Christophe, M.

Fernando, S.

Huynh, M.B.

Ludmilla, S.

Papy-Garcia, D.

Raisman-Vozari, R.

Sepulveda-Diaz, J.E.

International audienceA number of neurodegenerative diseases, as Parkinson, prion, and Alzheimer's diseases, has been directly associated with altered conformations of certain peptides or proteins that assemble to form highly organized aggregates, also called amyloid fibers. Glycosaminoglycans have shown to play important roles on fibrils formation, stability and resistance to proteolysis. This manuscript reviews from basic concepts on the biochemistry and biology of glycosaminoglycans to their implications in neurodegeneration with particular emphasis in pathologic protein aggregation. Prion protein, Aβ42, Tau, and α-synuclein, are all proteins that can interact with glycosaminoglycans. We document here how these interactions may modify protein conformation, aggregation kinetics, and fibers stabilization with important consequences in disease. We also raise questions which answers may make advance the understanding of the implication of GAGs in neurodegeneration

Papy-Garcia, Dulce

Christophe, Morin

Huynh, Minh Bao

Fernando, Sineriz

Ludmilla, Sissoeff

Sepulveda-Diaz, Julia Elisa

Raisman-Vozari, Rita

HAL - UPEC / UPEM

Glycosaminoglycans, protein aggregation and neurodegeneration.

Hal-Diderot

HAL Descartes

Radboud Repository

NARCIS 

Archive Ouverte en Sciences de l'Information et de la Communication

Glycosaminoglycans, protein aggregation and neurodegeneration.

Abstract

Similar works

Full text