Service-Learning in One State: Results of the North Carolina Service-Learning Inventory

Recent years have seen greatly expanded interest in service-learning among educators at both the K-12 and college levels. By most accounts, the initiation of service-learning programs and courses has come about in response to a recognized need to provide more effective citizenship education and to do a better job of preparing young people to be active members of their communities (see, for example, Barber). What is less clear, however, is the overall shape and substance of these programs. Because service-learning usually has a strong local component, not very much is known of the broader patterns and trends at the national and state levels

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms