Spherically Symmetric Solutions in Macroscopic Gravity

Schwarzschild's solution to the Einstein Field Equations was one of the first and most important solutions that lead to the understanding and important experimental tests of Einstein's theory of General Relativity. However, Schwarzschild's solution is essentially based on an ideal theory of gravitation, where all inhomogeneities are ignored. Therefore, any generalization of the Schwarzschild solution should take into account the effects of small perturbations that may be present in the gravitational field. The theory of Macroscopic Gravity characterizes the effects of the inhomogeneities through a non-perturbative and covariant averaging procedure. With similar assumptions on the geometry and matter content, a solution to the averaged field equations as dictated by Macroscopic Gravity are derived. The resulting solution provides a possible explanation for the flattening of galactic rotation curves, illustrating that Dark Matter is not real but may only be the result of averaging inhomogeneities in a spherically symmetric background.Comment: 14 pages, added and updated references, some paragraphs rewritten for clarity, typographical errors fixed, results have not change

Kinematics of gas and stars in circumnuclear star-forming regions of early type spirals

(Abbr.) We present high resolution (R~20000) spectra in the blue and the far red of cicumnuclear star-forming regions (CNSFRs) in three early type spirals (NGC3351, NGC2903 and NGC3310) which have allowed the study of the kinematics of stars and ionized gas in these structures and, for the first time, the derivation of their dynamical masses for the first two. In some cases these regions, about 100 to 150 pc in size, are seen to be composed of several individual star clusters with sizes between 1.5 and 4.9 pc estimated from Hubble Space Telescope (HST) images. The stellar dispersions have been obtained from the Calcium triplet (CaT) lines at $\lambda\lambda$ 8494,8542,8662 \AA, while the gas velocity dispersions have been measured by Gaussian fits to the H$\beta$ and [OIII] $\lambda\lambda$ 5007 \AA lines on the high dispersion spectra. Values of the stellar velocity dispersions are between 30 and 68 km/s. We apply the virial theorem to estimate dynamical masses of the clusters, assuming that systems are gravitationally bounded and spherically symmetric, and using previously measured sizes. The measured values of the stellar velocity dispersions yield dynamical masses of the order of 10$^7$ to 10$^8$ solar masses for the whole CNSFRs. Stellar and gas velocity dispersions are found to differ by about 20 to 30 km/s with the H$\beta$ emission lines being narrower than both the stellar lines and the [OIII] $\lambda\lambda$ 5007 \AA lines. The twice ionized oxygen, on the other hand, shows velocity dispersions comparable to those shown by stars, in some cases, even larger. We have found indications of the presence of two different kinematical components in the ionized gas of the regions...Comment: 4 pages, proceeding of the meeting "Young massive star clusters - Initial conditions and environments", Granada, Spain, 200

Ontologies for Intelligent e-Theraoy: Application to Obesity

[EN] In this paper we propose a new approach for mental e-health treatments named intelligent e-therapy (e-it) with capabilities for ambient intelligence and ubiquitous computing. The proposed e-it system supposes an evolution of cybertherapy and telepsychology tools used up to now. The e-it system is based in a knowledge base that includes all the knowledge related to the disorder and its treatment. We introduce the use of ontologies as the best option for the design of this knowledge base. We also present a fist e-it system for obesity treatment called etiobeZaragozá Álvarez, I.; Guixeres Provinciale, J.; Alcañiz Raya, ML. (2009). Ontologies for Intelligent e-Theraoy: Application to Obesity. Lecture Notes in Computer Science. 5518:894-901. doi:10.1007/978-3-642-02481-8_136S8949015518Baños, R.M., Botella, C., Perpiñá, C., Alcañiz, M., Lozano, J.A., Osma, J., Gallardo, M.: Virtual reality treatment of flying phobia. IEEE Transactions on Information Technology in Biomedicine 6(3), 206–212 (2002)Botella, C., Baños, R.M., Perpiña, C., et al.: Virtual reality treatment of claustrophobia: a case report. Behaviour Research & Therapy 36, 239–246 (1998)Hu, B., Dasmahapatra, S., Dupplaw, D., Lewis, P., Shadbolt, N.: Reflections on a medical ontology. International Journal of Human- Computer Studies 65(2007), 569–582 (2007)Rubin, D.L., Shah, N.H., Noy, N.F.: Biomedical ontologies: a functional perspective. Briefings in bioinformatics 9(1), 75–90 (2007)Stevens, R., Egaña Aranguren, M., Wolstencroft, K., Sattler, U., Drummond, N., Horridge, M., Rector, A.: Using OWL to model biological knowledge. International Journal of Human-Computer Studies 65(2007), 583–594 (2007)Park, S., Lee, J.K.: Rule identification using ontology while acquiring rules from Web pages. International Journal of Human-Computer Studies 65(2007), 644–658 (2007)Clark, K.L., McCabe, F.G.: Ontology schema for an agent belief store. International Journal of Human-Computer Studies 65(2007), 625–643 (2007)Gruber, T.R.: A Translation Approach to Portable Ontology Specifications. Knowledge Acquisition 5(2), 199–220 (1993)Franco, C., Bengtsson, B., Johannsson, G.: The GH/IGF-1 Axis in Obesity: Physiological and Pathological aspects. Metabolic syndrome and Related Disorders 4, 51–56 (2006

Fusion of secretory vesicles isolated from rat liver

Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy. The number of fused vesicles increases with increasing Ca2+-concentrations and is half maximal around 10–6 m. Other divalent cations (Ba2+, Sr2+, and Mg2+) were ineffective. Mg2+ inhibits Ca2+-induced fusion. Therefore, the fusion of secretory vesiclesin vitro is Ca2+ specific and exhibits properties similar to the exocytotic process of various secretory cells. Various substances affecting secretionin vivo (microtubular inhibitors, local anethetics, ionophores) were tested for their effect on membrane fusion in our system. The fusion of isolated secretory vesicles from liver was found to differ from that of pure phospholipid membranes in its temperature dependence, in its much lower requirement for Ca2+, and in its Ca2+-specificity. Chemical and enzymatic modifications of the vesicle membrane indicate that glycoproteins may account for these differences

Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study

Background: Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive impairment is rarely considered in the context of HIV and could explain part of the variability in neurocognitive performance among individuals with HIV. Setting: Women’s Interagency HIV Study, a prospective, multisite, observational study of US women with and without HIV. Methods: After a literature review, 79 medications (excluding statins) with NC-AE were identified and reported by Women’s Interagency HIV Study participants. We examined factors associated with self-reported use of these medications over a 10-year period. Generalized estimating equations for binary outcomes were used to assess sociodemographic, behavioral, and clinical characteristics associated with NC-AE medication use. Results: Three thousand three hundred women (71% with HIV) and data from ~42,000 visits were studied. HIV infection was associated with NC-AE medication use (odds ratio = 1.52; 95% confidence interval: 1.35 to 1.71). After adjustment for HIV infection status, other predictors of NC-AE medication use included having health insurance, elevated depressive symptoms, prior clinical AIDS, noninjection recreational drug use, and an annual household income of <$12,000 (Ps < 0.004). NC-AE medication use was less likely among women who drank 1–7 or 8–12 alcoholic drinks/week (vs. abstaining) (P < 0.04). Conclusions: HIV infection was associated with NC-AE medication use, which may influence determinations of HIV-associated neurocognitive impairment. Providers should consider the impact of NC-AE medications when evaluating patients with HIV and concurrent neurocognitive symptoms

Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider

This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-→e+e- and (for the ϒ(4S) only) e+e-→μ+μ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-→e+e- and e+e-→μ+μ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the ϒ(3S) and ϒ(2S) resonances, an additional uncertainty arises due to ϒ→e+e-X background. For data collected off the ϒ resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the ϒ(4S), 0.58% (0.72%) for the ϒ(3S), and 0.68% (0.88%) for the ϒ(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat à l’Energie Atomique and Institut National de Physique Nucléaire et de Physiquedes Particules (France), the Bundesministerium für Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e Innovación (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types