Health Outcome Predictive Evaluation for COVID 19 international registry (HOPE COVID-19), rationale and design

The disease produced by the new coronavirus known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), named COVID-19 (Coronavirus Disease-2019) has recently been classified as a pandemic by the World Health Organization (WHO). However, scarce clinical data is available and generally limited to the Chinese population due to the first cases were identified in Wuhan (Hubei, China).This article describes the rationale and design of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) registry (ClinicalTrials.gov Identifier: NCT04334291). With an ambispective cohort design, eligible patients are those discharged, deceased or alive, from any hospital center with a confirmed diagnosis or a COVID-19 high suspicion. With a current recruitment of more than 7000 cases, in 46 hospitals in 8 countries, since it is not possible to estimate the sample size based on literature reports, the investigators will try to get the maximum numbers of patients possible. The study primary objective is all cause mortality and aims to characterize the clinical profile of patients infected in order to develop a prognostic clinical score allowing, rapid logistic decision making. As secondary objectives, the analysis of other clinical events, the risk-adjusted influence of treatments and previous comorbidities of patients infected with the disease will be performed.The results of HOPE COVID-19 will contribute to a better understanding of this condition. We aim to describe the management of this condition as well as the outcomes in relation to the therapy chosen, in order to gain insight into improving patient care in the coming months. Clinical Trial registration: ClinicalTrials.gov. Unique identifier: NCT04334291

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

INTRODUCTION: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. RESULTS: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. DISCUSSION: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series

The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995â\u80\u932009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results During 2005â\u80\u932009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions

The Eleventh and Twelfth Data Releases of the Sloan Digital Sky Survey: Final Data from SDSS-III

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg2 of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg2 of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg2; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra. \ua9 2015. The American Astronomical Society

Ocular exposure to particulate matter and development of Pterygium: a case-control study

Background: Formation of pterygium has been mainly attributed to exposure to the ultraviolet (UV) radiation. Other factors such as dry weather, wind exposure and microtrauma with dust particles, have been linked to development of pterygium. Objective: To determine the association between ocular exposure to particulate matter and development of pterygium. Methods: This case-control study was conducted in a company dedicated to the production and marketing of toilets. We included a total of 90 cases identified in November 2013 and 184 controls. The diagnosis of pterygium was based on clinical examination. Variables studied included age and job tenure of the participants. Logistic regression analysis was used to assess the effect of exposure on developing pterygium. Results: All study participants were male. The mean age of the cases and controls was 39.9 (SD 9.5) and 37.8 (SD 7.3) years, respectively. 115 (42%) of the participants had a job tenure of 5?8 years. The percentages of cases and controls exposed to particulate matter were 31.1% (n=28) and 30.4% (n=56), respectively (OR 1.08, 95% CI 0.61 to 1.91). Conclusion: We could not observe any association between ocular exposure to particulate matter and development of pterygium

European Current Account Sustainability: New Evidence Based On Unit Roots and Fractional Integration

In this paper we examine current account sustainability for some European countries. However, instead of using classic approaches based on standard I(0)/I(1) procedures, we use other more recent techniques for unit roots along with fractionally integrated methods. Our findings can be summarized as follows: according to the Ng and Perron's (2001) procedure, exports and imports are non-stationary I(1) variables in most of the countries. However, using fractional methods, exports and imports are in most cases I(d) with d>1. With respect to the current accounts, the orders of integration are generally smaller than in the cases of exports and imports, in some cases even smaller than 1, though the unit root cannot be rejected in the majority of the countries. Therefore, we obtain little or no evidence of current account sustainability in the European countries examined.

Las tics una herramienta pedag?gica para integrar la animaci?n a la lectura en el grado primero A de la instituci?n educativa C?mara Junior sede ciudad Milagro, del barrio la Clarita, en el municipio de Armenia, Quindio

123 p. Recurso Electr?nicoEl trabajo de investigaci?n actual pretende ejecutar un an?lisis en el dominio que tienen las TICS en la animaci?n de la lectura preescolar. El proceso de investigaci?n formativa durante la aproximaci?n a la primera clase fue fundada a trav?s del diario de campo y la observaci?n, con la diligencia de diversos instrumentos en el curso de una investigaci?n cualitativa, por lo tanto, se evidencia la lejan?a de las pr?cticas pedag?gicas y educativas en el aula, en t?rminos de consolidaci?n de Tics como herramienta de aprendizaje en los ni?os. Este trabajo busca establecer nuevas pr?cticas en el aula en cuanto a las t?cnicas de ense?anza y aprendizaje y de esta manera hacer uso de las nuevas herramientas tecnol?gicas en la animaci?n a la lectura con los ni?os y ni?as de las escuelas de primaria en Colombia.The current research work aims to run a domain analysis with Tics in the animation of preschool reading. The formative research process during the approach to the first class was established through field diary and observation, with the diligence of various instruments in the course of a qualitative research, therefore, the remoteness of teaching practices evidenced and education in the classroom in terms of consolidation of Tics as a learning tool for children. This work seeks to establish new practices in the classroom in terms of teaching and learning techniques and thus make use of new technological tools in the promotion of reading with children from primary schools in Colombia. Keywords: Education, Tics, technology