Manufacturing and Testing of a Variable Chord Extension for Helicopter Rotor Blades

Helicopters are still an indispensable addition to aviation in this day and age. They are characterized by their ability to master both forward flight and hover. These characteristics result in a wide range of possible operations. Key for the design of the rotor blades is a blade design that always represents a compromise between the different flight conditions, which enables save and efficient flight in the various flight conditions. In order to operate the rotor blade even more efficient in all flight conditions, a new morphing concept, the so-called linear variable chord extension, has been developed. Here, the blade chord length in the root area is changed with the help of an elastic skin to adapt it to the respective flight condition. The simulations performed for this concept showed a promising increase in overall helicopter performance. The fabrication of the resulting demonstra- tor as well as the tests in the whirl-tower and wind tunnel will be presented in this paper. The results of the tests show that the concept of linear variable chord extension has a positive influence and a great potential for hovering flight

Design, Manufacture and Wind Tunnel Test of a Modular FishBAC Wing with Novel 3D Printed Skins

This paper introduces a new modular Fish Bone Active Camber morphing wing with novel 3D printed skin panels. These skin panels are printed using two different Thermoplastic Polyurethane (TPU) formulations: a soft, high strain formulation for the deformable membrane of the skin, reinforced with a stiffer formulation for the stringers and mounting tabs. Additionally, this is the first FishBAC device designed to be modular in its installation and actuation. Therefore, all components can be removed and replaced for maintenance purposes without having to remove or disassemble other parts. A 1 m span, 0.27 m chord morphing wing with a 25% chord FishBAC was built and tested mechanically and in a low-speed wind tunnel. Results show that the new design is capable of achieving the same large changes in airfoil lift coefficient (approximate ΔCL≈0.55) with a low drag penalty seen in previous FishBAC work, but with a much simpler, practical and modular design. Additionally, the device shows a change in the pitching moment coefficient of ΔCM≈0.1, which shows the potential that the FishBAC has as a control surface

The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers

FUNDING. Instituto de Salud Carlos III (FI17/00186, FI19/00083, MV20/00057, PI18/01532, PI19/01127 and PI22/01796), Gilead Fellowships (GLD22/00147). NIH grants AI155171, AI116228, AI078799, HL134539, DA047034, MH134823, amfAR ARCHE and the Bill and Melinda Gates Foundation.BACKGROUND. Persistent controllers (PCs) maintain antiretroviral-free HIV-1 control indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is essential to characterize the quality of the HIV reservoir in terms of these phenotypes in order to identify the factors that lead to HIV progression and to open new avenues toward an HIV cure. METHODS. The characterization of HIV-1 reservoir from peripheral blood mononuclear cells was performed using next-generation sequencing techniques, such as full-length individual and matched integration site proviral sequencing (FLIP-Seq; MIP-Seq). RESULTS. PCs and TCs, before losing virological control, presented significantly lower total, intact, and defective proviruses compared with those of participants on antiretroviral therapy (ART). No differences were found in total and defective proviruses between PCs and TCs. However, intact provirus levels were lower in PCs compared with TCs; indeed the intact/defective HIV-DNA ratio was significantly higher in TCs. Clonally expanded intact proviruses were found only in PCs and located in centromeric satellite DNA or zinc-finger genes, both associated with heterochromatin features. In contrast, sampled intact proviruses were located in permissive genic euchromatic positions in TCs. CONCLUSIONS. These results suggest the need for, and can give guidance to, the design of future research to identify a distinct proviral landscape that may be associated with the persistent control of HIV-1 without ART.Instituto de Salud Carlos III (FI17/00186, FI19/00083, MV20/00057, PI18/01532, PI19/01127, PI22/01796)Gilead Fellowships (GLD22/00147)NIH grants AI155171, AI116228, AI078799, HL134539, DA047034, MH134823, amfAR ARCHEBill and Melinda Gates Foundatio

Observation of Charge-Dependent Azimuthal Correlations in p-Pb Collisions and Its Implication for the Search for the Chiral Magnetic Effect

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