Assessment of allergen tolerance breakdown levels in local and classical allergic rhinitis

Local allergic rhinitis, a new endotype of allergic rhinitis discerned by researchers of the Spanish Allergy School, is now in the focus of interest of international allergological community. A special feature of local allergic rhinitis, which, being similar to conventional signs of allergic rhinitis, is, however, characterized by absence of systemic atopy manifestations, e.g., an increased total serum IgE content and positive allergic skin tests. In order to assess the level of tolerance breakdown to allergens in local and classical allergic rhinitis, we have studyed concentrations of IL-4, IL-22, and IFNγ in three biological fluids, blood, nasal secretions, and skin exudate. The whole study cohort consisted of 82 patients aged 18 to 60 years with established allergic rhinitis. The diagnosis was based on counseling by allergologist/immunologist, including clinical case history and possible inheritance of atopy as well as videorhinoscopy performed by an ENT specialist. The procedure of videorhinoscopy allowed to specify allergic origin of rhinitis and exclude the patients with non-allergic forms of the disease, but it did not enable us to differentiate between the endotypes of classic and local allergic rhinitis. Subsequently, all patients have been divided into two subgroups based on the criteria of systemic atopy: (1) with a high content of serum total IgE and positive skin allergy tests (n = 41) and (2) with a significantly lower concentration of IgE and negative allergy tests (n = 41). It was concluded that the patients with classic allergic rhinitis prevailed in the 1st subgroup, whereas local rhinitis predominated in the 2nd group. The study of IL-4, IL-22 and IFNγ concentrations in the three biological fluids allowed us to presume that the 1st subgroup was characterized by increased content of IL-4 and IL-22 in blood and skin exudate in comparison with controls, and the 2nd subgroup showed a decrease in IFNγ to control values. The cytokine concentrations in nasal secretions were not representative for the subgroups studied. The result has been interpreted as the absence of tolerance breakdown to causal allergens in the patients with local allergic rhinitis at the systemic level. The obtained data could be used in development of a diagnostic biomarker system for this specific endotype of allergic rhinitis, thus avoiding potential diagnostic errors which occurred in the past, when this endotype was classified as non-allergic form of the disease, thus administering non-adequate treatment, e.g., allergen-specific immunotherapy, which could be prescribed in these cases

Синаптические нейромолекулы и их роль в патогенезе аллергического ринита

Immune cells and molecules, as well as synaptic transmission molecules play a regulatory role in the communication pathways of the entire body when it is necessary to engage all body resources in the fight against infections or tumor cells wherever they appear. In potential allergy, the neuroimmune network controls allergen tolerance maintenance at both local and systemic levels.The review focuses on different neurotransmitters and our understanding of a balance and imbalance between the immune system and the nervous system in allergic inflammation, including allergic rhinitis. However, the pathogenesis of the two endotypes of rhinitis (conventional allergic rhinitis and local allergic rhinitis) and the impact of the neuroimmune network on it remain unresolved. мунные клетки и молекулы, а также синаптические нейромолекулы играют регуляторную роль в путях коммуникации на уровне всего организма, когда возникает необходимость максимального вовлечения ресурсов для отражения инфекций и подавления опухолей. При потенциальной аллергии нейроиммунная сеть контролирует поддержание аллергенной толерантности и на системном, и на локальном уровнях.Данный обзор фокусируется на рассмотрении разных нейромолекул и нашем понимании баланса и дисбаланса иммунной и нервной систем при аллергическом воспалении, включая аллергический ринит. Однако все еще остается нерешенным вопрос о механизмах патогенеза двух эндотипов ринита, классического аллергического ринита и локального аллергического ринита, и степени влияния на него нейроиммунной сети.

The Eurasian Modern Pollen Database (EMPD), version 2

The Eurasian (née European) Modern Pollen Database (EMPD) was established in 2013 to provide a public database of high-quality modern pollen surface samples to help support studies of past climate, land cover, and land use using fossil pollen. The EMPD is part of, and complementary to, the European Pollen Database (EPD) which contains data on fossil pollen found in Late Quaternary sedimentary archives throughout the Eurasian region. The EPD is in turn part of the rapidly growing Neotoma database, which is now the primary home for global palaeoecological data. This paper describes version 2 of the EMPD in which the number of samples held in the database has been increased by 60 % from 4826 to 8134. Much of the improvement in data coverage has come from northern Asia, and the database has consequently been renamed the Eurasian Modern Pollen Database to reflect this geographical enlargement. The EMPD can be viewed online using a dedicated map-based viewer at https://empd2.github.io and downloaded in a variety of file formats at https://doi.pangaea.de/10.1594/PANGAEA.909130 (Chevalier et al., 2019)Swiss National Science Foundation | Ref. 200021_16959

The Eurasian Modern Pollen Database (EMPD), version 2

The Eurasian (nee European) Modern Pollen Database (EMPD) was established in 2013 to provide a public database of high-quality modern pollen surface samples to help support studies of past climate, land cover, and land use using fossil pollen. The EMPD is part of, and complementary to, the European Pollen Database (EPD) which contains data on fossil pollen found in Late Quaternary sedimentary archives throughout the Eurasian region. The EPD is in turn part of the rapidly growing Neotoma database, which is now the primary home for global palaeoecological data. This paper describes version 2 of the EMPD in which the number of samples held in the database has been increased by 60% from 4826 to 8134. Much of the improvement in data coverage has come from northern Asia, and the database has consequently been renamed the Eurasian Modern Pollen Database to reflect this geographical enlargement. The EMPD can be viewed online using a dedicated map-based viewer at https://empd2.github.io and downloaded in a variety of file formats at https://doi.pangaea.de/10.1594/PANGAEA.909130 (Chevalier et al., 2019).Peer reviewe

Vegetation succession and climate change across the Plio-Pleistocene transition in eastern Azerbaijan, central Eurasia (2.77–2.45 Ma)

The Plio-Pleistocene transition marked a key moment in global climate history, characterised by the onset of major glaciations in the Northern Hemisphere. The palaeoenvironmental history of the Plio-Pleistocene transition is not well known for the Caspian Sea region, despite its importance for global climate dynamics. Here we present an independently 40Ar/39Ar dated, high-resolution terrestrial palynological record spanning the Plio-Pleistocene boundary based on a lacustrine-marine sedimentary sequence from eastern Azerbaijan. Despite complex pollen transport pathways and the proximity of closely stacked mountain vegetation belts in the Greater and Lesser Caucasus, the record shows that regional vegetation responded to Milankovitch forced glacial-interglacial cycles, tentatively correlated with global climatic records spanning MIS G8 to 98 (∼2.77–2.45 Ma). The persistence of mesophilous forests during glacial times indicates that some settings in the South Caspian Basin acted as glacial refugia, and that vegetation response to glaciations was muted by increased moisture availability, linked to Caspian transgression. The palynological record shows a relationship with global [delta]18O stacks and specifically to the obliquity record. We anticipate that precise correlation with the global climatostratigraphic timescale will allow better understanding of the nature and timing of important transgressive events in the Caspian Sea and their relevance on a global scale

Why the process is so Important for a DIRFloortime specialist

DIRFloortime® is a learning approach tailored to individual characteristics of the adult and child and based on establishing emotionally charged relationships, which is successfully used to help children with autistic spectrum disorders. An expert trained in DIRFloortime® offers her thoughts on the importance of the interaction process between children and adults during sessions and in the real-life setting. The paper reviews following the child’s lead and challenging — the main strategies of the DIRFloortime approach. It describes the concept of the circle of communication and characteristics of the interaction process, such as tempo, rhythm, duration, intensity, and content. The process of interaction with children affected by autistic spectrum disorder who have difficulties in communicating should be arranged so that they can be engaged and remain in this process with pleasure and joy as long as possible. The child must feel successful and valuable in the eyes of adults who help him/her grow up. Then the child will be able to cope with his fears, shyness, perceptual and motor challenges and to grow in a most harmonious way. This is why DIRFloortime creators and therapists give particular importance to the process of interaction

The Akchagylian stage (late Pliocene-early Pleistocene) in the North Caspian region: Pollen evidence for vegetation and climate change in the Urals-Emba region

Samples from 12 drillhole-cores from the Urals-Emba region to the north-east of the Caspian Sea were analysed for pollen and spores. The records reveal vegetation and climate changes for the late Pliocene to early Pleistocene within the time interval from ca. 3.6 to ca. 1.65 Ma. According to the results of the pollen analysis, at the beginning of the Akchagylian stage (3.6–3.4 Ma) there was a cooling and change in structure of the dendroflora, and steppe-dominated landscapes were present. At the end of the early Akchagylian, and continuing into the middle Akchagylian, a maximum variety of pollen from tree species occurred. The presence of mesophilic and thermophilic elements signifies a moderately warm and humid climate occurred at around 3.2 Ma, probably related to the ‘Mid-Pliocene Warm Period’. A second major cooling occurred at around 2.5 Ma coinciding with the onset of northern hemisphere glaciations. During this time, coniferous forests dominated by Picea, Pinus and Abies with lesser numbers of broad-leaved trees were established. At the end of the Akchagylian, at around 1.8 Ma, the climate became more arid and steppe landscapes were re-established. During the Akchagylian, alternations between forest- and steppe-dominated landscapes occurred at least three times in the Urals-Emba region. Results are compared with pollen spectra in surface samples, and with ostracods and foraminiferal assemblages in cores from the study region

Pollen evidence for Late Pliocene - Early Pleistocene vegetation and climate change in the North Caucasus, North-Western Caspian Region

Pollen and spores have been analysed in deposits of the Akchagylian-Apsheronian in the north-western Caspian Sea region, providing a picture of past vegetation and climate change for the late Pliocene to early Pleistocene. On the basis of pollen assemblages in sediment cores and outcrops from the North Caucasus (the Caucasus Mineral'nyye Vody region, the Tersko-Sunzhensky area and the foothills of Dagestan), climatic fluctuations, and related changes in vegetation can be recognized for the time from 3.6 to 0.8 Ma. The lower Akchagylian is characterized at first by an open landscape dominated by steppe vegetation. In the middle of the lower Akchagylian, the transgression of the palaeo-Caspian spread, and the treeless landscapes of the earliest Akchagylian were replaced by forests with thermophilic relicts. During the middle-upper Akchagylian and Apsheronian periods, the vegetation cover of the North Caucasus gradually changed: forests were replaced with steppe and semi-desert vegetation in response to episodes of aridification, and changes were evident in the structure of the dendroflora. The vegetation of the North Caucasus shows changes consistent with climatic warming at around 3.2 Ma which coincides with a period of warming in the Mediterranean and probable represents the "Mid Pliocene Warm Period"