429 research outputs found
SUGRA chaotic inflation and moduli stabilisation
Chaotic inflation predicts a large gravitational wave signal which can be
tested by the upcoming Planck satellite. We discuss a SUGRA implementation of
chaotic inflation in the presence of moduli fields, and find that inflation
does not work with a generic KKLT moduli stabilisation potential. A viable
model can be constructed with a fine-tuned moduli sector, but only for a very
specific choice of Kahler potential. Our analysis also shows that inflation
models satisfying \partial_{i} W_{\rm inf}=0 for all inflation sector fields
\phi_i can be combined successfully with a fine-tuned moduli sector.Comment: 20 pages, 4 figures, refs adde
Accidental Inflation in String Theory
We show that inflation in type IIB string theory driven by the volume modulus
can be realized in the context of the racetrack-based Kallosh-Linde model (KL)
of moduli stabilization. Inflation here arises through the volume modulus
slow-rolling down from a flat hill-top or inflection point of the scalar
potential. This situation can be quite generic in the landscape, where by
uplifting one of the two adjacent minima one can turn the barrier either to a
flat saddle point or to an inflection point supporting eternal inflation. The
resulting spectral index is tunable in the range of 0.93 < n_s < 1, and there
is only negligible production of primordial gravitational waves r < 10^{-6}.
The flatness of the potential in this scenario requires fine-tuning, which may
be justified taking into account the exponential reward by volume factors
preferring the regions of the universe with the maximal amount of slow-roll
inflation. This consideration leads to a tentative prediction of the spectral
index or depending on whether the
potential has a symmetry phi -> - phi or not.Comment: 15 pages, 6 figures, LaTeX, uses RevTex
Human neutrophils phagocytose and kill Acinetobacter baumanii and A. pittii
Acinetobacter baumannii is a common cause of health care associated infections worldwide. A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections other than those from A. baumannii. Knowledge of Acinetobacter virulence factors and their role in pathogenesis is scarce. Also, there are no detailed published reports on the interactions between A. pittii and human phagocytic cells. Using confocal laser and scanning electron microscopy, immunofluorescence, and live-cell imaging, our study shows that immediately after bacteria-cell contact, neutrophils rapidly and continuously engulf and kill bacteria during at least 4 hours of infection in vitro. After 3 h of infection, neutrophils start to release neutrophil extracellular traps (NETs) against Acinetobacter. DNA in NETs colocalizes well with human histone H3 and with the specific neutrophil elastase. We have observed that human neutrophils use large filopodia as cellular tentacles to sense local environment but also to detect and retain bacteria during phagocytosis. Furthermore, co-cultivation of neutrophils with human differentiated macrophages before infections shows that human neutrophils, but not macrophages, are key immune cells to control Acinetobacter. Although macrophages were largely activated by both bacterial species, they lack the phagocytic activity demonstrated by neutrophils
Lectures on Cosmic Inflation and its Potential Stringy Realizations
These notes present a brief introduction to Hot Big Bang cosmology and Cosmic
Inflation, together with a selection of some recent attempts to embed inflation
into string theory. They provide a partial description of lectures presented in
courses at Dubrovnik in August 2006, at CERN in January 2007 and at Cargese in
August 2007. They are aimed at graduate students with a working knowledge of
quantum field theory, but who are unfamiliar with the details of cosmology or
of string theory.Comment: 68 pages, lectures given at Dubrovnik, Aug 2006; CERN, January 2007;
and Cargese, Aug 200
Search for CP violation in decays
A model-independent search for direct CP violation in the Cabibbo suppressed
decay in a sample of approximately 370,000 decays is
carried out. The data were collected by the LHCb experiment in 2010 and
correspond to an integrated luminosity of 35 pb. The normalized Dalitz
plot distributions for and are compared using four different
binning schemes that are sensitive to different manifestations of CP violation.
No evidence for CP asymmetry is found.Comment: 13 pages, 8 figures, submitted to Phys. Rev.
First observation of the decay and a measurement of the ratio of branching fractions
The first observation of the decay using
data collected by the LHCb detector at a centre-of-mass energy of 7 TeV,
corresponding to an integrated luminosity of 36 pb, is reported. A
signal of events is obtained and the absence of signal is
rejected with a statistical significance of more than nine standard deviations.
The branching fraction is measured relative to
that of : , where the first uncertainty is statistical, the second systematic and
the third is due to the uncertainty on the ratio of the and
hadronisation fractions.Comment: 10 pages, 3 figures, submitted to Phys. Lett. B; ISSN 0370-269
Evidence for the η_b(1S) Meson in Radiative Υ(2S) Decay
We have performed a search for the η_b(1S) meson in the radiative decay of the Υ(2S) resonance using a sample of 91.6 × 10^6 Υ(2S) events recorded with the BABAR detector at the PEP-II B factory at the SLAC National Accelerator Laboratory. We observe a peak in the photon energy spectrum at E_γ = 609.3^(+4.6)_(-4.5)(stat)±1.9(syst) MeV, corresponding to an η_b(1S) mass of 9394.2^(+4.8)_(-4.9)(stat) ± 2.0(syst) MeV/c^2. The branching fraction for the decay Υ(2S) → γη_b(1S) is determined to be [3.9 ± 1.1(stat)^(+1.1)_(-0.9)(syst)] × 10^(-4). We find the ratio of branching fractions B[Υ(2S) → γη_b(1S)]/B[Υ(3S) → γη_b(1S)]= 0.82 ± 0.24(stat)^(+0.20)_(-0.19)(syst)
First observation of Bs -> D_{s2}^{*+} X mu nu decays
Using data collected with the LHCb detector in proton-proton collisions at a
centre-of-mass energy of 7 TeV, the semileptonic decays Bs -> Ds+ X mu nu and
Bs -> D0 K+ X mu nu are detected. Two structures are observed in the D0 K+ mass
spectrum at masses consistent with the known D^+_{s1}(2536) and
$D^{*+}_{s2}(2573) mesons. The measured branching fractions relative to the
total Bs semileptonic rate are B(Bs -> D_{s2}^{*+} X mu nu)/B(Bs -> X mu nu)=
(3.3\pm 1.0\pm 0.4)%, and B(Bs -> D_{s1}^+ X munu)/B(Bs -> X mu nu)= (5.4\pm
1.2\pm 0.5)%, where the first uncertainty is statistical and the second is
systematic. This is the first observation of the D_{s2}^{*+} state in Bs
decays; we also measure its mass and width.Comment: 8 pages 2 figures. Published in Physics Letters
University–industry collaboration: using meta-rules to overcome barriers to knowledge transfer
This is the final version of the article. Available from Springer Verlag via the DOI in this record.University–industry knowledge transfer is an important source wealth of creation for all partners; however, the practical management of this activity within universities is often hampered by procedural rigidity either through the absence of decision-making protocols to reconcile conflicting priorities or through the inconsistent implementation of existing policies. This is problematic, since it can impede operational effectiveness, prevent inter-organisational knowledge-creation and hamper organisational learning. This paper addresses this issue by adopting a cross-discipline approach and presenting meta-rules as a solution to aid organisational decision making. It is proposed that meta-rules can help resolve tensions arising from conflicting priorities between academics, knowledge transfer offices and industry and help facilitate strategic alignment of processes and policies within and between organisations. This research contributes to the growing debate on the strategic challenges of managing knowledge transfer and presents meta-rules as a practical solution to facilitate strategic alignment of internal and external stakeholder tensions. Meta-rules has previously only been applied in a computer intelligence context however, this research proves the efficacy of meta rules in a university–industry knowledge transfer context. This research also has practical implications for knowledge transfer office managers who can use meta-rules to help overcome resource limitations, conflicting priorities and goals of diverse internal and external stakeholders
Recurrent, Robust and Scalable Patterns Underlie Human Approach and Avoidance
BACKGROUND. Approach and avoidance behavior provide a means for assessing the rewarding or aversive value of stimuli, and can be quantified by a keypress procedure whereby subjects work to increase (approach), decrease (avoid), or do nothing about time of exposure to a rewarding/aversive stimulus. To investigate whether approach/avoidance behavior might be governed by quantitative principles that meet engineering criteria for lawfulness and that encode known features of reward/aversion function, we evaluated whether keypress responses toward pictures with potential motivational value produced any regular patterns, such as a trade-off between approach and avoidance, or recurrent lawful patterns as observed with prospect theory. METHODOLOGY/PRINCIPAL FINDINGS. Three sets of experiments employed this task with beautiful face images, a standardized set of affective photographs, and pictures of food during controlled states of hunger and satiety. An iterative modeling approach to data identified multiple law-like patterns, based on variables grounded in the individual. These patterns were consistent across stimulus types, robust to noise, describable by a simple power law, and scalable between individuals and groups. Patterns included: (i) a preference trade-off counterbalancing approach and avoidance, (ii) a value function linking preference intensity to uncertainty about preference, and (iii) a saturation function linking preference intensity to its standard deviation, thereby setting limits to both. CONCLUSIONS/SIGNIFICANCE. These law-like patterns were compatible with critical features of prospect theory, the matching law, and alliesthesia. Furthermore, they appeared consistent with both mean-variance and expected utility approaches to the assessment of risk. Ordering of responses across categories of stimuli demonstrated three properties thought to be relevant for preference-based choice, suggesting these patterns might be grouped together as a relative preference theory. Since variables in these patterns have been associated with reward circuitry structure and function, they may provide a method for quantitative phenotyping of normative and pathological function (e.g., psychiatric illness).National Institute on Drug Abuse (14118, 026002, 026104, DABK39-03-0098, DABK39-03-C-0098); The MGH Phenotype Genotype Project in Addiction and Mood Disorder from the Office of National Drug Control Policy - Counterdrug Technology Assessment Center; MGH Department of Radiology; the National Center for Research Resources (P41RR14075); National Institute of Neurological Disorders and Stroke (34189, 05236
- …