Gridiron-Gurus Final Report: Fantasy Football Performance Prediction

Gridiron Gurus is a desktop application that allows for the creation of custom AI profiles to help advise and compete against in a Fantasy Football setting. Our AI are capable of performing statistical prediction of players on both a season long and week to week basis giving them the ability to both draft and manage a fantasy football team throughout a season

Revaluing residues : effects of composts and vermicomposts from corn, fig and citrus residues on the development of Rosmarinus officinalis L. and Lavandula angustifolia L.

Intensive agricultural production generates large quantities of organic waste and residue worldwide. Health and environmental hazards can result with the improper disposal and accumulation of these materials. Composting and vermicomposting can be used to recycle crop residues, manures, and wastes as soil amendments and biofertilizers, thereby reducing the overall amount of waste and residue in the agroecosystem. In this study, separate composts and vermicomposts were prepared from three crop residues (citrus, maize, fig) and precomposted rabbit manure. Cuttings of rosemary and lavender were grown in the prepared substrates for 4 months. Initial and final substrates were characterized chemically and growth characteristics of the plants were measured. Vermicomposting resulted in significant reduction in carbon-to-nitrogen ratio (C/N) and an increase in total N (TN) compared to composting. Composts resulted in higher electric conductivity (EC) values than vermicomposts, implying that they may be more useful as soil amendments. Vermicomposted substrates had lower shoot/root ratio than composted substrates and could be due to the greater amount of humic compounds that promoted root development. Vermicomposts had significantly higher cation exchange capacity (CEC) values, which was found to be positively correlated to all plant growth traits, with the exception of branch number for rosemary plants. CEC was used as the main determining factor, which in conjunction with nutrient content helped explain the superior performance of vermicomposting over composting. It was concluded that vermicomposted citrus residues (VC) proved to be the superior substrate for both rosemary and lavender plants, as development traits were greater than both maize and fig residues for both species.M-A

JWST Reveals CH4_4, CO2_2, and H2_2O in a Metal-rich Miscible Atmosphere on a Two-Earth-Radius Exoplanet

Even though sub-Neptunes likely represent the most common outcome of planet formation, their natures remain poorly understood. In particular, planets near 1.5-2.5$\,R_\oplus$ often have bulk densities that can be explained equally well with widely different compositions and interior structures, resulting in grossly divergent implications for their formation. Here, we present the full 0.6-5.2$\,\mu \mathrm{m}$ JWST NIRISS/SOSS+NIRSpec/G395H transmission spectrum of the 2.2$\,R_\oplus$ TOI-270d ($4.78\,M_\oplus$, $T_\mathrm{eq}$=350-380 K), delivering unprecedented sensitivity for atmospheric characterization in the sub-Neptune regime. We detect five vibrational bands of CH$_4$ at 1.15, 1.4, 1.7, 2.3, and 3.3$\,\mu$m (9.4$\sigma$), the signature of CO$_2$ at 4.3$\,\mu$m (4.8$\sigma$), water vapor (2.5$\sigma$), and potential signatures of SO$_2$ at 4.0$\,\mu \mathrm{m}$ and CS$_2$ at 4.6$\,\mu\mathrm{m}$. Intriguingly, we find an overall highly metal-rich atmosphere, with a mean molecular weight of $5.47_{-1.14}^{+1.25}$. We infer an atmospheric metal mass fraction of $58_{-12}^{+8}\%$ and a C/O of $0.47_{-0.19}^{+0.16}$, indicating that approximately half the mass of the outer envelope is in high-molecular-weight volatiles (H$_2$O, CH$_4$, CO, CO$_2$) rather than H$_2$/He. We introduce a sub-Neptune classification scheme and identify TOI-270d as a "miscible-envelope sub-Neptune" in which H$_2$/He is well-mixed with the high-molecular-weight volatiles in a miscible supercritical metal-rich envelope. For a fully miscible envelope, we conclude that TOI-270d's interior is $90_{-4}^{+3}\,$wt$\,\%$ rock/iron, indicating that it formed as a rocky planet that accreted a few wt % of H$_2$/He, with the overall envelope metal content explained by magma-ocean/envelope reactions without the need for significant ice accretion. TOI-270d may well be an archetype of the overall population of sub-Neptunes.Comment: 25 pages, 12 figure

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.

Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias. Using DNA screening and sequencing methods, over 700 different LQTS-causing mutations have been identified in 13 genes worldwide. Despite this, the genetic cause of 30-50% of LQTS is presently unknown. MicroRNAs (miRNAs) are small (∼ 22 nucleotides) noncoding RNAs which post-transcriptionally regulate gene expression by binding complementary sequences within messenger RNAs (mRNAs). The human genome encodes over 1800 miRNAs, which target about 60% of human genes. Consequently, miRNAs are likely to regulate many complex processes in the body, indeed aberrant expression of various miRNA species has been implicated in numerous disease states, including cardiovascular diseases. MiR-1 and MiR-133A are the most abundant miRNAs in the heart and have both been reported to regulate cardiac ion channels. We hypothesized that, as a consequence of their role in regulating cardiac ion channels, genetic variation in the genes which encode MiR-1 and MiR-133A might explain some cases of LQTS. Four miRNA genes (miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2), which encode MiR-1 and MiR-133A, were sequenced in 125 LQTS probands. No genetic variants were identified in miR-1-1 or miR-133a-1; but in miR-1-2 we identified a single substitution (n.100A> G) and in miR-133a-2 we identified two substitutions (n.-19G> A and n.98C> T). None of the variants affect the mature miRNA products. Our findings indicate that sequence variants of miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2 are not a cause of LQTS in this cohort

A Pipeline Strategy for Grain Crop Domestication

In the interest of diversifying the global food system, improving human nutrition, and making agriculture more sustainable, there have been many proposals to domesticate wild plants or complete the domestication of semidomesticated orphan crops. However, very few new crops have recently been fully domesticated. Many wild plants have traits limiting their production or consumption that could be costly and slow to change. Others may have fortuitous preadaptations that make them easier to develop or feasible as high-value, albeit low-yielding, crops. To increase success in contemporary domestication of new crops, we propose a pipeline approach, with attrition expected as species advance through the pipeline. We list criteria for ranking domestication candidates to help enrich the starting pool with more preadapted, promising species. We also discuss strategies for prioritizing initial research efforts once the candidates have been selected: developing higher value products and services from the crop, increasing yield potential, and focusing on overcoming undesirable traits. Finally, we present new-crop case studies that demonstrate that wild species’ limitations and potential (in agronomic culture, shattering, seed size, harvest, cleaning, hybridization, etc.) are often only revealed during the early phases of domestication. When nearly insurmountable barriers were reached in some species, they have been (at least temporarily) eliminated from the pipeline. Conversely, a few species have moved quickly through the pipeline as hurdles, such as low seed weight or low seed number per head, were rapidly overcome, leading to increased confidence, farmer collaboration, and program expansion.Fil: DeHaan, Lee R.. The Land Institute; Estados UnidosFil: Van Tassel, David L.. The Land Institute; Estados UnidosFil: Anderson, James A.. University of Minnesota; Estados UnidosFil: Asselin, Sean R.. University of Manitoba; CanadáFil: Barnes, Richard. University of Minnesota; Estados UnidosFil: Baute, Gregory J.. University of British Columbia; CanadáFil: Cattani, Douglas J.. University of Manitoba; CanadáFil: Culman, Steve W.. Ohio State University; Estados UnidosFil: Dorn, Kevin M.. University of Minnesota; Estados UnidosFil: Hulke, Brent S.. United States Department of Agriculture. Agriculture Research Service; Estados UnidosFil: Kantar, Michael. University of British Columbia; CanadáFil: Larson, Steve. Forage and Range Research Laboratory; Estados UnidosFil: David Marks, M.. University of Minnesota; Estados UnidosFil: Miller, Allison J.. Saint Louis University; Estados UnidosFil: Poland, Jesse. Kansas State University; Estados UnidosFil: Ravetta, Damián Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: Rude, Emily. University of Wisconsin; Estados UnidosFil: Ryan, Matthew R.. Cornell University; Estados UnidosFil: Wyse, Don. University of Minnesota; Estados UnidosFil: Zhang, Xiaofei. University of Minnesota; Estados Unido

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Revaluing residues : effects of composts and vermicomposts from corn, fig and citrus residues on the development of Rosmarinus officinalis L. and Lavandula angustifolia L.

Intensive agricultural production generates large quantities of organic waste and residue worldwide. Health and environmental hazards can result with the improper disposal and accumulation of these materials. Composting and vermicomposting can be used to recycle crop residues, manures, and wastes as soil amendments and biofertilizers, thereby reducing the overall amount of waste and residue in the agroecosystem. In this study, separate composts and vermicomposts were prepared from three crop residues (citrus, maize, fig) and precomposted rabbit manure. Cuttings of rosemary and lavender were grown in the prepared substrates for 4 months. Initial and final substrates were characterized chemically and growth characteristics of the plants were measured. Vermicomposting resulted in significant reduction in carbon-to-nitrogen ratio (C/N) and an increase in total N (TN) compared to composting. Composts resulted in higher electric conductivity (EC) values than vermicomposts, implying that they may be more useful as soil amendments. Vermicomposted substrates had lower shoot/root ratio than composted substrates and could be due to the greater amount of humic compounds that promoted root development. Vermicomposts had significantly higher cation exchange capacity (CEC) values, which was found to be positively correlated to all plant growth traits, with the exception of branch number for rosemary plants. CEC was used as the main determining factor, which in conjunction with nutrient content helped explain the superior performance of vermicomposting over composting. It was concluded that vermicomposted citrus residues (VC) proved to be the superior substrate for both rosemary and lavender plants, as development traits were greater than both maize and fig residues for both species