Altas habilidades ou superdotação: levantamento dos artigos indexados no SciELO

A Declaração de Salamanca e a Política Nacional de Educação Especial são considerados os grandes marcos mundial e nacional, respectivamente, na área da inclusão. Estes documentos descrevem os estudantes que são considerados público alvo da educação especial, sendo que aqueles que apresentam altas habilidades ou superdotação estão contemplados nesta população. Diante da necessidade de pesquisas na área que proporcionem a consolidação e a produção de novos conhecimento, se faz necessário analisar as produções já existentes. O objetivo deste trabalho foi realizar uma pesquisa bibliográfica, na Scientific Eletronic Library Online, identificar as principais temáticas dos artigos, o ano, locais de publicação e principais autores. Encontramos 53 artigos científicos, sendo que “características”, “identificação”, “formação docente” e “esporte” foram as categorias temáticas com maior número de artigos. O ano de 2015 destacou-se com o maior número de produções, sendo que a Revista Brasileira de Educação Especial destaca-se como local de publicação.

Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability

Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron–sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. Increased oxidative damage or deficient DNA repair do not account for the observed genomic hyperrecombination. Impaired cell-cycle progression and genetic interactions of ZIM17 with components of the RFC-like complex involved in mitotic checkpoints indicate that replicative stress causes hyperrecombination in zim17Δ mutants. Furthermore, nuclear accumulation of pre-ribosomal particles in zim17Δ mutants reinforces the importance of iron–sulfur clusters in normal ribosome biosynthesis. We propose that compromised ribosome biosynthesis and cell-cycle progression are interconnected, together contributing to replicative stress and nuclear genome instability in zim17Δ mutants

Enhanced ozonation of selected pharmaceutical compounds by sonolysis

In search of new options to achieve removal of pharmaceuticals in the environment, combined ultrasound and ozonation has become a focus of intense investigation for wastewater treatment. In this study, three pharmaceuticals were selected as model compounds for degradation experiments: diclofenac (DCF), sulfamethoxazole (SMX) and carbamazepine (CBZ). Comparison of the degradation rates for both ozonation and combined ultrasound/ozonation treatments was performed on single synthetic solutions as well as on a mixture of the selected pharmaceuticals, under different experimental conditions. For single synthetic solutions, the efficiency removal for ozonation reached 73%, 51% and 59% after 40 min for DCF, SMX and CBZ, respectively. Comparable results were obtained for pharmaceuticals in mixture. However, the combined ultrasound/ozone treatment was found to increase degradation efficiencies for both DCF and SMX single solutions up to 94% and 61%, respectively, whereas lower removal yields, up to 56%, was noted for CBZ. Likewise, when the combined treatment was applied to the mixture, relatively low removal efficiencies was found for CBZ (44%) and 90% degradation yield was achieved for DCF

Removal of emerging contaminant and fouling control in membrane bioreactors by combined ozonation and sonolysis

The combination of chemical and biological treatment is a promising solution to remove emerging contaminants, e.g., pharmaceuticals, from wastewater for its future reuse. In this study, the combination of ozonation and ultrasound (O3/US) was examined as a pretreatment prior to membrane bioreactor (MBR). The effects of O3/US on the removal of selected pharmaceuticals, including diclofenac (DCF), sulfamethoxazole (SMX) and carbamazepine (CBZ), and MBR fouling control were investigated. The variation of the toxicity potential of the MBR influent was also assessed. The O3/US treatment was effective in reducing fouling, mainly due to its effects on the microbial metabolism products in the MBR. Extracellular polymeric substance (EPS) concentration was reduced by 50%. Improved operating conditions resulted in higher removal rates for pharmaceuticals in the MBR effluent, with removal efficiency in the range of 80e84%. However, the O3/US treatment alone was not efficient in removing the toxicity of wastewater. This was likely due to the formation of intermediate products that are more toxic than the parent compounds. These intermediate products were observed to be biologically oxidized by MBR, with a 80% reduction of the toxicity potential in the MBR permeate compared to the influent

ALTAS HABILIDADES OU SUPERDOTAÇÃO: LEVANTAMENTO DOS ARTIGOS INDEXADOS NO SciELO

A Declaração de Salamanca e a Política Nacional de Educação Especial são considerados os grandes marcos mundial e nacional, respectivamente, na área da inclusão. Estes documentos descrevem os estudantes que são considerados público alvo da educação especial, sendo que aqueles que apresentam altas habilidades ou superdotação estão contemplados nesta população. Diante da necessidade de pesquisas na área que proporcionem a consolidação e a produção de novos conhecimento, se faz necessário analisar as produções já existentes. O objetivo deste trabalho foi realizar uma pesquisa bibliográfica, na Scientific Eletronic Library Online, identificar as principais temáticas dos artigos, o ano, locais de publicação e principais autores. Encontramos 53 artigos científicos, sendo que “características”, “identificação”, “formação docente” e “esporte” foram as categorias temáticas com maior número de artigos. O ano de 2015 destacou-se com o maior número de produções, sendo que a Revista Brasileira de Educação Especial destaca-se como local de publicação

Colistin and polymyxin B for treatment of nosocomial infections in intensive care unit patients: pharmacoeconomic analysis

The emergence and rapid spread of multidrug-resistant gram-negative bacteria related to nosocomial infections is a growing worldwide problem, and polymyxins have become important due to the lack of new antibiotics. To evaluate the outcomes and pharmacoeconomic impact of using colistin and polymyxin B to treat nosocomial infections. Setting Neurosurgical, cardiovascular, or transplantation intensive care unit (ICU) at the Clinical Hospital of the University of Campinas (SAo Paulo, Brazil). A retrospective cohort study was conduct in patients in the ICU. The renal function was determined daily during treatment by measuring the serum creatinine. A cost minimization analysis was performed to compare the relative costs of treatment with colistin and polymyxin B. Main outcomes measure The outcomes were 30-day mortality and frequency and onset of nephrotoxicity after beginning treatment. Fifty-one patients treated with colistin and 51 with polymyxin B were included. 30-day mortality was observed in 25.49% and 33.33% of patients treated with colistin and polymyxin B, respectively; Nephrotoxicity was observed in 43.14% and 54.90% of patients in colistin and polymyxin B groups, respectively; and onset time of nephrotoxicity was 9.86 +/- 13.22days for colistin and 10.68 +/- 9.93days for polymyxin B group. Colistin treatment had a lower cost per patient compared to the cost for polymyxin B treatment (USD $13,389.37 vs. USD$13,639.16, respectively). We found no difference between 30-day mortality and nephrotoxicity between groups; however, colistin proved to be the best option from a pharmacoeconomic point of view4117480CAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível SuperiorCNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológico164796/2014-2; 02P4353/2015Sem informaçã

Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule produced in cis with its DNA template. However, it has also been suggested that recombinogenic DNA:RNA hybrids could be facilitated by the invasion of RNA molecules produced in trans in a Rad51-mediated reaction. Here, we tested the possibility that such DNA:RNA hybrids constitute a source of recombinogenic DNA damage taking advantage of Rad51-independent single-strand annealing (SSA) assays in the yeast Saccharomyces cerevisiae. For this, we used new constructs designed to induce expression of mRNA transcripts in trans with respect to the SSA system. We show that unscheduled and recombinogenic DNA:RNA hybrids that trigger the SSA event are formed in cis during transcription and in a Rad51-independent manner. We found no evidence that such hybrids form in trans and in a Rad51-dependent manner.Research was supported by the Spanish Ministry of Economy and Competitiveness (BFU2016-75058- P) and the European Union (FEDER). BG-G was funded by a grant from the Spanish Association Against Cancer (AECC)