Investigations on the cumulative fatigue life for a type 304-L stainless steel used for pressure water reactor

Les circuits des Réacteurs à Eau Pressurisée peuvent être soumis à la fatigue thermique. Les chargements rencontrés en service sont complexes. Aussi, le conservatisme des prévisions ne paraît pas toujours garanti. Un programme expérimental d'essais de fatigue a été réalisé à amplitude de déformation imposée sur l'acier 304-L avec des séquences à plusieurs niveaux. La loi de cumul linéaire de dommage ne permet pas d'estimer a durée de vie pour l'acier 304-L. Un effet d'histoire est mis en évidence. La loi bilinéaire proposée par Manson permet d'obtenir d'assez bonnes estimations

Accept'Hydro: a tool for evaluating potential wetland areas at floodplain scale.

National audienceAlluvial wetlands have the functions of hydrological regulation and water purification, but are also of interest for preventing flooding and improving the water quality of the natural environment that serves as a reserve for drinking water and biodiversity. Delimiting these areas is often difficult because it involves both the physical characteristics (topography, river morphology etc.) and hydrodynamic characteristics of the porous medium (permeability etc.) The proposed tool, Accept'Hydro, includes a hydrodynamic simulation of the river, the alluvial aquifer and their interaction, and produces maps of alluvial wetlands with using hydrological criteria. The tool's primary step consists of selecting the studied area using Google Maps, which automatically triggers the generation of a non-uniform mesh covering this area, as well as all the inputs needed for the hydrodynamic simulation to run. The hydrodynamic model based on the equations of Peyrard et al. (2008) allows water levels and flow rates in the river and the alluvial aquifer to be simulated with a non-uniform mesh (cells from 1 to 200 metres per side), combined with a good performance in CPU calculation time. The software program allows the impacts of climate change (changes in hydrology and temperature) and/or anthropogenic change on the hydrodynamic functioning of wetlands to be assessed, and the impact of infrastructure and hydropower facilities on the river to be tested

Simulation du fonctionnement hydrodynamique des milieux humides dans les plaines alluviales

International audienceLa modélisation hydrodynamique est peu utilisée afin de simuler le fonctionnement des milieux humides à l’échelle des plaines alluviales et nécessite souvent de nombreuses données d’entrée souvent difficiles à acquérir. On présente ici un outil de simulation, Accept’Hydro, qui est alimenté par quatre données d’entrée : le modèle numérique d’élévation (IGN), les données piézométriques (banque ADES), l’historique des débits rivières (banque HYDRO), et le réseau hydrographie (BD Carthage). Après l’étape de création automatique du maillage non-uniforme, adapté au domaine étudié, le logiciel génère en sortie les hauteurs d’eau et les vitesses d’écoulement dans la rivière et dans la nappe souterraine, au pas de temps journalier. Les données simulées, sur une période de temps minimal de 10 ans, sont traitées afin de cartographier les milieux humides potentiels en bordure de cours d’eau. De plus, cet outil permet d’intégrer des hypothèses sur l’évolution des débits afin de prendre en compte les modifications dues au change ment climatique, et d’en simuler les impacts sur le fonctionnement hydrologique. On présente ici les résultats d’Accept’Hydro sur la plaine alluviale de la Garonne et ses milieux humides pour la période 2004-2013, dans le département du Tarn-et-Garonne. Dans ce secteur, les simulations prévoient une diminution de la superficie des milieux humides pour l’horizon 2030, en partant d’hypothèses de diminution des débits saisonniers

The precision electroweak data in warped extra-dimension models

The Randall-Sundrum scenario with Standard Model fields in the bulk and a custodial symmetry is considered. We determine the several minimal quark representations allowing to address the anomalies in the forward-backward b-quark asymmetry A^b_FB, while reproducing the bottom and top masses via wave function overlaps. The calculated corrections of the Zbb coupling include the combined effects of mixings with both Kaluza-Klein excitations of gauge bosons and new b'-like states. It is shown that the mechanism, in which the left-handed doublet of third generation quarks results from a mixing on the UV boundary of introduced fields Q_1L and Q_2L, is necessary for phenomenological reasons. Within the obtained models, both the global fit of R_b with A^b_FB [at the various center of mass energies] and the fit of last precision electroweak data in the light fermion sector can simultaneously be improved significantly with respect to the pure Standard Model case, for M_KK = 3,4,5 TeV (first KK gauge boson) and a best-fit Higgs mass m_h > 115 GeV i.e. compatible with the LEP2 direct limit. The quantitative analysis of the oblique parameters S,T,U even shows that heavy Higgs mass values up to ~500 GeV may still give rise to an acceptable quality of the electroweak data fit, in contrast with the Standard Model. The set of obtained constraints on the parameter space, derived partly from precision electroweak data, is complementary of a future direct exploration of this parameter space at the LHC. In particular, we find that custodians, like b' modes, can be as light as ~1200 GeV i.e. a mass lying possibly in the potential reach of LHC.Comment: 24 pages, 8 figures. Added references, corrected typos and Higgs mass dependence discussion complete

Rab7A Is Required for Efficient Production of Infectious HIV-1

Retroviruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Rab proteins regulate specific steps in intracellular membrane trafficking by recruiting tethering, docking and fusion factors, as well as the actin- and microtubule-based motor proteins that facilitate vesicle traffic. Using virological tests and RNA interference targeting Rab proteins, we demonstrate that the late endosome-associated Rab7A is required for HIV-1 propagation. Analysis of the late steps of the HIV infection cycle shows that Rab7A regulates Env processing, the incorporation of mature Env glycoproteins into viral particles and HIV-1 infectivity. We also show that siRNA-mediated Rab7A depletion induces a BST2/Tetherin phenotype on HIV-1 release. BST2/Tetherin is a restriction factor that impedes HIV-1 release by tethering mature virus particles to the plasma membrane. Our results suggest that Rab7A contributes to the mechanism by which Vpu counteracts the restriction factor BST2/Tetherin and rescues HIV-1 release. Altogether, our results highlight new roles for a major regulator of the late endocytic pathway, Rab7A, in the late stages of the HIV-1 replication cycle

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects