Interviews with Burt Brumfield, Maxine Querbach, Roy Stanbaugh, Ed Hershler, Katie Schnetzer, Pat Halling, Barbara Howe, The Benishes, Emma Folck, William R. McFarland, and Brenda Greenwood

Interviews with Burt Brumfield, Maxine Querbach, Roy Stanbaugh, Ed Hershler, Katie Schnetzer, Pat Halling, Barbara Howe, The Benishes, Emma Folck, William R. McFarland, and Brenda Greenwood. 00:00:00 - Introduction, Burt Brumfield of Jetmore, KS on November 30, 1963 00:00:17 - Kissing pigeon fashion. 00:00:50 - Horse races 00:01:30 - Decoration Day (Memorial Day) 00:03:03 - School activities 00:03:26 - A blizzard hits during a literary 00:05:10 - Prairie fire 00:05:29 - Poem, A Poor Married Man 00:06:07 - Grandfather\u27s work on the sabbath in Indiana and the resulting death of a cow 00:07:25 - Father\u27s work on the sabbath and a subsequent cyclone 00:08:16 - Introduction, Maxine Querbach of Hanston, KS on December 21, 1963 00:08:30 - Story about an old bachelor 00:10:20 - Introduction, Roy Stanbaugh of Hanston, KS on December 30, 1963 00:10:36 - Story about the Dust Bowl 00:10:50 - Story about windy Kansas 00:11:14 - Story about Louie the Robber a modern day Robin Hood 00:12:18 - Story about older students chasing off the teacher 00:16:17 - Early smallpox treatments 00:17:22 - Introduction, Ed Herschler of Hanston, KS on January 4, 1963 00:17:44 - Blizzard of 1886 00:22:11 - Story of the Purple family murders in November of 1886 00:28:22 - Prairie fires 00:31:17 - Story about a 16-year-old female teacher being assaulted by local men 00:33:54 - Introduction, Katie Schnetzer, Pat Halling, and Barbara Howe of Hanston, KS on January 3, 1963 00:34:36 - Description of children\u27s games. Some description is in German 00:39:19 - Ghost stories 00:41:25 - Song, untitled, vocal 00:41:59 - Song, He Asked Me For a Date , vocal duet 00:43:17 - Song, Sippin\u27 Cider Through a Straw , vocal duet 00:46:37 - Song, Let\u27s Go Bowling on Bowling Green , vocal duet 00:47:36 - Introduction, Maxine Querbach of Hanston, KS 00:48:00 - Grasshopper swarms of the late 1800s 00:48:32 - Introduction, The Benishes , a musical group playing in Orwell, KS on January 5, 1963 00:49:23 - Song, untitled squaredance, fiddle and piano 01:06:13 - Introduction, Emma Folck of Little River, KS on January 1, 1964 01:06:30 - History of the Rhodes family in Rice County, KS in 1880 01:07:49 - Farm production in 1875 in Rice County, KS and the first courthouse 01:08:27 - Mother is bitten by a rattlesnake in 1879 01:09:38 - Pawnee Rock 01:10:00 - Story, John Brown\u27s Buddy 01:11:14 - Staying overnight in Lindsborg, KS in 1905 01:12:29 - Early agricultural practices 01:13:15 - Introduction, William R. McFarland of Cimmaron, KS on November 29, 1963 01:13:37 - Song, The Early Days , vocal and piano 01:17:56 - Song, Fifty Years Ago, vocal and piano 01:22:50 - Song, Oh, Those Christmas Days , vocal and piano 01:26:54 - Song, Arkansas Valley to the tune of Red River Valley , vocal and piano 01:30:10 - Introduction, Brenda Greenwood and friends of Cimmaron, KS on November 29, 1963 01:30:31 - Song, Cimmaron Schools to the tune of The Marine Hymn , vocalhttps://scholars.fhsu.edu/sackett/1084/thumbnail.jp

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

A Fine-Structure Map of Spontaneous Mitotic Crossovers in the Yeast Saccharomyces cerevisiae

Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas crossovers between repeated genes on non-homologous chromosomes can result in translocations. Using a genetic system that allows selection of daughter cells that contain the reciprocal products of mitotic crossing over, we mapped crossovers and gene conversion events at a resolution of about 4 kb in a 120-kb region of chromosome V of Saccharomyces cerevisiae. The gene conversion tracts associated with mitotic crossovers are much longer (averaging about 12 kb) than the conversion tracts associated with meiotic recombination and are non-randomly distributed along the chromosome. In addition, about 40% of the conversion events have patterns of marker segregation that are most simply explained as reflecting the repair of a chromosome that was broken in G1 of the cell cycle

Proctitis following stereotactic body radiation therapy for prostate cancer

Background Proctitis after radiation therapy for prostate cancer remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize rectal toxicity by reducing the volume of rectum receiving high radiation doses and offers the potential radiobiologic benefits of hypofractionation. This study sought to evaluate the incidence and severity of proctitis following SBRT for prostate cancer. Methods Between February 2008 and July 2011, 269 men with clinically localized prostate cancer were treated definitively with SBRT monotherapy at Georgetown University Hospital. All patients were treated to 35-36.25Gy in 5 fractions delivered with the CyberKnife Radiosurgical System (Accuray). Rectal bleeding was recorded and scored using the CTCAE v.4. Telangiectasias were graded using the Vienna Rectoscopy Score (VRS). Proctitis was assessed via the Bowel domain of the Expanded Prostate Index Composite (EPIC)-26 at baseline and at 1, 3, 6, 9, 12, 18 and 24 months post-SBRT. Results The median age was 69 years with a median prostate volume of 39 cc. The median follow-up was 3.9 years with a minimum follow-up of two years. The 2-year actuarial incidence of late rectal bleeding ≥ grade 2 was 1.5%. Endoscopy revealed VRS Grade 2 rectal telangiectasias in 11% of patients. All proctitis symptoms increased at one month post-SBRT but returned to near-baseline with longer follow-up. The most bothersome symptoms were bowel urgency and frequency. At one month post-SBRT, 11.2% and 8.5% of patients reported a moderate to big problem with bowel urgency and frequency, respectively. The EPIC bowel summary scores declined transiently at 1 month and experienced a second, more protracted decline between 6 months and 18 months before returning to near-baseline at two years post-SBRT. Prior to treatment, 4.1% of men felt their bowel function was a moderate to big problem which increased to 11.5% one month post-SBRT but returned to near-baseline at two years post-SBRT. Conclusions In this single institution cohort, the rate and severity of proctitis observed following SBRT is low. QOL decreased on follow-up; however, our results compare favorably to those reported for patients treated with alternative radiation modalities. Future prospective randomized studies are needed to confirm these observations

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Search for Darkonium in e+e- Collisions

Collider searches for dark sectors, new particles interacting only feebly with ordinary matter, have largely focused on identifying signatures of new mediators, leaving much of dark sector structures unexplored. In particular, the existence of dark matter bound states (darkonia) remains to be investigated. This possibility could arise in a simple model in which a dark photon (A0 ) is light enough to generate an attractive force between dark fermions. We report herein a search for a JPC ¼ 1−− darkonium state, the ϒD, produced in the reaction eþe− → γϒD, ϒD → A0 A0 A0 , where the dark photons subsequently decay into pairs of leptons or pions, using 514 fb−1 of data collected with the BABAR detector. No significant signal is observed, and we set bounds on the γ − A0 kinetic mixing as a function of the dark sector coupling constant for 0.001 < mA0 < 3.16 GeV and 0.05 < mϒD < 9.5 GeV.publishedVersio

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead