88 research outputs found
Tryptophan Scanning Analysis of the Membrane Domain of CTR-Copper Transporters
- Author
- A Dancis
- AE Klomp
- AE Klomp
- AK Boal
- AK Holzer
- AL Lamb
- AL Lamb
- AM Zimnicka
- AN Barry
- BE Cohen
- BE Kim
- Christopher J. De Feo
- CJ Feo De
- CJ Feo De
- D Mumberg
- DL Huffman
- DL Huffman
- E Gaggelli
- E Georgatsou
- EB Maryon
- EF Pettersen
- EM Rees
- GL Millhauser
- H Zhou
- H Zhou
- I Mingarro
- IG Macreadie
- IS Song
- J Beaudoin
- J Lee
- JF Eisses
- JJ Falke
- K Romisch
- L Banci
- LL Sharp
- M Arredondo
- M DiDonato
- MJ Petris
- ML Turski
- MM Pena
- MT Kuo
- P Emsley
- PA Cobine
- QC Dumay
- R Hassett
- R Safaei
- RY Hampton
- S Choe
- S Frillingos
- S Ishida
- S Lutsenko
- S Puig
- S Puig
- SA Monks
- Sara Mootien
- SG Aller
- SN Irizarry
- T Haremaki
- TD Rae
- U Hasler
- VA Panchenko
- Vinzenz M. Unger
- Y Guo
- YM Kuo
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Membrane proteins of the CTR family mediate cellular copper uptake in all eukaryotic cells and have been shown to participate in uptake of platinum-based anticancer drugs. Despite their importance for life and the clinical treatment of malignancies, directed biochemical studies of CTR proteins have been difficult because high-resolution structural information is missing. Building on our recent 7Ă
structure of the human copper transporter hCTR1, we present the results of an extensive tryptophan-scanning analysis of hCTR1 and its distant relative, yeast CTR3. The comparative analysis supports our previous assignment of the transmembrane helices and shows that most functionally and structurally important residues are clustered around the threefold axis of CTR trimers or engage in helix packing interactions. The scan also identified residues that may play roles in interactions between CTR trimers and suggested that the first transmembrane helix serves as an adaptor that allows evolutionarily diverse CTRs to adopt the same overall structure. Together with previous biochemical and biophysical data, the results of the tryptophan scan are consistent with a mechanistic model in which copper transport occurs along the center of the trimer
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
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- Antunes JR
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- Zachariadou A
- Zalewski P
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- Zelepoukine S
- Zeuner WD
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
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- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
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- Alexander J
- Alidra M
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- Almeida N
- Altenhofer G
- Altsybeev I
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- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
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- Andreev V
- Andreev Y
- Anghel IM
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at âs=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
- Yu I
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- Yumiceva F
- Yun JC
- Zabi A
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyaniy A
- Zeidler C
- Zeinali M
- Zeise M
- Zennamo J
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zinonos Z
- Zito G
- Zoeller MH
- Zorbilmez C
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
This is the pre-print version of the Published Article which can be accessed from the link below.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at âs=7ââTeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dNch/dΡ||Ρ|<0.5=5.78Âą0.01(stat)Âą0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from âs=0.9 to 7 TeV is [66.1Âą1.0(stat)Âą4.2(syst)]%. The mean transverse momentum is measured to be 0.545Âą0.005(stat)Âą0.015(syst)ââGeV/c. The results are compared with similar measurements at lower energies
Commissioning of the CMS high-level trigger with cosmic rays
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
Identification and Filtering of Uncharacteristic Noise in the CMS Hadron Calorimeter
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/1
- Field of study
VertaisarvioitupeerReviewe
Performance of CMS Hadron Calorimeter Timing and Synchronization using Test Beam, Cosmic Ray, and LHC Beam Data
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/1
- Field of study
Peer reviewe
Performance of the CMS drift tube chambers with cosmic rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
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- Zoeller MH
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/1
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPStudies of the performance of the CMS drift tube barrel muon system are described, with results based on data collected during the CMS Cosmic Run at Four Tesla. For most of these data, the solenoidal magnet was operated with a central field of 3.8 T. The analysis of data from 246 out of a total of 250 chambers indicates a very good muon reconstruction capability, with a coordinate resolution for a single hit of about 260 Îźm, and a nearly 100% efficiency for the drift tube cells. The resolution of the track direction measured in the bending plane is about 1.8 mrad, and the efficiency to reconstruct a segment in a single chamber is higher than 99%. The CMS simulation of cosmic rays reproduces well the performance of the barrel muon detector.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG,
and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT,
SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- Author
- Abiona O.M.
- Alvarado G.S.
- Andersen H.
- Baric R.S.
- Bock K.W.
- BoyogluâBarnum S.
- Browne S.
- Campbell T.âA.
- Carfi A.
- Chang L.A.
- Cook A.
- Corbett K. S.
- Dodson A.
- Donaldson M.M.
- DoriaâRose N.A.
- Douek N.
- Edwards D.K.
- Flach B.
- Flebbe D.R.
- Flynn B.
- Foulds K.
- Francica S.
- Gaudinski M.R.
- Gillespie R.A.
- Gordon I.
- Graham B.S.
- Greenhouse J.
- Himansu S.
- Kong W.âP.
- Kwong P.D.
- Lamb E.
- Ledgerwood J.E.
- Leung K.
- Lewis M.G.
- Lin B.C.
- Loomis R.J.
- Louder M.K.
- Martinez D.R.
- Mascola J.R.
- McDermott A.
- Minai M.
- Moliva J.I.
- Moore I.N.
- Morabito K.M.
- Nagata B.M.
- Nason M.C.
- Nji N.N.
- Noe A.T.
- Novik L.
- O'Connell S.
- O'Dell S.
- Pegu A.
- Pessaint L.
- Phung E.
- PutmanâTaylor T.
- Roederer M.
- Ruckwardt T.J.
- Schmidt S.D.
- Seder R.A.
- Shi W.
- Steingrebe K.
- StewartâJones G.
- Strasbaugh A.
- Sullivan N.J.
- Teng IâT.
- Todd J.âP.M.
- Van Ry A.
- Wang L.
- Werner A.P.
- Widge A.
- Yang E.S.
- Yap C.
- Zhang Y.
- Zhou T.
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman primates.
Methods: Nonhuman primates received 10 or 100 Îźg of mRNA-1273, a vaccine encoding the prefusion-stabilized spike protein of SARS-CoV-2, or no vaccine. Antibody and T-cell responses were assessed before upper- and lower-airway challenge with SARS-CoV-2. Active viral replication and viral genomes in bronchoalveolar-lavage (BAL) fluid and nasal swab specimens were assessed by polymerase chain reaction, and histopathological analysis and viral quantification were performed on lung-tissue specimens.
Results: The mRNA-1273 vaccine candidate induced antibody levels exceeding those in human convalescent-phase serum, with live-virus reciprocal 50% inhibitory dilution (ID50) geometric mean titers of 501 in the 10-Îźg dose group and 3481 in the 100-Îźg dose group. Vaccination induced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low or undetectable Th2 or CD8 T-cell responses. Viral replication was not detectable in BAL fluid by day 2 after challenge in seven of eight animals in both vaccinated groups. No viral replication was detectable in the nose of any of the eight animals in the 100-Îźg dose group by day 2 after challenge, and limited inflammation or detectable viral genome or antigen was noted in lungs of animals in either vaccine group.
Conclusions: Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung. (Funded by the National Institutes of Health and others.)
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