Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: A cohort study

Definitions of comorbid conditions. (DOCX 13 kb

Continuous Operation of Radial Multiterminal HVDC Systems Under DC Fault

For a large multi-terminal HVDC system, it is important that a DC fault on a single branch does not cause significant disturbance to the operation of the healthy parts of the DC network. Some DC circuit breakers (DCCBs), e.g. mechanical type, have low cost and power loss, but have been considered unsuitable for DC fault protection and isolation in a multi-terminal HVDC system due to their long opening time. This paper proposes the use of additional DC passive components and novel converter control combined with mechanical DCCBs to ensure that the healthy DC network can continue to operate without disruption during a DC fault on one DC branch. Two circuit structures, using an additional DC reactor, and a reactor and capacitor combination, connected to the DC-link node in a radial HVDC system are proposed to ensure over-current risk at the converters connected to the healthy network is minimized before the isolation of the faulty branch by mechanical DCCBs. Active control of DC fault current by dynamically regulating the DC components of the converter arm voltages is proposed to further reduce the fault arm current. Simulation of a radial three-terminal HVDC system demonstrates the effectiveness of the proposed method

Swift XRT Observations of the Afterglow of XRF 050416A

Swift discovered XRF 050416A with the BAT and began observing it with its narrow field instruments only 64.5 s after the burst onset. Its very soft spectrum classifies this event as an X-ray flash. The afterglow X-ray emission was monitored up to 74 days after the burst. The X-ray light curve initially decays very fast, subsequently flattens and eventually steepens again, similar to many X-ray afterglows. The first and second phases end about 172 and 1450 s after the burst onset, respectively. We find evidence of spectral evolution from a softer emission with photon index Gamma ~ 3.0 during the initial steep decay, to a harder emission with Gamma ~ 2.0 during the following evolutionary phases. The spectra show intrinsic absorption in the host galaxy. The consistency of the initial photon index with the high energy BAT photon index suggests that the initial phase of the X-ray light curve may be the low-energy tail of the prompt emission. The lack of jet break signatures in the X-ray afterglow light curve is not consistent with empirical relations between the source rest-frame peak energy and the collimation-corrected energy of the burst. The standard uniform jet model can give a possible description of the XRF 050416A X-ray afterglow for an opening angle larger than a few tens of degrees, although numerical simulations show that the late time decay is slightly flatter than expected from on-axis viewing of a uniform jet. A structured Gaussian-type jet model with uniform Lorentz factor distribution and viewing angle outside the Gaussian core is another possibility, although a full agreement with data is not achieved with the numerical models explored.Comment: Accepted for publication on ApJ; replaced with revised version: part of the discussion moved in an appendix; 11 pages, 6 figures; abstract shortened for posting on astro-p

Faint NUV/FUV Standards from Swift/UVOT, GALEX and SDSS Photometry

At present, the precision of deep ultraviolet photometry is somewhat limited by the dearth of faint ultraviolet standard stars. In an effort to improve this situation, we present a uniform catalog of eleven new faint (u sim17) ultraviolet standard stars. High-precision photometry of these stars has been taken from the Sloan Digital Sky Survey and Galaxy Evolution Explorer and combined with new data from the Swift Ultraviolet Optical Telescope to provide precise photometric measures extending from the Near Infrared to the Far Ultraviolet. These stars were chosen because they are known to be hot (20,000 < T_eff < 50,000 K) DA white dwarfs with published Sloan spectra that should be photometrically stable. This careful selection allows us to compare the combined photometry and Sloan spectroscopy to models of pure hydrogen atmospheres to both constrain the underlying properties of the white dwarfs and test the ability of white dwarf models to predict the photometric measures. We find that the photometry provides good constraint on white dwarf temperatures, which demonstrates the ability of Swift/UVOT to investigate the properties of hot luminous stars. We further find that the models reproduce the photometric measures in all eleven passbands to within their systematic uncertainties. Within the limits of our photometry, we find the standard stars to be photometrically stable. This success indicates that the models can be used to calibrate additional filters to our standard system, permitting easier comparison of photometry from heterogeneous sources. The largest source of uncertainty in the model fitting is the uncertainty in the foreground reddening curve, a problem that is especially acute in the UV.Comment: Accepted for publication in Astrophysical Journal. 31 pages, 13 figures, electronic tables available from ApJ or on reques

Nonquantum Gravity

One of the great challenges for 21st century physics is to quantize gravity and generate a theory that will unify gravity with the other three fundamental forces of nature. This paper takes the (heretical) point of view that gravity may be an inherently classical, i.e., nonquantum, phenomenon and investigates the experimental consequences of such a model. At present there is no experimental evidence of the quantum nature of gravity and the liklihood of definitive tests in the future is not at all certain. If gravity is, indeed, a nonquantum phenomenon, then it is suggested that evidence will most likely appear at mesoscopic scales.Comment: essentially the same as the version that appears in Foundations of Physics, 39, 331 (2009

Sequential Effects in Judgements of Attractiveness: The Influences of Face Race and Sex

In perceptual decision-making, a person’s response on a given trial is influenced by their response on the immediately preceding trial. This sequential effect was initially demonstrated in psychophysical tasks, but has now been found in more complex, real-world judgements. The similarity of the current and previous stimuli determines the nature of the effect, with more similar items producing assimilation in judgements, while less similarity can cause a contrast effect. Previous research found assimilation in ratings of facial attractiveness, and here, we investigated whether this effect is influenced by the social categories of the faces presented. Over three experiments, participants rated the attractiveness of own- (White) and other-race (Chinese) faces of both sexes that appeared successively. Through blocking trials by race (Experiment 1), sex (Experiment 2), or both dimensions (Experiment 3), we could examine how sequential judgements were altered by the salience of different social categories in face sequences. For sequences that varied in sex alone, own-race faces showed significantly less opposite-sex assimilation (male and female faces perceived as dissimilar), while other-race faces showed equal assimilation for opposite- and same-sex sequences (male and female faces were not differentiated). For sequences that varied in race alone, categorisation by race resulted in no opposite-race assimilation for either sex of face (White and Chinese faces perceived as dissimilar). For sequences that varied in both race and sex, same-category assimilation was significantly greater than opposite-category. Our results suggest that the race of a face represents a superordinate category relative to sex. These findings demonstrate the importance of social categories when considering sequential judgements of faces, and also highlight a novel approach for investigating how multiple social dimensions interact during decision-making

Transcription factor distribution in Escherichia coli: studies with FNR protein

Using chromatin immunoprecipitation (ChIP) and high-density microarrays, we have measured the distribution of the global transcription regulator protein, FNR, across the entire Escherichia coli chromosome in exponentially growing cells. Sixty-three binding targets, each located at the 5′ end of a gene, were identified. Some targets are adjacent to poorly transcribed genes where FNR has little impact on transcription. In stationary phase, the distribution of FNR was largely unchanged. Control experiments showed that, like FNR, the distribution of the nucleoid-associated protein, IHF, is little altered when cells enter stationary phase, whilst RNA polymerase undergoes a complete redistribution

UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models

MERTK tyrosine kinase is ectopically expressed in 30–50% of acute lymphoblastic leukemias (ALL) and over 80% of acute myeloid leukemias (AML) and is a potential therapeutic target. Here, we evaluated the utility of UNC2025, a MERTK tyrosine kinase inhibitor, for treatment of acute leukemia

X-ray Spectral Survey with XMM--Newton of a Complete Sample of Nearby Seyfert Galaxies

Results obtained from an X-ray spectral survey of nearby Seyfert galaxies using XMM--Newton are reported. The sample was optically selected, well defined, complete in B mag, and distance limited: it consists of the nearest (D<22 Mpc) 27 Seyfert galaxies (9 of type 1, 18 of type 2) taken from the Ho et al. (1997) sample. This is one of the largest atlases of hard X-ray spectra of low-L active galaxies ever assembled. All nuclear sources except two Sey 2s are detected between 2-10 keV, half for the first time ever, and average spectra are obtained for all of them. Nuclear luminosities reach values down to 10**38 erg/s. The shape of the distribution of X-ray parameters is affected by the presence of Compton-thick objects (> 30% among type 2s). The latter have been identified either directly from their intense FeK line and flat X-ray spectra, or indirectly with flux diagnostic diagrams which use isotropic indicators. After taking into account these highly absorbed sources, we find that (i) the intrinsic X-ray spectral properties (i.e., spectral shapes and luminosities above 2 keV) are consistent between type 1 and type 2 Sey, as expected from ``unified models'', (ii) Sey galaxies as a whole are distributed fairly continuously over the entire range of Nh, between 10**20 and 10**25 cm**-2, and (iii) while Sey 1s tend to have lower Nh and Sey 2s tend to have the highest, we find 30% and 10% exceptions, respectively. Overall the sample well represents the average intrinsic X-ray spectral properties of nearby AGN, including a proper estimate of the distribution of their absorbing columns. Finally, we conclude that, with the exception of a few cases, the present study agrees with predictions of unified models of Sey galaxies, and extends their validity down to very low luminosities.Comment: 23 pages, 4 tables, 4 figures, 2 Appendices with 27 source spectra and notes, to be published in the Astronomy & Astrophysics Journa