89 research outputs found
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chatterjee Sujash S.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Chen Ting-Wen
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Chiu Hua-Sheng
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Gunaratne Preethi H.
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Pan Yinghong
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Ektaben
- Patel Tushar
- Patil Sagar L.
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Singh Vivek P.
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Somvanshi Sonal
- Sood Anil
- Sood Anil K.
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumazin Pavel
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Wanding
- Zmuda Erik
- Zorman Barry
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Angulo Gonzalez Ana Maria
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Ayer Donald E.
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Eisenman Robert N.
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grandori Carla
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hurlin Peter J.
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Mora Pinero Edna M.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Richardson Anne B.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schaub Franz X.
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shaw Reid
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Trivedi Mihir
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Ventura Andrea
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhang Xiaoyang
- Zhao Fengmei
- Zhao Wei
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brennan Kevin
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Bullman Susan
- Burnette Andrew
- Byers Lauren Averett
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campbell Joshua D.
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Chen Jianhong
- Chen Ting-Wen
- Chen Zhong
- Cheng Feixiong
- Cheng Hui
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Chiu Hua-Sheng
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Coarfa Cristian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Diao Lixia
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Larry
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drill Esther
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flores Elsa R.
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gay Carl M.
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Gevaert Olivier
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Gunaratne Preethi
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Wencai
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mungall Karen L.
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Ojesina Akinyemi I.
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pedamallu Chandra Sekhar
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pickering Curtis R.
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Prunello Marcos
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rader Janet S.
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Rustgi Anil K.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Andre
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Shen Hui
- Shen Ronglei
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Onathan
- Stuart Joshua M.
- Stuart Joshua M.
- Su Tao
- Sumazin Pavel
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Alison M.
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsai Kenneth Y.
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Van Waes Carter
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Walter Vonn
- Wan Yunhu
- Wang Chen
- Wang Jing
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Jane H.
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Batiste Rebecca
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Guo Charles
- Gupta Rajarsi
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Hou Le
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kurc Tahsin
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nguyen Vu
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rao Arvind U. K.
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Saltz Joel
- Samaras Dimitris
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharma Ashish
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shmulevich Ilya
- Shriver Craig D.
- Shroyer Kenneth R.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Pankaj
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Onathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Thorsson Vésteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Arnam John
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhao Tianhao
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and
correlation with overall survival. TIL map structural patterns were grouped using standard
histopathological parameters. These patterns are enriched in particular T cell subpopulations
derived from molecular measures. TIL densities and spatial structure were differentially enriched
among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial
infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic
patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for
the TCGA image archives with insights into the tumor-immune microenvironment
Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies
- Author
- Adams Mark J.
- Adan Roger A.H.
- Adkins Amy E.
- Adkins Daniel E.
- Agrawal Arpana
- Alfredsson Lars
- Aliev Fazil
- Ando Tetsuya
- Andreassen Ole A.
- Bacanu Silviu-Alin
- Baker Jessica H.
- Batzler Anthony
- Bergen Andrew W.
- Berrettini Wade H.
- Bertelsen Sarah
- Biernacka Joanna M.
- Bierut Laura J.
- Bigdeli Tim B.
- Birgegård Andreas
- Boardman Jason D.
- Boden Joseph M.
- Boehm Ilka
- Boni Claudette
- Boomsma Dorret I.
- Brandt Harry
- Breen Gerome
- Brown Sandra A.
- Bryois Julien
- Bucholz Kathleen K.
- Buehren Katharina
- Bulik Cynthia M.
- Burghardt Roland
- Cassina Matgteo
- Chen Danfeng
- Chen Li-Shiun
- Choi Doo-Sup
- Chou Yi-Ling
- Cichon Sven
- Clarke Toni-Kim
- Clementi Maurizio
- Coleman Jonathan R.I.
- Cone Roger D.
- Copeland William E.
- Costello E. Jane
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James J.
- Culverhouse Robert C.
- Dahmen Norbert
- Danner Unna N.
- Davis Oliver S.P.
- de Wit Harriet
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Louisa
- Degortes Daniela
- DeSocio Janiece E.
- Diazgranados Nancy
- Dick Danielle M.
- Dikeos Dimitris
- Dina Christian
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Docherty Anna R.
- Domingue Benjamin W.
- Duncan Laramie E.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eriksson Johan G.
- Escaramís Geòrgia
- Esko Tõnu
- Estivill Xavier
- Farmer Anne
- Farrer Lindsay A.
- Favaro Angela
- Fernández-Aranda Fernando
- Fichter Manfred M.
- Fischer Krista
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forzan Monica
- Fox Louis
- Frank Josef
- Franklin Christopher S.
- Frye Mark A.
- Föcker Manuel
- Gallinger Steven
- Gaspar Héléna A.
- Gelernter Joel
- Giegling Ina
- Gillespie Nathan A.
- Giuranna Johanna
- Giusti-Rodríguez Paola
- Goate Alison M.
- Goldman David
- Gonidakis Fragiskos
- Gordon Scott
- Gorwood Philip
- Grove Jakob
- Grucza Richard A.
- Guillaume Sébastien
- Guo Yiran
- Gäbel Wolfgang
- Hack Laura M.
- Hakonarson Hakon
- Halmi Katherine A.
- Hancock Dana B.
- Hanscombe Ken B.
- Harris Kathleen Mullan
- Hartmann Annette M.
- Hartz Sarah M.
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Henders Anjali K.
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hesselbrock Victor
- Hewitt John K.
- Hinney Anke
- Hodgkinson Colin
- Hoffmann Per
- Hopfer Christian
- Horwood L. John
- Hottenga Jouke-Jan
- Huckins Laura M.
- Hudson James I.
- Hübel Christopher
- Iacono William G.
- Imgart Hartmut
- Inoko Hidetoshi
- Ising Marcus
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Emma C.
- Johnson Eric O.
- Jordan Jennifer
- Julià Antonio
- Kalsi Gursharan
- Kaminská Deborah
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karpyak Victor M.
- Karwautz Andreas
- Kas Martien J.H.
- Kaye Walter H.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Keyes Margaret
- Kiefer Falk
- Kiezebrink Kirsty
- Kim Youl-Ri
- Klump Kelly L.
- Knudsen Gun Peggy S.
- Koller Gabrielle
- Konte Bettina
- Kramer John
- Kranzler Henry R.
- Krauter Kenneth
- Kuperman Samuel
- La Via Maria C.
- Lahti Jari
- Lahti-Pulkkinen Marius
- Lai Dongbing
- Landén Mikael
- Larsen Janne T.
- Le Hellard Stephanie
- Leppä Virpi M.
- Levitan Robert D.
- Li Dong
- Lichtenstein Paul
- Ligthart Lannie
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lissowska Jolanta
- Loukola Anu
- Lucae Susanne
- Luykx Jurjen
- Lynskey Michael T.
- MacKillop James
- Madden Pamela A.F.
- Maes Hermine H.
- Magistretti Pierre J.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Maj Mario
- Mann Karl
- Mannik Katrin
- Marsal Sara
- Marshall Christian R.
- Martin Nicholas G.
- Mattheisen Manuel
- Mattingsdal Morten
- Mayora Monica Gratacos
- Mbarek Hamdi
- McClintick Jeanette N.
- McDevitt Sara
- McGue Matt
- McGuffin Peter
- McIntosh Andrew M.
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meulenbelt Ingrid
- Meyers Jacquelyn L.
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Mortensen Preben Bo
- Munn-Chernoff Melissa A.
- Murray Alison D.
- Männistö Satu
- Müller-Myhsok Bertram
- Nacmias Benedetta
- Navratilova Marie
- Neale Benjamin M.
- Nelson Elliot C.
- Norring Claes
- Ntalla Ioanna
- Nurnberger John I.
- Nöthen Markus M.
- Olsen Catherine M.
- Ophoff Roel A.
- O’Toole Julie K.
- Padyukov Leonid
- Palmer Abraham A.
- Palotie Aarno
- Palviainen Teemu
- Pantel Jacques
- Papezova Hana
- Parker Richard
- Pearson John F.
- Pedersen Nancy L.
- Penninx Brenda W.J.H.
- Perica Vesna Boraska
- Petersen Liselotte V.
- Peterson Roseann E.
- Pinto Dalila
- Polimanti Renato
- Porjesz Bernice
- Preuss Ulrich
- Rabionet Raquel
- Raevuori Anu
- Ramoz Nicolas
- Reichborn-Kjennerud Ted
- Reynolds Maureen D.
- Ricca Valdo
- Rice John P.
- Ridinger Monika
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rose Richard J.
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Ryu Euijung
- Räikkönen Katri
- Saccone Nancy L.
- Salvatore Jessica E.
- Sanchez-Roige Sandra
- Santonastaso Paolo
- Scherag André
- Scherbaum Norbert
- Scherer Stephen W.
- Schmidt Ulrike
- Schork Nicholas J.
- Schosser Alexandra
- Schuckit Marc A.
- Schwandt Melanie
- Seitz Jochen
- Shen Pei-Hong
- Sherva Richard
- Silberg Judy
- Slachtova Lenka
- Slagboom P. Eline
- Slof-Op’t Landt Margarita C.T.
- Slopien Agnieszka
- Sorbi Sandro
- Soyka Michael
- Stallings Michael C.
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuber Garret D.
- Sullivan Patrick F.
- Szatkiewicz Jin P.
- Tachmazidou Ioanna
- Tarter Ralph E.
- Tenconi Elena
- Thomas Nathaniel
- Thornton Laura M.
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tsitsika Artemis
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- van Elburg Annemarie A.
- van Furth Eric F.
- Vanyukov Michael M.
- Vrieze Scott
- Wade Tracey D.
- Wagner Gudrun
- Wall Tamara L.
- Walters Raymond K.
- Walton Esther
- Wang Jen-Chyong
- Watson Hunna J.
- Webb Bradley T.
- Wedow Robbee
- Werge Thomas
- Wetherill Leah
- Whiteman David C.
- Whitfield John B.
- Widen Elisabeth
- Wills Amanda G.
- Witt Stephanie H.
- Wodarz Norbert
- Woodside D. Blake
- Yao Shuyang
- Yilmaz Zeynep
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhao Hongyu
- Zhou Hang
- Zill Peter
- Zipfel Stephan
- Świątkowska Beata
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
First published: 16 February 202
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J. M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson S
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.'t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jun
- Liu Junfeng
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universitat Autònoma de Barcelona
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu X
- Zhu Xiang
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James F
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/12/2022
- Field of study
Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James G
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
- Fernández-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
- Foo Jerome C.
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Forzan Monica
- Frank Josef
- Frank Josef
- Frank Josef
- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
- Gandal Michael J.
- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
- Grabe Hans J.
- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
- Keel Pamela K.
- Kelsoe John R.
- Kelsoe John R.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
- Knowles James A.
- Knowles James A.
- Knudsen Gun Peggy S.
- Koenen Karestan C.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Konte Bettina
- Koromina Maria
- Kraft Julia
- Kranz Thorsten M.
- Kranzler Henry R.
- Kranzler Henry R.
- Krebs Kristi
- Krebs Marie-Odile
- Kretzschmar Warren W.
- Kubo Michiaki
- Kuo Po-Hsiu
- Kupka Ralph
- Kushner Steven A.
- Kutalik Zoltán
- Landén Mikael
- Landén Mikael
- Landén Mikael
- Larsen Janne T.
- Lavebratt Catharina
- Lawrence Jacob
- Lawrence Jacob
- Le Hellard Stephanie
- Leber Markus
- Leboyer Marion
- Leboyer Marion
- Lee Heon-Jeong
- Lee Phil H.
- Lee Phil H.
- Leppä Virpi M.
- Levey Daniel F.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Catrin
- Lewis Glyn
- Li Dong
- Li Dong
- Li Qingqin S.
- Li Qingqin S.
- Li Qingqin S.
- Li Yihan
- Liangpunsakul Suthat
- Liao Calwing
- Liao Calwing
- Liao Shih-Cheng
- Lichtenstein Paul
- Lichy Jack
- Lieb Klaus
- Lieb Klaus
- Lilenfeld Lisa
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lindquist Jennifer H.
- Lissowska Jolanta
- Lissowska Jolanta
- Lissowska Jolanta
- Liu Chih-Min
- Lochner Christine
- Lori Adriana
- Loughland Carmel
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
- Lundberg Martin
- Lundervold Astri
- Luykx Jurjen
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela A. F.
- Madduri Ravi
- Magistretti Pierre J.
- Magistretti Pierre J.
- Magnusson Patrik K.
- Magnusson Sigurdur H.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maihofer Adam
- Maj Mario
- Malaspina Dolores
- Mann J. John
- Mannik Katrin
- Maratou Eirini
- Marchini Jonathan
- Marsal Sara
- Marshall Christian R.
- Marshall Christian R.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martinez Elisa Docampo
- Martinsson Lina
- Mastorides Stephen
- Mathew Roy
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mattocks Kristin
- Mayora Monica Gratacos
- Mayoral Fermin
- Mayoral Fermin
- Mbarek Hamdi
- McArdle Rachel
- McDevitt Sara
- McElroy Susan L.
- McElroy Susan L.
- McGrath Patrick
- McGrath Patrick
- McGregor Nathaniel W.
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McKay James D.
- McMahon Benjamin
- McMahon Francis J.
- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
- Mehta Divya
- Melle Ingrid
- Melle Ingrid
- Metspalu Andres
- Metspalu Andres
- Meulenbelt Ingrid
- Meyer Laurence
- Meyer Paul
- Micali Nadia
- Michie Patricia
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Millischer Vincent
- Mirza Saira Saeed
- Mitchell James
- Mitchell James E.
- Mitchell Karen
- Mitchell Philip B.
- Mitchell Philip B.
- Mobascher Arian
- Molina Esther
- Mondimore Francis M.
- Monson Eric T.
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Montgomery Grant W.
- Montgomery Grant W.
- Moorman Jonathan
- Moran Jennifer L.
- Morgan Timothy
- Morken Gunnar
- Morken Gunnar
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mors Ole
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mortensen Preben Bo
- Moser Jennifer
- Mostafavi Sara
- Mowry Bryan
- Mullins Niamh
- Mullins Niamh
- Mullins Niamh
- Munn-Chernoff Melissa A.
- Muralidhar Sumitra
- Muralidhar Sumitra
- Murdoch Maureen
- Myers Richard M.
- Myers Richard M.
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nacmias Benedetta
- Nauck Matthias
- Navratilova Marie
- Neale Benjamin M.
- Ng Bernard
- Nievergelt Caroline
- Nievergelt Caroline M.
- Nimgaonkar Vishwajit
- Nivard Michel G.
- Nordentoft Merete
- Nordentoft Merete
- Nordentoft Merete
- Ntalla Ioanna
- Nurnberger John I.
- Nyholt Dale R.
- Nöthen Markus M.
- Nöthen Markus M.
- Nöthen Markus M.
- Nöthen Markus M.
- Oedegaard Ketil J.
- Okazaki Satoshi
- Okusaga Olaoluwa
- Olde Loohuis Loes M.
- Olsen Catherine M.
- Olsen Catherine M.
- Olsen Maren K.
- Olsson Tomas
- Ophoff Roel A.
- Ophoff Roel A.
- Ophoff Roel A.
- Oruc Lilijana
- Oskarsson Hogni
- Oslin David W.
- Otsuka Ikuo
- Oursler Kris Ann
- Owen Michael J.
- Owen Michael J.
- Owen Michael J.
- O’Brien Niamh
- O’Connell Kevin S.
- O’Donnell Christopher J.
- O’Donnell Christopher J.
- O’Donnell Christopher J.
- O’Donovan Claire
- O’Donovan Michael C.
- O’Donovan Michael C.
- O’Donovan Michael C.
- O’Reilly Paul F.
- O’Toole Julie K.
- Paciga Sara A.
- Paciga Sara A.
- Padyukov Leonid
- Painter Jodie N.
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantel Jacques
- Pantelis Chris
- Papezova Hana
- Papiol Sergi
- Pardiñas Antonio F.
- Parker Richard
- Pato Carlos
- Pato Carlos
- Pato Michele T.
- Pato Michele T.
- Patrinos George P.
- Pearson John F.
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L.
- Pedersen Nancy L.
- Penninx Brenda W. J. H.
- Penninx Brenda W. J. H.
- Perica Vesna Boraska
- Perlis Roy H.
- Perlis Roy H.
- Perry Amy
- Pestian John
- Petersen Liselotte V.
- Peterson Roseann E.
- Peyrot Wouter J.
- Pfennig Andrea
- Pimm Jonathan
- Pinto Dalila
- Pinto Dalila
- Pistis Giorgio
- Pistis Giorgio
- Porichi Evgenia
- Porteous David
- Porteous David J.
- Posthuma Danielle
- Posthuma Danielle
- Potash James B.
- Potash James B.
- Potash James B.
- Power Robert A.
- Powers Abigail
- Preisig Martin
- Preisig Martin
- Purves Kirstin L.
- Pyarajan Saiju
- Pyarajan Saiju
- Qiao Zhen
- Qin Xuejun
- Quested Digby
- Quested Digby
- Quiroz Jorge A.
- Qvist Per
- Raevuori Anu
- Raj Towfique
- Ramoni Rachel
- Ramos-Quiroga Josep Antoni
- Ramos-Quiroga Josep Antoni
- Ramoz Nicolas
- Ramoz Nicolas
- Rapaport Mark H.
- Ratcliffe Nora
- Rauchman Michael
- Regeer Eline J.
- Reichborn-Kjennerud Ted
- Reif Andreas
- Reif Andreas
- Reininghaus Eva Z.
- Rentería Miguel E.
- Ribasés Marta
- Ribasés Marta
- Ricca Valdo
- Rice John P.
- Rice John P.
- Richarte Vanesa
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ritschel Franziska
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Rivera Margarita
- Roberts Andrea
- Roberts Gloria
- Roberts Marion
- Robey Brooks
- Roepke Stefan
- Roepke Stefan
- Romero J. P. Casas
- Ross George
- Roth Julian
- Rouleau Guy A.
- Rouleau Guy A.
- Roussos Panos
- Rovaris Diego L.
- Rozanov Vsevolod
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Rybakowski Filip
- Saito Takeo
- Sanders Alan R.
- Santonastaso Paolo
- Schaefer Catherine
- Schall Ulrich
- Schalling Martin
- Scherag André
- Scherer Stephen W.
- Scherer Stephen W.
- Schilder Brian M.
- Schmahl Christian
- Schmahl Christian
- Schmidt Ulrike
- Schoevers Robert
- Schofield Peter R.
- Schofield Peter R.
- Schork Nicholas J.
- Schosser Alexandra
- Schott Björn H.
- Schulte Eva C.
- Schulte Eva C.
- Schulze Thomas G.
- Schulze Thomas G.
- Schulze Thomas G.
- Schwarze Cornelia E.
- Scott Laura J.
- Scott Laura J.
- Scott Rodney J.
- Seitz Jochen
- Selva Luis E.
- Senner Fanny
- Serretti Alessandro
- Serretti Alessandro
- Servatius Richard
- Shabalin Andrey
- Shannon Weickert Cynthia
- Sharma Satish
- Sharp Sally
- Shayan Shahpoor
- Shen Ling
- Sherman Scott
- Shi Jianxin
- Shi Jianxin
- Shilling Paul D.
- Shyn Stanley I.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C. B.
- Sirignano Lea
- Sirignano Lea
- Sklar Pamela
- Slachtova Lenka
- Slagboom P. Eline
- Slaney Claire
- Slof-Op ‘t Landt Margarita C. T.
- Sloofman Laura G.
- Slopien Agnieszka
- Smeland Olav B.
- Smeland Olav B.
- Smit Johannes H.
- Smith Daniel J.
- Smith Daniel J.
- Smith Daniel J.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- Sobell Janet L.
- Sokolowski Marcus
- Soler Artigas María
- Sonuga-Barke Edmund J. S.
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- Spijker Anne T.
- Sriram Peruvemba
- Stahl Eli A.
- Stahl Eli A.
- Stapley Todd
- Starnawska Anna
- Steen Vidar W.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Stein Dan J.
- Stein Murray B.
- Steinberg Stacy
- Steinberg Stacy
- Stephens Brady
- Stordal Eystein
- Strauss John S.
- Strauss John S.
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Striker Robert
- Strober Michael
- Strober Michael
- Strohmaier Jana
- Strollo Patrick
- Stuber Garret D.
- Su Mei-Hsin
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sun Yan
- Szatkiewicz Jin P.
- Sánchez-Mora Cristina
- Sánchez-Mora Cristina
- Tachmazidou Ioanna
- Tandon Neeraj
- Tansey Katherine E.
- Teismann Henning
- Tenconi Elena
- Terao Chikashi
- Teumer Alexander
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Thornton Laura M.
- Thornton Laura M.
- Tiemeier Henning
- Toma Claudio
- Tooney Paul
- Tortorella Alfonso
- Tozzi Federica
- Traylor Matthew
- Treasure Janet
- Treasure Janet
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Tsao Philip
- Tsao Philip S.
- Tsao Philip S.
- Tsao Philip S.
- Tsermpini Evangelia-Eirini
- Tsitsika Artemis
- Tsuang Ming T.
- Turecki Gustavo
- Turecki Gustavo
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Ursano Robert J.
- Vaaler Arne E.
- Van der Auwera Sandra
- van Elburg Annemarie A.
- van Furth Eric F.
- van Hemert Albert M.
- Vawter Marquis P.
- Vedder Helmut
- Vieta Eduard
- Viktorin Alexander
- Vilar-Ribó Laura
- Villareal Gerardo
- Vincent John B.
- Vincent John B.
- Visscher Peter M.
- Völzke Henry
- Völzke Henry
- Wade Tracey D.
- Wagner Gudrun
- Waldman Irwin D.
- Wallbom Agnes
- Walters James T. R.
- Walters James T. R.
- Walton Esther
- Wang Yunpeng
- Ware Erin B.
- Wasserman Danuta
- Watson Hunna J.
- Watson Hunna J.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Whitbourne Stacey B.
- Whiteman David C.
- Whiteman David C.
- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Chen Hu
- Chen Zhongyuan
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Ge Zhongqi
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leighton Jake S.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Jun
- Li Wei
- Liang Han
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Jianfang
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Li
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Peng Xinxin
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Piwnica-Worms Helen
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Sun Yutong
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Yumeng
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yao Fan
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Huiwen
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies
- …