Prospects of gravitational-wave follow-up through a wide-field ultraviolet satellite: A Dorado case study

The detection of gravitational waves from the binary neuron star merger GW170817 and electromagnetic counterparts GRB170817A and AT2017gfo kick-started the field of gravitational-wave multimessenger astronomy. The optically red to near-infrared emission ("red" component) of AT2017gfo was readily explained as produced by the decay of newly created nuclei produced by rapid neutron capture (a kilonova). However, the ultraviolet to optically blue emission ("blue" component) that was dominant at early times (up to 1.5 days) received no consensus regarding its driving physics. Among many explanations, two leading contenders are kilonova radiation from a lanthanide-poor ejecta component and shock interaction (cocoon emission). In this work, we simulate AT2017gfo-like light curves and perform a Bayesian analysis to study whether an ultraviolet satellite capable of rapid gravitational-wave follow-up, could distinguish between physical processes driving the early "blue" component. We find that ultraviolet data starting at 1.2 hr distinguishes the two early radiation models up to 160 Mpc, implying that an ultraviolet mission like Dorado would significantly contribute to insights into the driving emission physics of the postmerger system. While the same ultraviolet data and optical data starting at 12 hr have limited ability to constrain model parameters separately, the combination of the two unlocks tight constraints for all but one parameter of the kilonova model up to 160 Mpc. We further find that a Dorado-like ultraviolet satellite can distinguish the early radiation models up to at least 130 (60) Mpc if data collection starts within 3.2 (5.2) hr for AT2017gfo-like light curves

High frequency oscillations during magnetar flares

The recent discovery of high frequency oscillations during giant flares from the Soft Gamma Repeaters SGR 1806-20 and SGR 1900+14 may be the first direct detection of vibrations in a neutron star crust. If this interpretation is correct it offers a novel means of testing the neutron star equation of state, crustal breaking strain, and magnetic field configuration. We review the observational data on the magnetar oscillations, including new timing analysis of the SGR 1806-20 giant flare using data from the Ramaty High Energy Solar Spectroscopic Imager (RHESSI) and the Rossi X-ray Timing Explorer (RXTE). We discuss the implications for the study of neutron star structure and crust thickness, and outline areas for future investigation.Comment: 5 pages, 1 figure, to appear in the proceedings of the conference "Isolated Neutron Stars: from the Interior to the Surface" (April 2006, London), eds. D. Page, R. Turolla, & S. Zane, Astrophysics & Space Science in pres

Approximative Analytic Study of Fermions in Magnetar's Crust; Ultra-relativistic Plane Waves, Heun and Mathieu Solutions and Beyond

Working with a magnetic field periodic along $Oz$ and decaying in time, we deal with the Dirac-type equation characterizing the fermions evolving in magnetar's crust. For ultra-relativistic particles, one can employ the perturbative approach, to compute the conserved current density components. If the magnetic field is frozen and the magnetar is treated as a stationary object, the fermion's wave function is expressed in terms of the Heun's Confluent functions. Finally, we are extending some previous investigations on the linearly independent fermionic modes solutions to the Mathieu's equation and we discuss the energy spectrum and the Mathieu Characteristic Exponent.Comment: Accepted for publication in Astrophysics & Space Science, 15 pages, No figure

Multimessenger astronomy with the Einstein Telescope

Gravitational waves (GWs) are expected to play a crucial role in the development of multimessenger astrophysics. The combination of GW observations with other astrophysical triggers, such as from gamma-ray and X-ray satellites, optical/radio telescopes, and neutrino detectors allows us to decipher science that would otherwise be inaccessible. In this paper, we provide a broad review from the multimessenger perspective of the science reach offered by the third generation interferometric GW detectors and by the Einstein Telescope (ET) in particular. We focus on cosmic transients, and base our estimates on the results obtained by ET's predecessors GEO, LIGO, and Virgo.Comment: 26 pages. 3 figures. Special issue of GRG on the Einstein Telescope. Minor corrections include

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

The type II-plateau supernova 2017eaw in NGC 6946 and its red supergiant progenitor

We present extensive optical photometric and spectroscopic observations, from 4 to 482 days after explosion, of the Type II-plateau (II-P) supernova (SN) 2017eaw in NGC 6946. SN 2017eaw is a normal SN II-P intermediate in properties between, for example, SN 1999em and SN 2012aw and the more luminous SN 2004et, also in NGC 6946. We have determined that the extinction to SN 2017eaw is primarily due to the Galactic foreground and that the SN site metallicity is likely subsolar. We have also independently confirmed a tip-of-the-red-giant-branch (TRGB) distance to NGC 6946 of 7.73 ± 0.78 Mpc. The distances to the SN that we have also estimated via both the standardized candle method and expanding photosphere method corroborate the TRGB distance. We confirm the SN progenitor identity in pre-explosion archival Hubble Space Telescope (HST) and Spitzer Space Telescope images, via imaging of the SN through our HST Target of Opportunity program. Detailed modeling of the progenitor's spectral energy distribution indicates that the star was a dusty, luminous red supergiant consistent with an initial mass of ~15 M ⊙

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer's disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7 prion model, and its impact on the inflammatory profile, and provided potential CNS biomarkers for clinical investigation with the compound, including pharmacokinetic/pharmacodynamics and efficacy assessment by TSPO autoradiography and CSF proteomics. Then, we showed for the first time that blockade of microglial proliferation and modification of microglial phenotype leads to an attenuation of tau-induced neurodegeneration and results in functional improvement in P301S mice. Overall, this work strongly supports the potential for inhibition of CSF1R as a target for the treatment of Alzheimer's disease and other tau-mediated neurodegenerative diseases

Inflammatory biomarkers in Alzheimer's disease plasma

Introduction: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a \u201cHoly Grail\u201d of AD research and intensively sought; however, there are no well-established plasma markers. Methods: A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Results: Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APO\u3b54 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Discussion: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation

Constraints on dark matter-nucleon effective couplings in the presence of kinematically distinct halo substructures using the DEAP-3600 detector

DEAP-3600 is a single-phase liquid argon detector aiming to directly detect weakly interacting massive particles (WIMPs), located at SNOLAB (Sudbury, Canada). After analyzing data taken during the first year of operation, a null result was used to place an upper bound on the WIMP-nucleon, spin-independent, isoscalar cross section. This study reinterprets this result within a nonrelativistic effective field theory framework and further examines how various possible substructures in the local dark matter halo may affect these constraints. Such substructures are hinted at by kinematic structures in the local stellar distribution observed by the Gaia satellite and other recent astronomical surveys. These include the Gaia Sausage (or Enceladus), as well as a number of distinct streams identified in recent studies. Limits are presented for the coupling strength of the effective contact interaction operators O1, O3, O5, O8, and O11, considering isoscalar, isovector, and xenonphobic scenarios, as well as the specific operators corresponding to millicharge, magnetic dipole, electric dipole, and anapole interactions. The effects of halo substructures on each of these operators are explored as well, showing that the O5 and O8 operators are particularly sensitive to the velocity distribution, even at dark matter masses above 100 GeV=c