512 research outputs found
The XMM Cluster Survey: The Stellar Mass Assembly of Fossil Galaxies
This paper presents both the result of a search for fossil systems (FSs)
within the XMM Cluster Survey and the Sloan Digital Sky Survey and the results
of a study of the stellar mass assembly and stellar populations of their fossil
galaxies. In total, 17 groups and clusters are identified at z < 0.25 with
large magnitude gaps between the first and fourth brightest galaxies. All the
information necessary to classify these systems as fossils is provided. For
both groups and clusters, the total and fractional luminosity of the brightest
galaxy is positively correlated with the magnitude gap. The brightest galaxies
in FSs (called fossil galaxies) have stellar populations and star formation
histories which are similar to normal brightest cluster galaxies (BCGs).
However, at fixed group/cluster mass, the stellar masses of the fossil galaxies
are larger compared to normal BCGs, a fact that holds true over a wide range of
group/cluster masses. Moreover, the fossil galaxies are found to contain a
significant fraction of the total optical luminosity of the group/cluster
within 0.5R200, as much as 85%, compared to the non-fossils, which can have as
little as 10%. Our results suggest that FSs formed early and in the highest
density regions of the universe and that fossil galaxies represent the end
products of galaxy mergers in groups and clusters. The online FS catalog can be
found at http://www.astro.ljmu.ac.uk/~xcs/Harrison2012/XCSFSCat.html.Comment: 30 pages, 50 figures. ApJ published version, online FS catalog added:
http://www.astro.ljmu.ac.uk/~xcs/Harrison2012/XCSFSCat.htm
Quantitative signal properties from standardized MRIs correlate with multiple sclerosis disability
OBJECTIVE: To enable use of clinical magnetic resonance images (MRIs) to quantify abnormalities in normal appearing (NA) white matter (WM) and gray matter (GM) in multiple sclerosis (MS) and to determine associations with MS-related disability. Identification of these abnormalities heretofore has required specialized scans not routinely available in clinical practice.
METHODS: We developed an analytic technique which normalizes image intensities based on an intensity atlas for quantification of WM and GM abnormalities in standardized MRIs obtained with clinical sequences. Gaussian mixture modeling is applied to summarize image intensity distributions from T1-weighted and 3D-FLAIR (T2-weighted) images from 5010 participants enrolled in a multinational database of MS patients which collected imaging, neuroperformance and disability measures.
RESULTS: Intensity distribution metrics distinguished MS patients from control participants based on normalized non-lesional signal differences. This analysis revealed non-lesional differences between relapsing MS versus progressive MS subtypes. Further, the correlation between our non-lesional measures and disability was approximately three times greater than that between total lesion volume and disability, measured using the patient derived disease steps. Multivariate modeling revealed that measures of extra-lesional tissue integrity and atrophy contribute uniquely, and approximately equally, to the prediction of MS-related disability.
INTERPRETATION: These results support the notion that non-lesional abnormalities correlate more strongly with MS-related disability than lesion burden and provide new insight into the basis of abnormalities in NA WM. Non-lesional abnormalities distinguish relapsing from progressive MS but do not distinguish between progressive subtypes suggesting a common progressive pathophysiology. Image intensity parameters and existing biomarkers each independently correlate with MS-related disability
Identifying High Metallicity M Giants at Intragroup Distances with SDSS
Tidal stripping and three-body interactions with the central supermassive
black hole may eject stars from the Milky Way. These stars would comprise a set
of `intragroup' stars that trace the past history of interactions in our
galactic neighborhood. Using the Sloan Digital Sky Survey DR7, we identify
candidate solar metallicity red giant intragroup stars using color cuts that
are designed to exclude nearby M and L dwarfs. We present 677 intragroup
candidates that are selected between 300 kpc and 2 Mpc, and are either the
reddest intragroup candidates (M7-M10) or are L dwarfs at larger distances than
previously detected.Comment: 8 pages, 6 figures, 1 table (for full version, see
http://astro.phy.vanderbilt.edu/~palladl2), Accepted for publication in A
The merger history, AGN and dwarf galaxies of Hickson Compact Group 59
Compact group galaxies often appear unaffected by their unusually dense
environment. Closer examination can, however, reveal the subtle, cumulative
effects of multiple galaxy interactions. Hickson Compact Group (HCG) 59 is an
excellent example of this situation. We present a photometric study of this
group in the optical (HST), infrared (Spitzer) and X-ray (Chandra) regimes
aimed at characterizing the star formation and nuclear activity in its
constituent galaxies and intra-group medium. We associate five dwarf galaxies
with the group and update the velocity dispersion, leading to an increase in
the dynamical mass of the group of up to a factor of 10 (to 2.8e13 Msun), and a
subsequent revision of its evolutionary stage. Star formation is proceeding at
a level consistent with the morphological types of the four main galaxies, of
which two are star-forming and the other two quiescent. Unlike in some other
compact groups, star-forming complexes across HCG 59 closely follow mass-radius
scaling relations typical of nearby galaxies. In contrast, the ancient globular
cluster populations in galaxies HCG 59A and B show intriguing irregularities,
and two extragalactic HII regions are found just west of B. We age-date a faint
stellar stream in the intra-group medium at ~1 Gyr to examine recent
interactions. We detect a likely low-luminosity AGN in HCG 59A by its ~10e40
erg/s X-ray emission; the active nucleus rather than star formation can account
for the UV+IR SED. We discuss the implications of our findings in the context
of galaxy evolution in dense environments.Comment: 38 pages, 17 figures. Please visit "http://tinyurl.com/isk-hcg59" for
a full-resolution PDF. Accepted for publication in the Astrophysical Journa
Tidal streams in newly discovered M32 analogues: evidence for the stripping scenario
We present two newly-discovered compact elliptical (cE) galaxies, exhibiting
clear evidence of tidal steams, and found during a search of SDSS DR7 for cE
candidates. The structural parameters of the cEs are derived using GALFIT,
giving effective radii, Re, of 388 and 263 parsecs, and B-band mean surface
brightnesses within Re of 19.4 and 19.2 magnitudes per arcsec squared. We have
re-analysed the SDSS spectra, which indicate that they possess young to
intermediate-age stellar populations. These two cEs provide direct evidence, a
"smoking gun", for the process of tidal stripping that is believed to be the
origin of M32-type galaxies. Both are in small groups with a large spiral
fraction, suggesting that we may be seeing the formation of such cE galaxies in
dynamically young environments. The more compact of the galaxies is found in a
small group not unlike the Local Group, and thus provides an additional model
for understanding M32.Comment: 9 pages, 10 figures. Accepted to MNRA
The outer halos of elliptical galaxies
Recent progress is summarized on the determination of the density
distributions of stars and dark matter, stellar kinematics, and stellar
population properties, in the extended, low surface brightness halo regions of
elliptical galaxies. With integral field absorption spectroscopy and with
planetary nebulae as tracers, velocity dispersion and rotation profiles have
been followed to ~4 and ~5-8 effective radii, respectively, and in M87 to the
outer edge at ~150 kpc. The results are generally consistent with the known
dichotomy of elliptical galaxy types, but some galaxies show more complex
rotation profiles in their halos and there is a higher incidence of
misalignments, indicating triaxiality. Dynamical models have shown a range of
slopes for the total mass profiles, and that the inner dark matter densities in
ellipticals are higher than in spiral galaxies, indicating earlier assembly
redshifts. Analysis of the hot X-ray emitting gas in X-ray bright ellipticals
and comparison with dynamical mass determinations indicates that non-thermal
components to the pressure may be important in the inner ~10 kpc, and that the
properties of these systems are closely related to their group environments.
First results on the outer halo stellar population properties do not yet give a
clear picture. In the halo of one bright galaxy, lower [alpha/Fe] abundances
indicate longer star formation histories pointing towards late accretion of the
halo. This is consistent with independent evidence for on-going accretion, and
suggests a connection to the observed size evolution of elliptical galaxies
with redshift.Comment: 8 pages. Invited review to appear in the proceedings of "Galaxies and
their Masks" eds. Block, D.L., Freeman, K.C. & Puerari, I., 2010, Springer
(New York
Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis
Interferon-beta (IFNβ) is used to inhibit disease activity in multiple sclerosis (MS), but its mechanisms of action are incompletely understood, individual treatment response varies, and biological markers predicting response to treatment have yet to be identified.he relationship between the molecular response to IFNβ and treatment response was determined in 85 patients using a longitudinal design in which treatment effect was categorized by brain magnetic resonance imaging as good (n = 70) or poor response (n = 15). Molecular response was quantified using a customized cDNA macroarray assay for 166 IFN-regulated genes (IRGs).The molecular response to IFNβ differed significantly between patients in the pattern and number of regulated genes. The molecular response was strikingly stable for individuals for as long as 24 months, however, suggesting an individual ‘IFN response fingerprint’. Unexpectedly, patients with poor response showed an exaggerated molecular response. IRG induction ratios demonstrated an exaggerated molecular response at both the first and 6-month IFNβ injections.MS patients exhibit individually unique but temporally stable biological responses to IFNβ. Poor treatment response is not explained by the duration of biological effects or the specific genes induced. Rather, individuals with poor treatment response have a generally exaggerated biological response to type 1 IFN injections. We hypothesize that the molecular response to type I IFN identifies a pathogenetically distinct subset of MS patients whose disease is driven in part by innate immunity. The findings suggest a strategy for biologically based, rational use of IFNβ for individual MS patients
Switching Multiple Sclerosis Patients with Breakthrough Disease to Second-Line Therapy
BACKGROUND: Multiple sclerosis (MS) patients with breakthrough disease on immunomodulatory drugs are frequently offered to switch to natalizumab or immunosuppressants. The effect of natalizumab monotherapy in patients with breakthrough disease is unknown. METHODS: This is an open-label retrospective cohort study of 993 patients seen at least four times at the University of California San Francisco MS Center, 95 had breakthrough disease on first-line therapy (60 patients switched to natalizumab, 22 to immunosuppressants and 13 declined the switch [non-switchers]). We used Poisson regression adjusted for potential confounders to compare the relapse rate within and across groups before and after the switch. RESULTS: In the within-group analyses, the relapse rate decreased by 70% (95% CI 50,82%; p<0.001) in switchers to natalizumab and by 77% (95% CI 59,87%; p<0.001) in switchers to immunosuppressants; relapse rate in non-switchers did not decrease (6%, p =  0.87). Relative to the reduction among non-switchers, the relapse rate was reduced by 68% among natalizumab switchers (95% CI 19,87%; p = 0.017) and by 76% among the immunosuppressant switchers (95% CI 36,91%; p = 0.004). CONCLUSIONS: Switching to natalizumab or immunosuppressants in patients with breakthrough disease is effective in reducing clinical activity of relapsing MS. The magnitude of the effect and the risk-benefit ratio should be evaluated in randomized clinical trials and prospective cohort studies
Is macroporosity controlled by complexed clay and soil organic carbon?
Multi-scale evidence of rapid, climate-induced soil structural changes occurring at yearly to decadal timescales is mounting. As a result, it has become increasingly important to identify the properties and mechanisms controlling the development and maintenance of soil structure and associated macroporosity. This is especially relevant since macroporosity has disproportionate effects on saturated hydraulic conductivity ( ) which strongly influences water storage and flux, thus, affecting the water cycle. In this study, we use decision trees and piecewise linear regression to assess the influence of soil and climate properties on effective porosity (EP; a proxy of macroporosity) in both surface and subsurface horizons under varying land-use and management practices. Data from 1,491 pedons (3,679 horizons) spanning five ecoregions representing bioclimate (e.g., potential vegetation) across the conterminous US demonstrate that, at a continental scale, EP in surface (A) and subsurface (B) horizons is strongly dependent on the complexed fraction of the total mass of soil organic carbon (SOC) and clay; a combined fraction that we refer to as complexed organic carbon and clay (COCC). EP showed a slight positive response to COCC in A horizons but increased steeply with increasing COCC in B horizons. This is because the smaller values of COCC in B horizons reflect a larger pool of clay that has a greater potential to accommodate and complex additions of SOC promoting stronger organo-mineral bonds and the concomitant development and maintenance of soil structure in these horizons. In contrast, larger values of COCC in A horizons reflect conditions where all or most of the clay fraction is effectively complexed with SOC resulting in a larger pool of non-complexed soil organic matter with varying contrasting effects on macroporosity that ultimately mute the response of EP to increases in COCC. In surface horizons, indirect factors such as mean annual precipitation and land use were important predictors of EP, whereas COCC was more influential in controlling EP within the subsoil. The EP-COCC relationship also holds within ecoregions but its effect is mitigated by soil and climate interactions suggesting that the effect of climate on this relationship is indirect and complex. Plowed surface horizons and horizons underlying plowed layers showed greater homogenization (due to disturbance effects reducing heterogeneity in the soil) as well as a reduction in the magnitude and rate of change of EP as a function of COCC compared to undisturbed horizons. Our findings suggest that the complexed fraction of clay and SOC is important for controlling macroporosity and at ecoregion scales and that the EP-COCC relationship may be an important framework for understanding and predicting future land use- and climate-induced changes in soil hydraulic properties.publishedVersio
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