Propagating Stress-Strain Curve Variability in Multi-Material Problems: Temperature-Dependent Material Tests to Plasticity Models to Structural Failure Predictions

This chapter presents a practical methodology for characterizing and propagating the effects of temperature-dependent material strength and failure-criteria variability to structural model predictions. The application involves a cylindrical canister (“can”) heated and pressurized to failure. Temperature dependence and material sample-to-sample stochastic variability are inferred from very limited experimental data of a few replicate uniaxial tension tests at each of seven temperatures spanning the 800°C temperature excursion experienced by the can, for each of several stainless steel alloys that make up the can. The load-displacement curves from the material tests are used to determine effective temperature-dependent stress-strain relationships in ductile-metal plasticity models used in can-level model predictions. Particularly challenging aspects of the problem are the appropriate inference, representation, and propagation of temperature dependence and material stochastic variability from just a few experimental data curves at a few temperatures (as sparse discrete realizations or samples from a random field of temperature-dependent stress-strain behavior), for multiple such materials involved in the problem. Currently unique methods are demonstrated that are relatively simple and effective

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death

Listes générales des inscriptions et des monuments du Champa et du Cambodge /

Includes bibliographical referencesAt head of title: École française d'Extrême-Orient.Mode of access: Internet