80 research outputs found

    On the Genesis of the Deposits of Uranium in Germany

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    Zusammenfassung In Deutschland sind magmatogene (magmatische, pegmatitische), hydrothermogene (pneumatolytische, hydrothermale), chemogene (zementative, infiltrative) und klastogene (Seifen-) Uran-Vorkommen bekannt. Bergbaulich gewonnen wurde Uran hierzulande bisher aus hydrothermalen, zementativen und infiltrativen Lagerstätten. Einige dieser Lagerstätten in Sachsen und Thüringen gehören zu den bedeutendsten ihrer Art in der Welt. Im Ergebnis von 45 Jahren Bergbautätigkeit und den anschließenden 25 Jahren Sanierungsarbeiten entstanden unzählige unter- und übertägige Aufschlüsse sowie eine Vielzahl von geowissenschaftlichen Arbeiten. Dennoch sind einige Fragen zur Entstehung dieser Lagerstätten, insbesondere was die Herkunft des Urans betrifft, nach wie vor umstritten. Dieser Beitrag ist ein Versuch, ein geochemisch, mineralogisch und lagerstättenkundlich plausibles Gesamtmodell der Genese der deutschen Uranlagerstätten zu entwerfen. Dabei spielen Sapropelite eine besondere Rolle als Metallquellen des Urans. Abstract There are magmatogene (magmatic, pegmatitic), hydrothermogene (pneumatolytic, hydrothermal), chemogene (cementation, infiltration) and clastogene (placer) occurrences of uranium in Germany. But only hydrothermal and supergene deposits were mined in this country. Some of these deposits in Saxony and Thuringia belong to the most important of its kind in the world. After 45 years of mining activity followed by 25 years of renovation many underground and surface exposures were originated and scientific publications were written. Nevertheless some features of the genesis of these deposits and particularly the origin of uranium are still controversially. This paper is an attempt to sketch a geochemical, mineralogical and geological plausible general model of the genesis of the uranium deposits in Germany. Sapropelites are of particular importance as sources of uranium.researc

    A 6 bp Z-DNA hairpin binds two Zα domains from the human RNA editing enzyme ADAR1

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    AbstractThe Zα domain of the human RNA editing enzyme double-stranded RNA deaminase I (ADAR1) binds to left-handed Z-DNA with high affinity. We found by analytical ultracentrifugation and CD spectroscopy that two Zα domains bind to one d(CG)3T4(CG)3 hairpin which contains a stem of six base pairs in the Z-DNA conformation. Both wild-type Zα and a C125S mutant show a mean dissociation constant of 30 nM as measured by surface plasmon resonance and analytical ultracentrifugation. Our data suggest that short (≥6 bp) segments of Z-DNA within a gene are able to recruit two ADAR1 enzymes to that particular site

    Crystallographic, Optical, and Electronic Properties of the Cs2AgBi1–xInxBr6 Double Perovskite: Understanding the Fundamental Photovoltaic Efficiency Challenges

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    We present a crystallographic and optoelectronic study of the double perovskite Cs2AgBi1–xInxBr6. From structural characterization we determine that the indium cation shrinks the lattice and shifts the cubic-to-tetragonal phase transition point to lower temperatures. The absorption onset is shifted to shorter wavelengths upon increasing the indium content, leading to wider band gaps, which we rationalize through first-principles band structure calculations. Despite the unfavorable band gap shift, we observe an enhancement in the steady-state photoluminescence intensity, and n-i-p photovoltaic devices present short-circuit current greater than that of neat Cs2AgBiBr6 devices. In order to evaluate the prospects of this material as a solar absorber, we combine accurate absorption measurements with thermodynamic modeling and identify the fundamental limitations of this system. Provided radiative efficiency can be increased and the choice of charge extraction layers are specifically improved, this material could prove to be a useful wide band gap solar absorber

    Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

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    Some species responded successfully to prehistoric changes in climate [1, 2], while others failed to adapt and became extinct [3]. The factors that determine successful climate adaptation remain poorly understood. We constructed a reference genome and studied physiological adaptations in the Alpine marmot (Marmota marmota), a large ground-dwelling squirrel exquisitely adapted to the "ice-age" climate of the Pleistocene steppe [4, 5]. Since the disappearance of this habitat, the rodent persists in large numbers in the high-altitude Alpine meadow [6, 7]. Genome and metabolome showed evidence of adaptation consistent with cold climate, affecting white adipose tissue. Conversely, however, we found that the Alpine marmot has levels of genetic variation that are among the lowest for mammals, such that deleterious mutations are less effectively purged. Our data rule out typical explanations for low diversity, such as high levels of consanguineous mating, or a very recent bottleneck. Instead, ancient demographic reconstruction revealed that genetic diversity was lost during the climate shifts of the Pleistocene and has not recovered, despite the current high population size. We attribute this slow recovery to the marmot's adaptive life history. The case of the Alpine marmot reveals a complicated relationship between climatic changes, genetic diversity, and conservation status. It shows that species of extremely low genetic diversity can be very successful and persist over thousands of years, but also that climate-adapted life history can trap a species in a persistent state of low genetic diversity.This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001134), the UK Medical Research Council (FC001134), and the Wellcome Trust (FC001134). CB and AC are supported by the Agence Nationale de la Recherche (project ANR-13-JSV7-0005) and the Centre National de la Recherche Scientifique (CNRS), CB is supported by the Rhône-Alpes region (Grant 15.005146.01). LD is supported by Agence Nationale de la Recherche (project ANR-12-ADAP-0009). TIG is supported by a Leverhulme Early Career Fellowship (Grant ECF-2015-453) and a NERC grant (NE/N013832/1). JMG is supported by a Hertha Finberg Fellowship (FWF T703). LDR is supported by the Diabetes UK RD Lawrence Fellowship (16/0005382)

    Nutzung und Probleme von Samba in heterogenen Netzen am Beispiel des CSN

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    Probleme bei der Bereitstellung eines Browsing Dienstes via Samba in (fremdadministrierten) heterogenen Netzen. Lösungen und Konfigurationsmöglichkeiten werden behandelt

    Dynamisches Bandbreitenmanagement im Chemnitzer StudentenNetz

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    Das Chemnitzer StudentenNetz (CSN) setzt seit mehreren Jahren ein System zur automatischen Regelung der Bandbreite ("DynShaper") basierend auf den Grundlagen der Diplomarbeit von Jan Horbach "Dynamische Bandbreitenbeschränkung mit QoS" ein. Aufgrund der weiterhin bestehenden Notwendigkeit zum Einsatz dieses Systems, ist es nötig die DynShaper-Software zu überarbeiten, um ihre Implementierung an die Standards des CSN anzupassen und die unvollständige Dokumentation zu ergänzen. Hauptaugenmerk liegt dabei auf der Integration des Systems in die bestehende Softwarearchitektur des CSN und der Schaffung einer modularen Implementierung zur Evaluierung anderer Berechnungsverfahren
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