443 research outputs found
A simple approach to obtain hybrid Au-loaded polymeric nanoparticles with a tunable metal load
A new strategy to nanoengineer multi-functional polymer-metal hybrid nanostructures is reported. By using this protocol the hurdles of most of the current developments concerning covalent and non-covalent attachment of polymers to preformed inorganic nanoparticles (NPs) are overcome. The strategy is based on the in situ reduction of metal precursors using the polymeric nanoparticle as a nanoreactor. Gold nanoparticles and poly(dl-lactic-co-glycolic acid), PLGA, are located in the core and shell, respectively. This novel technique enables the production of PLGA NPs smaller than 200 nm that bear either a single encapsulated Au NP or several smaller NPs with tunable sizes and a 100% loading efficiency. In situ reduction of Au ions inside the polymeric NPs was achieved on demand by using heat to activate the reductive effect of citrate ions. In addition, we show that the loading of the resulting Au NPs inside the PLGA NPs is highly dependent on the surfactant used. Electron microscopy, laser irradiation, UV-Vis and fluorescence spectroscopy characterization techniques confirm the location of Au nanoparticles. These promising results indicate that these hybrid nanomaterials could be used in theranostic applications or as contrast agents in dark-field imaging and computed tomography
Parsec-Scale Images of Flat-Spectrum Radio Sources in Seyfert Galaxies
We present high angular resolution (~2 mas) radio continuum observations of
five Seyfert galaxies with flat-spectrum radio nuclei, using the VLBA at 8.4
GHz. The goal of the project is to test whether these flat-spectrum cores
represent thermal emission from the accretion disk, as inferred previously by
Gallimore et al. for NGC 1068, or non-thermal, synchrotron self-absorbed
emission, which is believed to be responsible for more powerful, flat-spectrum
nuclear sources in radio galaxies and quasars. In four sources (T0109-383, NGC
2110, NGC 5252, Mrk 926), the nuclear source is detected but unresolved by the
VLBA, indicating brightness temperatures in excess of 10^8 K and sizes, on
average, less than 1 pc. We argue that the radio emission is non-thermal and
synchrotron self-absorbed in these galaxies, but Doppler boosting by
relativistic outflows is not required. Synchrotron self-absorption brightness
temperatures suggest intrinsic source sizes smaller than ~0.05-0.2 pc, for
these four galaxies, the smallest of which corresponds to a light-crossing time
of ~60 light days or 10^4 gravitational radii for a 10^8 M_sun black hole.
We also present MERLIN and VLA observations of NGC 4388, which was undetected
by the VLBA, and argue that the observed, flat-spectrum, nuclear radio emission
in this galaxy represents optically thin, free-free radiation from dense
thermal gas on scales ~0.4 to a few pc. It is notable that the two Seyfert
galaxies with detected thermal nuclear radio emission (NGC 1068 and NGC 4388)
both have large X-ray absorbing columns, suggesting that columns in excess of
\~10^{24} cm^{-2} are needed for such disks to be detectable. (Abridged)Comment: 36 pages including 5 tables and 4 figures; accepted for publication
in Ap
The Gaia-ESO Survey: the chemical structure of the Galactic discs from the first internal data release
Most high-resolution spectroscopic studies of the Galactic discs were mostly
confined to objects in the solar vicinity. Here we aim at enlarging the volume
in which individual chemical abundances are used to characterise both discs,
using the first internal data release of the Gaia-ESO survey. We derive and
discuss the abundances of eight elements (Mg, Al, Si, Ca, Ti, Fe, Cr, Ni, and
Y). The trends of these elemental abundances with iron are very similar to
those in the solar neighbourhood. We find a natural division between alpha-rich
and alpha-poor stars, best seen in the bimodality of the [Mg/M] distributions
in bins of metallicity, which we attribute to thick- and thin-disc sequences,
respectively. With the possible exception of Al, the observed dispersion around
the trends is well described by the expected errors, leaving little room for
astrophysical dispersion. Using previously derived distances from Recio-Blanco
et al. (2014b), we further find that the thick-disc is more extended vertically
and is more centrally concentrated towards the inner Galaxy than the thin-disc,
which indicates a shorter scale-length. We derive the radial and vertical
gradients in metallicity, iron, four alpha-element abundances, and Al for the
two populations, taking into account the identified correlation between R_GC
and |Z|. Radial metallicity gradient is found in the thin disc. The positive
radial individual [alpha/M] gradients found are at variance from the gradients
observed in the RAVE survey. The thin disc also hosts a negative vertical
metallicity gradient, accompanied by positive individual [alpha/M] and [Al/M]
gradients. The thick-disc, presents no radial metallicity gradient, a shallower
vertical metallicity gradient than the thin-disc, an alpha-elements-to-iron
radial gradient in the opposite sense than that of the thin disc, and positive
vertical individual [alpha/M] and [Al/M] gradients.Comment: 24 pages, 10 figure
The Gaia-ESO Survey: the most metal-poor stars in the Galactic bulge
We present the first results of the EMBLA survey (Extremely Metal-poor BuLge
stars with AAOmega), aimed at finding metal-poor stars in the Milky Way bulge,
where the oldest stars should now preferentially reside. EMBLA utilises
SkyMapper photometry to pre-select metal-poor candidates, which are
subsequently confirmed using AAOmega spectroscopy. We describe the discovery
and analysis of four bulge giants with -2.72<=[Fe/H]<=-2.48, the lowest
metallicity bulge stars studied with high-resolution spectroscopy to date.
Using FLAMES/UVES spectra through the Gaia-ESO Survey we have derived
abundances of twelve elements. Given the uncertainties, we find a chemical
similarity between these bulge stars and halo stars of the same metallicity,
although the abundance scatter may be larger, with some of the stars showing
unusual [{\alpha}/Fe] ratios.Comment: 7 pages, 5 figures. Accepted for publication by MNRA
Brain aging and Parkinson's disease: new therapeutic approaches using drugs delivery systems
ABSTRACT
The etiology and pathogenesis of Parkinson’s disease (PD) is unknown, aging being the
strongest risk factor for brain degeneration. Understanding PD pathogenesis and how
aging increases the risk of disease would aid the development of therapies able to slow
or prevent the progression of this neurodegenerative disorder. In this review we provide
an overview of the most promising therapeutic targets and strategies to delay the loss of
dopaminergic neurons observed both in PD and aging. Among them, handling alphasynuclein
toxicity, enhancing proteasome and lysosome clearance, ameliorating
mitochondrial disruptions and modifying the glial environment are so far the most
promising candidates. These new and conventional drugs may present problems related
to their labile nature and to the difficulties in reaching the brain. Thus, we highlight the
latest types of drug delivery system (DDS)-based strategies for PD treatment, including
DDS for local and systemic drug delivery. Finally, the ongoing challenges for the
discovery of new targets and the opportunities for DDS-based therapies to improve and
efficacious PD therapy will be discussed
Characterisation of the Galactic thin disc with Corot targets
We use kinematical and chemical properties of 754 Corot stars to characterise
the stellar populations of the Milky Way disc in three beams close the Galactic
plane. From the atmospheric parameters derived in Gazzano et al. (2010) with
the Matisse algorithm, we derived stellar distances using isochrones. Combining
these data with proper motions, we provide the complete kinematical description
of stars in three Corot fields. Finally, we used kinematical criteria to
identify the Galactic populations in our sample and study their
characteristics, particularly their chemistry. Comparing our kinematics with
the Besancon Galactic model, we show that, within 3-sigma, simulated and
observed kinematical distributions are in good agreement. We study the
characteristics of the thin disc, finding a correlation that is significant at
a value of 2-sigma between the V-velocity component and the metallicity for two
different radial distance bins (8-9kpc and 9-10kpc; but not for the most inner
bin 7-8kpc, probably because of the uncertainties in the abundances) which
could be interpreted as radial migration evidence. We also measured a radial
metallicity gradient value of -0.097+/-0.015dex/kpc with giant stars, and
-0.053+/-0.015dex/kpc with dwarfs. Finally, we identified metal-rich stars with
peculiar high [alpha/Fe] values in the directions pointing to the inner part of
the Galaxy. Applying the same methodology to the planet-hosting stars detected
by Corot shows that they mainly belong to the thin disc population with normal
chemical and kinematical properties.Comment: Astronomy & Astrophysics, in pres
The Gaia-ESO survey : Processing FLAMES-UVES spectra
Date of Acceptance: 19/03/2014The Gaia-ESO Survey is a large public spectroscopic survey that aims to derive radial velocities and fundamental parameters of about 105 Milky Way stars in the field and in clusters. Observations are carried out with the multi-object optical spectrograph FLAMES, using simultaneously the medium-resolution (R ~ 20 000) GIRAFFE spectrograph and the high-resolution (R ~ 47 000) UVES spectrograph. In this paper we describe the methods and the software used for the data reduction, the derivation of the radial velocities, and the quality control of the FLAMES-UVES spectra. Data reduction has been performed using a workflow specifically developed for this project. This workflow runs the ESO public pipeline optimizing the data reduction for the Gaia-ESO Survey, automatically performs sky subtraction, barycentric correction and normalisation, and calculates radial velocities and a first guess of the rotational velocities. The quality control is performed using the output parameters from the ESO pipeline, by a visual inspection of the spectra and by the analysis of the signal-to-noise ratio of the spectra. Using the observations of the first 18 months, specifically targets observed multiple times at different epochs, stars observed with both GIRAFFE and UVES, and observations of radial velocity standards, we estimated the precision and the accuracy of the radial velocities. The statistical error on the radial velocities is σ ~ 0.4 km s-1 and is mainly due to uncertainties in the zero point of the wavelength calibration. However, we found a systematic bias with respect to the GIRAFFE spectra (~0.9 km s-1) and to the radial velocities of the standard stars (~0.5 km s-1) retrieved from the literature. This bias will be corrected in the future data releases, when a common zero point for all the set-ups and instruments used for the survey is be established.Peer reviewe
The Gaia-ESO Survey : The analysis of high-resolution UVES spectra of FGK-type stars
Date of Acceptance: 01/09/2014Context. The ongoing Gaia-ESO Public Spectroscopic Survey is using FLAMES at the VLT to obtain high-quality medium-resolution Giraffe spectra for about 105 stars and high-resolution UVES spectra for about 5000 stars. With UVES, the Survey has already observed 1447 FGK-type stars. Aims. These UVES spectra are analyzed in parallel by several state-of-the-art methodologies. Our aim is to present how these analyses were implemented, to discuss their results, and to describe how a final recommended parameter scale is defined. We also discuss the precision (method-to-method dispersion) and accuracy (biases with respect to the reference values) of the final parameters. These results are part of the Gaia-ESO second internal release and will be part of its first public release of advanced data products. Methods. The final parameter scale is tied to the scale defined by the Gaia benchmark stars, a set of stars with fundamental atmospheric parameters. In addition, a set of open and globular clusters is used to evaluate the physical soundness of the results. Each of the implemented methodologies is judged against the benchmark stars to define weights in three different regions of the parameter space. The final recommended results are the weighted medians of those from the individual methods. Results. The recommended results successfully reproduce the atmospheric parameters of the benchmark stars and the expected Teff-log g relation of the calibrating clusters. Atmospheric parameters and abundances have been determined for 1301 FGK-type stars observed with UVES. The median of the method-to-method dispersion of the atmospheric parameters is 55 K for Teff, 0.13 dex for log g and 0.07 dex for [Fe/H]. Systematic biases are estimated to be between 50-100 K for Teff, 0.10-0.25 dex for log g and 0.05-0.10 dex for [Fe/H]. Abundances for 24 elements were derived: C, N, O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Mo, Ba, Nd, and Eu. The typical method-to-method dispersion of the abundances varies between 0.10 and 0.20 dex. Conclusions. The Gaia-ESO sample of high-resolution spectra of FGK-type stars will be among the largest of its kind analyzed in a homogeneous way. The extensive list of elemental abundances derived in these stars will enable significant advances in the areas of stellar evolution and Milky Way formation and evolution.Peer reviewe
The Infrared Nuclear Emission of Seyfert Galaxies on Parsec Scales: Testing the Clumpy Torus models
We present subarcsecond resolution mid-infrared (mid-IR) photometry in the
wavelength range from 8 to 20 micron of eighteen Seyfert galaxies, reporting
high spatial resolution nuclear fluxes for the entire sample. We construct
spectral energy distributions (SEDs) that the AGN dominates adding near-IR
measurements from the literature at similar angular resolution. The IR SEDs of
intermediate-type Seyferts are flatter and present higher 10 to 18 micron
ratios than those of Seyfert 2. We fit the individual SEDs with clumpy torus
models using the in-house-developed BayesClumpy tool. The models reproduce the
high spatial resolution measurements. Regardless of the Seyfert type, even with
high spatial resolution data, near- to mid-IR SED fitting poorly constrains the
radial extent of the torus. For the Seyfert 2, we find that edge-on geometries
are more probable than face-on views, with a number of clouds along equatorial
rays of N = 5-15. The 10 micron silicate feature is generally modeled in
shallow absorption. For the intermediate-type Seyferts, N and the inclination
angle of the torus are lower than those of the Seyfert 2 nuclei, with the
silicate feature appearing in weak emission or absent. The columns of material
responsible for the X-ray absorption are larger than those inferred from the
model fits for most of the galaxies, which is consistent with X-ray absorbing
gas being located within the dust sublimation radius whereas the mid-IR flux
arises from an area farther from the accretion disc. The fits yield both the
bolometric luminosity of the intrinsic AGN and the torus integrated luminosity,
from which we derive the reprocessing efficiency of the torus. In the models,
the outer radial extent of the torus scales with the AGN luminosity, and we
find the tori to be confined to scales less than 5 pc.Comment: 26 pages, 8 figures, 9 tables. Accepted for publication in Ap
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