Chemical Distribution of the Dynamical Ejecta in the Neutron Star Merger GW170817

GW170817 and its associated electromagnetic counterpart AT2017gfo continue to be a treasure trove as observations and modeling continue. Recent precision astrometry of AT2017gfo with the Hubble Space Telescope combined with previous constraints from Very Long Baseline Interferometry (VLBI) constraints narrowed down the inclination angle to 19-25 deg (90\% confidence). This paper explores how the inclusion of precise inclination information can reveal new insights about the ejecta properties, in particular, about the composition of the dynamical ejecta of AT2017gfo. Our analysis relies on updated kilonova modeling, which includes state-of-the-art heating rates, thermalization efficiencies, and opacities and is parameterized by $\bar{Y}_{\rm e,dyn}$, the average electron fraction of the dynamical ejecta component. Using this model, we incorporate the latest inclination angle constraint of AT2017gfo into a light curve fitting framework to derive updated parameter estimates. Our results suggest that the viewing angle of the observer is pointed towards the lanthanide-poor ($Y_{\rm e,dyn}\gtrsim0.25$), squeezed polar dynamical ejecta component, which can explain the early blue emission observed in the light curve of AT2017gfo. In contrast to a recent claim of spherical ejecta powering AT2017gfo, our study indicates that the composition of the dynamical ejecta has a strong angular dependence, with a lanthanide-rich ($Y_{\rm e,dyn}\lesssim0.25$), tidal component distributed around the merger plane with a half-opening angle of $35^\circ$. The inclination angle constraint reduces $\bar{Y}_{\rm e,dyn}$ from $0.24$ to $0.22$, with values $0.17\lesssim Y_{\rm e, dyn} \lesssim0.41$ enabling the robust production of $r$-process elements up to the $3^{\rm rd}$ peak in the tidal dynamical ejecta.Comment: 8 pages, 6 figure

Effect of spatial concentration fluctuations on effective kinetics in diffusion-reaction systems

International audienceThe effect of spatial concentration fluctuations on the reaction of two solutes, A þ B* C, is considered. In the absence of fluctuations, the concentration of solutes decays as Adet ¼ Bdet t 1. Contrary to this, experimental and numerical studies suggest that concentrations decay significantly slower. Existing theory suggests a t d/4 scaling in the asymptotic regime (d is the dimensionality of the problem). Here we study the effect of fluctuations using the classical diffusion-reaction equation with random initial conditions. Initial concentrations of the reactants are treated as correlated random fields.We use the method of moment equations to solve the resulting stochastic diffusion-reaction equation and obtain a solution for the average concentrations that deviates from t 1 to t d/4 behavior at characteristic transition time t . We also derive analytical expressions for t as a function of Damköhler number and the coefficient of variation of the initial concentration

Listening carefully: increased perceptual acuity for species discrimination in multispecies signalling assemblages

Communication is a fundamental component of evolutionary change because of its role in mate choice and sexual selection. Acoustic signals are a vital element of animal communication and sympatric species may use private frequency bands to facilitate intraspecific communication and identification of conspecifics (acoustic communication hypothesis, ACH). If so, animals should show increasing rates of misclassification with increasing overlap in frequency between their own calls and those used by sympatric heterospecifics. We tested this on the echolocation of the horseshoe bat, Rhinolophus capensis, using a classical habituation-dishabituation experiment in which we exposed R. capensis from two phonetic populations to echolocation calls of sympatric and allopatric horseshoe bat species (Rhinolophus clivosus and Rhinolophus damarensis) and different phonetic populations of R. capensis. As predicted by the ACH, R. capensis from both test populations were able to discriminate between their own calls and calls of the respective sympatric horseshoe bat species. However, only bats from one test population were able to discriminate between calls of allopatric heterospecifics and their own population when both were using the same frequency. The local acoustic signalling assemblages (ensemble of signals from sympatric conspecifics and heterospecifics) of the two populations differed in complexity as a result of contact with other phonetic populations and sympatric heterospecifics. We therefore propose that a hierarchy of discrimination ability has evolved within the same species. Frequency alone may be sufficient to assess species membership in relatively simple acoustic assemblages but the ability to use additional acoustic cues may have evolved in more complex acoustic assemblages to circumvent misidentifications as a result of the use of overlapping signals. When the acoustic signal design is under strong constraints as a result of dual functions and the available acoustic space is limited because of co-occurring species, species discrimination is mediated through improved sensory acuity in the receiver

To seek or speak? Dual function of an acoustic signal limits its versatility in communication

The perception of different attributes of conspecifics is an integral part of intraspecific communication. It can facilitate the recognition of interaction partners or the assessment of potential mates. Acoustic signals can encode fine-scaled information through the interplay of acoustic variability and specificity. A reliable vocal signature is both unique within a class and variable between classes. Therefore, acoustic complexity might be associated with the number of classes to be discriminated. We investigated the assumption that limitations to signal design may affect the communicative functionality of a signal. To do so, we chose a signal with potentially dual functionality which may therefore display such limitations. In bats, echolocation is used primarily for foraging and orientation but there is increasing support for its additional role in communication. An acoustic analysis of echolocation pulses of the bat Rhinolophus clivosus confirmed sex and individual vocal signatures in echolocation pulses. A habituation edishabituation playback experiment suggested that bats perceived these signatures because listening bats clearly discriminated between the sexes (two classes) and between individuals (representatives of a multiclass category), although to different degrees. The simple acoustic structure of these vocalizations provides sufficient specificity for sex discrimination but has limitations for individual discrimination because pulse parameters of individuals increasingly overlapped with increasing group size. We conclude that selection for the primary function of echolocation restricts the acoustic space available for communication. However, we frequently observed echolocation pulses with conspicuous structural modifications. Statistical analyses revealed that these vocalizations yielded increased individual distinctiveness. Such added systematic variation may indicate a communicative function and perhaps a signalling intent of the emitter, although the latter has yet to be tested. The findings suggest that the required specificity for effective communication could be obtained through modification of echolocation variants when adaptations for orientation and foraging constrain the evolution of complex communication signatures

Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer

BACKGROUND & AIMS: Germline mutations in the DNA mismatch repair (MMR) genes MSH2, MSH6, or MLH1 predispose to colorectal cancer (CRC) with an autosomal dominant inheritance pattern. The protein encoded by PMS2 is also essential for MMR; however, alterations in this gene have been documented only in extremely rare cases. We addressed this unexpected finding by analyzing a large series of CRCs. METHODS: Expression of MSH2, MSH6, MLH1, and PMS2 was studied by immunohistochemistry in 1048 unselected, consecutive CRCs. Where absence of MMR proteins was detected, microsatellite instability and cytosine methylation of the respective gene promoter were analyzed. The DNA of patients presenting with PMS2-deficient cancers was examined for germline and somatic alterations in the PMS2 gene. RESULTS: An aberrant pattern of MMR protein expression was detected in 13.2% of CRCs. Loss of expression of MSH2, MSH6, or MLH1 was found in 1.4%, 0.5%, and 9.8%, respectively. PMS2 deficiency accompanied by microsatellite instability was found in 16 cases (1.5%) with a weak family history of cancer. The PMS2 promoter was not hypermethylated in these cases. Despite interference of the PMS2 pseudogenes, we identified several heterozygous germline mutations in the PMS2 gene. CONCLUSIONS: PMS2 defects account for a small but significant proportion of CRCs and for a substantial fraction of tumors with microsatellite instability. However, the penetrance of heterozygous germline mutations in PMS2 is considerably lower than that of mutations in other MMR genes. The possible underlying causes of this unorthodox inheritance pattern are discussed

Chemical Distribution of the Dynamical Ejecta in the Neutron Star Merger GW170817

International audienceGW170817 and its associated electromagnetic counterpart AT2017gfo continue to be a treasure trove as observations and modeling continue. Recent precision astrometry of AT2017gfo with the Hubble Space Telescope combined with previous constraints from Very Long Baseline Interferometry (VLBI) constraints narrowed down the inclination angle to 19-25 deg (90% confidence). This paper explores how the inclusion of precise inclination information can reveal new insights about the ejecta properties, in particular, about the composition of the dynamical ejecta of AT2017gfo. Our analysis relies on updated kilonova modeling, which includes state-of-the-art heating rates, thermalization efficiencies, and opacities and is parameterized by $\bar{Y}_{\rm e,dyn}$, the average electron fraction of the dynamical ejecta component. Using this model, we incorporate the latest inclination angle constraint of AT2017gfo into a light curve fitting framework to derive updated parameter estimates. Our results suggest that the viewing angle of the observer is pointed towards the lanthanide-poor ($Y_{\rm e,dyn}\gtrsim0.25$), squeezed polar dynamical ejecta component, which can explain the early blue emission observed in the light curve of AT2017gfo. In contrast to a recent claim of spherical ejecta powering AT2017gfo, our study indicates that the composition of the dynamical ejecta has a strong angular dependence, with a lanthanide-rich ($Y_{\rm e,dyn}\lesssim0.25$), tidal component distributed around the merger plane with a half-opening angle of $35^\circ$. The inclination angle constraint reduces $\bar{Y}_{\rm e,dyn}$ from $0.24$ to $0.22$, with values $0.17\lesssim Y_{\rm e, dyn} \lesssim0.41$ enabling the robust production of $r$-process elements up to the $3^{\rm rd}$ peak in the tidal dynamical ejecta