Automatic and ironic behavior are both mediated by changes in the self-concept

Recent accounts suggest that prime-to-behavior effects are mediated by changes to the active self-concept. Likewise, recent reports of post-suppression behavioral rebound have attributed changes to behavior to changes in the self-concept. According to such accounts, whenever an activated trait or stereotype can be easily incorporated into the active self, behavioral assimilation (i.e., behavior consistent with the activated concept) is likely to ensue. Yet, little evidence has emerged to directly support the mediating role of changes to the self-concept. The present research was designed to examine whether changes to the active self-concept are responsible for changes in behavior following stereotype suppression and priming. Participants who suppressed or were primed with stereotypes of the elderly were more likely to endorse stereotypic traits as self-descriptive and to behave in stereotypic ways. Critically, the former effect significantly mediated the latter. Implications for theories of concept activation and behavior are discussed. (C) 2011 Elsevier Inc. All rights reserved

Hyaluronan in mesenchymal stromal cell lineage differentiation from human pluripotent stem cells:application in serum free culture

BACKGROUND: Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both stem cell renewal and differentiation. However, responses to HA in culture are influenced by interaction with a range of cognate factors and receptors including components of blood serum supplements, which alter results. These may contribute to variation in cell batch production yield and phenotype as well as heighten the risks of adventitious pathogen transmission in the course of cell processing for therapeutic applications. MAIN: Here we characterise differentiation of a human embryo/pluripotent stem cell derived Mesenchymal Stromal Cell (hESC/PSC-MSC)-like cell population by culture on a planar surface coated with HA in serum-free media qualified for cell production for therapy. Resulting cells met minimum criteria of the International Society for Cellular Therapy for identification as MSC by expression of. CD90, CD73, CD105, and lack of expression for CD34, CD45, CD14 and HLA-II. They were positive for other MSC associated markers (i.e.CD166, CD56, CD44, HLA 1-A) whilst negative for others (e.g. CD271, CD71, CD146). In vitro co-culture assessment of MSC associated functionality confirmed support of growth of hematopoietic progenitors and inhibition of mitogen activated proliferation of lymphocytes from umbilical cord and adult peripheral blood mononuclear cells, respectively. Co-culture with immortalized THP-1 monocyte derived macrophages (Mɸ) concurrently stimulated with lipopolysaccharide as a pro-inflammatory stimulus, resulted in a dose dependent increase in pro-inflammatory IL6 but negligible effect on TNFα. To further investigate these functionalities, a bulk cell RNA sequence comparison with adult human bone marrow derived MSC and hESC substantiated a distinctive genetic signature more proximate to the former.CONCLUSION: Cultivation of human pluripotent stem cells on a planar substrate of HA in serum-free culture media systems is sufficient to yield a distinctive developmental mesenchymal stromal cell lineage with potential to modify the function of haematopoietic lineages in therapeutic applications.</p

myCopter: Enabling Technologies for Personal Air Transport Systems - an Early Progress Report

This paper describes the European Commission (EC) Framework 7 funded project myCopter (2011-2014). The project is still at an early stage so the paper starts with the current transportation issues faced by developed countries and describes a means to solve them through the use of personal aerial transportation. The concept of personal air vehicles (PAV) is briefly reviewed and how this project intends to tackle the problem from a different perspective described. It is argued that the key reason that many PAV concepts have failed is because the operational infrastructure and socio-economic issues have not been properly addressed; rather, the start point has been the design of the vehicle itself. Some of the key aspects that would make a personal aerial transport system (PATS) viable include the required infrastructure and associated technologies, the skill levels and machine interfaces needed by the occupant or pilot and the views of society as a whole on the acceptability of such a proposition. The myCopter project will use these areas to explore the viability of PAVs within a PATS. The paper reports upon the early progress made within the project. An initial reference set of PAV requirements has been collated. A non-physical flight simulation model capable of providing a wide range of handling qualities characteristics has been developed and its function has undergone limited verification. Results from this exercise show that the model behaves as intended and that it can deliver a predictable range of vehicle dynamics. The future direction of the themes of work described within the paper are then described

A Brauer's theorem and related results

Given a square matrix A, a Brauer's theorem [Brauer A., Limits for the characteristic roots of a matrix. IV. Applications to stochastic matrices, Duke Math. J., 1952, 19(1), 75-91] shows how to modify one single eigenvalue of A via a rank-one perturbation without changing any of the remaining eigenvalues. Older and newer results can be considered in the framework of the above theorem. In this paper, we present its application to stabilization of control systems, including the case when the system is noncontrollable. Other applications presented are related to the Jordan form of A and Wielandt's and Hotelling's deflations. An extension of the aforementioned Brauer's result, Rado's theorem, shows how to modify r eigenvalues of A at the same time via a rank-r perturbation without changing any of the remaining eigenvalues. The same results considered by blocks can be put into the block version framework of the above theorem. © 2012 Versita Warsaw and Springer-Verlag Wien.This work is supported by Fondecyt 1085125, Chile, the Spanish grant DGI MTM2010-18228 and the Programa de Apoyo a la Investigacion y Desarrollo (PAID-06-10) of the UPV.Bru García, R.; Cantó Colomina, R.; Soto, RL.; Urbano Salvador, AM. (2012). A Brauer's theorem and related results. Central European Journal of Mathematics. 10(1):312-321. https://doi.org/10.2478/s11533-011-0113-0S312321101Brauer A., Limits for the characteristic roots of a matrix. IV. Applications to stochastic matrices, Duke Math. J., 1952, 19(1), 75–91Crouch P.E., Introduction to Mathematical Systems Theory, Mathematik-Arbeitspapiere, Bremen, 1988Delchamps D.F., State-Space and Input-Output Linear Systems, Springer, New York, 1988Hautus M.L.J., Controllability and observability condition of linear autonomous systems, Nederl. Akad. Wetensch. Indag. Math., 1969, 72, 443–448Kailath T., Linear Systems, Prentice Hall Inform. System Sci. Ser., Prentice Hall, Englewood Cliffs, 1980Langville A.N., Meyer C.D., Deeper inside PageRank, Internet Math., 2004, 1(3), 335–380Perfect H., Methods of constructing certain stochastic matrices. II, Duke Math. J., 1955, 22(2), 305–311Saad Y., Numerical Methods for Large Eigenvalue Problems, Classics Appl. Math., 66, SIAM, Philadelphia, 2011Soto R.L., Rojo O., Applications of a Brauer theorem in the nonnegative inverse eigenvalue problem, Linear Algebra Appl., 2006, 416(2–3), 844–856Wilkinson J.H., The Algebraic Eigenvalue Problem, Clarendon Press, Oxford, 196

A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi

Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to administer. Fluconazole monotherapy is frequently recommended in national guidelines but is a fungistatic drug compromised by uncertainty over optimal dosing and a paucity of clinical end-point outcome data. Methods: From July 2010 until March 2011, HIV infected adults with a first episode of cryptococcal meningitis were recruited at Queen Elizabeth Central Hospital, Blantyre, Malawi. Patients were treated with oral fluconazole monotherapy 800 mg daily, as per national guidelines. ART was started at 4 weeks. Outcomes and factors associated with treatment failure were assessed 4, 10 and 52 weeks after fluconazole initiation. Results: Sixty patients were recruited. 26/60 (43%) died by 4 weeks. 35/60 (58.0%) and 43/56 (77%) died or failed treatment by 10 or 52 weeks respectively. Reduced consciousness (Glasgow Coma Score ,14 of 15), moderate/severe neurological disability (modified Rankin Score .3 of 5) and confusion (Abbreviated Mental Test Score ,8 of 10) were all common at baseline and associated with death or treatment failure. ART prior to recruitment was not associated with better outcomes. Conclusions: Mortality and treatment failure from cryptococcal meningitis following initiation of treatment with 800 mg oral fluconazole is unacceptably high. To improve outcomes, there is an urgent need for better therapeutic strategies and point-of-care diagnostics, allowing earlier diagnosis before development of neurological deficit

"Black holes in the fabric of the nation": Refugees in Mohsin Hamid’s "Exit West".

This article explores the representation of refugees in Mohsin Hamid’s Exit West (2017), a novel which marks an early and particularly prominent literary response to the ‘international refugee crisis’. In a distinct echo of Salman Rushdie’s claim, a quarter of a century ago, that it ‘may be argued that the past is a country from which we have all emigrated’, Hamid’s novel similarly claims that ‘we are all migrants through time.’ Moreover, like Rushdie’s fiction, Hamid’s novel incorporates elements of magical realism and fable. Its protagonists, Nadia and Saeed, escape their unnamed war-torn city through a ‘door’ that instantaneously transports them to Mykonos; they subsequently travel through other such ‘doors’ to London and San Francisco. Their story is interspersed with a series of vignettes in which other refugees also find themselves magically transported to ‘first-world’ nations. As well as considering the ways in which Hamid’s novel seeks to humanize refugees, this article considers the novel’s evocation of a world in which human beings have – like capital, images, and (mis)information – gained access to largely ungovernable networks of instantaneous travel across vast distances. It argues that Hamid’s novel is not just ‘about’ refugees but also constitutes a reflection on how they, and their journeys, are represented and mediated by actually-existing technologies

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. METHODS: To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. RESULTS: There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. CONCLUSIONS: These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk

Very Low Levels of 25-Hydroxyvitamin D Are Not Associated With Immunologic Changes or Clinical Outcome in South African Patients With HIV-Associated Cryptococcal Meningitis

Background. Vitamin D deficiency is associated with impaired immune responses and increased susceptibility to a number of intracellular pathogens in individuals infected with human immunodeficiency virus (HIV). It is not known whether such an association exists with Cryptococcus neoformans. Methods. Levels of 25-hydroxyvitamin D (25[OH]D) were measured in 150 patients with cryptococcal meningitis (CM) and 150 HIV-infected controls in Cape Town, South Africa, and associations between vitamin D deficiency and CM were examined. The 25-hydroxyvitamin D levels and cryptococcal notifications were analyzed for evidence of reciprocal seasonality. Associations between 25(OH)D levels and disease severity, immune responses, and microbiological clearance were investigated in the patients with CM. Results. Vitamin D deficiency (plasma 25[OH]D ≤50 nmol/L) was present in 74% of patients. Vitamin D deficiency was not associated with CM (adjusted odds ratio, 0.93 [95% confidence interval, .6–1.6]; P = .796). Levels of 25(OH)D showed marked seasonality, but no reciprocal seasonality was seen in CM notifications. No significant associations were found between 25(OH)D levels and fungal burden or levels of tumor necrosis factor α, interferon γ, interleukin 6, soluble CD14, or neopterin in cerebrospinal fluid. Rates of fungal clearance did not vary according to vitamin D status. Conclusions. Vitamin D deficiency does not predispose to the development of CM, or lead to impaired immune responses or microbiological clearance in HIV-infected patients with CM

Hospital-acquired invasive pulmonary aspergillosis in patients with hepatic failure

<p>Abstract</p> <p>Background</p> <p>Invasive pulmonary aspergillosis (IPA) is a rapid, progressive, fatal disease that occurs mostly in immunocompromised patients. Patients with severe liver disease are at a heightened risk for infections. Little is known about the clinical presentation including predisposing factors and treatment of IPA in patients with hepatic failure.</p> <p>Methods</p> <p>Medical records of patients with hepatic failure between November 2005 and February 2007 were reviewed for lung infection. Nine medical records of definitive diagnosis of IPA and three of probable IPA were identified.</p> <p>Results</p> <p>The main predisposing factors were found to be prolonged antibiotic therapy and steroid exposure. Clinical signs and radiological findings were non-specific and atypical. Timely use of caspofungin was found to reduce the mortality due to the disease.</p> <p>Conclusion</p> <p>A high index of suspicion is required for early IPA diagnosis in patients with hepatic failure.</p