2,398 research outputs found

    Rigid C^*-tensor categories of bimodules over interpolated free group factors

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    Given a countably generated rigid C^*-tensor category C, we construct a planar algebra P whose category of projections Pro is equivalent to C. From P, we use methods of Guionnet-Jones-Shlyakhtenko-Walker to construct a rigid C^*-tensor category Bim whose objects are bifinite bimodules over an interpolated free group factor, and we show Bim is equivalent to Pro. We use these constructions to show C is equivalent to a category of bifinite bimodules over L(F_infty).Comment: 50 pages, many figure

    Probing topcolor-assisted technicolor from top charge asymmetry and triple-top production at the LHC

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    In a topcolor-assisted technicolor model (TC2) with large FCNC top quark couplings, we study its correlated contributions to the top quark forward-backward asymmetry (AFBA_{FB}) at the Tevatron, the top charge asymmetry (ACA_{C}) and the triple-top production at the LHC. Under current constraints on the top quark from the LHC and Tevatron(such as the total and differential production rates), we scan the parameter space of such a TC2 model. We find that in the allowed parameter space the TC2 model can explain the Tevatron measured AFBA_{FB} at 2σ2\sigma level, but meanwhile significantly enhance ACA_{C} at the LHC. Such enhanced ACA_{C}, albeit currently allowed by the LHC measurement at 2σ2\sigma level, will serve as a test of TC2 with the improvement of measurement precision at the LHC. Then with all the constraints (including the requirement to explain AFBA_{FB} at 2σ2\sigma level and satisfying the current LHC measurement of ACA_{C} at 2σ2\sigma level), we find that the TC2 model can induce sizable triple-top production at the 14 TeV LHC (the production rate can maximally reach 16 pb). Due to the low SM backgrounds, the triple-top production can also be a good probe for TC2 model, complementary to ACA_{C}.Comment: 15 pages, 5 figures, new constraints from LHC addded, published version(Phys. Lett. B

    Deficiency of Cks1 leads to learning and long-term memory defects and p27 dependentformation of neuronal cofilin aggregates

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    In mitotic cells, the cyclin-dependent kinase (CDK) subunit protein CKS1 regulates S phase entry by mediating degradation of the CDK inhibitor p27. Although mature neurons lack mitotic CDKs, we found that CKS1 was actively expressed in post-mitotic neurons of the adult hippocampus. Interestingly, Cks1 knockout (Cks1−/−) mice exhibited poor long-term memory, and diminished maintenance of long-term potentiation in the hippocampal circuits. Furthermore, there was neuronal accumulation of cofilin-actin rods or cofilin aggregates, which are associated with defective dendritic spine maturation and synaptic loss. We further demonstrated that it was the increased p27 level that activated cofilin by suppressing the RhoA kinase-mediated inhibitory phosphorylation of cofilin, resulting in the formation of cofilin aggregates in the Cks1−/− neuronal cells. Consistent with reports that the peptidyl-prolyl-isomerase PIN1 competes with CKS1 for p27 binding, we found that inhibition of PIN1 diminished the formation of cofilin aggregates through decreasing p27 levels, thereby activating RhoA and increasing cofilin phosphorylation. Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability

    Suitability of PSA-detected localised prostate cancers for focal therapy: Experience from the ProtecT study

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    This article is available through a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. Copyright @ 2011 Cancer Research UK.Background: Contemporary screening for prostate cancer frequently identifies small volume, low-grade lesions. Some clinicians have advocated focal prostatic ablation as an alternative to more aggressive interventions to manage these lesions. To identify which patients might benefit from focal ablative techniques, we analysed the surgical specimens of a large sample of population-detected men undergoing radical prostatectomy as part of a randomised clinical trial. Methods: Surgical specimens from 525 men who underwent prostatectomy within the ProtecT study were analysed to determine tumour volume, location and grade. These findings were compared with information available in the biopsy specimen to examine whether focal therapy could be provided appropriately. Results: Solitary cancers were found in prostatectomy specimens from 19% (100 out of 525) of men. In addition, 73 out of 425 (17%) men had multiple cancers with a solitary significant tumour focus. Thus, 173 out of 525 (33%) men had tumours potentially suitable for focal therapy. The majority of these were small, well-differentiated lesions that appeared to be pathologically insignificant (38–66%). Criteria used to select patients for focal prostatic ablation underestimated the cancer's significance in 26% (34 out of 130) of men and resulted in overtreatment in more than half. Only 18% (24 out of 130) of men presumed eligible for focal therapy, actually had significant solitary lesions. Conclusion: Focal therapy appears inappropriate for the majority of men presenting with prostate-specific antigen-detected localised prostate cancer. Unifocal prostate cancers suitable for focal ablation are difficult to identify pre-operatively using biopsy alone. Most lesions meeting criteria for focal ablation were either more aggressive than expected or posed little threat of progression.National Institute for Health Researc

    Falls efficacy: Extending the understanding of self-efficacy in older adults towards managing falls

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    Shawn Leng-Hsien Soh - ORCID: 0000-0002-8725-5182 https://orcid.org/0000-0002-8725-5182Janet Thomas - ORCID: 0000-0002-1037-7923 https://orcid.org/0000-0002-1037-7923Judith Lane - ORCID: 0000-0003-0413-8421 https://orcid.org/0000-0003-0413-8421Publisher's accepted article replaced by VoR 2021-09-02Falls efficacy is a widely studied construct. The understanding of falls efficacy has evolved over time. Falls efficacy was initially perceived to be suitably used as a measure of fear of falling. However, further research suggested that falls efficacy and fear of falling are distinct constructs, and therefore, would be inappropriate to be used as a proxy. Instead, some researchers posited that falls efficacy is synonymous with balance confidence. Falls efficacy has been conventionally understood as the perceived ability of individuals to perform activities without losing balance or falling. A recently conducted systematic review by the authors on existing falls efficacy related measures had revealed a fresh perspective of recognising falls efficacy as a perceived ability to manage a threat of a fall. Falls efficacy, with a broadened interpreted construct, relates to the individual’s perceived self-efficacy of performing necessary actions needed in different scenarios, including pre-fall, near-fall, fall-landing and completed fall. The conventional interpretation of falls efficacy needs a rethinking of perspective. An extended understanding of falls efficacy would provide an integral approach towards improving the agency of individual to deal with falls and would enhance person-centred care.https://doi.org/10.22540/JFSF-06-1316pubpub

    Toward an Aqueous Solar Battery: Direct Electrochemical Storage of Solar Energy in Carbon Nitrides

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    Graphitic carbon nitrides have emerged as an earth-abundant family of polymeric materials for solar energy conversion. Herein, a 2D cyanamide-functionalized polyheptazine imide (NCN-PHI) is reported, which for the first time enables the synergistic coupling of two key functions of energy conversion within one single material: light harvesting and electrical energy storage. Photo-electrochemical measurements in aqueous electrolytes reveal the underlying mechanism of this solar battery material: the charge storage in NCN-PHI is based on the photoreduction of the carbon nitride backbone and charge compensation is realized by adsorption of alkali metal ions within the NCN-PHI layers and at the solution interface. The photoreduced carbon nitride can thus be described as a battery anode operating as a pseudocapacitor, which can store light-induced charge in the form of long-lived, trapped electrons for hours. Importantly, the potential window of this process is not limited by the water reduction reaction due to the high intrinsic overpotential of carbon nitrides for hydrogen evolution, potentially enabling new applications for aqueous batteries. Thus, the feasibility of light-induced electrical energy storage and release on demand by a one-component light-charged battery anode is demonstrated, which provides a sustainable solution to overcome the intermittency of solar radiation

    Probing Lorentz and CPT violation with space-based experiments

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    Space-based experiments offer sensitivity to numerous unmeasured effects involving Lorentz and CPT violation. We provide a classification of clock sensitivities and present explicit expressions for time variations arising in such experiments from nonzero coefficients in the Lorentz- and CPT-violating Standard-Model Extension.Comment: 15 page
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