Methanesulfonic acid (MSA) migration in polar ice : data synthesis and theory

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cryosphere 11 (2017): 2439-2462, doi:10.5194/tc-11-2439-2017.Methanesulfonic acid (MSA; CH3SO3H) in polar ice is a unique proxy of marine primary productivity, synoptic atmospheric transport, and regional sea-ice behavior. However, MSA can be mobile within the firn and ice matrix, a post-depositional process that is well known but poorly understood and documented, leading to uncertainties in the integrity of the MSA paleoclimatic signal. Here, we use a compilation of 22 ice core MSA records from Greenland and Antarctica and a model of soluble impurity transport in order to comprehensively investigate the vertical migration of MSA from summer layers, where MSA is originally deposited, to adjacent winter layers in polar ice. We find that the shallowest depth of MSA migration in our compilation varies over a wide range (∼ 2 to 400 m) and is positively correlated with snow accumulation rate and negatively correlated with ice concentration of Na+ (typically the most abundant marine cation). Although the considered soluble impurity transport model provides a useful mechanistic framework for studying MSA migration, it remains limited by inadequate constraints on key physico-chemical parameters – most notably, the diffusion coefficient of MSA in cold ice (DMS). We derive a simplified version of the model, which includes DMS as the sole parameter, in order to illuminate aspects of the migration process. Using this model, we show that the progressive phase alignment of MSA and Na+ concentration peaks observed along a high-resolution West Antarctic core is most consistent with 10−12 m2 s−1 < DMS < 10−11 m2 s−1, which is 1 order of magnitude greater than the DMS values previously estimated from laboratory studies. More generally, our data synthesis and model results suggest that (i) MSA migration may be fairly ubiquitous, particularly at coastal and (or) high-accumulation regions across Greenland and Antarctica; and (ii) can significantly change annual and multiyear MSA concentration averages. Thus, in most cases, caution should be exercised when interpreting polar ice core MSA records, although records that have undergone severe migration could still be useful for inferring decadal and lower-frequency climate variability.Matthew Osman acknowledges government support awarded by DoD, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship, 32 CFR 168a. This work was supported by the US NSF (ANT-0632031 and PLR-1205196 to Sarah B. Das, and NSF-MRI-1126217 to Matthew J. Evans) and a Woods Hole Oceanographic Institution Interdisciplinary Research award to Sarah B. Das and Olivier Marchal

Greenlandic ice archives of North Atlantic Common Era climate

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Oceanography and Applied Ocean Science and Engineering at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2019.The Common Era (A.D. 1– present) represents a crucial period for climatic studies, documenting the timespan over which human activities have become an increasingly domineering force in shaping Earth’s landscape, climate, and ecology. Direct, quantifiable records of climatic phenomena are severely limited over much of the Common Era, necessitating high-resolution, naturally-derived proxies to extend climatic insights beyond the satellite and instrumental era, particularly across remote high-latitude and maritime regions of the North Atlantic. Here, I use modern, data-driven and physically-based modeling approaches to gain new insights into North Atlantic climate variability from the Greenlandic ice core archive. First, I investigate the climatic fidelity of ice core glaciochemical climate proxies at the microphysical-scale. I show that several soluble chemical species – key among them methanesulfonic acid (MSA) – undergo rapid vertical migration through a super-cooled liquidadvection process along ice crystal grain-boundaries. I demonstrate that significant multi-year MSA changes occur only under low snow-accumulation and high-impurity-content conditions, thus mitigating the phenomenon over much of Greenland. Building upon these findings, I then investigate the cause of declining 19th and 20th-century MSA concentrations across the interior Greenland Ice Sheet. My results illustrate that Greenlandic MSA records provide a new proxy for North Atlantic planktonic biomass changes, illuminating a 10 ± 7% decline in marine productivity over the Industrialera. I next present a new climate record from a previously-unexplored coastal ice cap in west-central Greenland. Using a physically-constrained ice cap flowline inversion model, I identify marked centennial-scale changes in coastal precipitation during the last millennium, including a ~40% increase in coastal precipitation since the industrial-onset. These changes are drastically larger than those observed from inland Greenland records, revealing enhanced sensitivity in west Greenlandic hydroclimates to regional Atlantic and Arctic-wide temperature variability. Finally, leveraging a compilation of nearly 30 annual-resolution Greenland water-isotope records, I isolate coherent signatures of atmospheric circulation variability to reconstruct changes in the North Atlantic eddydriven jet-stream over the last millennium, exposing progressively enhanced variability during the past two-centuries consistent with amplified Arctic thermal-wind forcing. This thesis thus illuminates new Common Era climatic and ecologic changes, and expands the scope of the Greenlandic ice archive as proxies of the coupled North Atlantic climate system.To my various funders: scientific research – especially the polar variety – is wicked expensive, and this dissertation wouldn’t have been possible without the big-bucks graciously provided by the U.S. Department of Defense Office of Naval Research (National Defense Science and Engineering Graduate fellowship), the National Science Foundation’s Office of Polar Programs (1205196, 1418256), as well as generous support from the Woods Hole Oceanographic Institution. An Ocean Outlook Fellowship from the Bjerknes Centre (Bergen, Norway) bred much creativity, and is also much-appreciated

Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated Topoisomerase I to promote genome stability

Peer reviewedPublisher PD

Global warming in the pipeline

Improved knowledge of glacial-to-interglacial global temperature change implies that fast-feedback equilibrium climate sensitivity is at least ~4{\deg}C for doubled CO2 (2xCO2), with likely range 3.5-5.5{\deg}C. Greenhouse gas (GHG) climate forcing is 4.1 W/m2 larger in 2021 than in 1750, equivalent to 2xCO2 forcing. Global warming in the pipeline is greater than prior estimates. Eventual global warming due to today's GHG forcing alone -- after slow feedbacks operate -- is about 10{\deg}C. Human-made aerosols are a major climate forcing, mainly via their effect on clouds. We infer from paleoclimate data that aerosol cooling offset GHG warming for several millennia as civilization developed. A hinge-point in global warming occurred in 1970 as increased GHG warming outpaced aerosol cooling, leading to global warming of 0.18{\deg}C per decade. Aerosol cooling is larger than estimated in the current IPCC report, but it has declined since 2010 because of aerosol reductions in China and shipping. Without unprecedented global actions to reduce GHG growth, 2010 could be another hinge point, with global warming in following decades 50-100% greater than in the prior 40 years. The enormity of consequences of warming in the pipeline demands a new approach addressing legacy and future emissions. The essential requirement to "save" young people and future generations is return to Holocene-level global temperature. Three urgently required actions are: 1) a global increasing price on GHG emissions, 2) purposeful intervention to rapidly phase down present massive geoengineering of Earth's climate, and 3) renewed East-West cooperation in a way that accommodates developing world needs.Comment: 48 pages, 27 figures. Correction of formatting error on page 21, which messed up placement of all following figure

No Consistent Simulated Trends in the Atlantic Meridional Overturning Circulation for the Past 6,000 Years

The Atlantic Meridional Overturning Circulation (AMOC) is a key feature of the North Atlantic with global ocean impacts. The AMOC's response to past changes in forcings during the Holocene provides important context for the coming centuries. Here, we investigate AMOC trends using an emerging set of transient simulations using multiple global climate models for the past 6,000 years. Although some models show changes, no consistent trend in overall AMOC strength during the mid-to-late Holocene emerges from the ensemble. We interpret this result to suggest no overall change in AMOC, which fits with our assessment of available proxy reconstructions. The decadal variability of the AMOC does not change in ensemble during the mid- and late-Holocene. There are interesting AMOC changes seen in the early Holocene, but their nature depends a lot on which inputs are used to drive the experiment

Rationale and study design of the MINERVA study: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction-UK multicentre collaboration

Introduction The purpose of this study is to assess the ability of two new ECG markers (Regional Repolarisation Instability Index (R2I2) and Peak Electrical Restitution Slope) to predict sudden cardiac death (SCD) or ventricular arrhythmia (VA) events in patients with ischaemic cardiomyopathy undergoing implantation of an implantable cardioverter defibrillator for primary prevention indication. Methods and analysis Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction is a prospective, open label, single blinded, multicentre observational study to establish the efficacy of two ECG biomarkers in predicting VA risk. 440 participants with ischaemic cardiomyopathy undergoing routine first time implantable cardioverter-defibrillator (ICD) implantation for primary prevention indication are currently being recruited. An electrophysiological (EP) study is performed using a non-invasive programmed electrical stimulation protocol via the implanted device. All participants will undergo the EP study hence no randomisation is required. Participants will be followed up over a minimum of 18 months and up to 3 years. The first patient was recruited in August 2016 and the study will be completed at the final participant follow-up visit. The primary endpoint is ventricular fibrillation or sustained ventricular tachycardia >200 beats/min as recorded by the ICD. The secondary endpoint is SCD. Analysis of the ECG data obtained during the EP study will be performed by the core lab where blinding of patient health status and endpoints will be maintained. Ethics and dissemination Ethical approval has been granted by Research Ethics Committees Northern Ireland (reference no. 16/NI/0069). The results will inform the design of a definitive Randomised Controlled Trial (RCT). Dissemination will include peer reviewed journal articles reporting the qualitative and quantitative results, as well as presentations at conferences and lay summaries

Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium

Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (,0.1% frequency), non-synonymous variants. Our findings implicate the MYO19 and KIF18B genes and rare variants in SPAG9 and RUNDC1 as candidates worthy of further investigation. Burden testing and functional studies are planned

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London