Interview with Edel Bhreathnach Irish Medieval History and its Possible Future Directions

This interview took place at the Discovery Programme, Dublin, on 25th September 2014. Edel Bhreathnach discussed the state-of-art in EarlyIrish Medieval History and her opinions about the Irish educational systemand the future of Irish Medieval Studies. She also provides some hints about the directions she is taking with her own research projects.Keywords: Edel Bhreathnach; Irish History; Medieval History; Discovery Programme; Monastic Ireland; Mapping Death; UCD Míchael Ó Cléirigh Insitute

Taboos and Penitence: Christian Conversion and Popular Religion in Early Medieval Ireland

This is a study of the so-called Irish Penitentials. The documents which compose this documental corpus were either produced in Ireland, or influenced the production of Irish documents, between the sixth and the eighth centuries. The penitential literature most likely originated in Britain, was further developed in Ireland, and spread from those areas to the European continent. The Irish penitentials have been accessed by scholars in support of various research investigations, but quite often..

Long-term Periodicities in the Flux from Low Mass X-ray Binaries

Using data from the All Sky Monitor (ASM) on the Rossi X-ray Timing Explorer (RXTE) we have searched for long term periodicities in the X-ray flux of GX 1+4, Sco X-2 (GX 349+2), and GX 339-4. For GX 1+4 we also used data from BATSE and Galactic Centre scans performed by RXTE. We find no evidence for X-ray modulations at the suggested ~304 d orbital period of GX 1+4. However, we find tentative evidence for a periodicity at 420 d to 460 d. An upper limit of 15% peak-to-peak is set on any sinusoidal modulation in the 1.5 - 3.0 keV flux of Sco X-2 for periods in the 30 to 100 d range. For GX 339-4 we confirm the Low State modulation and report the detection of significant low-frequency modulations in both the High State and Very High State. We fail to detect this modulation in the Off State. We show that if the reported orbital period of GX 339-4 lies in the range 0.5 - 1.7 d, then it is not present in the RXTE ASM light curve.Comment: 7 pages, 8 figures. Accepted for publication in Advanced in Space Research, 16th of March 200

Edel Bhreathnach, Ireland in the Medieval World AD 400-1000: Landscape, kingship and religion

Teaching medieval history in the 21st century, particularly Irish medieval history can be a challenging task. Most people identify better with more recent historical periods, finding it too complex to comprehend the distant past and its historical sources. Another factor that quite often makes the teaching of medieval history difficult is the lack of good textbooks. While there are a number of useful textbooks on early Irish history, Ireland in the Medieval World AD 400-1000 will greatly assi..

Neuroablative surgical treatments for pain due to cancer.

Cancer pain is common and challenging to manage - it is estimated that approximately 30% of cancer patients have pain that is not adequately controlled by analgesia. This paper discusses safe and effective neuroablative treatment options for refractory cancer pain. Current management of cancer pain predominantly focuses on the use of medications, resulting in a relative loss of knowledge of these surgical techniques and the erosion of the skills required to perform them. Here, we review surgical methods of modulating various points of the neural axis with the aim to expand the knowledge base of those managing cancer pain. Integration of neuroablative approaches may lead to higher rates of pain relief, and the opportunity to dose reduce analgesic agents with potential deleterious side effects. With an ever-increasing population of cancer patients, it is essential that neurosurgeons maintain or train in these techniques in tandem with the oncological multi-disciplinary team

An Analysis of Factors Contributing to the Development of Total Parenteral Nutrition‐Induced Cholestasis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141659/1/jpen0586.pd

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of the phenolic moiety and any attached chemical groups define whether the polyphenol is absorbed in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged. Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites

Increasing source to image distance for AP pelvis imaging – impact on radiation dose and image quality

Aim: A quantative primary study to determine whether increasing source to image distance (SID), with and without the use of automatic exposure control (AEC) for antero-posterior (AP) pelvis imaging, reduces dose whilst still producing an image of diagnostic quality. Methods: Using a computed radiography (CR) system, an anthropomorphic pelvic phantom was positioned for an AP examination using the table bucky. SID was initially set at 110 cm, with tube potential set at a constant 75 kVp, with two outer chambers selected and a fine focal spot of 0.6 mm. SID was then varied from 90 cm to 140 cm with two exposures made at each 5 cm interval, one using the AEC and another with a constant 16 mAs derived from the initial exposure. Effective dose (E) and entrance surface dose (ESD) were calculated for each acquisition. Seven experienced observers blindly graded image quality using a 5-point Likert scale and 2 Alternative Forced Choice software. Signal-to-Noise Ratio (SNR) was calculated for comparison. For each acquisition, femoral head diameter was also measured for magnification indication. Results: Results demonstrated that when increasing SID from 110 cm to 140 cm, both E and ESD reduced by 3.7% and 17.3% respectively when using AEC and 50.13% and 41.79% respectively, when the constant mAs was used. No significant statistical (T-test) difference (p ¼ 0.967) between image quality was detected when increasing SID, with an intra-observer correlation of 0.77 (95% confidence level). SNR reduced slightly for both AEC (38%) and no AEC (36%) with increasing SID. Conclusion: For CR, increasing SID significantly reduces both E and ESD for AP pelvis imaging without adversely affecting image quality

Chemical Interactions and Their Role in the Microphase Separation of Block Copolymer Thin Films

The thermodynamics of self-assembling systems are discussed in terms of the chemical interactions and the intermolecular forces between species. It is clear that there are both theoretical and practical limitations on the dimensions and the structural regularity of these systems. These considerations are made with reference to the microphase separation that occurs in block copolymer (BCP) systems. BCP systems self-assemble via a thermodynamic driven process where chemical dis-affinity between the blocks driving them part is balanced by a restorative force deriving from the chemical bond between the blocks. These systems are attracting much interest because of their possible role in nanoelectronic fabrication. This form of self-assembly can obtain highly regular nanopatterns in certain circumstances where the orientation and alignment of chemically distinct blocks can be guided through molecular interactions between the polymer and the surrounding interfaces. However, for this to be possible, great care must be taken to properly engineer the interactions between the surfaces and the polymer blocks. The optimum methods of structure directing are chemical pre-patterning (defining regions on the substrate of different chemistry) and graphoepitaxy (topographical alignment) but both centre on generating alignment through favourable chemical interactions. As in all self-assembling systems, the problems of defect formation must be considered and the origin of defects in these systems is explored. It is argued that in these nanostructures equilibrium defects are relatively few and largely originate from kinetic effects arising during film growth. Many defects also arise from the confinement of the systems when they are ‘directed’ by topography. The potential applications of these materials in electronics are discussed