Algunas plantas nuevas o interesantes para la flora de Badajoz

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Algunas plantas de interés de la Sierra de Aguafría (Monesterio, Badajoz)

Se comentan once taxones de plantas vasculares presentes en la Sierra de Aguafría (Sierra Morena occidental, sur de la provincia de Badajoz), de valor corológico por tratarse de especies nuevas, raras o poco conocidas para la provincia o Sierra Morena. Se trata de Armeria capitella Pau, Erica lusitanica Rudolphi, Eupatorium cannabinum L. subsp. cannabinum, Genista falcata Brot., Halimium halimifolium (L.) Willk. subsp. halimifolium, Molinia caerulea subsp. arundinacea (Schrank) H. K. G. Paul, Osmunda regalis L., Osyris lanceolata Hochst. & Steud., Prunus cerasus L., Quercus pyrenaica Willd. y Sibthorpia europaea L. Para cada uno de ellos se aportan datos ecológicos, así como referencias previas sobre su distribución en la región.his work analyses eleven taxa of vascular plants located in the Sierra de Aguafría (Western Sierra Morena, Southern Badajoz Province) that are new or almost unknown for the region: Armeria capitella Pau, Erica lusitanica Rudolphi, Eupatorium cannabinum L. subsp. cannabinum, Genista falcata Brot., Halimium halimifolium (L.) Willk. subsp. halimifolium, Molinia caerulea subsp. arundinacea (Schrank) H. K. G. Paul, Osmunda regalis L., Osyris lanceolata Hochst. & Steud., Prunus cerasus L., Quercus pyrenaicaWilld. and Sibthorpia europaea L. We include ecological data for each species and references about their distribution throughout the region

Anthemis alpestris (Hoffmanns. & Link) R. Fern. (Compositae, Asteroideae), novedad corológica para el parque natural Sierra de Aracena (Huelva)

Se hace referencia a la presencia de Anthemis alpestris (Hoffmanns. & Link) R. Fern. en el Parque Natural Sierra de Aracena (Huelva, suroeste de España) como novedad florística provincial y para Sierra Morena occidental

Some interesting plants from the Sierra de Aguafría (Monesterio, Badajoz, Southwestern Spain)

Se comentan once taxones de plantas vasculares presentes en la Sierra de Aguafría (Sierra Morena occidental, sur de la provincia de Badajoz), de valor corológico por tratarse de especies nuevas, raras o poco conocidas para la provincia o Sierra Morena. Se trata de Armeria capitella Pau, Erica lusitanica Rudolphi, Eupatorium cannabinum L. subsp. cannabinum, Genista falcata Brot., Halimium halimifolium (L.) Willk. subsp. halimifolium, Molinia caerulea subsp. arundinacea (Schrank) H. K. G. Paul, Osmunda regalis L., Osyris lanceolata Hochst. & Steud., Prunus cerasus L., Quercus pyrenaica Willd. y Sibthorpia europaea L. Para cada uno de ellos se aportan datos ecológicos, así como referencias previas sobre su distribución en la región.This work analyses eleven taxa of vascular plants located in the Sierra de Aguafría (Western Sierra Morena, Southern Badajoz Province) that are new or almost unknown for the region: Armeria capitella Pau, Erica lusitanica Rudolphi, Eupatorium cannabinum L. subsp. cannabinum, Genista falcata Brot., Halimium halimifolium (L.) Willk. subsp. halimifolium, Molinia caerulea subsp. arundinacea (Schrank) H. K. G. Paul, Osmunda regalis L., Osyris lanceolata Hochst. & Steud., Prunus cerasus L., Quercus pyrenaicaWilld. and Sibthorpia europaea L. We include ecological data for each species and references about their distribution throughout the region

Innovative and thorough practice to certify reference materials for sensory defects of olive oil

An important problem in the olive sector is the occasional mismatch of results obtained by different tasting panels when the same olive oil sample is analysed. These discrepancies could be minimised by using reference materials (RM) for taster training. A comprehensive protocol based on the combined use of sensory and instrumental analysis for the certification of olive oil batches as RMs, developed within the framework of the project ’Operational Group INTERPANEL’, is proposed. Similarity indices (R2, cosθ and NEAR) applied on GC–MS fingerprints, allow a successful homogeneity and stability assessment of produced batches. Furthermore, the use of robust statistics combined with a set of instructions developed to remove outliers were applied with excellent results on sensory data set provided by supra-panel composed by more than 100 qualified tasters. This work is the first to provide a comprehensive protocol for certification of real olive oil samples as RM for sensory analysis.European Agricultural Fund for Rural Development (EAFRD)Consejería de Agricultura, Ganadería, Pesca y Desarrollo SostenibleBiblioteca de la Universidad de Granad

ClinPrior: an algorithm for diagnosis and novel gene discovery by network-based prioritization

BackgroundWhole-exome sequencing (WES) and whole-genome sequencing (WGS) have become indispensable tools to solve rare Mendelian genetic conditions. Nevertheless, there is still an urgent need for sensitive, fast algorithms to maximise WES/WGS diagnostic yield in rare disease patients. Most tools devoted to this aim take advantage of patient phenotype information for prioritization of genomic data, although are often limited by incomplete gene-phenotype knowledge stored in biomedical databases and a lack of proper benchmarking on real-world patient cohorts.MethodsWe developed ClinPrior, a novel method for the analysis of WES/WGS data that ranks candidate causal variants based on the patient's standardized phenotypic features (in Human Phenotype Ontology (HPO) terms). The algorithm propagates the data through an interactome network-based prioritization approach. This algorithm was thoroughly benchmarked using a synthetic patient cohort and was subsequently tested on a heterogeneous prospective, real-world series of 135 families affected by hereditary spastic paraplegia (HSP) and/or cerebellar ataxia (CA).ResultsClinPrior successfully identified causative variants achieving a final positive diagnostic yield of 70% in our real-world cohort. This includes 10 novel candidate genes not previously associated with disease, 7 of which were functionally validated within this project. We used the knowledge generated by ClinPrior to create a specific interactome for HSP/CA disorders thus enabling future diagnoses as well as the discovery of novel disease genes.ConclusionsClinPrior is an algorithm that uses standardized phenotype information and interactome data to improve clinical genomic diagnosis. It helps in identifying atypical cases and efficiently predicts novel disease-causing genes. This leads to increasing diagnostic yield, shortening of the diagnostic Odysseys and advancing our understanding of human illnesses

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Notes on the presence of Sorbus domestica L. (Rosaceae) en Ciudad Real

Se estudia la presencia de Sorbus domestica L. una de las especies arbóreas más raras localizadas en Ciudad Real