Acute Physiological and Metabolic responses for 40-minutes of Samba Dance

Dance is an enjoyable health-promoting physical activity that many people worldwide incorporate into their lifestyles today. Therefore, dance improves your heart health, overall muscle strength, balance, and coordination, and reduces depression. We aim to gain insights into the effects of samba dance on the cardiorespiratory and metabolic response during an acute session of this dance style for 40-minutes. The study was carried out on 20 female samba dancers. All of them performed two procedures: (1) a cardiopulmonary exercise test on a treadmill for physical fitness aptitude verification and (2) a 40-minutes of samba dancing monitored by analysis of expired gases. The results were: At peak exercise: oxygen uptake (VO2) =32.7 mL.kg-1.min-1; heart rate (HR) =183 bpm; the pulse of oxygen (PO2) =10.9 mL.HR-1, energy expenditure (EE) = 9.9 kcal.min-1and metabolic equivalent (METs)=13.5.Overall, each session of the dance of 40-minutes was performed at a mean VO2 of 22.8 mL.kg-1.min-1 (70%VO2max), heart rate of 162 bpm (89%HRmax), energy expenditure (EE) of 6.5 kcal.min-1 (66%max), metabolic equivalent (METs) of 6.3 (62%max), and the rate of perceived exertion (RPE) of 11.8/20. In conclusion: The findings of the current investigation might suggest that the moderate and vigorous-intensity of the exercise verified in an acute samba dance session is enough to induce a chronic training effect recommended by the criteria established by the American College of Sports Medicine for improving cardiorespiratory fitness. This information may lead to a better understanding of the energy expenditure of samba dance and add to the compendium of physical activity.

Physiological, morphological characteristics and blood profile of female elite Brazilian soccer players according to position

The main goal of this study was to identify the performance parameters and blood profile found among female soccer players. The second aim was to examine if there were any systematic differences between players assigned to different playing positions. Thirty-six players (age: 23.7 ± 3.5 y; weight: 61.9 ± 5.7 kg; height: 165.7± 6.2 cm) underwent a set of laboratory tests (cardiopulmonary exercise test, skinfold measurements, Wingate test, sit-and-reach test, and blood biochemical tests). The following results were verified: maximal oxygen uptake (53±3.9 mL.kg-1.min-1), second ventilatory threshold (11.5 ± 0.8 km.h-1), body fat (14.1 ± 2.9%), Wingate anaerobic test (peak power: 9.5 ± 0.8 w.kg-1; mean power: 7.3 ± 0.4 w.kg-1 and fatigue index: 55.5 ± 4.9%),  flexibility test [sit-and-reach]  (18.1 ± 2.9 cm) and biochemical parameters of blood (Hb:13.9 ± 0.3 g.dL-1; iron: 85.2 ± 12.6 µ.dL-1; calcium: 9.2±0.5 mg.dL-1;  total cholesterol: 204.7 ± 34.7 mg.dL-1; HDL-c: 50.7± 3.6 mg.dL-1; LDL-c: 125.8± 23.3 mg.dL-1; triglycerides: 96.8±18.5 mg.dL-1). In conclusion, the current results indicate that present elite players' physiological characteristics are similar to those previously shown, despite the rapid changes of the female soccer game worldwide. However, data showed that different playing positions had different physiological and anthropometrics differences.

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation

Natural Organic Acid as Green Catalyst for Xanthenones Synthesis: Methodology, Mechanism and Calcium Channel Blocking Activity

<div><p>Xanthenones were synthesized via one-pot tricomponent reaction, under solvent-free conditions, using aldehydes, phenolic and cyclic 1,3-dicarbonyl compounds. Natural organic acids (NOAs), compounds present in many living metabolisms, were used as potential green catalysts. NOA are considered to be more eco-friendly and user-friendly alternative to traditional methodologies. Optimization studies showed that oxalic acid was the best NOA catalyst for such reaction furnishing the xanthenones with up to 93% of yield. Theoretical calculations were performed to evaluate this reaction mechanism and regioselectivity. The results showed that the regiospecificity of this three-component reaction is kinetically and thermodynamically controlled by the addition of β-naphthol C2, instead of C10, to the aldehyde. Our results also disclosed two xanthenones as novel calcium channels blockers. Eco-friendly reaction conditions, easy workup procedure, short reaction times and good yields are some of the advantages of our methodology.</p></div

Time-dependent analysis of extra length of stay and mortality due to ventilator-associated pneumonia in intensive-care units of ten limited-resources countries: findings of the International Nosocomial Infection Control Consortium (INICC)

Ventilator-associated pneumonias (VAPs) are a worldwide problem that significantly increases patient morbidity, mortality, and length of stay (LoS), and their effects should be estimated to account for the timing of infection. The purpose of the study was to estimate extra LoS and mortality in an intensive-care unit (ICU) due to a VAP in a cohort of 69 248 admissions followed for 283 069 days in ICUs from 10 countries. Data were arranged according to the multi-state format. Extra LoS and increased risk of death were estimated independently in each country, and their results were combined using a random-effects meta-analysis. VAP prolonged LoS by an average of 2.03 days (95% CI 1.52-2.54 days), and increased the risk of death by 14% (95% CI 2-27). The increased risk of death due to VAP was explained by confounding with patient morbidity

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation