Adaptation of the Landau-Migdal Quasiparticle Pattern to Strongly Correlated Fermi Systems

A quasiparticle pattern advanced in Landau's first article on Fermi liquid theory is adapted to elucidate the properties of a class of strongly correlated Fermi systems characterized by a Lifshitz phase diagram featuring a quantum critical point (QCP) where the density of states diverges. The necessary condition for stability of the Landau Fermi Liquid state is shown to break down in such systems, triggering a cascade of topological phase transitions that lead, without symmetry violation, to states with multi-connected Fermi surfaces. The end point of this evolution is found to be an exceptional state whose spectrum of single-particle excitations exhibits a completely flat portion at zero temperature. Analysis of the evolution of the temperature dependence of the single-particle spectrum yields results that provide a natural explanation of classical behavior of this class of Fermi systems in the QCP region.Comment: 26 pages, 14 figures. Dedicated to 100th anniversary of A.B.Migdal birthda

Excited State Proton Transfer in the Lysosome of Live Lung Cells:Normal and Cancer Cells

Dynamics of excited state proton transfer(ESPT) in the lysosome region of live lung cells (normaland cancer) is studied by picosecond time-resolved confocal microscopy. For this, we used a fluorescent probe, pyranine (8- hydroxy-pyrene-1,3,6-trisulfonate, HPTS). From the colocalization of HPTS with a lysotracker dye (lysotracker yellow), we confirmed that HPTS resides in the lysosome for both of the cells. The diffusion coefficient (Dt) in the lysosome region was obtained from fluorescence correlation spectroscopy (FCS). From Dt, the viscosity of lysosome is estimated to be ∼40 and ∼30 cP in the cancer and normal cells, respectively. The rate constants of the elementary steps of ESPT in a normal lung cell (WI38) are compared with those in a lung cancer cell (A549). It is observed that the time constant of the initial proton transfer process in a normal cell (τPT = 40 ps) is similar to that in a cancer cell. The recombination of the geminate ion pair is slightly faster (τrec = 25 ps) in the normal cell than that (τrec = 30 ps) in a cancer cell. The time constant of the dissociation (τdiss) of the geminate ion pair for the cancer cell (τdiss = 80 ps) is 1.5 times faster compared to that (τdiss = 120 ps) in a normal cell