The Elections in Uganda, February 2016

On 18 February, Uganda conducted presidential and parliamentary elections. Incumbent president Yoweri Museveni of the National Resistance Movement (NRM) won the multiparty contest for a third consecutive time. If his reign as the NRM leader during Uganda’s stint as a one-party state is counted, the February elections marked the beginning of Museveni’s fifth overall term as president. The NRM continues to dominate parliament, having won a super-majority of the contested seats. Opposition members who competed for both the presidential seat and a seat in parliament contested the results of the election, and the primary opposition candidate Kizza Besigye was placed under house arrest. International observers questioned the integrity of the results, specifically in rural areas that were poorly monitored, and opposition strongholds in urban centres suffered logistical problems. The elections reconfirmed the strength of the NRM following years of political infighting.Am 18. Februar 2016 wurden in Uganda Präsidentschafts- und Parlamentswahlen abgehalten. Der Amtsinhaber, Präsident Yoweri Museveni von der National Resistance Movement (NRM), konnte den Parteienwettbewerb zum dritten Mal nacheinander für sich entscheiden. Bezieht man die Zeit ein, in der er als Führer der NRM über den damaligen Einparteienstaat Uganda herrschte, markieren die Februarwahlen den Beginn der fünften Präsidentschaftsperiode Musevenis. Die NRM hat auch die große Mehrheit der Parlamentssitze gewonnen und dominiert damit weiterhin das Parlament. Mitglieder der Opposition, die für die Präsidentschaft oder einen Sitz im Parlament kandidiert hatten, stellten die Wahlergebnisse infrage. Der wichtigste Kandidat der Opposition, Kizza Besigye, wurde unter Hausarrest gestellt. Auch internationale Beobachter bezweifelten die Integrität der Ergebnisse, insbesondere in ländlichen Regionen, wo das Wahlgeschehen nur unzureichend beobachtet werden konnte; in Hochburgen der Opposition in städtischen Zentren hatte es zudem logistische Probleme gegeben. Nach Jahren interner Machtkämpfe wurde die Stärke der NRM erneut bestätigt

The Politics of Land Reform in Uganda

When do citizens obey the law? What determines when people conform to or dismiss legal/institutional arrangements? Citizens pursue economic interests, and governments capture the productive potential of their citizenry through institutional incentives. Alternatively, governments incentivize that same potential into the informal economy with institutional failures. Savvy citizens know when they can prosper in formal and informal markets, and they choose between those markets to protect their interests. They evaluate risks and rewards, and they choose. Protecting property - whither government or non-government protection - is foundational to both types of markets, and can determine citizens' choice. In this study, successive governments in Uganda have attracted mass participation in productive economic sectors, and they have also repelled investment. My longitudinal study investigates land laws and policies throughout Uganda's colonial and post-colonial history in order to distill lessons about when citizens partake in formal market institutions. Citizens adopt laws when the governments make it in their interest to adopt them, and they shirk new institutional arrangements when those arrangements are too costly. However, because secure property rights are so fundamental to market transactions, Ugandans around the country create their own local institutions that are accessible, efficient, cheap, and that reflect community relationships. While these land relationships have problems, they illustrate a fundamental demand for secure property rights. Establishing and defining property rights are political choices, they go through political processes, and they subject to the influence of politically powerful groups. The workings of these informal institutions, and the relative failure of government programs, provide lessons for political scientists, policy experts, and Ugandan legislators

The Aviation Education Teacher Resource Center: A Unique Strategy to Improve Math and Science Education

A unique program that enhances the applied mathematics and science knowledge of teachers was established at Embry Riddle Aeronautical University (ERAU). The program provides materials, equipment, education, and curriculum development services to educators at no cost. This model of collaboration between a university and a school district is presented as a template to enhance staff development efforts in other districts. Although this program presents a specific orientation of interest unique to the collaborating institutions, it clearly demonstrates how resources can be acquired and assembled by capitalizing on the strengths of the participants

Expression of Nuclear Receptor Coactivators in the Human Fetal Membranes at Term before and after Labor

Human fetal membranes play an important role in term and preterm labor and are responsive to steroids. We examined the expression of steroid receptor coactivators in fetal membranes obtained prior to and following labor at term. Proteins were localized by immunohistochemistry, Western analysis was carried out in nuclear extracts, and mRNA levels were determined by real-time RT-PCR. SRC-1, SRC-2, p300, and PCAF proteins were present in all nuclear extracts. The amnion nuclei expressed higher levels of SRC-1, p300, and PCAF than nuclei from the chorion-decidua, whereas the reverse was true for SRC-2. Chorion-decidua from patients before labor expressed higher levels of SRC-1 than those from patients after labor. Also, the PCAF level was higher in the amnion obtained before labor than the same tissue obtained after labor. In contrast to the protein expression, mRNA levels of SRC-1 and p300 were higher in the chorion-decidua compared to the amnion, whereas there was no difference in levels of SRC-2 and PCAF mRNAs between these two tissues. These data underline that the regulation of the expression of the coactivators in these tissues occurs during labor and is complex and tissue specific

Rapid communication A rapid and reversible change in dopamine transporters induced by methamphetamine

Abstract Because high doses of methamphetamine promote free radical formation, and striatal dopamine transporters are rapidly inactivated by oxidative events, we determined the effect of a single high dose of methamphetamine on dopamine transporter activity in striatal synaptosomes. One hour after methamphetamine administration, dopamine uptake decreased by 48%. This dramatic decline was totally reversed by 24 h after treatment. These findings suggest that methamphetamine reversibly decreases dopamine transporter activity by oxidative mechanisms

V1647 Orionis: Reinvigorated Accretion and the Re-Appearance of McNeil's Nebula

In late 2003, the young eruptive variable star V1647 Orionis optically brightened by over 5 magnitudes, stayed bright for around 26 months, and then decline to its pre-outburst level. In August 2008 the star was reported to have unexpectedly brightened yet again and we herein present the first detailed observations of this new outburst. Photometrically, the star is now as bright as it ever was following the 2003 eruption. Spectroscopically, a pronounced P Cygni profile is again seen in Halpha with an absorption trough extending to -700 km/s. In the near-infrared, the spectrum now possesses very weak CO overtone bandhead absorption in contrast to the strong bandhead emission seen soon after the 2003 event. Water vapor absorption is also much stronger than previously seen. We discuss the current outburst below and relate it to the earlier event.Comment: 6 pages, 3 figure

Data proliferation, reconciliation, and synthesis in viral ecology

The fields of viral ecology and evolution have rapidly expanded in the last two decades, driven by technological improvements, and motivated by efforts to discover potentially zoonotic wildlife viruses under the rubric of pandemic prevention. One consequence has been a massive proliferation of host-virus association data, which comprise the backbone of research in viral macroecology and zoonotic risk prediction. These data remain fragmented across numerous data portals and projects, each with their own scope, structure, and reporting standards. Here, we propose that synthesis of host-virus association data is a central challenge to improve our understanding of the global virome and develop foundational theory in viral ecology. To illustrate this, we build an open reconciled mammal-virus database from four key published datasets, applying a standardized taxonomy and metadata. We show that reconciling these datasets provides a substantially richer view of the mammal virome than that offered by any one individual database. We argue for a shift in best practice towards the incremental development and use of synthetic datasets in viral ecology research, both to improve comparability and replicability across studies, and to facilitate future efforts to use machine learning to predict the structure and dynamics of the global virome

Influence of GluN2 subunit identity on NMDA receptor function

AbstractN-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels (‘ionotropic’ receptors) activated by the major excitatory neurotransmitter, l-glutamate. While the term ‘the NMDAR’ is often used it obscures the fact that this class of receptor contains within it members whose properties are as different as they are similar. This heterogeneity was evident from early electrophysiological, pharmacological and biochemical assessments of the functional properties of NMDARs and while the molecular basis of this heterogeneity has taken many years to elucidate, it indicated from the outset that the diversity of NMDAR phenotypes could allow this receptor family to subserve a variety of functions in the mammalian central nervous system. In this review we highlight some recent studies that have identified structural elements within GluN2 subunits that contribute to the heterogeneous biophysical properties of NMDARs, consider why some recently described novel pharmacological tools may permit better identification of native NMDAR subtypes, examine the evidence that NMDAR subtypes differentially contribute to the induction of long-term potentiation and long-term depression and discuss how through the use of chimeric proteins additional insights have been obtained that account for NMDAR subtype-dependency of physiological and pathophysiological signalling.This article is part of the Special Issue entitled ‘Glutamate Receptor-Dependent Synaptic Plasticity’

The future of zoonotic risk prediction

In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat to humans. To support the extensive task of laboratory characterization, scientists may increasingly rely on data-driven rubrics or machine learning models that learn from known zoonoses to identify which animal pathogens could someday pose a threat to global health. We synthesize the findings of an interdisciplinary workshop on zoonotic risk technologies to answer the following questions. What are the prerequisites, in terms of open data, equity and interdisciplinary collaboration, to the development and application of those tools? What effect could the technology have on global health? Who would control that technology, who would have access to it and who would benefit from it? Would it improve pandemic prevention? Could it create new challenges? This article is part of the theme issue 'Infectious disease macroecology: parasite diversity and dynamics across the globe'.Peer reviewe

Clinical Relevance of Dissolution Testing in Quality by Design

Quality by design (QbD) has recently been introduced in pharmaceutical product development in a regulatory context and the process of implementing such concepts in the drug approval process is presently on-going. This has the potential to allow for a more flexible regulatory approach based on understanding and optimisation of how design of a product and its manufacturing process may affect product quality. Thus, adding restrictions to manufacturing beyond what can be motivated by clinical quality brings no benefits but only additional costs. This leads to a challenge for biopharmaceutical scientists to link clinical product performance to critical manufacturing attributes. In vitro dissolution testing is clearly a key tool for this purpose and the present bioequivalence guidelines and biopharmaceutical classification system (BCS) provides a platform for regulatory applications of in vitro dissolution as a marker for consistency in clinical outcomes. However, the application of these concepts might need to be further developed in the context of QbD to take advantage of the higher level of understanding that is implied and displayed in regulatory documentation utilising QbD concepts. Aspects that should be considered include identification of rate limiting steps in the absorption process that can be linked to pharmacokinetic variables and used for prediction of bioavailability variables, in vivo relevance of in vitro dissolution test conditions and performance/interpretation of specific bioavailability studies on critical formulation/process variables. This article will give some examples and suggestions how clinical relevance of dissolution testing can be achieved in the context of QbD derived from a specific case study for a BCS II compound