether peroral contraceptives were necessary including in case of the administration of isotretinoin. Conclusion. The similarity of errors in medical aid rendered for acne as well as high percentage of errors relating to medical aid rendered to patients demand the development of consistent measures to improve the quality of medical aid rendered to such patients and repeated expert examination using preliminary (prompt) control of the quality of medical aid.Цель. Получение информации о типичных ошибках оказания медицинской помощи пациентам с акне в кожно-венерологических диспансерах (КВД) Санкт-Петербурга для разработки мер, направленных на улучшение качества медицинской помощи (КМП) данной группе пациентов. Материал и методы. Проведена тематическая экспертиза КМП 55 наблюдений пациентов с акне, которые получали лечение в КВД Санкт-Петербурга в 2013 г. Изучение КМП проводилось с применением Автоматизированной технологии экспертизы КМП. Результаты. Доля случаев оказания медицинской помощи надлежащего качества пациентам с акне составляла 49%. В структуре ошибок оказания медицинской помощи преобладали ошибки лечения и диагноза. Ошибки лечения были представлены преимущественно неверным сочетанием препаратов, наиболее часто одномоментным назначением антибактериальных препаратов для наружного и системного применения, поздним назначением комедолитической терапии, а также применением патогенетически необоснованной терапии. Ошибками постановки диагноза считали отсутствие указаний на форму и/или степень тяжести акне, наиболее важными ошибками сбора информации - отсутствие обследования женщин у гинеколога для решения вопроса о необходимости применения комбинированных оральных контрацептивов, в том числе и при назначении изотретиноина. Заключение. Сходство характера ошибок медицинской помощи при акне, а также их высокий удельный вес при оказании медицинской помощи пациентам требуют разработки системных мероприятий по улучшению КМП этим больным и повторной экспертизы с применением индикаторов промежуточного (оперативного) контроля КМП

Measurement of the Xi-p Scattering Cross Sections at Low Energy

In this paper we report cross-section measurements for $\Xi^-p$ elastic and inelastic scatterings at low energy using a scintillating fiber active target. Upper limit on the total cross-section for the elastic scattering was found to be 24 mb at 90% confidence level, and the total cross section for the $\Xi^-p\to\Lambda\Lambda$ reaction was found to be $4.3^{+6.3}_{-2.7}$ mb. We compare the results with currently competing theoretical estimates.Comment: 9 page

Genetic parameter estimations of new traits of morphological quality on gilthead seabream (Sparus aurata) by using IMAFISH_ML software

In this study, a total of 18 novel productive traits, three related to carcass [cNiT] and fifteen related to morphometric [mNiT]), were measured in gilthead seabream (Sparus aurata) using Non-invasive Technologies (NiT) as implemented in IMAFISH_ML (MatLab script). Their potential to be used in industrial breeding programs were evaluated in 2348 offspring reared under different production systems (estuarine ponds, oceanic cage, inland tank) at harvest. All animals were photographed, and digitally measured and main genetic parameters were estimated. Heritability for growth traits was medium (0.25–0.37) whereas for NiT traits medium-high (0.24–0.61). In general, genetic correlations between mNiT, cNiT and growth and traits were high and positive. Image analysis artifacts such as fin unfold or shades, that may interfere in the precision of some digital measurements, were discarded as a major bias factor since heritability of NiT traits after correcting them were no significantly different from original ones. Indirect selection of growth traits through NiT traits produced a better predicted response than directly measuring Body Weight (13–23%), demonstrating that this methodological approach is highly cost-effective in terms of accuracy and data processing time.Versión del edito

The COSINE-100 liquid scintillator veto system

This paper describes the liquid scintillator veto system for the COSINE-100 dark matter experiment and its performance. The COSINE-100 detector consists of eight NaI(Tl) crystals immersed in 2200 L of linear alkylbenzene-based liquid scintillator. The liquid scintillator tags between 65 and 75% of the internal 40K background in the 2–6 keV energy region. We also describe the background model for the liquid scintillator, which is primarily used to assess its energy calibration and threshold

Search for sterile neutrino oscillation using RENO and NEOS data

We present a reactor model independent search for sterile neutrino oscillation using 2\,509\,days of RENO near detector data and 180 days of NEOS data. The reactor related systematic uncertainties are significantly suppressed as both detectors are located at the same reactor complex of Hanbit Nuclear Power Plant. The search is performed by electron antineutrino\,($\overline{\nu}_e$) disappearance between six reactors and two detectors with baselines of 294\,m\,(RENO) and 24\,m\,(NEOS). A spectral comparison of the NEOS prompt-energy spectrum with a no-oscillation prediction from the RENO measurement can explore reactor $\overline{\nu}_e$ oscillations to sterile neutrino. Based on the comparison, we obtain a 95\% C.L. excluded region of $0.1<|\Delta m_{41}^2|<7$\,eV$^2$. We also obtain a 68\% C.L. allowed region with the best fit of $|\Delta m_{41}^2|=2.41\,\pm\,0.03\,$\,eV$^2$ and $\sin^2 2\theta_{14}$=0.08$\,\pm\,$0.03 with a p-value of 8.2\%. Comparisons of obtained reactor antineutrino spectra at reactor sources are made among RENO, NEOS, and Daya Bay to find a possible spectral variation.Comment: 6 pages, 5 figures: This manuscript has been significantly revised by the joint reanalysis by RENO and NEOS Collaborations. (In the previous edition, the RENO collaboration used publicly available NEOS data to evaluate the expected neutrino spectrum at NEOS.

Measurement of the cosmic muon annual and diurnal flux variation with the COSINE-100 detector

We report measurements of annual and diurnal modulations of the cosmic-ray muon rate in the Yangyang underground laboratory (Y2L) using 952 days of COSINE-100 data acquired between September 2016 and July 2019. A correlation of the muon rate with the atmospheric temperature is observed and its amplitude on the muon rate is determined. The effective atmospheric temperature and muon rate variations are positively correlated with a measured effective temperature coefficient of αT = 0.80 ± 0.11. This result is consistent with a model of meson production in the atmosphere. We also searched for a diurnal modulation in the underground muon rate by comparing one-hour intervals. No significant diurnal modulation of the muon rate was observed

Context-dependent interactions and the regulation of species richness in freshwater fish

Species richness is regulated by a complex network of scale-dependent processes. This complexity can obscure the influence of limiting species interactions,

Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats

Peer reviewe

Search for boosted dark matter in COSINE-100

We search for energetic electron recoil signals induced by boosted dark matter (BDM) from the galactic center using the COSINE-100 array of NaI(Tl) crystal detectors at the Yangyang Underground Laboratory. The signal would be an excess of events with energies above 4 MeV over the well-understood background. Because no excess of events are observed in a 97.7 kg·yr exposure, we set limits on BDM interactions under a variety of hypotheses. Notably, we explored the dark photon parameter space, leading to competitive limits compared to direct dark photon search experiments, particularly for dark photon masses below 4 MeV and considering the invisible decay mode. Furthermore, by comparing our results with a previous BDM search conducted by the Super-Kamionkande experiment, we found that the COSINE-100 detector has advantages in searching for low-mass dark matter. This analysis demonstrates the potential of the COSINE-100 detector to search for MeV electron recoil signals produced by the dark sector particle interactions

An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA’s analysis method

The DAMA/LIBRA collaboration has reported the observation of an annual modulation in the event rate that has been attributed to dark matter interactions over the last two decades. However, even though tremendous efforts to detect similar dark matter interactions were pursued, no definitive evidence has been observed to corroborate the DAMA/LIBRA signal. Many studies assuming various dark matter models have attempted to reconcile DAMA/LIBRA’s modulation signals and null results from other experiments, however no clear conclusion can be drawn. Apart from the dark matter hypothesis, several studies have examined the possibility that the modulation is induced by variations in detector’s environment or their specific analysis methods. In particular, a recent study presents a possible cause of the annual modulation from an analysis method adopted by the DAMA/LIBRA experiment in which the observed annual modulation could be reproduced by a slowly varying time-dependent background. Here, we study the COSINE-100 data using an analysis method similar to the one adopted by the DAMA/LIBRA experiment and observe a significant annual modulation, however the modulation phase is almost opposite to that of the DAMA/LIBRA data. Assuming the same background composition for COSINE-100 and DAMA/LIBRA, simulated experiments for the DAMA/LIBRA without dark matter signals also provide significant annual modulation with an amplitude similar to DAMA/LIBRA with opposite phase. Even though this observation does not directly explain the DAMA/LIBRA results directly, this interesting phenomenon motivates more profound studies of the time-dependent DAMA/LIBRA background data