108 research outputs found
A conservation roadmap for the subterranean biome
- Author
- Amorim Isabel R.
- Bichuette Maria Elina
- Biswas Jayant
- BlackEagle Cory W.
- Boonyanusith Chaichat
- Boston Penelope J.
- Cal Reynold N.
- Cardoso Pedro
- Cheeptham Naowarat
- Deharveng Louis
- Di Lorenzo Tiziana
- Eme David
- Faille Arnaud
- Fenolio Dante
- Ferreira Rodrigo Lopes
- Fiser Cene
- Fiser Ziga
- Galassi Diana M. P.
- Gon Samuel M. Ohukaniohia
- Goudarzi Forough
- Griebler Christian
- Halse Stuart
- Hoch Hannelore
- Howarth Francis G.
- Kale Enock
- Katz Aron D.
- Kovac Lubomir
- Lilley Thomas M.
- Mammola Stefano
- Manchi Shirish
- Manenti Raoul
- Martinez Alejandro
- Medellin Rodrigo A.
- Meierhofer Melissa B.
- Miller Ana Z.
- Miller Bruce W.
- Moldovan Oana Teodora
- Niemiller Matthew L.
- Peck Stewart B.
- Pellegrini Thais Giovannini
- Phillips-Lander Charity M.
- Pipan Tanja
- Poot Celso
- Racey Paul A.
- Sanchez-Fernandez David
- Sendra Alberto
- Shear William A.
- Silva Marconi Souza
- Taiti Stefano
- Tian Mingyi
- Venarsky Michael P.
- Vieira Borges Paulo Alexandre
- Wynne J. Judson
- Yancovic Pakarati Sebastian
- Zagmajster Maja
- Zhao Yahui
- Publication venue
- Publication date
- 01/09/2021
- Field of study
The 15th UN Convention on Biological Diversity (CBD) (COP15) will be held in Kunming, China in October 2021. Historically, CBDs and other multilateral treaties have either alluded to or entirely overlooked the subterranean biome. A multilateral effort to robustly examine, monitor, and incorporate the subterranean biome into future conservation targets will enable the CBD to further improve the ecological effectiveness of protected areas by including groundwater resources, subterranean ecosystem services, and the profoundly endemic subsurface biodiversity. To this end, we proffer a conservation roadmap that embodies five conceptual areas: (1) science gaps and data management needs; (2) anthropogenic stressors; (3) socioeconomic analysis and conflict resolution; (4) environmental education; and (5) national policies and multilateral agreements.Peer reviewe
The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems II: A 1 to 20 Micron Spectrum of the Planetary-Mass Companion VHS 1256-1257 b
- Author
- Absil Olivier
- Balmer William O.
- Biller Beth A.
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Briesemeister Zackery W.
- Bryan Marta L
- Calissendorff Per
- Cantalloube Faustine
- Carter Aarynn L.
- Chauvin Gael
- Chen Christine H.
- Choquet Elodie
- Christiaens Valentin
- Cugno Gabriele
- Currie Thayne
- Danielski Camilla
- De Furio Matthew
- Dupuy Trent J.
- Factor Samuel M.
- Faherty Jacqueline K.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Franson Kyle
- Girard Julien H.
- Gonzales Eileen C.
- Grady Carol A.
- Greenbaum Alexandra Z.
- Henning Thomas
- Hines Dean C.
- Hinkley Sasha
- Hoch Kielan K. W.
- Hood Callie E.
- Howe Alex R.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant M.
- Kenworthy Matthew A.
- Kervella Pierre
- Kraus Adam L.
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Lawson Kellen
- Lazzoni Cecilia
- Leisenring Jarron M.
- Lew Ben W. P.
- Liu Michael C.
- Liu Pengyu
- Llop-Sayson Jorge
- Lloyd James P.
- Macintosh Bruce
- Marino Sebastian
- Marley Mark S.
- Marois Christian
- Martinez Raquel A.
- Matthews Brenda C.
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael W.
- Metchev Stanimir
- Meyer Michael R.
- Miles Brittany E.
- Millar-Blanchaer Maxwell A.
- Molliere Paul
- Moran Sarah E.
- Morley Caroline V.
- Mukherjee Sagnick
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall D.
- Petrus Simon
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Ray Shrishmoy
- Rebollido Isabel
- Redai Jea Adams
- Ren Bin B.
- Rickman Emily
- Sallum Steph
- Samland Matthias
- Sargent B.
- Schlieder Joshua E.
- Schneider Glenn
- Skemer Andrew
- Stapelfeldt Karl R.
- Stone Jordan M.
- Tamura Motohide
- Tan Xianyu
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Vos Johanna M.
- Wagner Kevin
- Wang Jason J.
- Ward-Duong Kimberly
- Whiteford Niall
- Wolff Schuyler G.
- Worthen Kadin
- Wyatt Mark C.
- Ygouf Marie
- Zhang Keming
- Zhang Xi
- Zhang Zhoujian
- Zhou Yifan
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2023
- Field of study
We present the highest fidelity spectrum to date of a planetary-mass object.
VHS 1256 b is a <20 MJup widely separated (∼8\arcsec, a =
150 au), young, planetary-mass companion that shares photometric colors and
spectroscopic features with the directly imaged exoplanets HR 8799 c, d, and e.
As an L-to-T transition object, VHS 1256 b exists along the region of the
color-magnitude diagram where substellar atmospheres transition from cloudy to
clear. We observed VHS 1256~b with \textit{JWST}'s NIRSpec IFU and MIRI MRS
modes for coverage from 1 μm to 20 μm at resolutions of ∼1,000 -
3,700. Water, methane, carbon monoxide, carbon dioxide, sodium, and potassium
are observed in several portions of the \textit{JWST} spectrum based on
comparisons from template brown dwarf spectra, molecular opacities, and
atmospheric models. The spectral shape of VHS 1256 b is influenced by
disequilibrium chemistry and clouds. We directly detect silicate clouds, the
first such detection reported for a planetary-mass companion.Comment: Accepted ApJL Iterations of spectra reduced by the ERS team are
hosted at this link:
https://github.com/bemiles/JWST_VHS1256b_Reduction/tree/main/reduced_spectr
The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems IV: NIRISS Aperture Masking Interferometry Performance and Lessons Learned
- Author
- Absil Olivier
- Balmer William O.
- Betti Sarah K.
- Biller Beth
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Briesemeister Zackery W.
- Bryan Marta L.
- Calissendorff Per
- Cantalloube Faustine
- Carter Aarynn
- Chauvin Gael
- Chen Christine H.
- Choquet Elodie
- Christiaens Valentin
- Cooper Rachel
- Cugno Gabriele
- Currie Thayne
- Danielski Camilla
- de Furio Matthew
- Dupuy Trent J.
- Factor Samuel
- Faherty Jacqueline K.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Franson Kyle
- Girard Julien H.
- Gonzales Eileen C.
- Grady Carol A.
- Greebaum Alexandra Z.
- Henning Thomas
- Hines Dean C.
- Hinkley Sasha
- Hoch Kielan K. W.
- Hood Callie E.
- Howe Alex R.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant M.
- Kenworthy Matthew A.
- Kervella Pierre
- Kitzmann Daniel
- Kraus Adam L.
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Lawson Kellen
- Lazzoni Cecilia
- Leisenring Jarron M.
- Lew Ben W. P.
- Liu Michael C.
- Liu Pengyu
- Llop-Sayson Jorge
- Lloyd James P.
- Lueber Anna
- Macintosh Bruce
- Manjavacas Elena
- Marino Sebastian
- Marley Mark S.
- Marois Christian
- Martinez Raquel A.
- Matthews Brenda C.
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael W.
- Metchev Stanimir
- Meyer Michael
- Miles Brittany E.
- Millar-Blanchaer Maxwell A.
- Molliere Paul
- Moran Sarah E.
- Morley Caroline V.
- Mukherjee Sagnick
- Palma-Bifani Paulina
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall D.
- Petrus Simon
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Ray Shrishmoy
- Rebollido Isabel
- Redai Jea Adams
- Ren Bin B.
- Rickman Emily
- Sallum Steph
- Samland Matthias
- Sargent B. A.
- Schlieder Joshua E.
- Schneider Glenn
- Sivaramakrishnan Anand
- Skemer Andrew
- Stapelfeldt Karl R.
- Stone Jordan M.
- Suarez Genaro
- Sutlieff Ben J.
- Tamura Motohide
- Tan Xianyu
- Thatte Deepashri
- Theissen Christopher A.
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Vos Johanna M.
- Wagner Kevin
- Wang Jason J.
- Ward-Duong Kimberly
- Whiteford Niall
- Wolff Schuyler G.
- Worthen Kadin
- Wyatt Mark C.
- Ygouf Marie
- Zhang Keming
- Zhang Xi
- Zhang Zhoujian
- Zhou Yifan
- Publication venue
- Publication date
- 17/10/2023
- Field of study
We present a performance analysis for the aperture masking interferometry
(AMI) mode on board the James Webb Space Telescope Near Infrared Imager and
Slitless Spectrograph (JWST/NIRISS). Thanks to self-calibrating observables,
AMI accesses inner working angles down to and even within the classical
diffraction limit. The scientific potential of this mode has recently been
demonstrated by the Early Release Science (ERS) 1386 program with a deep search
for close-in companions in the HIP 65426 exoplanetary system. As part of ERS
1386, we use the same dataset to explore the random, static, and calibration
errors of NIRISS AMI observables. We compare the observed noise properties and
achievable contrast to theoretical predictions. We explore possible sources of
calibration errors, and show that differences in charge migration between the
observations of HIP 65426 and point-spread function calibration stars can
account for the achieved contrast curves. Lastly, we use self-calibration tests
to demonstrate that with adequate calibration, NIRISS AMI can reach contrast
levels of ∼9−10 mag. These tests lead us to observation planning
recommendations and strongly motivate future studies aimed at producing
sophisticated calibration strategies taking these systematic effects into
account. This will unlock the unprecedented capabilities of JWST/NIRISS AMI,
with sensitivity to significantly colder, lower mass exoplanets than
ground-based setups at orbital separations inaccessible to JWST coronagraphy.Comment: 20 pages, 12 figures, submitted to AAS Journal
The \textit{JWST} Early Release Science Program for Direct Observations of Exoplanetary Systems III: Aperture Masking Interferometric Observations of the star HIP\,65426 at 3.8μm
- Author
- Absil Olivier
- Balmer William O.
- Betti Sarah K.
- Biller Beth
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Briesemeister Zackery W.
- Bryan Marta L.
- Calissendorff Per
- Cantalloube Faustine
- Carter Aarynn
- Chauvin Gael
- Chen Christine H.
- Choquet Elodie
- Christiaens Valentin
- Cooper Rachel
- Cugno Gabriele
- Currie Thayne
- Danielski Camilla
- de Furio Matthew
- Dupuy Trent J.
- Factor Samuel
- Faherty Jacqueline K.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Franson Kyle
- Girard Julien H.
- Gonzales Eileen C.
- Grady Carol A.
- Greebaum Alexandra Z.
- Henning Thomas
- Hines Dean C.
- Hinkley Sasha
- Hoch Kielan K. W.
- Hood Callie E.
- Howe Alex R.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant M.
- Kenworthy Matthew A.
- Kervella Pierre
- Kitzmann Daniel
- Kraus Adam L.
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Lawson Kellen
- Lazzoni Cecilia
- Leisenring Jarron M.
- Lew Ben W. P.
- Liu Michael C.
- Liu Pengyu
- Llop-Sayson Jorge
- Lloyd James P.
- Lueber Anna
- Macintosh Bruce
- Manjavacas Elena
- Marino Sebastian
- Marley Mark S.
- Marois Christian
- Martinez Raquel A.
- Matthews Brenda C.
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael W.
- Metchev Stanimir
- Meyer Michael
- Miles Brittany E.
- Millar-Blanchaer Maxwell A.
- Molliere Paul
- Moran Sarah E.
- Morley Caroline V.
- Mukherjee Sagnick
- Palma-Bifani Paulina
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall D.
- Petrus Simon
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Ray Shrishmoy
- Rebollido Isabel
- Redai Jea Adams
- Ren Bin B.
- Rickman Emily
- Sallum Steph
- Samland Matthias
- Sargent B. A.
- Schlieder Joshua E.
- Schneider Glenn
- Sivamarakrishnan Anand
- Skemer Andrew
- Stapelfeldt Karl R.
- Stone Jordan M.
- Suarez Genaro
- Sutlieff Ben J.
- Tamura Motohide
- Tan Xianyu
- Thatte Deepashri
- Theissen Christopher A.
- Tokovinin Andrei
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Vos Johanna M.
- Wagner Kevin
- Wang Jason J.
- Ward-Duong Kimberly
- Whiteford Niall
- Wolff Schuyler G.
- Worthen Kadin
- Wyatt Mark C.
- Ygouf Marie
- Zhang Keming
- Zhang Xi
- Zhang Zhoujian
- Zhou Yifan
- Publication venue
- Publication date
- 17/10/2023
- Field of study
We present aperture masking interferometry (AMI) observations of the star HIP
65426 at 3.8μm as a part of the \textit{JWST} Direct Imaging Early
Release Science (ERS) program obtained using the Near Infrared Imager and
Slitless Spectrograph (NIRISS) instrument. This mode provides access to very
small inner working angles (even separations slightly below the Michelson limit
of 0.5λ/D for an interferometer), which are inaccessible with the
classical inner working angles of the \textit{JWST} coronagraphs. When combined
with \textit{JWST}'s unprecedented infrared sensitivity, this mode has the
potential to probe a new portion of parameter space across a wide array of
astronomical observations. Using this mode, we are able to achieve a contrast
of ΔmF380M∼7.8\,mag relative to the host star at a separation
of {\sim}0.07\arcsec but detect no additional companions interior to the
known companion HIP\,65426\,b. Our observations thus rule out companions more
massive than 10{-}12\,\rm{M\textsubscript{Jup}} at separations
∼10−20au from HIP\,65426, a region out of reach of ground or
space-based coronagraphic imaging. These observations confirm that the AMI mode
on \textit{JWST} is sensitive to planetary mass companions orbiting at the
water frost line, even for more distant stars at ∼100\,pc. This result
will allow the planning and successful execution of future observations to
probe the inner regions of nearby stellar systems, opening essentially
unexplored parameter space.Comment: 15 pages, 9 figures, submitted to ApJ Letter
Recommended from our members
The JWST Early-release Science Program for Direct Observations of Exoplanetary Systems II: A 1 to 20 μ m Spectrum of the Planetary-mass Companion VHS 1256–1257 b
- Author
- Absil Olivier
- Balmer William O.
- Biller Beth A.
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Briesemeister Zackery W.
- Bryan Marta L
- Calissendorff Per
- Cantalloube Faustine
- Carter Aarynn L.
- Chauvin Gael
- Chen Christine H.
- Choquet Elodie
- Christiaens Valentin
- Cugno Gabriele
- Currie Thayne
- Danielski Camilla
- De Furio Matthew
- Dupuy Trent J.
- Factor Samuel M.
- Faherty Jacqueline K.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Franson Kyle
- Girard Julien H.
- Gonzales Eileen C.
- Grady Carol A.
- Greenbaum Alexandra Z.
- Henning Thomas
- Hines Dean C.
- Hinkley Sasha
- Hoch Kielan K. W.
- Hood Callie E.
- Howe Alex R.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant M.
- Kenworthy Matthew A.
- Kervella Pierre
- Kraus Adam L.
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Lawson Kellen
- Lazzoni Cecilia
- Leisenring Jarron M.
- Lew Ben W. P.
- Liu Michael C.
- Liu Pengyu
- Llop-Sayson Jorge
- Lloyd James P.
- Macintosh Bruce
- Marino Sebastian
- Marley Mark S.
- Marois Christian
- Martinez Raquel A.
- Matthews Brenda C.
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael W.
- Metchev Stanimir
- Meyer Michael R.
- Miles Brittany E.
- Millar-Blanchaer Maxwell A.
- Molliere Paul
- Moran Sarah E.
- Morley Caroline V.
- Mukherjee Sagnick
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall D.
- Petrus Simon
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Ray Shrishmoy
- Rebollido Isabel
- Redai Jea Adams
- Ren Bin B.
- Rickman Emily
- Sallum Steph
- Samland Matthias
- Sargent B.
- Schlieder Joshua E.
- Schneider Glenn
- Skemer Andrew
- Stapelfeldt Karl R.
- Stone Jordan M.
- Tamura Motohide
- Tan Xianyu
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Vos Johanna M.
- Wagner Kevin
- Wang Jason J.
- Ward-Duong Kimberly
- Whiteford Niall
- Wolff Schuyler G.
- Worthen Kadin
- Wyatt Mark C.
- Ygouf Marie
- Zhang Keming
- Zhang Xi
- Zhang Zhoujian
- Zhou Yifan
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2023
- Field of study
We present the highest fidelity spectrum to date of a planetary-mass object. VHS 1256 b is a MJup widely separated (∼8″, a = 150 au), young, planetary-mass companion that shares photometric colors and spectroscopic features with the directly imaged exoplanets HR 8799c, d, and e. As an L-to-T transition object, VHS 1256 b exists along the region of the color–magnitude diagram where substellar atmospheres transition from cloudy to clear. We observed VHS 1256 b with JWST's NIRSpec IFU and MIRI MRS modes for coverage from 1 to 20 μm at resolutions of ∼1000–3700. Water, methane, carbon monoxide, carbon dioxide, sodium, and potassium are observed in several portions of the JWST spectrum based on comparisons from template brown dwarf spectra, molecular opacities, and atmospheric models. The spectral shape of VHS 1256 b is influenced by disequilibrium chemistry and clouds. We directly detect silicate clouds, the first such detection reported for a planetary-mass companion
Recommended from our members
The JWST Early Release Science Program for the Direct Imaging and Spectroscopy of Exoplanetary Systems
- Author
- Absil Olivier
- Adams Jea
- Baraffe Isabelle
- Barman Travis
- Biller Beth
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Bryan Marta
- Carter Aarynn L.
- Chauvin Gael
- Chen Christine
- Choquet Elodie
- Currie Thayne
- Danielski Camilla
- Factor Samuel M.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Furio Matthew De
- Grady Carol
- Greenbaum Alexandra
- H. Girard Julien
- Henning Thomas
- Hines Dean
- Hinkley Sasha
- Hoch Kielan K. W.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant
- Kenworthy Matthew
- Kervella Pierre
- Kraus Adam
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Launhardt Ralf
- Lazzoni Cecilia
- Leisenring Jarron
- Liu Michael C.
- Lloyd James
- Marino Sebastian
- Marley Mark
- Marois Christian
- Martinez Raquel
- Matthews Brenda
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael
- Metchev Stanimir
- Meyer Michael
- Miles Brittany
- Millar-Blanchaer Maxwell A.
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall
- Petrus Simon
- Phillips Mark
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Rameau Julien
- Ray Shrishmoy
- Rebollido Isabel
- Rickman Emily
- Sallum Stephanie
- Samland Matthias
- Sargent B.
- Schlieder Joshua E.
- Schneider Glenn
- Sivaramakrishnan Anand
- Skemer Andrew
- Stapelfeldt Karl
- Stone Jordan M.
- Tamura Motohide
- Tremblin Pascal
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Wagner Kevin
- Wang Jason
- Ward-Duong Kimberly
- Whiteford Niall
- Wyatt Mark
- Ygouf Marie
- Zhou Yifan
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2022
- Field of study
The direct characterization of exoplanetary systems with high-contrast imaging is among the highest priorities for the broader exoplanet community. As large space missions will be necessary for detecting and characterizing exo-Earth twins, developing the techniques and technology for direct imaging of exoplanets is a driving focus for the community. For the first time, JWST will directly observe extrasolar planets at mid-infrared wavelengths beyond 5 μm, deliver detailed spectroscopy revealing much more precise chemical abundances and atmospheric conditions, and provide sensitivity to analogs of our solar system ice-giant planets at wide orbital separations, an entirely new class of exoplanet. However, in order to maximize the scientific output over the lifetime of the mission, an exquisite understanding of the instrumental performance of JWST is needed as early in the mission as possible. In this paper, we describe our 55 hr Early Release Science Program that will utilize all four JWST instruments to extend the characterization of planetary-mass companions to ∼15 μm as well as image a circumstellar disk in the mid-infrared with unprecedented sensitivity. Our program will also assess the performance of the observatory in the key modes expected to be commonly used for exoplanet direct imaging and spectroscopy, optimize data calibration and processing, and generate representative data sets that will enable a broad user base to effectively plan for general observing programs in future Cycles
The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. IV. NIRISS Aperture Masking Interferometry Performance and Lessons Learned
- Author
- Absil Olivier
- Balmer William O.
- Betti Sarah K.
- Biller Beth
- Boccaletti Anthony
- Bonavita Mariangela
- Bonnefoy Mickael
- Booth Mark
- Bowler Brendan P.
- Briesemeister Zackery W.
- Bryan Marta L.
- Calissendorff Per
- Cantalloube Faustine
- Carter Aarynn
- Chauvin Gael
- Chen Christine H.
- Choquet Elodie
- Christiaens Valentin
- Cooper Rachel
- Cugno Gabriele
- Currie Thayne
- Danielski Camilla
- De Furio Matthew
- Dupuy Trent J.
- Factor Samuel M.
- Faherty Jacqueline K.
- Fitzgerald Michael P.
- Fortney Jonathan J.
- Franson Kyle
- Girard Julien H.
- Gonzales Eileen C.
- Grady Carol A.
- Greebaum Alexandra Z.
- Henning Thomas
- Hines Dean C.
- Hinkley Sasha
- Hoch Kielan K. W.
- Hood Callie E.
- Howe Alex R.
- Janson Markus
- Kalas Paul
- Kammerer Jens
- Kennedy Grant M.
- Kenworthy Matthew A.
- Kervella Pierre
- Kitzmann Daniel
- Kraus Adam L.
- Kuzuhara Masayuki
- Lagage Pierre-Olivier
- Lagrange Anne-Marie
- Lawson Kellen
- Lazzoni Cecilia
- Leisenring Jarron M.
- Lew Ben W. P.
- Liu Michael C.
- Liu Pengyu
- Llop-Sayson Jorge
- Lloyd James P.
- Lueber Anna
- Macintosh Bruce
- Manjavacas Elena
- Marino Sebastian
- Marley Mark S.
- Marois Christian
- Martinez Raquel A.
- Matthews Brenda C.
- Matthews Elisabeth C.
- Mawet Dimitri
- Mazoyer Johan
- McElwain Michael W.
- Metchev Stanimir
- Meyer Michael R.
- Miles Brittany E.
- Millar-Blanchaer Maxwell A.
- Molliere Paul
- Moran Sarah E.
- Morley Caroline V.
- Mukherjee Sagnick
- Palma-Bifani Paulina
- Pantin Eric
- Patapis Polychronis
- Perrin Marshall D.
- Petrus Simon
- Pueyo Laurent
- Quanz Sascha P.
- Quirrenbach Andreas
- Ray Shrishmoy
- Rebollido Isabel
- Redai Jea Adams
- Ren Bin B.
- Rickman Emily
- Sallum Steph
- Samland Matthias
- Sargent B. A.
- Schlieder Joshua E.
- Schneider Glenn
- Sivaramakrishnan Anand
- Skemer Andrew
- Stapelfeldt Karl R.
- Stone Jordan M.
- Sutlieff Ben J.
- Suárez Genaro
- Tamura Motohide
- Tan Xianyu
- Thatte Deepashri
- Theissen Christopher A.
- Uyama Taichi
- Vasist Malavika
- Vigan Arthur
- Vos Johanna M.
- Wagner Kevin
- Wang Jason J.
- Ward-Duong Kimberly
- Whiteford Niall
- Wolff Schuyler G.
- Worthen Kadin
- Wyatt Mark C.
- Ygouf Marie
- Zhang Keming
- Zhang Xi
- Zhang Zhoujian
- Zhou Yifan
- Zurlo Alice
- Publication venue
- The American Astronomical Society
- Publication date
- 01/01/2024
- Field of study
We present a performance analysis for the aperture masking interferometry (AMI) mode on board the James Webb Space Telescope Near Infrared Imager and Slitless Spectrograph (JWST/NIRISS). Thanks to self-calibrating observables, AMI accesses inner working angles down to and even within the classical diffraction limit. The scientific potential of this mode has recently been demonstrated by the Early Release Science (ERS) 1386 program with a deep search for close-in companions in the HIP 65426 exoplanetary system. As part of ERS 1386, we use the same data set to explore the random, static, and calibration errors of NIRISS AMI observables. We compare the observed noise properties and achievable contrast to theoretical predictions. We explore possible sources of calibration errors and show that differences in charge migration between the observations of HIP 65426 and point-spread function calibration stars can account for the achieved contrast curves. Lastly, we use self-calibration tests to demonstrate that with adequate calibration NIRISS F380M AMI can reach contrast levels of ∼9–10 mag at ≳λ/D. These tests lead us to observation planning recommendations and strongly motivate future studies aimed at producing sophisticated calibration strategies taking these systematic effects into account. This will unlock the unprecedented capabilities of JWST/NIRISS AMI, with sensitivity to significantly colder, lower-mass exoplanets than lower-contrast ground-based AMI setups, at orbital separations inaccessible to JWST coronagraphy
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
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- Bao Yangyi
- Bao Yangyi
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- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
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- Beck Kristen
- Becker Annette
- Beckers Johannes
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- Bedognetti Davide
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- Bell Charles J M
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- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
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- Biediger Ronald J
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- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
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- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
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- Brockstedt Dirk G
- Brody Joshua
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- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
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- Butterfield Lisa H
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- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
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- Zloza Andrew
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- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at √s=0.9 and 2.36 TeV
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- Publication venue
- Publication date
- 01/01/2010
- Field of study
Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at root s = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(ch)/d eta vertical bar(vertical bar eta vertical bar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date
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- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
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- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
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- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
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- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
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- Albayrak Elif Asli
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- Aldá Júnior Walter Luiz
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- Tytgat Michael
- Tyurin Nikolay
- Tzeng Yeng-Ming
- Ujvari Balazs
- Ulmer Keith
- Ungaro Donatella
- Uplegger Lorenzo
- Urscheler Christina
- Uvarov Lev
- Uzun Dilber
- Uzunian Andrey
- Vaandering Eric Wayne
- Valdata Marisa
- Valls Nil
- Valuev Vyacheslav
- Van Doninck Walter
- Van Haevermaet Hans
- Van Hove Pierre
- Van Mechelen Pierre
- Van Mulders Petra
- Van Onsem Gerrit Patrick
- Van Remortel Nick
- Van Spilbeeck Alex
- Vander Velde Catherine
- Vanelderen Lukas
- Vanini Sara
- Vanlaer Pascal
- Varela Joao
- Varelas Nikos
- Vartak Adish
- Vasquez Sierra Ricardo
- Vaughan Jennifer
- Vavilov Sergey
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veelken Christian
- Veeraraghavan Venkatesh
- Velasco Mayda
- Velicanu Dragos
- Velkovska Julia
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Vergili Latife Nukhet
- Vergili Mehmet
- Verwilligen Piet
- Verzetti Mauro
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vichoudis Paschalis
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Viviani Claudio
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vodopiyanov Igor
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volodko Anton
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Philipp
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Walzel Gerhard
- Wan Zongru
- Wang Dayong
- Wang Jian
- Wang Jian
- Wang Minzu
- Wang Siguang
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickens John
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
- Williams Grayson
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wolf Matthias
- Wolf Roger
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
- …