La reproducción asistida post mortem y sus futuras implicancias en la sucesión del padre fallecido en el Perú

El presente trabajo de investigación titulado “La reproducción asistida post mortem y sus futuras implicancias en la sucesión del padre fallecido en el Perú”, tuvo como objetivo general el “Determinar si es que existe una necesidad verdadera para la creación de una regulación jurídico legal para el tratamiento de la sucesión de los hijos nacidos debido a la reproducción asistida post mortem” La presente investigación se realizó con el enfoque cualitativo, de tipo básico y se utilizó el diseño interpretativo, bibliográfico y documental, además se utilizó como instrumento la Guía de Entrevista y el Análisis Documental. Se llegó a la conclusión que existe una necesidad verdadera para la creación de una regulación jurídico legal para el tratamiento de la sucesión de los hijos nacidos debido a la reproducción asistida post mortem, ya que permitirá el resolver controversias relacionadas a la temática vista, devenida de la ambigüedad de la norma actual que trata las técnicas de reproducción asistida en el país, que fije los alcances y límites de la práctica y fijando los derechos sucesorios, para evitar la desprotección económico-financiera del menor por nacer

Addressing the need for improved land cover map products for policy support

CITATION: Szantoi, Z. et al. 2020. Addressing the need for improved land cover map products for policy support. Environmental Science & Policy, 12:28-35, doi:10.1016/j.envsci.2020.04.005.The original publication is available at https://www.sciencedirect.comThe continued increase of anthropogenic pressure on the Earth’s ecosystems is degrading the natural environment and then decreasing the services it provides to humans. The type, quantity, and quality of many of those services are directly connected to land cover, yet competing demands for land continue to drive rapid land cover change, affecting ecosystem services. Accurate and updated land cover information is thus more important than ever, however, despite its importance, the needs of many users remain only partially attended. A key underlying reason for this is that user needs vary widely, since most current products – and there are many available – are produced for a specific type of end user, for example the climate modelling community. With this in mind we focus on the need for flexible, automated processing approaches that support on-demand, customized land cover products at various scales. Although land cover processing systems are gradually evolving in this direction there is much more to do and several important challenges must be addressed, including high quality reference data for training and validation and even better access to satellite data. Here, we 1) present a generic system architecture that we suggest land cover production systems evolve towards, 2) discuss the challenges involved, and 3) propose a step forward. Flexible systems that can generate on-demand products that match users’ specific needs would fundamentally change the relationship between users and land cover products – requiring more government support to make these systems a reality.Publisher's versio

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Spatially enabling the Global Framework for Climate Services: Reviewing geospatial solutions to efficiently share and integrate climate data & information

In November 2016, the Paris Agreement entered into force calling Parties to strengthen their cooperation for enhancing adaptation and narrowing the gap between climate science and policy. Moreover, climate change has been identified as a central challenge for sustainable development by the United Nations 2030 Agenda for Sustainable Development. Data provide the basis for a reliable scientific understanding and knowledge as well as the foundation for services that are required to take informed decisions. In consequence, there is an increasing need for translating the massive amount of climate data and information that already exists into customized tools, products and services to monitor the range of climate change impacts and their evolution. It is crucial that these data and information should be made available not in the way that they are collected, but in the way that they are being used by the largest audience possible. Considering that climate data is part of the broader Earth observation and geospatial data domain, the aim of this paper is to review the state-of-the-art geospatial technologies that can support the delivery of efficient and effective climate services, and enhancing the value chain of climate data in support of the objectives of the Global Framework for Climate Services. The major benefit of spatially-enabling climate services is that it brings interoperability along the entire climate data value chain. It facilitates storing, visualizing, accessing, proces- sing/analyzing, and integrating climate data and information and enables users to create value-added products and services

Thyroid function in heart failure with preserved ejection fraction (HFpEF) – evaluation of serum and myocardial thyroid hormones in an animal model of HFpEF

Trabajo presentado en el 19th European Congress of Endocrinology, celebrado en Lisboa (Portugal) del 20 al 23 de mayo de 2017.[Introduction]: Thyroid hormones play a central role in the regulation of the cardiovascular system. Heart failure with preserved ejection fraction (HFpEF) is responsible for more than 50% of all heart failure cases and its main pathophysiological alteration is diastolic dysfunction. Diminished thyroid function is known to predominantly impair diastolic function, however the thyroid hormone status in HFpEF remains largely unknown.[Methods]: We evaluated an animal model of HFpEF, ZSF1 Obese rats (ZSF1-Ob, n=13), and their control group, ZSF1 Lean rats (ZSF1-Ln, n=11), with serial echocardiography followed by invasive hemodynamic recordings and tissue collections at 20 weeks. Serum TSH was quantified by ELISA. Thyroxine (T4) and triiodothyronine (T3) were quantified in serum, left ventricle and visceral adipose tissue by radioimmunoassay (RIA).[Results]: At 20 weeks of age, ZSF1-Ob group developed HF with diastolic dysfunction, as shown by an increased E/E’ on echocardiography, a prolonged time constant of isovolumetric relaxation, an elevated end-diastolic pressure and upward shifted end-diastolic pressure-volume relationship on invasive hemodynamic evaluation. Serum levels of thyroid hormones were significantly decreased in ZSF1-Ob rats (T3: 5.96±4.65 vs 35.85±9.39 ng/dL in ZSF1-Ln, P<0.001; T4: 1.51±0.64 vs 3.49±1.35 μg/dl in ZSF1-Ln, P<0.001), while the levels of serum TSH were not significantly different between the two groups (0.65±0.38 ng/ml in ZSF1-Ln vs 0.79±0.57 ng/ml in ZSF1-Ob, P=0.531). Left ventricle levels of thyroid hormones were significantly decreased in ZSF1-Ob rats (T3: 3.87±0.85 vs 10.51±7.91 ng/g in ZSF1-Ln, P=0.012; T4: 0.99±0.43 vs 2.02±0.60 ng/g in ZSF1-Ln, P=0.016). The levels of T3 and T4 in visceral adipose tissue were not significantly different between the two groups.[Conclusion]: We observed a decrease in serum and myocardial thyroid hormone levels in an animal model of HFpEF. This may contribute to impaired diastolic function and, therefore, may constitute an interesting therapeutic target in HFpEF.Peer reviewe

High co-infection rates of babesia bovis, <em>babesia bigemina</em>, and anaplasma marginale in water buffalo in western cuba

International audienceWater buffalo is important livestock in several countries in the Latin American and Caribbean regions. This buffalo species can be infected by tick-borne hemoparasites and remains a carrier of these pathogens which represent a risk of infection for more susceptible species like cattle. Therefore, studies on the epidemiology of tick-borne hemoparasites in buffaloes are required. In this study, the prevalence of Babesia bovis, Babesia bigemina, and Anaplasma marginale were determined in water buffalo herds of western Cuba. To this aim, a cross-sectional study covering farms with large buffalo populations in the region was performed. Eight buffalo herds were randomly selected, and blood samples were collected from 328 animals, including 63 calves (3-14months), 75 young animals (3-5years), and 190 adult animals (>5years). Species-specific nested PCR and indirect ELISA assays were used to determine the molecular and serological prevalences of each hemoparasite, respectively. The molecular and serological prevalence was greater than 50% for the three hemoparasites. Differences were found in infection prevalence among buffalo herds, suggesting that local epidemiological factors may influence infection risk. Animals of all age groups were infected, with a higher molecular prevalence of B. bigemina and A. marginale in young buffalo and calves, respectively, while a stepwise increase in seroprevalence of B. bovis and B. bigemina from calves to adult buffaloes was found. The co-infection by the three pathogens was found in 12% of animals, and when analyzed by pair, the co-infections of B. bovis and B. bigemina, B. bigemina and A. marginale, and B. bovis and A. marginale were found in 20%, 24%, and 26%, respectively, underlying the positive interaction between these pathogens infecting buffaloes. These results provide evidence that tick-borne pathogen infections can be widespread among water buffalo populations in tropical livestock ecosystems. Further studies should evaluate whether these pathogens affect the health status and productive performance of water buffalo and infection risk of these pathogens in cattle cohabiting with buffalo

Active Uptake of Dendritic Cell-Derived Exovesicles by Epithelial Cells Induces the Release of Inflammatory Mediators through a TNF-α-Mediated Pathway

Dendritic cells (DCs) can release hundreds of membrane vesicles, called exovesicles, which are able to activate resting DCs and distribute antigen. Here, we examined the role of mature DC-derived exovesicles in innate and adaptive immunity, in particular their capacity to activate epithelial cells. Our analysis of exovesicle contents showed that exovesicles contain major histocompatibility complex-II, CD40, and CD83 molecules in addition to tumor necrosis factor (TNF) receptors, TNFRI and TNFRII, and are important carriers of TNF-α. These exovesicles are rapidly internalized by epithelial cells, inducing the release of cytokines and chemokines, but do not transfer an alloantigen-presenting capacity to epithelial cells. Part of this activation appears to involve the TNF-α-mediated pathway, highlighting the key role of DC-derived exovesicles, not only in adaptive immunity, but also in innate immunity by triggering innate immune responses and activating neighboring epithelial cells to release cytokines and chemokines, thereby amplifying the magnitude of the innate immune response

A satellite-based surface radiation climatology derived by combining climate data records and near-real-time data

This study presents a method for adjusting long-term climate data records (CDRs) for the integrated use with near-real-time data using the example of surface incoming solar irradiance (SIS). Recently, a 23-year long (1983–2005) continuous SIS CDR has been generated based on the visible channel (0.45–1 μm) of the MVIRI radiometers onboard the geostationary Meteosat First Generation Platform. The CDR is available from the EUMETSAT Satellite Application Facility on Climate Monitoring (CM SAF). Here, it is assessed whether a homogeneous extension of the SIS CDR to the present is possible with operationally generated surface radiation data provided by CM SAF using the SEVIRI and GERB instruments onboard the Meteosat Second Generation satellites. Three extended CM SAF SIS CDR versions consisting of MVIRI-derived SIS (1983–2005) and three different SIS products derived from the SEVIRI and GERB instruments onboard the MSG satellites (2006 onwards) were tested. A procedure to detect shift inhomogeneities in the extended data record (1983–present) was applied that combines the Standard Normal Homogeneity Test (SNHT) and a penalized maximal T-test with visual inspection. Shift detection was done by comparing the SIS time series with the ground stations mean, in accordance with statistical significance. Several stations of the Baseline Surface Radiation Network (BSRN) and about 50 stations of the Global Energy Balance Archive (GEBA) over Europe were used as the ground-based reference. The analysis indicates several breaks in the data record between 1987 and 1994 probably due to artefacts in the raw data and instrument failures. After 2005 the MVIRI radiometer was replaced by the narrow-band SEVIRI and the broadband GERB radiometers and a new retrieval algorithm was applied. This induces significant challenges for the homogenisation across the satellite generations. Homogenisation is performed by applying a mean-shift correction depending on the shift size of any segment between two break points to the last segment (2006–present). Corrections are applied to the most significant breaks that can be related to satellite changes. This study focuses on the European region, but the methods can be generalized to other regions. To account for seasonal dependence of the mean-shifts the correction was performed independently for each calendar month. In comparison to the ground-based reference the homogenised data record shows an improvement over the original data record in terms of anomaly correlation and bias. In general the method can also be applied for the adjustment of satellite datasets addressing other variables to bridge the gap between CDRs and near-real-time data