Research network on interoperability of applications and software for networked enterprises in the Valencian Region (INTERVAL)

Enterprise interoperability is a tool for enhancing the competitiveness of firms, and its importance is brought out by the fact one of the EC’s strategic aims is to accomplish interoperability among European firms by the year 2010. Nevertheless, in the particular case of the Valencian Region (Spain), research into enterprise interoperability is still badly structured, fragmented, overlapping and, in many cases, practically non-existent. The INTERVAL project has been set up in an attempt to solve this problem. The scheme plans to carry out a series of initiatives aimed at integrating research activities and applying them to the complicated Valencian business sector. By so doing these companies would benefit from the application of knowledge created specifically for them and adapted to fit their characteristics. In this paper we present the details of the project, including its goals, aims, activities, results achieved, the methodology used to accomplish them, the economic and/or technological advantages, as well as possible applications and future lines of research

Influence of adiposity and sex on SARS-CoV-2 antibody response in vaccinated university students: A cross-sectional ESFUERSO study

Prior studies have identified various determinants of differential immune responses to COVID-19. This study focused on the Ig-G anti-RBD marker, analyzing its potential correlations with sex, vaccine type, body fat percentage, metabolic risk, perceived stress, and previous COVID-19 exposure. In this study, data (available in S1 Data) were obtained from 108 participants from the ESFUERSO cohort, who completed questionnaires detailing their COVID-19 experiences and stress levels assessed through the SISCO scale. IgG anti-RBD concentrations were quantified using an ELISA assay developed by UNAM. Multiple regression analysis was employed to control for covariates, including sex, age, body fat percentage, body mass index (BMI), and perceived stress. This sample comprised young individuals (average age of 21.4 years), primarily consisting of females (70%), with a substantial proportion reporting a family history of diabetes, hypertension, or obesity. Most students had received the Moderna or Pfizer vaccines, and 91% displayed a positive anti-RBD response. A noteworthy finding was the interaction between body fat percentage and sex. In males, increased adiposity was associated with decreased Ig-G anti-RBD concentration; in females, the response increased. Importantly, this pattern remained consistent regardless of the vaccine received. No significant associations were observed for dietary habits or perceived stress variables. This research reports the impact of sex and body fat percentage on the immune response through Ig-G anti-RBD levels to COVID-19 vaccines. The implications of these findings offer a foundation for educational initiatives and the formulation of preventive policies aimed at mitigating health disparities

Relación entre la enseñanza teórica y práctica en la materia de Biomoléculas de la carrera de Biología de la FES Iztacala

En el segundo semestre de la carrera de Biología impartida en la FES Iztacala de la UNAM, se ubica la asignatura de Biomoléculas, donde se enseña mediante teoría y práctica, la estructura, función y actividad de las moléculas biológicas. La materia presenta alto índice de reprobación, por lo que se requiere desarrollar estrategias que mejoren el aprendizaje de los alumnos. En el presente trabajo se propone el uso de un instrumento de medición que correlacione el aprendizaje en el salón de clases y el del laboratorio, con la finalidad de elegir las actividades prácticas a realizar durante el curso. Los resultados muestran diferencias significativas en la relación que existe entre el trabajo en laboratorio y la teoría entre las dos prácticas que se probaron. El instrumento utilizado permitió diferenciar la eficiencia de las prácticas, lo que posibilita seleccionarlas para mejorar el aprendizaje de la asignatura de Biomoléculas.The Biomolecules Module is located in the second semester of the Biology course that is taught at FES Iztacala, UNAM. In this module, the structure, function, and activity of biomolecules is taught through theory and laboratory practice. The Biomolecules course has a high failure rate; therefore, the development of strategies that improve student learning is needed. In the present work we propose the use of an evaluation instrument that correlates what students learn in the classroom and in the laboratory; this would allow us to choose correctly the laboratory practices to be performed during the course. The results show significant differences in the relationship between laboratory work and theory of the two laboratory practices that were assessed. Therefore the evaluation instrument tested in the present work does allow us to differentiate the efficiency of the practices for teaching the subject of Biomolecules, enabling to choose the best practice to improve the learning

Relación entre la percepción de aprendizaje personal, la habilidad práctica y el aprendizaje teórico de una actividad teórico-práctica

Uno de los principales retos en la enseñanza de la bioquímica el desarrollo y evaluación de actividades experimentales. Un criterio surgido de la evaluación de las actividades experimentales es la percepción propia de aprendizaje. Este criterio no ha sido evaluado con relación al desarrollo de habilidades prácticas o adquisición de conocimiento teórico. El objetivo de esta investigación fue determinar la relación entre la percepción propia en los estudiantes, el aprendizaje teórico, y el desarrollo de habilidades prácticas. Se contrastaron los resultados obtenidos en cuestionarios de percepción y aprendizaje con los de una actividad experimental en un grupo de estudiantes de la Carrera de Biología de la FES lztacala. Encontramos que la percepción propia de los estudiantes no tiene relación con la habilidad (t= 0.029, sig. bilateral = 0.910, n = 18), pero se encuentra relacionada con su aprendizaje teórico (t = 0.303, sig. bilateral= 0.221, n = 18).One of the main challenges in the teaching of biochemistry is the development and evaluation of experimental. An emerged criterion for the evaluation of experimental activities is the student's own perception of learning, however these criteria have not been evaluated in relation to the development of practical skills or acquisition of theoretical knowledge. The objective ofthis research was to determine the relationship between self-perception in students, theoretical learning, and the development of practical skills. These criteria were evaluated in a biology student group from FES-Iztacala after an experimental activity. We found that the student's own perception is not related to practical ability (r = 0.029, bilateral significance = 0.910, n = 18), but it's related to their theoretical learning (t = 0.303, sig. bilateral O 0.221, n = 18)

Actividad experimental enfocada en la enseñanza de la glucólisis

Uno de los objetivos más desafiantes durante la enseñanza de la bioquímica es la integración de los procesos bioquímicos, por lo que asociarlos con las experiencias cotidianas de los estudiantes puede facilitar su comprensión. La glucólisis es un proceso ubicuo tanto en la vida como en los programas de bioquímica del todo el mundo. A pesar de la importancia de este proceso, son escasas las actividades experimentales enfocadas en dicha ruta metabólica. El objetivo de este estudio fue desarrollar una actividad experimental centrada en la observación del proceso de glucólisis en bacterias extraídas de un yogurt comercial. Esta actividad les permite a los estudiantes observar un proceso bioquímico en un elemento de su vida cotidiana, mientras que desarrollan su habilidad práctica en la aplicación de técnicas bioquímicas básicas, así como su comprensión sobre la glucólisis.One of the most challenging goals in the teaching of biochemistry is the integration of biochemical processes, therefore associating them with student's daily life experiences might facilitate their comprehension. Glycolysis is a ubiquitous process both in life as in biochemistry programs around the world. Despite the importance of this process, there are few experimental activities focused on said metabolic pathway. The objective ofthis study was to develop, and experimental activity focused on the observation of the glycolytic process in bacteria extracted from a commercial yogurt. This activity allows students to observe a biochemical process in an element f their daily life, while at the same time developing their practical skill in the application of basic biochemical techniques as well as their understanding about glycolysis

Neutralizing anti-RBD fraction for SARS-CoV-2 is associated with the interaction waist circumference and sex. An ESFUERSO preliminary report on university students

In a previous study we reported that 25% of college students had a family history of type 2 diabetes (T2D), and 39% of hypertension. Interestingly, between 17 to 47% reported not knowing about T2D or hypertension, neither the existing obesity-metabolic problems (ESFUERSO study). The COVID-19 pandemic forced confinement and modifications in food intake, physical activity, and psychological stress. This study aimed to analyze if the immune Ig-G anti-RBD (protective epitope in S protein) response associated with type of vaccination, metabolic risk, perceived stress, and history of COVID-19 contacts. We included 116 students at the 3th year of follow up in the ESFUERSO cohort at Reynosa. Mean age 21.4 (SD 1.04) years old, BMI 28 (6.6), females 70% (81/116). The serum concentration of Ig-G anti-RGB measured by ELISA adjusted by sex, age, body fat percentage, and BMI was analyzed. Researchers performed a multiple regression analysis with Stata V17.0. We found that 70% of the students had a family history of diabetes, hypertension, and/or obesity at baseline. Only 5 (4%) students did not have any vaccine at the time of the study, 102 (88%) were vaccinated with Moderna or Pfizer and 9 (8%) with other vaccines (Cansino, Sinovac). The prevalence of positive anti-RBD was 91%. The body fat percentage interacted with sex (p=0.034) explaining the serum concentration of anti-RBD decreased as adiposity increases in men, but increased in women. The interaction remained is spite of type of vaccination. We found no differences among metabolic risks for food consumption, distress, uncertainty, lack of sleep, sadness, and anxiety were associated with metabolic problems. Our model predicts neutralizing anti-RBD had multiplicative interaction by sex and body fat percentage (increases in females and decreases in males), with no effects on stress score or food consumption

Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL

descripción no proporcionada por scopusThis work was supported in part by funds from Ministerio de Economía y Competitividad (SAF2015-70561-R; MINECO/FEDER, EU to J.F.-P. and M.V.-M.); Ministerio de Ciencia, Innovación y Universidades (RTI2018-093330-B-I00; MCIU/FEDER, EU to J.F.-P. and J.S.); Fundación Ramón Areces (CIVP19S7917 to J.F.-P.); Comunidad de Madrid (B2017/BMD-3778; LINFOMAS-CM to J.F.-P.); Asociación Española Contra el Cáncer (AECC, 2018; PROYE18054PIRI to J.F.-P. and LABAE20049RODR to S.R-P.); Spanish National Research and Development Plan, Instituto de Salud Carlos III and FEDER (PI20/01837 to S.R.-P. and PI21/01641 to R.T.-R.); Proyecto Desarrollo Tecnológico (DTS19/00111 to S.R.-P.); Instituto de Investigación Sanitaria Fundación Jiménez Díaz to J.F.-P. Institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSO; IAP-DRCLAS at Harvard and Fundación Asisa (086812) are also acknowledged

Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL

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The mechanisms of detoxification of As(III), dimethylarsinic acid (DMA) and As(V) in the microalga Chlorella vulgaris

The response of Chlorella vulgaris when challenged by As(III), As(V) and dimethylarsinic acid (DMA) was assessed through experiments on adsorption, efflux and speciation of arsenic (reduction, oxidation, methylation and chelation with glutathione/phytochelatin [GSH/PC]). Our study indicates that at high concentrations of phosphate (1.62 mM of HPO42−), upon exposure to As(V), cells are able to shift towards methylation of As(V) rather than PC formation. Treatment with As(V) caused a moderate decrease in intracellular pH and a strong increase in the concentration of free thiols (GSH). Passive surface adsorption was found to be negligible for living cells exposed to DMA and As(V). However, adsorption of As(III) was observed to be an active process in C. vulgaris, because it did not show saturation at any of the exposure periods. Chelation of As(III) with GS/PC and to a lesser extent hGS/hPC is a major detoxification mechanism employed by C. vulgaris cells when exposed to As(III). The increase of bound As-GS/PC complexes was found to be strongly related to an increase in concentration of As(III) in media. C. vulgaris cells did not produce any As-GS/PC complex when exposed to As(V). This may indicate that a reduction step is needed for As(V) complexation with GSH/PC. C. vulgaris cells formed DMASV-GS upon exposure to DMA independent of the exposure period. As(III) triggers the formation of arsenic complexes with PC and homophytochelatins (hPC) and their compartmentalisation to vacuoles. A conceptual model was devised to explain the mechanisms involving ABCC1/2 transport. The potential of C. vulgaris to bio-remediate arsenic from water appeared to be highly selective and effective without the potential hazard of reducing As(V) to As(III), which is more toxic to humans