Analyzing connectivity in collective transportation line networks by means of hypergraphs

In this paper we will show how hypergraphs and some measures related to them can help in extracting information about Collective Transportation Line Networks. We will also prove that these measures satisfy certain properties that validate their use to compare the connectivity of different networks. © 2013 EDP Sciences and Springer.This work was partially supported by Ministerio de Educacion, Ciencia e Innovacion (Spain)/FEDER under project MTM2009-14243 and by Junta de Andalucia (Spain)/FEDER under excellence proyects P09-TEP-5022 and FQM-5849. Special thanks are due to two anonymous referees for their valuable comments and advice.Barrena, E.; De-Los-Santos, A.; Mesa López-Colmenar, JA.; Perea Rojas Marcos, F. (2013). Analyzing connectivity in collective transportation line networks by means of hypergraphs. European Physical Journal - Special Topics. 215(1):93-108. https://doi.org/10.1140/epjst/e2013-01717-3S931082151D.J. Watts, S.H. Strogatz, Nature 393, 440 (1998)V. Latora, M. Marchiori, Phys. Rev. Lett. 87, 198701 (2001)V. Latora, M. Marchiori, Physica A 314, 109 (2002)R. Criado, B. Hernández-Bermejo, M. Romance, Int. J. Bifurcation Chaos 17, 2289 (2007)A. De-Los-Santos, G. Laporte, J.A. Mesa, F. Perea, Transp. Res. Part C: Emerging Technol. 20, 34 (2012)E. Barrena, A. De-Los-Santos, J.A. Mesa, F. Perea, Technical proofs of paper “Analyzing Connectivity in Collective Transportation Line Networks by means of Hypergraphs”, http://grupo.us.es/transfers/ (2012)C. Berge, Graphs and Hypergraphs (Elsevier Science Ltd., 1985)C. Berge, Hypergraphs: combinatorics of finite sets (North Holland)D.J. Watts, Small Worlds: The Dynamics of Networks between Order and Randomness (Princeton University Press, Princeton, 1999), p. 262M.E.J. Newman, Technical report, Santa Fe Institute (2001)M.E.J. Newman, Phys. Rev. E 64, 016131 (2001)M.E.J. Newman, Phys. Rev. E 64, 016132 (2001)E. Estrada, J.A. Rodríguez-Velázquez, Phys. A: Statist. Mech. Appl. 364, 581 (2006)R. Dechter, Constraint Processing (Morgan Kaufmann, 2003), p. 450P. Sen, S. Dasgupta, A. Chatterjee, P.A. Sreeram, G. Mukherjee, S.S. Manna, Phys. Rev. E 67 (2003)P. Crucitti, V. Latora, M. Marchiori, A. Rapisarda, Physica A 320, 642 (2002) [cond-mat/0205601]V. Latora, M. Marchiori, Chaos Solitons Fract. 20, 69 (2004)V. Latora, M. Marchiori, Eur. Phys. J. B 32, 249 (2002

Impact of a training project for primary health-care providers (FOCO project) in the HIV screening and HIV late diagnosis

Poster [P043] OBJECTIVE Reducing HIV late diagnosis remains an epidemiological challenge . The objective of this project was to promote early HIV diagnosis through the training of primary health - care providers (PHCP) . METHODS HIV specialists conducted training sessions in 108 primary care centers (PCC) from six Spanish regions during 2016 and 2017 , and with 1804 PHCP involved . The intervention was evaluated using a pre - experimental design collecting the dependent variables both in the six months before and after the intervention . Number of requests for HIV tests from the PCC trained and clinical data of new HIV diagnosed patients were collected . Parametric and non - parametric tests were used to assess differences between pre and post - intervention data . RESULTS 3. Differences in clinical variables in pre and post intervention period

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for genotyping/phenotyping were analyzed from protocol-defined virologic failures (PDVFs) with viral load (VL) >= 400 copies/mL at failure/later time points. Post hoc analyses were deep sequencing in AMBER, and HIV-1 proviral DNA from baseline samples (VL = 3 thymidine analog-associated mutations (24% not fully susceptible to tenofovir) detected at screening. All achieved VL <50 copies/mL at week 48 or prior discontinuation. D/C/F/TAF has a high genetic barrier to resistance; no darunavir, primary PI, or tenofovir RAMs were observed through 48 weeks in AMBER and EMERALD. Only one postbaseline M184I/V RAM was observed in HIV-1 of an AMBER participant. In EMERALD, baseline archived RAMs to darunavir, emtricitabine, and tenofovir in participants with prior VF did not preclude virologic response

Author correction : roadmap for naming uncultivated archaea and bacteria

Correction to: Nature Microbiology https://doi.org/10.1038/s41564-020-0733-x , published online 8 June 2020. In the version of this Consensus Statement originally published, Pablo Yarza was mistakenly not included in the author list. Also, in Supplementary Table 1, Alexander Jaffe was missing from the list of endorsees. These errors have now been corrected and the updated Supplementary Table 1 is available online

Roadmap for naming uncultivated Archaea and Bacteria

The assembly of single-amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) has led to a surge in genome-based discoveries of members affiliated with Archaea and Bacteria, bringing with it a need to develop guidelines for nomenclature of uncultivated microorganisms. The International Code of Nomenclature of Prokaryotes (ICNP) only recognizes cultures as ‘type material’, thereby preventing the naming of uncultivated organisms. In this Consensus Statement, we propose two potential paths to solve this nomenclatural conundrum. One option is the adoption of previously proposed modifications to the ICNP to recognize DNA sequences as acceptable type material; the other option creates a nomenclatural code for uncultivated Archaea and Bacteria that could eventually be merged with the ICNP in the future. Regardless of the path taken, we believe that action is needed now within the scientific community to develop consistent rules for nomenclature of uncultivated taxa in order to provide clarity and stability, and to effectively communicate microbial diversity

To split or not to split: an opinion on dividing the genus Burkholderia

The genus Burkholderia is a large group of species of bacteria that inhabit a wide range of environments. We previously recommended, based on multilocus sequence analysis, that the genus be separated into two distinct groups—one that consists predominantly of human, plant, and animal pathogens, including several opportunistic pathogens, and a second, much larger group of species comprising plant-associated beneficial and environmental species that are primarily known not to be pathogenic. This second group of species is found mainly in soils, frequently in association with plants as plant growth-promoting bacteria. They also possess genetic traits that bestow them with an added potential for agriculture and soil restoration, such as nitrogen fixation, phosphate solubilization, iron sequestration, and xenobiotic degradation, and they are not pathogenic. In this review, we present an update of current information on this second group of Burkholderia species, with the goal of focusing attention on their use in agriculture and environmental remediation. We describe their distribution in the environment, their taxonomy and genetic features, and their relationship with plants as either associative nitrogen-fixers or legume-nodulating/nitrogen-fixing bacteria. We also propose that a concerted and coordinated effort be made by researchers on Burkholderia to determine if a definitive taxonomic split of this very large genus is justified, especially now as we describe here for the first time intermediate groups based upon their 16S rRNA sequences. We need to learn more about the plant-associated Burkholderia strains regarding their potential for pathogenicity, especially in those strains intermediate between the two groups, and to discover whether gene exchange occurs between the symbiotic and pathogenic Burkholderia species. The latter studies will require both field and laboratory analyses of gene loss and gain