Measurement of CP observables in B± → D(⁎)K± and B± → D(⁎)π± decays

Measurements of CP observables in B ± →D (⁎) K ± and B ± →D (⁎) π ± decays are presented, where D (⁎) indicates a neutral D or D ⁎ meson that is an admixture of D (⁎)0 and D¯ (⁎)0 states. Decays of the D ⁎ meson to the Dπ 0 and Dγ final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± π ∓ , K + K − and π + π − final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb −1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± →D ⁎ K ± and B ± →D ⁎ π ± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± →DK ± and B ± →Dπ ± decays is an update of previous LHCb measurements. The B ± →DK ± results are the most precise to date

First observation of forward Z→bbˉZ \rightarrow b \bar{b} production in pppp collisions at s=8\sqrt{s}=8 TeV

The decay Z→bb¯ is reconstructed in pp collision data, corresponding to 2 fb −1 of integrated luminosity, collected by the LHCb experiment at a centre-of-mass energy of s=8 TeV. The product of the Z production cross-section and the Z→bb¯ branching fraction is measured for candidates in the fiducial region defined by two particle-level b -quark jets with pseudorapidities in the range 2.220 GeV and dijet invariant mass in the range 4520$GeV and dijet invariant mass in the range$45 < m_{jj} < 165$GeV. From a signal yield of$5462 \pm 763$$Z \rightarrow b \bar{b}$events, where the uncertainty is statistical, a production cross-section times branching fraction of$332 \pm 46 \pm 59$pb is obtained, where the first uncertainty is statistical and the second systematic. The measured significance of the signal yield is 6.0 standard deviations. This measurement represents the first observation of the$Z \rightarrow b \bar{b}$production in the forward region of$pp$ collisions

Glycosaminoglycans, protein aggregation and neurodegeneration.

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HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology

Item does not contain fulltextHeparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates. In Alzheimer's disease, heparan sulphates accumulate at the intracellular level in disease neurons where they co-localize with the neurofibrillary pathology, while they persist at the neuronal cell membrane in normal brain. However, it is unknown whether HS3ST2 and its 3-O-sulphated heparan sulphate products are involved in the mechanisms leading to the abnormal phosphorylation of tau in Alzheimer's disease and related tauopathies. Here, we first measured the transcript levels of all human heparan sulphate sulphotransferases in hippocampus of Alzheimer's disease (n = 8; 76.8 +/- 3.5 years old) and found increased expression of HS3ST2 (P < 0.001) compared with control brain (n = 8; 67.8 +/- 2.9 years old). Then, to investigate whether the membrane-associated 3-O-sulphated heparan sulphates translocate to the intracellular level under pathological conditions, we used two cell models of tauopathy in neuro-differentiated SH-SY5Y cells: a tau mutation-dependent model in cells expressing human tau carrying the P301L mutation hTau(P301L), and a tau mutation-independent model in where tau hyperphosphorylation is induced by oxidative stress. Confocal microscopy, fluorescence resonance energy transfer, and western blot analyses showed that 3-O-sulphated heparan sulphates can be internalized into cells where they interact with tau, promoting its abnormal phosphorylation, but not that of p38 or NF-kappaB p65. We showed, in vitro, that the 3-O-sulphated heparan sulphates bind to tau, but not to GSK3B, protein kinase A or protein phosphatase 2, inducing its abnormal phosphorylation. Finally, we demonstrated in a zebrafish model of tauopathy expressing the hTau(P301L), that inhibiting hs3st2 (also known as 3ost2) expression results in a strong inhibition of the abnormally phosphorylated tau epitopes in brain and in spinal cord, leading to a complete recovery of motor neuronal axons length (n = 25; P < 0.005) and of the animal motor response to touching stimuli (n = 150; P < 0.005). Our findings indicate that HS3ST2 centrally participates to the molecular mechanisms leading the abnormal phosphorylation of tau. By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau. We propose HS3ST2 as a novel therapeutic target for Alzheimer's disease

International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

•We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's. Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days. Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs. Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically

Measurement of CP asymmetries in two-body B-(s)(0)-meson decays to charged pions and kaons

The time-dependent CP asymmetries in B0\u2192\u3c0+\u3c0- and Bs0\u2192K+K- decays are measured using a data sample of p p collisions corresponding to an integrated luminosity of 3.0 fb-1, collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV. The same data sample is used to measure the time-integrated CP asymmetries in B0\u2192K+\u3c0- and Bs0\u2192\u3c0+K- decays. The results are C\u3c0+\u3c0-=-0.34\ub10.06\ub10.01, S\u3c0+\u3c0-=-0.63\ub10.05\ub10.01, CK+K-=0.20\ub10.06\ub10.02, SK+K-=0.18\ub10.06\ub10.02, AK+K-\u394\u393=-0.79\ub10.07\ub10.10, ACPB0=-0.084\ub10.004\ub10.003, and ACPBs0=0.213\ub10.015\ub10.007, where the first uncertainties are statistical and the second systematic. Evidence for CP violation is found in the Bs0\u2192K+K- decay for the first time

Evidence for the Rare Decay Sigma(+) -> p mu(+)mu(-)

none796A search for the rare decay Σ+→pμ+μ- is performed using pp collision data recorded by the LHCb experiment at center-of-mass energies s=7 and 8 TeV, corresponding to an integrated luminosity of 3 fb-1. An excess of events is observed with respect to the background expectation, with a signal significance of 4.1 standard deviations. No significant structure is observed in the dimuon invariant mass distribution, in contrast with a previous result from the HyperCP experiment. The measured Σ+→pμ+μ- branching fraction is (2.2-1.3+1.8)×10-8, where statistical and systematic uncertainties are included, which is consistent with the standard model prediction.noneAaij R.; Adeva B.; Adinolfi M.; Ajaltouni Z.; Akar S.; Albrecht J.; Alessio F.; Alexander M.; Alfonso Albero A.; Ali S.; Alkhazov G.; Alvarez Cartelle P.; Alves A.A.; Amato S.; Amerio S.; Amhis Y.; An L.; Anderlini L.; Andreassi G.; Andreotti M.; Andrews J.E.; Appleby R.B.; Archilli F.; D'Argent P.; Arnau Romeu J.; Artamonov A.; Artuso M.; Aslanides E.; Atzeni M.; Auriemma G.; Baalouch M.; Babuschkin I.; Bachmann S.; Back J.J.; Badalov A.; Baesso C.; Baker S.; Balagura V.; Baldini W.; Baranov A.; Barlow R.J.; Barschel C.; Barsuk S.; Barter W.; Baryshnikov F.; Batozskaya V.; Battista V.; Bay A.; Beaucourt L.; Beddow J.; Bedeschi F.; Bediaga I.; Beiter A.; Bel L.J.; Beliy N.; Bellee V.; Belloli N.; Belous K.; Belyaev I.; Ben-Haim E.; Bencivenni G.; Benson S.; Beranek S.; Berezhnoy A.; Bernet R.; Berninghoff D.; Bertholet E.; Bertolin A.; Betancourt C.; Betti F.; Bettler M.O.; Van Beuzekom M.; Bezshyiko I.; Bifani S.; Billoir P.; Birnkraut A.; Bizzeti A.; Bjorn M.; Blake T.; Blanc F.; Blusk S.; Bocci V.; Boettcher T.; Bondar A.; Bondar N.; Bordyuzhin I.; Borghi S.; Borisyak M.; Borsato M.; Bossu F.; Boubdir M.; Bowcock T.J.V.; Bowen E.; Bozzi C.; Braun S.; Brodzicka J.; Brundu D.; Buchanan E.; Burr C.; Bursche A.; Buytaert J.; Byczynski W.; Cadeddu S.; Cai H.; Calabrese R.; Calladine R.; Calvi M.; Calvo Gomez M.; Camboni A.; Campana P.; Campora Perez D.H.; Capriotti L.; Carbone A.; Carboni G.; Cardinale R.; Cardini A.; Carniti P.; Carson L.; Carvalho Akiba K.; Casse G.; Cassina L.; Cattaneo M.; Cavallero G.; Cenci R.; Chamont D.; Chapman M.G.; Charles M.; Charpentier P.; Chatzikonstantinidis G.; Chefdeville M.; Chen S.; Cheung S.F.; Chitic S.-G.; Chobanova V.; Chrzaszcz M.; Chubykin A.; Ciambrone P.; Cid Vidal X.; Ciezarek G.; Clarke P.E.L.; Clemencic M.; Cliff H.V.; Closier J.; Coco V.; Cogan J.; Cogneras E.; Cogoni V.; Cojocariu L.; Collins P.; Colombo T.; Comerma-Montells A.; Contu A.; Coombs G.; Coquereau S.; Corti G.; Corvo M.; Costa Sobral C.M.; Couturier B.; Cowan G.A.; Craik D.C.; Crocombe A.; Cruz Torres M.; Currie R.; D'Ambrosio C.; Da Cunha Marinho F.; Da Silva C.L.; Dall'Occo E.; Dalseno J.; Davis A.; De Aguiar Francisco O.; De Bruyn K.; De Capua S.; De Cian M.; De Miranda J.M.; De Paula L.; De Serio M.; De Simone P.; Dean C.T.; Decamp D.; Del Buono L.; Dembinski H.-P.; Demmer M.; Dendek A.; Derkach D.; Deschamps O.; Dettori F.; Dey B.; Di Canto A.; Di Nezza P.; Dijkstra H.; Dordei F.; Dorigo M.; Dosil Suarez A.; Douglas L.; Dovbnya A.; Dreimanis K.; Dufour L.; Dujany G.; Durante P.; Durham J.M.; Dutta D.; Dzhelyadin R.; Dziewiecki M.; Dziurda A.; Dzyuba A.; Easo S.; Egede U.; Egorychev V.; Eidelman S.; Eisenhardt S.; Eitschberger U.; Ekelhof R.; Eklund L.; Ely S.; Esen S.; Evans H.M.; Evans T.; Falabella A.; Farley N.; Farry S.; Fazzini D.; Federici L.; Ferguson D.; Fernandez G.; Fernandez Declara P.; Fernandez Prieto A.; Ferrari F.; Ferreira Lopes L.; Ferreira Rodrigues F.; Ferro-Luzzi M.; Filippov S.; Fini R.A.; Fiorini M.; Firlej M.; Fitzpatrick C.; Fiutowski T.; Fleuret F.; Fontana M.; Fontanelli F.; Forty R.; Franco Lima V.; Frank M.; Frei C.; Fu J.; Funk W.; Furfaro E.; Farber C.; Gabriel E.; Gallas Torreira A.; Galli D.; Gallorini S.; Gambetta S.; Gandelman M.; Gandini P.; Gao Y.; Garcia Martin L.M.; Garcia Pardinas J.; Garra Tico J.; Garrido L.; Gascon D.; Gaspar C.; Gavardi L.; Gazzoni G.; Gerick D.; Gersabeck E.; Gersabeck M.; Gershon T.; Ghez P.; Giani S.; Gibson V.; Girard O.G.; Giubega L.; Gizdov K.; Gligorov V.V.; Golubkov D.; Golutvin A.; Gomes A.; Gorelov I.V.; Gotti C.; Govorkova E.; Grabowski J.P.; Graciani Diaz R.; Granado Cardoso L.A.; Grauges E.; Graverini E.; Graziani G.; Grecu A.; Greim R.; Griffith P.; Grillo L.; Gruber L.; Gruberg Cazon B.R.; Grunberg O.; Gushchin E.; Guz Y.; Gys T.; Gobel C.; Hadavizadeh T.; Hadjivasiliou C.; Haefeli G.; Haen C.; Haines S.C.; Hamilton B.; Han X.; Hancock T.H.; Hansmann-Menzemer S.; Harnew N.; Harnew S.T.; Hasse C.; Hatch M.; He J.; Hecker M.; Heinicke K.; Heister A.; Hennessy K.; Henrard P.; Henry L.; Van Herwijnen E.; Hess M.; Hicheur A.; Hill D.; Hopchev P.H.; Hu W.; Huang W.; Huard Z.C.; Hulsbergen W.; Humair T.; Hushchyn M.; Hutchcroft D.; Ibis P.; Idzik M.; Ilten P.; Jacobsson R.; Jalocha J.; Jans E.; Jawahery A.; Jiang F.; John M.; Johnson D.; Jones C.R.; Joram C.; Jost B.; Jurik N.; Kandybei S.; Karacson M.; Kariuki J.M.; Karodia S.; Kazeev N.; Kecke M.; Keizer F.; Kelsey M.; Kenzie M.; Ketel T.; Khairullin E.; Khanji B.; Khurewathanakul C.; Kim K.E.; Kirn T.; Klaver S.; Klimaszewski K.; Klimkovich T.; Koliiev S.; Kolpin M.; Kopecna R.; Koppenburg P.; Kosmyntseva A.; Kotriakhova S.; Kozeiha M.; Kravchuk L.; Kreps M.; Kress F.; Krokovny P.; Krzemien W.; Kucewicz W.; Kucharczyk M.; Kudryavtsev V.; Kuonen A.K.; Kvaratskheliya T.; Lacarrere D.; Lafferty G.; Lai A.; Lanfranchi G.; Langenbruch C.; Latham T.; Lazzeroni C.; Le Gac R.; Leflat A.; Lefrancois J.; Lefevre R.; Lemaitre F.; Lemos Cid E.; Leroy O.; Lesiak T.; Leverington B.; Li P.-R.; Li T.; Li Y.; Li Z.; Liang X.; Likhomanenko T.; Lindner R.; Lionetto F.; Lisovskyi V.; Liu X.; Loh D.; Loi A.; Longstaff I.; Lopes J.H.; Lucchesi D.; Lucio Martinez M.; Luo H.; Lupato A.; Luppi E.; Lupton O.; Lusiani A.; Lyu X.; Machefert F.; Maciuc F.; Macko V.; Mackowiak P.; Maddrell-Mander S.; Maev O.; Maguire K.; Maisuzenko D.; Majewski M.W.; Malde S.; Malecki B.; Malinin A.; Maltsev T.; Manca G.; Mancinelli G.; Marangotto D.; Maratas J.; Marchand J.F.; Marconi U.; Marin Benito C.; Marinangeli M.; Marino P.; Marks J.; Martellotti G.; Martin M.; Martinelli M.; Martinez Santos D.; Martinez Vidal F.; Massafferri A.; Matev R.; Mathad A.; Mathe Z.; Matteuzzi C.; Mauri A.; Maurice E.; Maurin B.; Mazurov A.; McCann M.; McNab A.; McNulty R.; Mead J.V.; Meadows B.; Meaux C.; Meier F.; Meinert N.; Melnychuk D.; Merk M.; Merli A.; Michielin E.; Milanes D.A.; Millard E.; Minard M.-N.; Minzoni L.; Mitzel D.S.; Mogini A.; Molina Rodriguez J.; Mombacher T.; Monroy I.A.; Monteil S.; Morandin M.; Morello M.J.; Morgunova O.; Moron J.; Morris A.B.; Mountain R.; Muheim F.; Mulder M.; Muller D.; Muller J.; Muller K.; Muller V.; Naik P.; Nakada T.; Nandakumar R.; Nandi A.; Nasteva I.; Needham M.; Neri N.; Neubert S.; Neufeld N.; Neuner M.; Nguyen T.D.; Nguyen-Mau C.; Nieswand S.; Niet R.; Nikitin N.; Nikodem T.; Nogay A.; O'Hanlon D.P.; Oblakowska-Mucha A.; Obraztsov V.; Ogilvy S.; Oldeman R.; Onderwater C.J.G.; Ossowska A.; Otalora Goicochea J.M.; Owen P.; Oyanguren A.; Pais P.R.; Palano A.; Palutan M.; Panshin G.; Papanestis A.; Pappagallo M.; Pappalardo L.L.; Parker W.; Parkes C.; Passaleva G.; Pastore A.; Patel M.; Patrignani C.; Pearce A.; Pellegrino A.; Penso G.; Pepe Altarelli M.; Perazzini S.; Pereima D.; Perret P.; Pescatore L.; Petridis K.; Petrolini A.; Petrov A.; Petruzzo M.; Picatoste Olloqui E.; Pietrzyk B.; Pietrzyk G.; Pikies M.; Pinci D.; Pisani F.; Pistone A.; Piucci A.; Placinta V.; Playfer S.; Plo Casasus M.; Polci F.; Poli Lener M.; Poluektov A.; Polyakov I.; Polycarpo E.; Pomery G.J.; Ponce S.; Popov A.; Popov D.; Poslavskii S.; Potterat C.; Price E.; Prisciandaro J.; Prouve C.; Pugatch V.; Puig Navarro A.; Pullen H.; Punzi G.; Qian W.; Qin J.; Quagliani R.; Quintana B.; Rachwal B.; Rademacker J.H.; Rama M.; Ramos Pernas M.; Rangel M.S.; Raniuk I.; Ratnikov F.; Raven G.; Ravonel Salzgeber M.; Reboud M.; Redi F.; Reichert S.; Dos Reis A.C.; Remon Alepuz C.; Renaudin V.; Ricciardi S.; Richards S.; Rihl M.; Rinnert K.; Robbe P.; Robert A.; Rodrigues A.B.; Rodrigues E.; Rodriguez Lopez J.A.; Rogozhnikov A.; Roiser S.; Rollings A.; Romanovskiy V.; Romero Vidal A.; Rotondo M.; Rudolph M.S.; Ruf T.; Ruiz Valls P.; Ruiz Vidal J.; Saborido Silva J.J.; Sadykhov E.; Sagidova N.; Saitta B.; Salustino Guimaraes V.; Sanchez Mayordomo C.; Sanmartin Sedes B.; Santacesaria R.; Santamarina Rios C.; Santimaria M.; Santovetti E.; Sarpis G.; Sarti A.; Satriano C.; Satta A.; Saunders D.M.; Savrina D.; Schael S.; Schellenberg M.; Schiller M.; Schindler H.; Schmelling M.; Schmelzer T.; Schmidt B.; Schneider O.; Schopper A.; Schreiner H.F.; Schubiger M.; Schune M.H.; Schwemmer R.; Sciascia B.; Sciubba A.; Semennikov A.; Sepulveda E.S.; Sergi A.; Serra N.; Serrano J.; Sestini L.; Seyfert P.; Shapkin M.; Shcheglov Y.; Shears T.; Shekhtman L.; Shevchenko V.; Siddi B.G.; Silva Coutinho R.; Silva De Oliveira L.; Simi G.; Simone S.; Sirendi M.; Skidmore N.; Skwarnicki T.; Smith I.T.; Smith J.; Smith M.; Soares Lavra L.; Sokoloff M.D.; Soler F.J.P.; Souza De Paula B.; Spaan B.; Spradlin P.; Stagni F.; Stahl M.; Stahl S.; Stefko P.; Stefkova S.; Steinkamp O.; Stemmle S.; Stenyakin O.; Stepanova M.; Stevens H.; Stone S.; Storaci B.; Stracka S.; Stramaglia M.E.; Straticiuc M.; Straumann U.; Strokov S.; Sun J.; Sun L.; Swientek K.; Syropoulos V.; Szumlak T.; Szymanski M.; T'Jampens S.; Tayduganov A.; Tekampe T.; Tellarini G.; Teubert F.; Thomas E.; Van Tilburg J.; Tilley M.J.; Tisserand V.; Tobin M.; Tolk S.; Tomassetti L.; Tonelli D.; Tourinho Jadallah Aoude R.; Tournefier E.; Traill M.; Tran M.T.; Tresch M.; Trisovic A.; Tsaregorodtsev A.; Tsopelas P.; Tully A.; Tuning N.; Ukleja A.; Usachov A.; Ustyuzhanin A.; Uwer U.; Vacca C.; Vagner A.; Vagnoni V.; Valassi A.; Valat S.; Valenti G.; Vazquez Gomez R.; Vazquez Regueiro P.; Vecchi S.; Van Veghel M.; Velthuis J.J.; Veltri M.; Veneziano G.; Venkateswaran A.; Verlage T.A.; Vernet M.; Vesterinen M.; Viana Barbosa J.V.; Vieira D.; Vieites Diaz M.; Viemann H.; Vilasis-Cardona X.; Vitti M.; Volkov V.; Vollhardt A.; Voneki B.; Vorobyev A.; Vorobyev V.; Voss C.; De Vries J.A.; Vazquez Sierra C.; Waldi R.; Walsh J.; Wang J.; Wang Y.; Ward D.R.; Wark H.M.; Watson N.K.; Websdale D.; Weiden A.; Weisser C.; Whitehead M.; Wicht J.; Wilkinson G.; Wilkinson M.; Williams M.; Williams M.; Williams T.; Wilson F.F.; Wimberley J.; Winn M.; Wishahi J.; Wislicki W.; Witek M.; Wormser G.; Wotton S.A.; Wyllie K.; Xie Y.; Xu M.; Xu Q.; Xu Z.; Xu Z.; Yang Z.; Yang Z.; Yao Y.; Yin H.; Yu J.; Yuan X.; Yushchenko O.; Zarebski K.A.; Zavertyaev M.; Zhang L.; Zhang Y.; Zhelezov A.; Zheng Y.; Zhu X.; Zhukov V.; Zonneveld J.B.; Zucchelli S.Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Alfonso Albero, A.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Archilli, F.; D'Argent, P.; Arnau Romeu, J.; Artamonov, A.; Artuso, M.; Aslanides, E.; Atzeni, M.; Auriemma, G.; Baalouch, M.; Babuschkin, I.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Balagura, V.; Baldini, W.; Baranov, A.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Baryshnikov, F.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Beiter, A.; Bel, L. J.; Beliy, N.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Beranek, S.; Berezhnoy, A.; Bernet, R.; Berninghoff, D.; Bertholet, E.; Bertolin, A.; Betancourt, C.; Betti, F.; Bettler, M. O.; Van Beuzekom, M.; Bezshyiko, I.; Bifani, S.; Billoir, P.; Birnkraut, A.; Bizzeti, A.; Bjorn, M.; Blake, T.; Blanc, F.; Blusk, S.; Bocci, V.; Boettcher, T.; Bondar, A.; Bondar, N.; Bordyuzhin, I.; Borghi, S.; Borisyak, M.; Borsato, M.; Bossu, F.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brodzicka, J.; Brundu, D.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Byczynski, W.; Cadeddu, S.; Cai, H.; Calabrese, R.; Calladine, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D. H.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Cattaneo, M.; Cavallero, G.; Cenci, R.; Chamont, D.; Chapman, M. G.; Charles, M.; Charpentier, P.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, S. F.; Chitic, S. -G.; Chobanova, V.; Chrzaszcz, M.; Chubykin, A.; Ciambrone, P.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collins, P.; Colombo, T.; Comerma-Montells, A.; Contu, A.; Coombs, G.; Coquereau, S.; Corti, G.; Corvo, M.; Costa Sobral, C. M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Currie, R.; D'Ambrosio, C.; Da Cunha Marinho, F.; Da Silva, C. L.; Dall'Occo, E.; Dalseno, J.; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Serio, M.; De Simone, P.; Dean, C. T.; Decamp, D.; Del Buono, L.; Dembinski, H. -P.; Demmer, M.; Dendek, A.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Nezza, P.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Douglas, L.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Durante, P.; Durham, J. M.; Dutta, D.; Dzhelyadin, R.; Dziewiecki, M.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Farley, N.; Farry, S.; Fazzini, D.; Federici, L.; Ferguson, D.; Fernandez, G.; Fernandez Declara, P.; Fernandez Prieto, A.; Ferrari, F.; Ferreira Lopes, L.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fini, R. A.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fontana, M.; Fontanelli, F.; Forty, R.; Franco Lima, V.; Frank, M.; Frei, C.; Fu, J.; Funk, W.; Furfaro, E.; Farber, C.; Gabriel, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garcia Martin, L. M.; Garcia Pardinas, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, P.; Giani, S.; Gibson, V.; Girard, O. 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First Observation of the Rare Purely Baryonic Decay &ITB&IT0 -> &ITp&IT(&ITp&IT)over-bar-

The first observation of the decay of a B0 meson to a purely baryonic final state, B-0 -> p$(p)over-bar-$ , is reported. The proton-proton collision data sample used was collected with the LHCb experiment at center-of-mass energies of 7 and 8 TeV and corresponds to an integrated luminosity of 3.0 fb(-1). The branching fraction is determined to be B(B-0 -> p$(p)over-bar-$) = (1.25 +/- 0.27 +/- 0.18) x 10(-8), where the first uncertainty is statistical and the second systematic. The decay mode B-0 -> p$(p)over-bar-$ is the rarest decay of the B-0 meson observed to date. The decay B-s(0 )-> p$(p)over-bar-$ is also investigated. No signal is seen and the upper limit B(B-s(0) -> p$(p)over-bar-$) < 1.5 x 10(-8) at 90% confidence level is set on the branching fraction

Search for the rare decay Lambda(+)(c) -> p mu(+ )mu(-)

A search for the flavor-changing neutral-current decay \u39bc+\u2192p\u3bc+\u3bc- is reported using a data set corresponding to an integrated luminosity of 3.0 fb-1 collected by the LHCb Collaboration. No significant signal is observed outside of the dimuon mass regions around the \u3c6 and \u3c9 resonances, and an upper limit is placed on the branching fraction of B(\u39bc+\u2192p\u3bc+\u3bc-)&lt;7.7(9.6) 710-8 at 90%(95%) confidence level. A significant signal is observed in the \u3c9 dimuon mass region for the first time

Observation of B-s(0) -> (D)over-bar*(0)phi and search for B-0 -> (D)over-bar(0)phi decays

The first observation of the Bs0\u2192D\u304 170\u3c6 decay is reported, with a significance of more than seven standard deviations, from an analysis of pp collision data corresponding to an integrated luminosity of 3 fb-1, collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV. The branching fraction is measured relative to that of the topologically similar decay B0\u2192D\u3040\u3c0+\u3c0- and is found to be B(Bs0\u2192D\u304 170\u3c6)=(3.7\ub10.5\ub10.3\ub10.2) 710-5, where the first uncertainty is statistical, the second systematic, and the third from the branching fraction of the B0\u2192D\u3040\u3c0+\u3c0- decay. The fraction of longitudinal polarization in this decay is measured to be fL=(73\ub115\ub14)%. The most precise determination of the branching fraction for the Bs0\u2192D\u3040\u3c6 decay is also obtained, B(Bs0\u2192D\u3040\u3c6)=(3.0\ub10.3\ub10.2\ub10.2) 710-5. An upper limit, B(B0\u2192D\u3040\u3c6)&lt;2.0 (2.3) 710-6 at 90% (95%) confidence level is set. A constraint on the \u3c9-\u3c6 mixing angle \u3b4 is set at |\u3b4|&lt;5.2\ub0 (5.5\ub0) at 90% (95%) confidence level