813 research outputs found
Record Maximum Oscillation Frequency in C-face Epitaxial Graphene Transistors
- Author
- Badmaev A.
- Berger C.
- Biercuk M. J.
- Cheng R.
- Claire Berger
- Datta S.
- de Heer W. A.
- Hu Y.
- James Palmer
- Jan Kunc
- John D. Cressler
- John Hankinson
- Kedzierski J.
- Kim K.
- Krithivasan R.
- Liao L.
- Liao L.
- Liao L.
- Lin Y. M.
- Lin Y.-M.
- Meric I.
- Meyer D. J.
- Ming Ruan
- Moon J. S.
- Moon J. S.
- Moon J. S.
- Nelson Lourenco
- Nienhaus H.
- Partha Sarathi Chakraborty
- Robin F.
- Robinson J. A.
- Rui Dong
- Schmitz A. E.
- Schwierz F.
- Sprinkle M.
- Sun D.
- Walt A. de Heer
- Wu X. S.
- Wu Y. Q.
- Wu Y. Q.
- Xia F. N.
- Yike Hu
- Zelei Guo
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 01/01/2013
- Field of study
Full text linkThe maximum oscillation frequency (fmax) quantifies the practical upper bound
for useful circuit operation. We report here an fmax of 70 GHz in transistors
using epitaxial graphene grown on the C-face of SiC. This is a significant
improvement over Si-face epitaxial graphene used in the prior high frequency
transistor studies, exemplifying the superior electronics potential of C-face
epitaxial graphene. Careful transistor design using a high {\kappa} dielectric
T-gate and self-aligned contacts, further contributed to the record-breaking
fmax
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Compressed representation of a partially defined integer function over multiple arguments
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- Zumerle G
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
Get PDFIn OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
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- Abbiendi G
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- Kenny Iii RP
- Kesisoglou S
- Khachatryan V
- Khakzad M
- Khalatyan S
- Khalid S
- Khalil S
- Khalil S
- Khan A
- Khan WA
- Kharchilava A
- Khotilovich V
- Khukhunaishvili A
- Khurana R
- Khurshid T
- Kiesenhofer W
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- Kim Y
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- Kinnunen R
- Kirakosyan M
- Kirn M
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- Kirschenmann H
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- Klima B
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- Klute M
- Klyukhin V
- Knuenz V
- Knutsson A
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- Kotov K
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- Kozlov G
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- Krammer M
- Krasnikov N
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- Kreczko L
- Kreis B
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- Kropivnitskaya A
- Krpic D
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- Kubik A
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- Locci E
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- Lokhtin I
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- Luthra A
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- Martschei D
- Maruyama S
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- Melo A
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- Menasce D
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- Meneghelli M
- Meneguzzo AT
- Meng X
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- Mercier D
- Meridiani P
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- Mikulec I
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- Mohanty AK
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- Mossolov V
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- Muniz L
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- Neumeister N
- Newbold DM
- Newman HB
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- Newsom CR
- Nguyen D
- Nguyen H
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- Nicolaou C
- Niegel M
- Nikitenko A
- Nirunpong K
- Nishu N
- Nogima H
- Noonan D
- Norbeck E
- Nourbakhsh S
- Novaes SF
- Nowack A
- Nowak F
- Ntomari E
- Nuernberg A
- Nuttens C
- Nuzzo S
- O'Brien C
- O'Dell V
- Oberst O
- Obertino MM
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- Ofierzynski RA
- Oguri V
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- Palencia Cortezon E
- Palichik V
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- Panagiotou A
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- Panwalkar S
- Paoletti S
- Paolucci P
- Papacz P
- Papadopoulos I
- Papageorgiou A
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- Paramatti R
- Paramesvaran S
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- Pardo PL
- Parida B
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- Pastika N
- Pastrone N
- Patel R
- Patras V
- Patterson JR
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- Paus C
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- Pesaresi M
- Peterman A
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- Petrucciani G
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- Pierro GA
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- Pimiae M
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- Piparo D
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- Piroue P
- Pitzl D
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- Plestina R
- Pol ME
- Polatoz A
- Polese G
- Polic D
- Poll A
- Pollack B
- Pompili A
- Pooth O
- Popov A
- Popov V
- Potenza A
- Potenza R
- Pozdnyakov A
- Pozzobon N
- Prado Da Silva WL
- Primavera F
- Prokofyev O
- Prosper H
- Ptochos F
- Puerta Pelayo J
- Pugliese G
- Puigh D
- Puljak I
- Qazi S
- Qian SJ
- Quan X
- Quast G
- Quertenmont L
- Quintario Olmeda A
- Rabbertz K
- Racz A
- Radburn-Smith BC
- Radi A
- Radics B
- Ragazzi S
- Rahatlou S
- Rahbaran B
- Rahmat R
- Raics P
- Raidal M
- Rakness G
- Ralph D
- Ramirez Vargas JE
- Rander J
- Ranjan K
- Rappoccio S
- Raspereza A
- Rathjens D
- Ratnikov F
- Ratnikova N
- Ratti SP
- Raupach F
- Raval A
- Raymond DM
- Razis PA
- Rebane L
- Rebassoo F
- Redaelli N
- Redjimi R
- Redondo I
- Reece W
- Reid ID
- Reis T
- Reithler H
- Rekovic V
- Remington R
- Renker D
- Rennefeld J
- Reucroft S
- Reyes-Santos MA
- Ribeiro Cipriano PM
- Ribnik J
- Riccardi C
- Richards A
- Richman J
- Riedl C
- Rikova MI
- Rinkevicius A
- Rios AAO
- Rizzi A
- Ro SR
- Roberts J
- Robles J
- Robmann P
- Rodenburg M
- Rodozov M
- Rodrigo T
- Rodrigues Antunes J
- Rodriguez JL
- Rodriguez-Marrero AY
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- Roecker S
- Rogan C
- Rogerson S
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- Rohringer C
- Rohringer H
- Roland B
- Roland C
- Roland G
- Rolandi G
- Romanowska-Rybinska K
- Romeo F
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- Romero L
- Rommerskirchen T
- Ronchese P
- Ronga FJ
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- Rosowsky A
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- Rougny R
- Rovelli C
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- Ruchti R
- Rudolph M
- Ruiz-Jimeno A
- Rumerio P
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- Rusakov SV
- Ruspa M
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- Ryan MJ
- Ryckbosch D
- Ryd A
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- Ryutin R
- Sabes D
- Sacchi R
- Safarzadeh B
- Safonov A
- Safronov G
- Saha A
- Saini LK
- Saka H
- Sakharov A
- Sakulin H
- Sakuma T
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- Sala S
- Salazar Ibarguen HA
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- Sammet J
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- Santoro A
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- Sarkar S
- Sarycheva L
- Sasseville M
- Sauerland P
- Savin A
- Savrin V
- Scarborough T
- Schaefer C
- Schael S
- Schettler H
- Scheurer A
- Schilling F-P
- Schizzi A
- Schlein P
- Schleper P
- Schlieckau E
- Schmidt A
- Schmidt R
- Schmitt M
- Schmitz SA
- Schnetzer S
- Schoefbeck R
- Schoerner-Sadenius T
- Schott G
- Schroeder M
- Schul N
- Schum T
- Schwick C
- Scodellaro L
- Searle M
- Seez C
- Segala M
- Segoni I
- Seidel M
- Seitz C
- Seixas J
- Sekmen S
- Sellers P
- Selvaggi G
- Selvaggi M
- Semenov S
- Sen N
- Sen S
- Sengupta S
- Senkin S
- Seo E
- Seo H
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- Serin M
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- Sexton-Kennedy E
- Sguazzoni G
- Shah MA
- Sharan M
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- Sharma A
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- Sharma V
- Sharma V
- Sharp P
- Sheldon P
- Shepherd-Themistocleous CH
- Shi X
- Shipkowski SP
- Shipsey I
- Shiu JG
- Shivpuri RK
- Shmatov S
- Shoaib M
- Shrestha S
- Shreyber I
- Shukla P
- Shumeiko N
- Sibille J
- Siegrist P
- Sigamani M
- Sikler F
- Silkworth C
- Silva P
- Silvers D
- Silverwood H
- Silvestris L
- Simon M
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- Simonis HJ
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- Singh G
- Singh J
- Singovsky A
- Sinthuprasith T
- Sirois Y
- Siroli G
- Sirunyan AM
- Skhirtladze N
- Skuja A
- Slaunwhite J
- Smirnov I
- Smirnov V
- Smith J
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- Smith WH
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- Snoek H
- Snook B
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- Snowball M
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- Soares MS
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- Sobron Sanudo M
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- Sonmez N
- Sonnenschein L
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- Spalding WJ
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- Sperka D
- Sphicas P
- Spiegel L
- Spiga D
- Spiridonov A
- Spiropulu M
- Sprenger D
- Squillacioti P
- Squires M
- Stadie H
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- Starodumov A
- Staykova Z
- Steggemann J
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- Stephans GSF
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- Stieger B
- Stober FM
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- Stoynev S
- Strauss J
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- Sumowidagdo S
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- Svintradze I
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- Teo WD
- Teodorescu L
- Teyssier D
- Thea A
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- Thomsen J
- Thyssen F
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- Tiras E
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- Traczyk P
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- Travaglini R
- Trayanov R
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- Tricomi A
- Tripathi M
- Trocino D
- Trocsanyi ZL
- Troendle D
- Tropiano A
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- Tsang KV
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- Tsirou A
- Tu Y
- Tucker J
- Tully C
- Tumasyan A
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- Tuovinen E
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- Tuuva T
- Tuve C
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- Tyurin N
- Tzeng YM
- Ujvari B
- Ulmer KA
- Ulrich R
- Ungaro D
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- Urscheler C
- Uvarov L
- Uzunian A
- Vaandering EW
- Valls N
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- Van Mulders P
- Van Onsem GP
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- Van Spilbeeck A
- Vander Velde C
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- Vazquez Valencia F
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- Veeraraghavan V
- Velasco M
- Velicanu D
- Velkovska J
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- Venturi A
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- Verdini PG
- Veres GI
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- Vergili M
- Verwilligen P
- Verzetti M
- Veszpremi V
- Vesztergombi G
- Veverka J
- Vidal Marono M
- Vidal R
- Vila I
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- Villella I
- Vinogradov A
- Virdee T
- Viret S
- Virto AL
- Vischia P
- Vishnevskiy D
- Vitulo P
- Vizan Garcia JM
- Vlasov E
- Vlimant JR
- Vodopiyanov I
- Vogel H
- Volkov A
- Volobouev I
- Volodko A
- Volpe R
- Vorobiev I
- Vorobyev A
- Vorobyev A
- Voutilainen M
- Vuosalo C
- Vutova M
- Wagner P
- Wagner SR
- Wagner-Kuhr J
- Wakefield S
- Wallny R
- Walsh R
- Walsh S
- Waltenberger W
- Walzel G
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- Wang J
- Wang M
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- Wang X
- Wang Z
- Wardle N
- Wasserbaech S
- Wayand S
- Wayne M
- Weber H
- Weber HA
- Weber M
- Weber M
- Wehrli L
- Weiler T
- Weinberg M
- Wendland L
- Weng Y
- Wenger EA
- Werner JS
- West C
- Wetzel J
- Whitbeck A
- Whitmore J
- Whyntie T
- Wickramage N
- Widl E
- Wilken R
- Wilkinson R
- Williams G
- Williams T
- Willmott C
- Wimpenny S
- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
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- Wood JS
- Worm SD
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- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
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- Yang Y
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
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- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFA search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
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- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
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- Alver B
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- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
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- Andreev Y
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- Antunes JR
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- Cockerill DJA
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- Colafranceschi S
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- Collard C
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- Contardo D
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- Conway J
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- Cooper SI
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- Correa Martins Junior M
- Cortezon EP
- Cossutti F
- Costa M
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- Coughlan JA
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- Cutajar M
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
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- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
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- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunovic Z
- Apanasevich L
- Appelt E
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- Arcidiacono R
- Arenton MW
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- Asawatangtrakuldee C
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- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
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- Yi K
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- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Yilmaz Y
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- Yumiceva F
- Yun JC
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- Zeyrek M
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Abbiendi G
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- Vodopiyanov I
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- Volobouev I
- Volodko A
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- Vorobyev A
- Vorobyev A
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- Yi K
- Yildirim E
- Yilmaz Y
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- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
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- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
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- Zarubin A
- Zatserklyaniy A
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- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
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- Zhu B
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- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFJet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
A reference human induced pluripotent stem cell line for large-scale collaborative studies
- Author
- Abu-Bonsrah D
- Aggarwal S
- Ahfeldt T
- Anderson KM
- Arenas E
- Ballard S
- Basundra R
- Beccari MS
- Blauwendraat C
- Blockwick J
- Bosco DA
- Bu G
- Buxton P
- Calatayud Aristoy C
- Casey JM
- Chen MY
- Cleveland DW
- Coccia E
- Cohen S
- Conklin BR
- Cookson MR
- Coon SL
- Cross E
- Crusius D
- Deshmukh M
- Dong J
- Dou D
- Erlebach L
- Faghri F
- Funes S
- Gabriele RMC
- Heinrich L
- Held A
- Holzbaur ELF
- Hughes S
- Janssen LJM
- Johnson Chase K
- Kampmann M
- Kanaujiya J
- Khanna R
- Kinner-Bibeau L
- Kirwan P
- Kronenberg-Versteeg D
- Lara E
- Li E
- Lourenco VS
- Lyu G
- Marioni JC
- Matia M
- McDonough JA
- Medura C
- Meijer M
- Merkle FT
- Nalls MA
- Narayan P
- Nelson MP
- Nevin ZS
- Oguro H
- Pantazis CB
- Papademetriou J
- Paquet D
- Parish CL
- Peng L
- Pisupati V
- Pratt G
- Priebe T
- Qi YA
- Raman M
- Ramos DM
- Raulin AC
- Reilly L
- Rose IVL
- Rosen LU
- Santiana M
- Sarrafha L
- Scholz SW
- Schüle B
- Sebesta D
- Skarnes WC
- Stadler J
- Timmerman V
- Tompkins C
- van der Kant R
- Van Lent J
- Verstreken P
- Vitale D
- Wainger BJ
- Ward ME
- Welzer M
- Wray S
- Yang A
- Zanellati MC
- Zhang K
- Zou J
- Öttl M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2022
- Field of study
Get PDFHuman induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned candidate human iPSC lines and deeply characterized their genetic properties using whole genome sequencing, their genomic stability upon CRISPR-Cas9-based gene editing, and their phenotypic properties including differentiation to commonly used cell types. These studies identified KOLF2.1J as an all-around well-performing iPSC line. We then shared KOLF2.1J with groups around the world who tested its performance in head-to-head comparisons with their own preferred iPSC lines across a diverse range of differentiation protocols and functional assays. On the strength of these findings, we have made KOLF2.1J and its gene-edited derivative clones readily accessible to promote the standardization required for large-scale collaborative science in the stem cell field
Viruses Associated with Ovarian Degeneration in Apis mellifera L. Queens
- Author
- A Baker
- A Patel
- AC Highfield
- AMM Abd-Alla
- AP Lourenco
- Benjamin Dainat
- C Yue
- C Yue
- CA Mullin
- CM Nelson
- D Tentcheva
- D Vanengelsdorp
- D Vanengelsdorp
- DL Anderson
- E Genersch
- E Maori
- ED Tanaka
- FM Ausubel
- François Cousserans
- G Brun
- G Lanzi
- G Tettamanti
- H Berthoud
- HO Gutzeit
- I de Buron
- I Fries
- IC Capella
- J Büning
- J Fievet
- J Iqbal
- JM Ruijter
- Joachim R. de Miranda
- JR de Miranda
- JR de Miranda
- JR de Miranda
- JR Ongus
- JR Ongus
- JW Rhodes
- K Czekonska
- K Hartfelder
- K Patricio
- KR Guidugli-Lazzarini
- L Gauthier
- Laurent Gauthier
- M Dreux
- MA Aizen
- Magali Tournaire
- Marc Ravallec
- Max Bergoin
- MF Allen
- MH Haydak
- ML Winston
- MP Chauzat
- O Berenyi
- P Neumann
- PS Ramamurty
- RE Snodgrass
- Robert Cramer
- S Camazine
- S Gisder
- SC Seehuus
- SG Potts
- SL Nielsen
- SM Valles
- T Fujiyuki
- T Fujiyuki
- TC Webster
- TP Liu
- W Engels
- W Fyg
- W Fyg
- Y Le Conte
- YP Chen
- YP Chen
- YP Chen
- YP Chen
- YP Chen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Get PDFQueen fecundity is a critical issue for the health of honeybee (Apis mellifera L.) colonies, as she is the only reproductive female in the colony and responsible for the constant renewal of the worker bee population. Any factor affecting the queen's fecundity will stagnate colony development, increasing its susceptibility to opportunistic pathogens. We discovered a pathology affecting the ovaries, characterized by a yellow discoloration concentrated in the apex of the ovaries resulting from degenerative lesions in the follicles. In extreme cases, marked by intense discoloration, the majority of the ovarioles were affected and these cases were universally associated with egg-laying deficiencies in the queens. Microscopic examination of the degenerated follicles showed extensive paracrystal lattices of 30 nm icosahedral viral particles. A cDNA library from degenerated ovaries contained a high frequency of deformed wing virus (DWV) and Varroa destructor virus 1 (VDV-1) sequences, two common and closely related honeybee Iflaviruses. These could also be identified by in situ hybridization in various parts of the ovary. A large-scale survey for 10 distinct honeybee viruses showed that DWV and VDV-1 were by far the most prevalent honeybee viruses in queen populations, with distinctly higher prevalence in mated queens (100% and 67%, respectively for DWV and VDV-1) than in virgin queens (37% and 0%, respectively). Since very high viral titres could be recorded in the ovaries and abdomens of both functional and deficient queens, no significant correlation could be made between viral titre and ovarian degeneration or egg-laying deficiency among the wider population of queens. Although our data suggest that DWV and VDV-1 have a role in extreme cases of ovarian degeneration, infection of the ovaries by these viruses does not necessarily result in ovarian degeneration, even at high titres, and additional factors are likely to be involved in this pathology
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