93 research outputs found
Emotional Stability in Stress and the Rorschach Personality Test of High School Football Players.
Communications and cosmopolitanism.
The view that certain media, in their technological form, open up possibilities which foster or create a form of cosmopolitanism amongst their users or consumers finds its origin in the media theory of Marshall McLuhan
The c-Myc/TBX3 axis promotes cellular transformation of sarcoma-initiating cells
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical
management is highly complex. This is partly due to a lack of understanding of the
molecular mechanisms underpinning the transformation of mesenchymal stromal/stem
cells (MSCs) which are presumed to be the sarcoma-initiating cells. c-Myc is amplified/
overexpressed in a range of sarcomas where it has an established oncogenic role and
there is evidence that it contributes to the malignant transformation of MSCs. T-box
transcription factor 3 (TBX3) is upregulated by c-Myc in a host of sarcoma subtypes where
it promotes proliferation, tumor formation, migration, and invasion. This study investigated
whether TBX3 is a c-Myc target in human MSCs (hMSCs) and whether overexpressing
TBX3 in hMSCs can phenocopy c-Myc overexpression to promote malignant
transformation. Using siRNA, qRT-PCR, luciferase reporter and chromatinimmunoprecipitation assays, we show that c-Myc binds and directly activates TBX3
transcription in hMSCs at a conserved E-box motif. When hMSCs were engineered to
stably overexpress TBX3 using lentiviral gene transfer and the resulting cells characterised
in 2D and 3D, the overexpression of TBX3 was shown to promote self-renewal, bypass
senescence, and enhance proliferation which corresponded with increased levels of cell
cycle progression markers (cyclin A, cyclin B1, CDK2) and downregulation of the p14ARF/
MDM2/p53 tumor suppressor pathway. Furthermore, TBX3 promoted the migratory and
invasive ability of hMSCs which associated with increased levels of markers of migration
(Vimentin, SLUG, SNAIL, TWIST1) and invasion (MMP2, MMP9). Transcriptomic analysis
revealed that genes upregulated upon TBX3 overexpression overlapped with c-myc
targets, were involved in cell cycle progression, and were associated with
sarcomagenesis. Together, the data described indicate that the c-Myc/TBX3
oncogenic molecular pathway may be a key mechanism that transforms hMSCs
into sarcomas.South Africa Medical Research Council (SAMRC);
National Research Foundation (NRF);
Cancer Association of South Africa (CANSA);
Universities of Cape Town and Pretoria.https://www.frontiersin.org/journals/oncologydm2022ImmunologyOral Pathology and Oral Biolog
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The Met Office Unified Model Global Atmosphere 6.0/6.1 and JULES Global Land 6.0/6.1 configurations
We describe Global Atmosphere 6.0 and Global Land 6.0: the latest science configurations of the Met Office Unified Model and JULES land surface model developed for use across all timescales. Global Atmosphere 6.0 includes the ENDGame dynamical core, which significantly increases mid-latitude variability improving a known model bias. Alongside developments of the modelâs physical parametrisations, ENDGame also increases variability in the tropics, which leads to an improved representation of tropical cyclones and other tropical phenomena. Further developments of the atmospheric and land surface parametrisations improve other aspects of model performance, including the forecasting of surface weather phenomena. We also describe Global Atmosphere 6.1 and Global Land 6.1, which include a small number of long-standing differences from our main trunk configurations that we continue to require for operational global weather prediction. Since July 2014, GA6.1/GL6.1 has been used by the Met Office for operational global NWP, whilst GA6.0/GL6.0 was implemented in its remaining global prediction systems over the following year
Influence of electric fishing lights on sink rates of baited hooks in Brazilian pelagic longline fisheries: implications for seabird bycatch
The Future of Rheumatoid Arthritis and Hand Surgery - Combining Evolutionary Pharmacology and Surgical Technique
Rheumatoid arthritis is a systemic autoimmune disease of uncertain aetiology, which is characterized primarily by synovial inflammation with secondary skeletal destructions
The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. Neither virus infects humans, and a number of GBV-A variants were identified in wild New World monkeys that were captured. Subsequently, a related human virus was identified [named GBV-C or hepatitis G virus (HGV)], and recently a more distantly related virus (named GBV-D) was discovered in bats. Only GBV-B, a second species within the genus Hepacivirus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. The other GB viruses have however not been assigned to a genus within the family Flaviviridae. Based on phylogenetic relationships, genome organization and pathogenic features of the GB viruses, we propose to classify GBV-A-like viruses, GBV-C and GBV-D as members of a fourth genus in the family Flaviviridae, named Pegivirus (pe, persistent; g, GB or G). We also propose renaming âGBâ viruses within the tentative genus Pegivirus to reflect their host origin
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15â20 July 2017
This work was produced as part of the activities of FAPESP Research,\ud
Disseminations and Innovation Center for Neuromathematics (grant\ud
2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud
FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud
supported by a CNPq fellowship (grant 306251/2014-0)
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
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