The calibration of the first Large-Sized Telescope of the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) represents the next generation of very high-energy gamma-ray observatory, which will provide broad coverage of gamma rays from 20 GeV to 300 TeV with unprecedented sensitivity. CTA will employ three different sizes of telescopes, and the Large-Sized Telescopes (LSTs) of 23-m diameter dish will provide the sensitivity in the lowest energies down to 20 GeV. The first LST prototype has been inaugurated in October 2018 at La Palma (Canary Islands, Spain) and has entered the commissioning phase. The camera of the LST consists of 265 PMT modules. Each module is equipped with seven high-quantum-efficiency Photomultiplier Tubes (PMTs), a slow control board, and a readout board. Ensuring high uniformity and precise characterization of the camera is the key aspects leading to the best performance and low systematic uncertainty of the LST cameras. Therefore, prior to the installation on site, we performed a quality check of all PMT modules. Moreover, the absolute calibration of light throughput is essential to reconstruct the amount of light received by the telescope. The amount of light is affected by the atmosphere, by the telescope optical system and camera, and can be calibrated using the ring-shaped images produced by cosmic-ray muons. In this contribution, we will show the results of off-site quality control of PMT modules and on-site calibration using muon rings. We will also highlight the status of the development of Silicon Photomultiplier modules that could be considered as a replacement of PMT modules for further improvement of the camera

Electrocatalytic CO2 conversion to C2 products: Catalysts design, market perspectives and techno-economic aspects

The energy crisis caused by the incessant growth in global energy demand joint to its associated greenhouse emissions motivates the urgent need to control and mitigate atmospheric CO2 levels. Leveraging CO2 as carbon pool to produce value-added products represents a cornerstone of the circular economy. Among the CO2 utilization strategies, electrochemical reduction of CO2 conversion to produce fuels and chemicals is booming due to its versatility and end-product flexibility. Herein most of the studies focused on C1 products although C2 and C2+ compounds are chemically and economically more appealing targets requiring advanced catalytic materials. Still, despite the complex pathways for C2+ products formation, their multiple and assorted applications have motivated the search of suitable electrocatalysts. In this review, we gather and analyse in a comprehensive manner the progress made regarding C2+ products considering not only the catalyst design and the electrochemistry features but also techno-economic aspects in order to envisage the most profitable scenarios. This state-of-the-art analysis showcases that electrochemical reduction of CO2 to C2 products will play a key role in the decarbonisation of the chemical industry paving the way towards a low-carbon future

Optimizing Jastrow factors for the transcorrelated method

We investigate the optimization of flexible tailored real-space Jastrow factors for use in the transcorrelated (TC) method in combination with highly accurate quantum chemistry methods, such as initiator full configuration interaction quantum Monte Carlo (FCIQMC). Jastrow factors obtained by minimizing the variance of the TC reference energy are found to yield better, more consistent results than those obtained by minimizing the variational energy. We compute all-electron atomization energies for the challenging first-row molecules C2, CN, N2, and O2 and find that the TC method yields chemically accurate results using only the cc-pVTZ basis set, roughly matching the accuracy of non-TC calculations with the much larger cc-pV5Z basis set. We also investigate an approximation in which pure three-body excitations are neglected from the TC-FCIQMC dynamics, saving storage and computational costs, and show that it affects relative energies negligibly. Our results demonstrate that the combination of tailored real-space Jastrow factors with the multi-configurational TC-FCIQMC method provides a route to obtaining chemical accuracy using modest basis sets, obviating the need for basis-set extrapolation and composite techniques

Changes in Muscle Metabolism are Associated with Phenotypic Variability in Golden Retriever Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is an X-chromosome-linked disorder and the most common monogenic disease in people. Affected boys are diagnosed at a young age, become non-ambulatory by their early teens, and succumb to cardiorespiratory failure by their thirties. Despite being a monogenic condition resulting from mutations in the DMD gene, affected boys have noteworthy phenotypic variability. Efforts have identified genetic modifiers that could modify disease progression and be pharmacologic targets. Dogs affected with golden retriever muscular dystrophy (GRMD) have absent dystrophin and demonstrate phenotypic variability at the functional, histopathological, and molecular level. Our laboratory is particularly interested in muscle metabolism changes in dystrophin-deficient muscle. We identified several metabolic alterations, including myofiber type switching from fast (type II) to slow (type I), reduced glycolytic enzyme expression, reduced and morphologically abnormal mitochondria, and differential AMP-kinase phosphorylation (activation) between hypertrophied and wasted muscle. We hypothesize that muscle metabolism changes are, in part, responsible for phenotypic variability in GRMD. Pharmacological therapies aimed at modulating muscle metabolism can be tested in GRMD dogs for efficacy

VALES VI: ISM enrichment in star-forming galaxies up to z∼\sim0.2 using 12^{12}CO(1-0), 13^{13}CO(1-0) and C18^{18}O(1-0) line luminosity ratios

We present Atacama Large Millimeter/sub-millimeter Array (ALMA) observations towards 27 low-redshift ($0.02< z<0.2$) star-forming galaxies taken from the Valpara\'iso ALMA/APEX Line Emission Survey (VALES). We perform stacking analyses of the $^{12}$CO($1-0$), $^{13}$CO($1-0$) and C$^{18}$O($1-0$) emission lines to explore the $L'$ ($^{12}$CO($1-0$))/$L'$($^{13}$CO($1-0$))) (hereafter $L'$($^{12}$CO)/$L'$($^{13}$CO)) and $L'$($^{13}$CO($1-0$))/$L'$(C$^{18}$O($1-0$)) (hereafter $L'$($^{13}$CO)/$L'$(C$^{18}$O) line luminosity ratio dependence as a function of different global galaxy parameters related to the star formation activity. The sample has far-IR luminosities $10^{10.1-11.9}$L$_{\odot}$ and stellar masses of $10^{9.8-10.9}$M$_{\odot}$ corresponding to typical star-forming and starburst galaxies at these redshifts. On average we find a $L'$($^{12}$CO)/$L'$($^{13}$CO) line luminosity ratio value of 16.1$\pm$2.5. Galaxies with evidences of possible merging activity tend to show higher $L'$($^{12}$CO)/$L'$($^{13}$CO) ratios by a factor of two, while variations of this order are also found in galaxy samples with higher star formation rates or star formation efficiencies. We also find an average $L'$($^{13}$CO)/$L'$(C$^{18}$O) line luminosity ratio of 2.5$\pm$0.6, which is in good agreement with those previously reported for starburst galaxies. We find that galaxy samples with high $L_{\text{IR}}$, SFR and SFE show low $L'$($^{13}$CO)/$L'$(C$^{18}$O) line luminosity ratios with high $L'$($^{12}$CO)/$L'$($^{13}$CO) line luminosity ratios, suggesting that these trends are produced by selective enrichment of massive stars in young starbursts.Comment: 16 pages, 10 figures to be published in MNRA

Scientific Opinion on the safety and efficacy of Urea for ruminants

Urea supplementation to feed for ruminants provides non-protein nitrogen for microbial protein synthesis in the rumen and thus in part replaces other dietary protein sources. Urea supplementation of feed for ruminants at doses up to 1 % of complete feed DM (corresponding to 0.3 g/kg bw/day) is considered safe when given to animals with a well adapted ruminal microbiota and fed diets rich in easily digestible carbohydrates. Based on the metabolic fate of urea in ruminants, the use of urea in ruminant nutrition does not raise any concern for consumers\u2019 safety. Urea is considered to be non irritant to skin and eyes and its topical use suggests that it is not a dermal sensitiser. The risk of exposure by inhalation would be low. The substitution of protein by urea in well balanced feed for ruminants would not result in an increased environmental nitrogen load. Urea is an effective source of non-protein nitrogen substituting for dietary protein in ruminants

Strange particle production in proton-proton collisions at s=0.9\sqrt{s}=0.9 TeV with ALICE at the LHC

The production of mesons containing strange quarks (K$^0_s$, $\phi$) and both singly and doubly strange baryons ($\Lambda$, Anti-$\Lambda$, and $\Xi$+Anti-$\Xi$) are measured at central rapidity in pp collisions at $\sqrt{s}$ = 0.9 TeV with the ALICE experiment at the LHC. The results are obtained from the analysis of about 250 k minimum bias events recorded in 2009. Measurements of yields (dN/dy) and transverse momentum spectra at central rapidities for inelastic pp collisions are presented. For mesons, we report yields () of 0.184 $\pm$ 0.002 stat. $\pm$ 0.006 syst. for K$^0_s$ and 0.021 $\pm$ 0.004 stat. $\pm$ 0.003 syst. for $\phi$. For baryons, we find = 0.048 $\pm$ 0.001 stat. $\pm$ 0.004 syst. for $\Lambda$, 0.047 $\pm$ 0.002 stat. $\pm$ 0.005 syst. for Anti-$\Lambda$ and 0.0101 $\pm$ 0.0020 stat. $\pm$ 0.0009 syst. for $\Xi$+Anti-$\Xi$. The results are also compared with predictions for identified particle spectra from QCD-inspired models and provide a baseline for comparisons with both future pp measurements at higher energies and heavy-ion collisions.Comment: 33 pages, 21 captioned figures, 10 tables, authors from page 28, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387

Two-pion Bose-Einstein correlations in central Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/388

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98