Merger rates of dark matter haloes: a comparison between EPS and N-body results

We calculate merger rates of dark matter haloes using the Extended Press-Schechter approximation (EPS) for the Spherical Collapse (SC) and the Ellipsoidal Collapse (EC) models. Merger rates have been calculated for masses in the range $10^{10}M_{\odot}\mathrm{h}^{-1}$ to $10^{14}M_{\odot}\mathrm{h}^{-1}$ and for redshifts $z$ in the range 0 to 3 and they have been compared with merger rates that have been proposed by other authors as fits to the results of N-body simulations. The detailed comparison presented here shows that the agreement between the analytical models and N-body simulations depends crucially on the mass of the descendant halo. For some range of masses and redshifts either SC or EC models approximate satisfactory the results of N-body simulations but for other cases both models are less satisfactory or even bad approximations. We showed, by studying the parameters of the problem that a disagreement --if it appears-- does not depend on the values of the parameters but on the kind of the particular solution used for the distribution of progenitors or on the nature of EPS methods. Further studies could help to improve our understanding about the physical processes during the formation of dark matter haloes.Comment: 29 pages, 9 figure

Neutrinos in Non-linear Structure Formation - The Effect on Halo Properties

We use N-body simulations to find the effect of neutrino masses on halo properties, and investigate how the density profiles of both the neutrino and the dark matter components change as a function of the neutrino mass. We compare our neutrino density profiles with results from the N-one-body method and find good agreement. We also show and explain why the Tremaine-Gunn bound for the neutrinos is not saturated. Finally we study how the halo mass function changes as a function of the neutrino mass and compare our results with the Sheth-Tormen semi-analytic formulae. Our results are important for surveys which aim at probing cosmological parameters using clusters, as well as future experiments aiming at measuring the cosmic neutrino background directly.Comment: 20 pages, 8 figure

The Exoplanet Orbit Database

We present a database of well determined orbital parameters of exoplanets. This database comprises spectroscopic orbital elements measured for 427 planets orbiting 363 stars from radial velocity and transit measurements as reported in the literature. We have also compiled fundamental transit parameters, stellar parameters, and the method used for the planets discovery. This Exoplanet Orbit Database includes all planets with robust, well measured orbital parameters reported in peer-reviewed articles. The database is available in a searchable, filterable, and sortable form on the Web at http://exoplanets.org through the Exoplanets Data Explorer Table, and the data can be plotted and explored through the Exoplanets Data Explorer Plotter. We use the Data Explorer to generate publication-ready plots giving three examples of the signatures of exoplanet migration and dynamical evolution: We illustrate the character of the apparent correlation between mass and period in exoplanet orbits, the selection different biases between radial velocity and transit surveys, and that the multiplanet systems show a distinct semi-major axis distribution from apparently singleton systems.Comment: 9 pages, 7 figures (5 color), preprint style. Accepted to PASP v.2: includes changes suggested by referee, including important and corrections and clarification

Connecting stellar mass and star-formation rate to dark matter halo mass out to z ~ 2

We have constructed an extended halo model (EHM) which relates the total stellar mass and star-formation rate (SFR) to halo mass (M_h). An empirical relation between the distribution functions of total stellar mass of galaxies and host halo mass, tuned to match the spatial density of galaxies over 0<z<2 and the clustering properties at z~0, is extended to include two different scenarios describing the variation of SFR on M_h. We also present new measurements of the redshift evolution of the average SFR for star-forming galaxies of different stellar mass up to z=2, using data from the Herschel Multi-tiered Extragalactic Survey (HerMES) for infrared-bright galaxies. Combining the EHM with the halo accretion histories from numerical simulations, we trace the stellar mass growth and star-formation history in halos spanning a range of masses. We find that: (1) The intensity of the star-forming activity in halos in the probed mass range has steadily decreased from z~2 to 0; (2) At a given epoch, halos in the mass range between a few times 10^{11} M_Sun and a few times 10^{12} M_Sun are the most efficient at hosting star formation; (3) The peak of SFR density shifts to lower mass halos over time; (4) Galaxies that are forming stars most actively at z~2 evolve into quiescent galaxies in today's group environments, strongly supporting previous claims that the most powerful starbursts at z~2 are progenitors of today's elliptical galaxies.Comment: 15 pages, 12 figures, accepted for publication in MNRA

A metric space for Type Ia supernova spectra

We develop a new framework for use in exploring Type Ia supernovae (SNe Ia) spectra. Combining principal component analysis (PCA) and partial least square (PLS) analysis we are able to establish correlations between the principal components (PCs) and spectroscopic/photometric SNe Ia features. The technique was applied to ∼120 SN and ∼800 spectra from the Nearby Supernova Factory. The ability of PCA to group together SNe Ia with similar spectral features, already explored in previous studies, is greatly enhanced by two important modifications: (1) the initial data matrix is built using derivatives of spectra over the wavelength, which increases the weight of weak lines and discards extinction, and (2) we extract time evolution information through the use of entire spectral sequences concatenated in each line of the input data matrix. These allow us to define a stable PC parameter space which can be used to characterize synthetic SN Ia spectra by means of real SN features. Using PLS, we demonstrate that the information from important previously known spectral indicators (namely the pseudo-equivalent width of Si II 5972 Å/Si II 6355 Å and the line velocity of S II 5640 Å/Si II 6355 Å) at a given epoch is contained within the PC space and can be determined through a linear combination of the most important PCs. We also show that the PC space encompasses photometric features like B/V magnitudes, B − V colours and SALT2 parameters c and x1. The observed colours and magnitudes, which are heavily affected by extinction, cannot be reconstructed using this technique alone. All the above-mentioned applications allowed us to construct a metric space for comparing synthetic SN Ia spectra with observations

The potential utility of B cell-directed biologic therapy in autoimmune diseases

Increasing awareness of the importance of aberrant B cell regulation in autoimmunity has driven the clinical development of novel B cell-directed biologic therapies with the potential to treat a range of autoimmune disorders. The first of these drugs—rituximab, a chimeric monoclonal antibody against the B cell-specific surface marker CD20—was recently approved for treating rheumatoid arthritis in patients with an inadequate response to other biologic therapies. The aim of this review is to discuss the potential use of rituximab in the management of other autoimmune disorders. Results from early phase clinical trials indicate that rituximab may provide clinical benefit in systemic lupus erythematosus, Sjögren’s syndrome, vasculitis, and thrombocytopenic purpura. Numerous case reports and several small pilot studies have also been published reporting the use of rituximab in conditions such as myositis, antiphospholipid syndrome, Still’s disease, and multiple sclerosis. In general, the results from these preliminary studies encourage further testing of rituximab therapy in formalized clinical trials. Based on results published to date, it is concluded that rituximab, together with other B cell-directed therapies currently under clinical development, is likely to provide an important new treatment option for a number of these difficult-to-treat autoimmune disorders

Dynamic Chromatin Organization during Foregut Development Mediated by the Organ Selector Gene PHA-4/FoxA

Central regulators of cell fate, or selector genes, establish the identity of cells by direct regulation of large cohorts of genes. In Caenorhabditis elegans, foregut (or pharynx) identity relies on the FoxA transcription factor PHA-4, which activates different sets of target genes at various times and in diverse cellular environments. An outstanding question is how PHA-4 distinguishes between target genes for appropriate transcriptional control. We have used the Nuclear Spot Assay and GFP reporters to examine PHA-4 interactions with target promoters in living embryos and with single cell resolution. While PHA-4 was found throughout the digestive tract, binding and activation of pharyngeally expressed promoters was restricted to a subset of pharyngeal cells and excluded from the intestine. An RNAi screen of candidate nuclear factors identified emerin (emr-1) as a negative regulator of PHA-4 binding within the pharynx, but emr-1 did not modulate PHA-4 binding in the intestine. Upon promoter association, PHA-4 induced large-scale chromatin de-compaction, which, we hypothesize, may facilitate promoter access and productive transcription. Our results reveal two tiers of PHA-4 regulation. PHA-4 binding is prohibited in intestinal cells, preventing target gene expression in that organ. PHA-4 binding within the pharynx is limited by the nuclear lamina component EMR-1/emerin. The data suggest that association of PHA-4 with its targets is a regulated step that contributes to promoter selectivity during organ formation. We speculate that global re-organization of chromatin architecture upon PHA-4 binding promotes competence of pharyngeal gene transcription and, by extension, foregut development