29 research outputs found
The Groebke-Blackburn-Bienayme Reaction
Imidazo[1,2a]pyridine is a wellâknown scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DSâ1 and it also serves as a broadly applied pharmacophore in drug discovery. The scaffold revoked a wave of interest when Groebke, Blackburn and BienaymĂ© reported independently a new three component reaction resulting in compounds with the imidazo[1,2âa]âheterocycles as a core structure. During the course of two decades the Groebke Blackburn BienaymĂ© (GBBâ3CR) reaction has emerged as a very important multicomponent reaction (MCR), resulting in over a hundred patents and a great number of publications in various fields of interest. Now two compounds derived from GBBâ3CR chemistry received FDA approval. To celebrate the first 20 years of GBBâchemistry , we present an overview of the chemistry of the GBBâ3CR, including an analysis of each of the three starting material classes, solvents and catalysts. Additionally, a list of patents and their applications and a more inâdepth summary of the biological targets that were addressed, including structural biology analysis, is given