Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis

PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Prospects for Measuring Vtb via s-channel Single Top at ATLAS

The production of single top quarks via the electroweak interaction promises to provide new opportunities to both test the Standard Model and search for new physics. In particular, electroweak top production provides the only means to directly measure the CKM matrix element Vtb at ATLAS. The s-channel has the lowest rate, but is the best theoretically understood mechanism of electroweak top production. An evaluation of the potential for background suppression and Vtb measurement in this channel is presented. It is found that significant background suppression can be achieved and Vtb can be measured in the s-channel to a statistical precision of 2.8% after 30 inverse femtobarns of integrated luminosity at the LHC

Design and implementation of an integrated management system for ochratoxin A in the coffee production chain

n/

Reputation, Game Theory and Entrepreneurial Sustainability

Abstract: This manuscript provides a novel approach to reputational management as a driver of entrepreneurial sustainability, using game theory to integrate three dimensions of reputation. First, if the entrepreneur perceives reputation as a risk source, the analysis is framed as a prisoner’s dilemma schema that is solved by protecting against reputational threats from entrepreneurial sustainability. Second, if the entrepreneur perceives reputation as a competitive advantage, the analysis is framed as an innovator’s dilemma that is solved by getting reputational opportunities from entrepreneurial sustainability. Third, if reputation is perceived as a strategic asset, the analysis is framed as a coordination game schema that results in the development of a reputational intelligence skill that has the potential to become crucial for success in entrepreneurial sustainability. Consequently, this manuscript provides an original multidisciplinary analysis of reputational management by relating well-known theoretical results from game theory to organizational realities

INTEGRAL timing and localization performance

In this letter we report on the accuracy of the attitude, misalignment, orbit and time correlation which are used to perform scientific analyses of the INTEGRAL data. The boresight attitude during science pointings has an accuracy of 3 arcsec. At the center of the field, the misalignments have been calibrated leading to a location accuracy of 4 to 40 arcsec for the different instruments. The spacecraft position is known within 10 meters. The relative timing between instruments could be reconstructed within 10 microsec and the absolute timing within 40 microsec.Comment: 5 pages, 2 figures, accepted for publication in A+A letters, INTEGRAL special issu

An efficient hardware architecture for a neural network activation function generator

This paper proposes an efficient hardware architecture for a function generator suitable for an artificial neural network (ANN). A spline-based approximation function is designed that provides a good trade-off between accuracy and silicon area, whilst also being inherently scalable and adaptable for numerous activation functions. This has been achieved by using a minimax polynomial and through optimal placement of the approximating polynomials based on the results of a genetic algorithm. The approximation error of the proposed method compares favourably to all related research in this field. Efficient hardware multiplication circuitry is used in the implementation, which reduces the area overhead and increases the throughput

New Halogenated Phenylbacteriochlorins and Their Efficiency in Singlet-Oxygen Sensitization

Halogenated phenylbacteriochlorins are synthesized with high yields in a two-step procedure. They have strong absorbances in the red and are very stable to air and light at room temperature. Flash photolysis measurements show that the triplet states of these bacteriochlorins have 30 μs lifetimes in deaerated toluene, that are quenched with diffusion-controlled rate constants by molecular oxygen. Time-resolved photoacoustic measurements, with nanosecond and nanocalorie resolution, show that these bacteriochlorins sensitize the formation of singlet oxygen with nearly unity quantum yield. However, singlet-oxygen phosphorescence measurements indicate that physical quenching occurs before the singlet-oxygen molecules diffuse into solution, and nearly half of the sensitized singlet states are lost