Evidence for energy injection and a fine-tuned central engine at optical wavelengths in GRB 070419A

We present a comprehensive multiwavelength temporal and spectral analysis of the FRED GRB 070419A. The early-time emission in the $\gamma$-ray and X-ray bands can be explained by a central engine active for at least 250 s, while at late times the X-ray light curve displays a simple power-law decay. In contrast, the observed behaviour in the optical band is complex (from 10$^2$ up to 10$^6$ s). We investigate the light curve behaviour in the context of the standard forward/reverse shock model; associating the peak in the optical light curve at $\sim$450 s with the fireball deceleration time results in a Lorenz factor $\Gamma \approx 350$ at this time. In contrast, the shallow optical decay between 450 and 1500 s remains problematic, requiring a reverse shock component whose typical frequency is above the optical band at the optical peak time for it to be explained within the standard model. This predicts an increasing flux density for the forward shock component until t $\sim$ 4 $\times$ 10$^6$ s, inconsistent with the observed decay of the optical emission from t $\sim$ 10$^4$ s. A highly magnetized fireball is also ruled out due to unrealistic microphysic parameters and predicted light curve behaviour that is not observed. We conclude that a long-lived central engine with a finely tuned energy injection rate and a sudden cessation of the injection is required to create the observed light curves - consistent with the same conditions that are invoked to explain the plateau phase of canonical X-ray light curves of GRBs.Comment: 9 pages, 10 figures, accepted for publication in MNRA

Actors and networks or agents and structures: towards a realist view of information systems

Actor-network theory (ANT) has achieved a measure of popularity in the analysis of information systems. This paper looks at ANT from the perspective of the social realism of Margaret Archer. It argues that the main issue with ANT from a realist perspective is its adoption of a `flat' ontology, particularly with regard to human beings. It explores the value of incorporating concepts from ANT into a social realist approach, but argues that the latter offers a more productive way of approaching information systems

Deep ASKAP EMU Survey of the GAMA23 field: Properties of radio sources

We present the Australian Square Kilometre Array Pathfinder (ASKAP) observations of the Galaxy and Mass Assembly (GAMA)-23h field. The survey was carried out at 887.5 MHz and covers a 83 square degree field. We imaged the calibrated visibility data, taken as part of the Evolutionary Mapping of Universe (EMU) Early Science Programme, using the latest version of the ASKAPSoft pipeline. The final mosaic has an angular resolution of 10 arcsec and a central rms noise of around 38 $\mu$Jy beam$^{-1}$. The derived radio source catalogue has 39812 entries above a peak flux density threshold of 5$\sigma$. We searched for the radio source host galaxy counterparts using the GAMA spectroscopic (with an i-band magnitude limit of 19.2 mag) and multi-wavelength catalogues that are available as part of the collaboration. We identified hosts with GAMA spectroscopic redshifts for 5934 radio sources. We describe the data reduction, imaging, and source identification process, and present the source counts. Thanks to the wide area covered by our survey, we obtain very robust counts down to 0.2 mJy. ASKAP's exceptional survey speed, providing efficient, sensitive and high resolution mapping of large regions of the sky in conjunction with the multi-wavelength data available for the GAMA23 field, allowed us to discover 63 giant radio galaxies. The data presented here demonstrate the excellent capabilities of ASKAP in the pre-SKA era.Comment: 18 pages, 15 figures, accepted by MNRA

Gamma-Ray Emission Concurrent with the Nova in the Symbiotic Binary V407 Cygni

Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce X-ray emission but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable gamma-ray (0.1-10 GeV) emission from the recently-detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary, and that particles can be accelerated effectively to produce pi0 decay gamma-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.Comment: 38 pages, includes Supplementary Online Material; corresponding authors: C.C. Cheung, A.B. Hill, P. Jean, S. Razzaque, K.S. Woo

The Rapid ASKAP Continuum Survey I: Design and First Results

The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia, and will cover the full ASKAP band of $700-1800$ MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey (NVSS) and Sydney University Molonglo Sky Survey (SUMSS) radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with $\sim 15$ arcsecond resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination $+41^\circ$ made over a 288 MHz band centred at 887.5 MHz.Comment: 24 pages, 17 figures, 4 tables. For associated data see https://data.csiro.au/collections/domain/casdaObservation/results/PRAS110%20-%20The%20Rapid%20ASKAP%20Continuu

Extreme Properties Of GRB061007: A Highly Energetic Or A Highly Collimated Burst?

GRB061007 is the brightest gamma-ray burst (GRB) to be detected by Swift and is accompanied by an exceptionally luminous afterglow that had a V-band magnitude <11.1 at 80s after the prompt emission. From the start of the Swift observations the afterglow decayed as a power law with a slope of \alpha_X=1.66+/-0.01 in the X-ray and \alpha_{opt}=1.64+/-0.01 in the UV/optical, up to the point that it was no longer detected above background in the optical or X-ray bands. The brightness of this GRB and the similarity in the decay rate of the X-ray, optical and gamma-ray emission from 100s after the trigger distinguish this burst from others and present a challenge to the fireball model. The lack of a cooling or jet break in the afterglow up to \~10^5s constrains any model that can produce the large luminosity observed in GRB061007, which we found to require either an excessively large kinetic energy or highly collimated outflow. Analysis of the multi-wavelength spectral and high-resolution temporal data taken with Swift suggest an early time jet-break to be a more plausible scenario. This must have occurred within 80s of the prompt emission, which places an upper limit on the jet opening angle of \theta_j=0.8deg. Such a highly collimated outflow resolves the energy budget problem presented in a spherical emission model, reducing the isotropic equivalent energy of this burst to E_{\gamma}^{corr}=10^{50} ergs; consistent with other GRBs.Comment: Accepted by MNRAS, 11 pages, 3 figure

Is complementary and alternative medicine (CAM) cost-effective? a systematic review

BACKGROUND: Out-of-pocket expenditures of over $34 billion per year in the US are an apparent testament to a widely held belief that complementary and alternative medicine (CAM) therapies have benefits that outweigh their costs. However, regardless of public opinion, there is often little more than anecdotal evidence on the health and economic implications of CAM therapies. The objectives of this study are to present an overview of economic evaluation and to expand upon a previous review to examine the current scope and quality of CAM economic evaluations. METHODS: The data sources used were Medline, AMED, Alt-HealthWatch, and the Complementary and Alternative Medicine Citation Index; January 1999 to October 2004. Papers that reported original data on specific CAM therapies from any form of standard economic analysis were included. Full economic evaluations were subjected to two types of quality review. The first was a 35-item checklist for reporting quality, and the second was a set of four criteria for study quality (randomization, prospective collection of economic data, comparison to usual care, and no blinding). RESULTS: A total of 56 economic evaluations (39 full evaluations) of CAM were found covering a range of therapies applied to a variety of conditions. The reporting quality of the full evaluations was poor for certain items, but was comparable to the quality found by systematic reviews of economic evaluations in conventional medicine. Regarding study quality, 14 (36%) studies were found to meet all four criteria. These exemplary studies indicate CAM therapies that may be considered cost-effective compared to usual care for various conditions: acupuncture for migraine, manual therapy for neck pain, spa therapy for Parkinson's, self-administered stress management for cancer patients undergoing chemotherapy, pre- and post-operative oral nutritional supplementation for lower gastrointestinal tract surgery, biofeedback for patients with "functional" disorders (eg, irritable bowel syndrome), and guided imagery, relaxation therapy, and potassium-rich diet for cardiac patients. CONCLUSION: Whereas the number and quality of economic evaluations of CAM have increased in recent years and more CAM therapies have been shown to be of good value, the majority of CAM therapies still remain to be evaluated

Unexpected circular radio objects at high Galactic latitude

Large scale structure and cosmolog

A short gamma-ray burst apparently asssociated with an elliptical galaxy at redshift z=0.225

Gamma Ray Bursts (GRBs) are bright, brief flashes of high energy photons that have fascinated scientists for 30 years. They come in two classes: long (>2 s), softspectrum bursts and short, hard events. The major progress to date on understanding GRBs has been for long bursts which are typically at high redshift (z ~ 1) and are in sub-luminous star-forming host galaxies. They are likely produced in core-collapse explosions of massive stars. Until the present observation, no short GRB had been accurately (<10") and rapidly (minutes) located. Here we report the detection of X-ray afterglow from and the localization of short burst GRB050509b. Its position on the sky is near a luminous, non-starforming elliptical galaxy at a redshift of 0.225, exactly the type of location one would expect if the origin of this GRB is the long-proposed fiery merger of neutron star (NS) or black hole (BH) binaries. The X-ray afterglow is found to be weak and fading below detection within a few hours and no optical afterglow is detected to stringent limits, explaining the past difficulty in localizing short GRBs.Comment: 16 pages, 3 figures updated figure

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease