Anxiety, Stress, Depression, and Patients’ Responses to Periodontal Treatment: Periodontists’ Knowledge and Professional Behavior

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142063/1/jper0064.pd

Gestión del Talento Humano y el Compromiso Organizacional en la Facultad de Educación de la Universidad Nacional Federico Villarreal Lima, 2018

Este informe representa un resumen de la investigación titulada Gestión del talento humano y el compromiso organizacional en la facultad de educación de la Universidad Nacional Federico Villarreal Lima, 2018. El objetivo fue establecer la relación entre la Gestión del talento humano y el compromiso organizacional en la facultad de educación de la Universidad Nacional Federico Villarreal Lima, 2018. La investigación tuvo un enfoque cuantitativo, de alcance descriptivo correlacional y el diseño fue no experimental transversal. La población fue de 106 catedráticos de la facultad de educación de la Universidad Nacional Federico Villarreal, 2018. Para la recolección de los datos se utilizaron los cuestionarios de las variables gestión del talento humano y compromiso organizacional; se realizó la confiabilidad de Alpha de Cronbach para ambas variables. El procesamiento de datos se realizó con el software SPSS (versión 22). Se comprobó la hipótesis con la prueba no paramétrica Rho de Spearman, con un resultado de Rho de Spearman = 0.879** la correlación es significativa al nivel 0,01 bilateral, interpretándose como alta relación positiva entre las variables con una p = 0.00 (p<0.01), rechazándose la hipótesis nula

Análisis técnico económico para la adquisición de un equipo de izaje y su incidencia en la reducción de costos en el mantenimiento de las bombas verticales Goulds VIC –T, de la plataforma de bombeo PLS2, en minera Shahuindo SAC

La presente tesis de estudio titulada “Análisis técnico económico para la adquisición de un equipo de izaje y su incidencia en la reducción de costos en el mantenimiento de las bombas verticales Goulds Vic –T, de la plataforma de bombeo PLS2, en minera Shahuindo SAC”, presenta las oportunidades de mejora que se pueden implementar para las tareas de mantenimiento de las bombas verticales Goulds Vic-T en minera Shahuindo, donde al estudio realizado que actualmente estas actividades de mantenimiento se realizan con equipos de izaje móvil con grúa telescópica de 50 Tn; representando un alto costo en las tareas que se realizan, mismas que se pueden reducir si se optara por adquirir un equipo de trabajo de mayor disponibilidad y de instalación permanente. Considerando los criterios de Costo de proyecto, términos contractuales, tecnología, diseño, tiempo de entrega y medio ambiente, además de la parte económica el presente estudio nos brinda alternativas para proponer mejoras en la forma de realizar el trabajo asegurando la calidad y seguridad del mismo donde la parte económica representa un ahorro del 15.04% de ahorro siendo el equipo más viable de implementación, siendo este una grúa pórtico donde además el tiempo de recuperación de la inversión sería en 3 años.The present study thesis entiled, “Technical- economic analysis for the acquisition of a lifting equipmet and its impacto n the reductión of costs in the maintenance of the Goulds Vic-T vertical pumps, of the PLS2 pumping platform, in Shahuindo SAC mining Company”, presents the improvement opportunities that can be implemented for the maintenance tasks of the Goulds Vic-T vertical pumps in Shauindo mining, where the study carried out that currently these maintenance activities are carried out with mobile lifting equipment with a 50 Tn telescopic crane; representing a high cost in the tasks that are carried out, which can be reduced if you choose to acquire a work team with greater availability and permanent installation. Considering the criteria of Project cost, contractual terms, thechnology, design, delivery time and environmet, in additión to the economic part, this study offers us alternatives to propose improvements in the way of carrying out the work, ensuring its quiality and safety. Where the economic part represents a saving of 15.04% of saving, being the most viable equipment for implementation, this being a gantry crane where, in adittión, the recovery time of the investment would be in 3 yearsTesi

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Alignment of the CMS tracker with LHC and cosmic ray data

© CERN 2014 for the benefit of the CMS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI.The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study

BackgroundThe PERFORM study aimed to understand causes of febrile childhood illness by comparing molecular pathogen detection with current clinical practice.MethodsFebrile children and controls were recruited on presentation to hospital in 9 European countries 2016-2020. Each child was assigned a standardized diagnostic category based on retrospective review of local clinical and microbiological data. Subsequently, centralised molecular tests (CMTs) for 19 respiratory and 27 blood pathogens were performed.FindingsOf 4611 febrile children, 643 (14%) were classified as definite bacterial infection (DB), 491 (11%) as definite viral infection (DV), and 3477 (75%) had uncertain aetiology. 1061 controls without infection were recruited. CMTs detected blood bacteria more frequently in DB than DV cases for N. meningitidis (OR: 3.37, 95% CI: 1.92-5.99), S. pneumoniae (OR: 3.89, 95% CI: 2.07-7.59), Group A streptococcus (OR 2.73, 95% CI 1.13-6.09) and E. coli (OR 2.7, 95% CI 1.02-6.71). Respiratory viruses were more common in febrile children than controls, but only influenza A (OR 0.24, 95% CI 0.11-0.46), influenza B (OR 0.12, 95% CI 0.02-0.37) and RSV (OR 0.16, 95% CI: 0.06-0.36) were less common in DB than DV cases. Of 16 blood viruses, enterovirus (OR 0.43, 95% CI 0.23-0.72) and EBV (OR 0.71, 95% CI 0.56-0.90) were detected less often in DB than DV cases. Combined local diagnostics and CMTs respectively detected blood viruses and respiratory viruses in 360 (56%) and 161 (25%) of DB cases, and virus detection ruled-out bacterial infection poorly, with predictive values of 0.64 and 0.68 respectively.InterpretationMost febrile children cannot be conclusively defined as having bacterial or viral infection when molecular tests supplement conventional approaches. Viruses are detected in most patients with bacterial infections, and the clinical value of individual pathogen detection in determining treatment is low. New approaches are needed to help determine which febrile children require antibiotics.FundingEU Horizon 2020 grant 668303