Corrosion study of pipeline material for seabed sediment in tropical climate

Corrosive environments such as marine sediments can cause corrosion to steel pipelines at any time when certain conditions are met. Seabed sediment could cause severe corrosion damage due to its corrosiveness to the pipelines buried under it. Many consequences could take place in case if there is incident in oil/gas pipelines. Successfully identifying elements of corrosion in marine sediment would enhance the future of steel structure protection and monitoring systems. This article focuses on the behaviour of corrosion rate of steel located near shore environment and the aim is to determine the effect of sediment on corrosion of steel. To investigate that, simulated near shore sediment conditions have been used where the steel coupons buried in sediments which have different characteristics. Weight loss technique has been implemented to determine the weight loss rate of the steel specimens. Based on the results of this study, metal weight loss increases as the duration of exposure to seabed sediment environment become longer. The sea sediment simulated condition has given significant levels of corrosion. Conclusively, the corrosion rate of steel in seabed sediment located in tropical region is complicated and further studies are suggested

Salinity changes in the estuary and the coastal sea adjacent to the portmouth at Cochin

The article deals with the details of salinity changes in the Cochin estuary and its influence and interrelations with the Vembanad lake

Distribution of finfish resources along southeast coast of India in relation to certain environmental parameters

This paper embodies the distribution pattern of major finfish resources along the southeast coast of India as observed during the cruises operated by FORV Sagar Sampada. A total of 16 cruises (1985-90) operated along latitude 7° 15'- 15°00' N and longitude 75°50'- 82°3r E hauled a total catch 37.5 tonnes with a catch rate of 537 kg/hr. The catch was constituted mainly by threadfin breams (43%), perches (14%), barracudas (9.72%), carangids (8.56%) and elasmobranchs (4.81%). Seasonally higher catch rates were obtained during July- September period. Depth range of 60 - 80 m had denser population of finfish resources. Water temperature and salinity appeared to influence the distribution of major finfishes more than dissolved oxygen. Groups such as threadfin breams were found preferring cooler waters of Wadge Bank area, while barracudas appear to occupy warmer waters of Gulf of Mannar

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.

The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated. This may result from alterations in TP53 family members, including the TP53 homologue TP63. Here we demonstrate that TP63 has an antiapoptotic role in melanoma and is responsible for mediating chemoresistance. Although p63 was not expressed in primary melanocytes, up-regulation of p63 mRNA and protein was observed in melanoma cell lines and clinical samples, providing the first evidence of significant p63 expression in this lineage. Upon genotoxic stress, endogenous p63 isoforms were stabilized in both nuclear and mitochondrial subcellular compartments. Our data provide evidence of a physiological interaction between p63 with p53 whereby translocation of p63 to the mitochondria occurred through a codependent process with p53, whereas accumulation of p53 in the nucleus was prevented by p63. Using RNA interference technology, both isoforms of p63 (TA and ΔNp63) were demonstrated to confer chemoresistance, revealing a novel oncogenic role for p63 in melanoma cells. Furthermore, expression of p63 in both primary and metastatic melanoma clinical samples significantly correlated with melanoma-specific deaths in these patients. Ultimately, these observations provide a possible explanation for abrogation of the p53-mediated apoptotic pathway in melanoma, implicating novel approaches aimed at sensitizing melanoma to therapeutic agents

A comparative study of various modalities of treatment of liver abscess

In the 54 selected cases 47 cases are having amoebic liver abscess and 7 patients are having pyogenic liver abscess. • Amoebic liver abscess is commonly seen in the age group between 30-50 years and the pyogenic liver abscess commonly seen in the age group more than 60 years. • In amoebic liver abscess males are commonly affected than the females (8.4 : 1). In pyogenic liver abscess there is equal distribution with slight difference (1.3 : 1). • All the patients included in the study are belonging to low socioeconomic groups. • Right lobe abscess in 48 patients, left lobe abscess in 5 patients, both lobes abscess in one patient. • In amoebic liver abscess 85.7% patients are having abdominal pain. It is higher than pyogenic liver abscess. Fever is seen all the patients of pyogenic liver abscess. In both types half of the patients and one third of the patients having vomiting and diarrhoea. • Tenderness and hepatomegaly is common in amoebic liver abscess and jaundice is common in pyogenic liver abscess patients. • < 5cm abscess the treatment is drugs alone. Metronidazole for amoebic abscess and antimicrobials for pyogenic abscess. • >5cm abscess ultrasound guided aspiration, percutaneous catheter drainage, laparoscopic drainage method .any one can be opted with drugs. • In case of rupture and multiple abscess open surgical method is ideal. • In laparoscopic drainage method 50% reduction of the abscess cavity seen in most of the patients with in a day in percutaneous method within 3 days in needle aspiration up to a week some patients require 10-15 days. • The duration of hospital stay is 4 days in laparoscopic drainage method, 5 days in percutaneous catheter drainage, 7-10 days in needle aspiration method. • No secondary procedure needed in laparoscopic method. Two third of the patients required secondary procedure in ultrasound guided needle aspiration. • No complication occurred in laparoscopic method. Infection rate is high in percutaneous catheter drainage and open surgical method. • 100% recovery rate is higher in patients treated with laparoscopic method. 80% recovery rate is higher in patients treated with percutaneous drainage and needle aspiration method. CONCLUSION: In case of abscess size is less than 5 cm drugs alone is enough. If the abscess size is more than 5 cm and large abscess without complications any one of the following method of treatment options may be carried out: 1. Ultrasound guided needle aspiration with drugs, 2. Percutaneous catheter drainage method drugs, 3. Laparoscopic drainage method with drugs. Among these the best option is laparoscopic drainage method. If the abscess has ruptured with peritonitis open surgical method is best option. In multiple abscesses both laparoscopic method and open surgical methods can be tried. To minimise the hospital stay laparoscopic drainage method is the best method

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Peer reviewedPublisher PD

Medullary Thyroid Carcinoma: Targeted Therapies and Future Directions

Medullary thyroid cancer (MTC) is a rare neuroendocrine neoplasm that accounts for approximately 5% of all thyroid malignancies. The natural history of MTC is characterized by early lymph node and distant metastases, making complete surgical cure often impossible. Conventional chemotherapy and external beam radiation have been largely ineffective in altering the natural history of MTC. Therefore, there is a great need to develop novel therapeutic strategies to affect symptom control and reduce tumor burden in patients with widely disseminated disease. Here, we review several pathways which have been shown to be vital in MTC tumorigenesis and focus on the pathways of interest for which targeted drug therapies are currently being developed

Language Identification in Short Utterances Using Long Short-Term Memory (LSTM) Recurrent Neural Networks

Zazo R, Lozano-Diez A, Gonzalez-Dominguez J, T. Toledano D, Gonzalez-Rodriguez J (2016) Language Identification in Short Utterances Using Long Short-Term Memory (LSTM) Recurrent Neural Networks. PLoS ONE 11(1): e0146917. doi:10.1371/journal.pone.0146917Long Short Term Memory (LSTM) Recurrent Neural Networks (RNNs) have recently outperformed other state-of-the-art approaches, such as i-vector and Deep Neural Networks (DNNs), in automatic Language Identification (LID), particularly when dealing with very short utterances (similar to 3s). In this contribution we present an open-source, end-to-end, LSTM RNN system running on limited computational resources (a single GPU) that outperforms a reference i-vector system on a subset of the NIST Language Recognition Evaluation (8 target languages, 3s task) by up to a 26%. This result is in line with previously published research using proprietary LSTM implementations and huge computational resources, which made these former results hardly reproducible. Further, we extend those previous experiments modeling unseen languages (out of set, OOS, modeling), which is crucial in real applications. Results show that a LSTM RNN with OOS modeling is able to detect these languages and generalizes robustly to unseen OOS languages. Finally, we also analyze the effect of even more limited test data (from 2.25s to 0.1s) proving that with as little as 0.5s an accuracy of over 50% can be achieved.This work has been supported by project CMC-V2: Caracterizacion, Modelado y Compensacion de Variabilidad en la Señal de Voz (TEC2012-37585-C02-01), funded by Ministerio de Economia y Competitividad, Spain

Genetic variability among _Coleus sp_ studied by RAPD banding pattern analysis

Genetic improvement of the medicinal plants depends upon the existence, nature and extent of the genetic variability available for manipulation. Genetic analysis with RAPD markers has been extensively used to determine genetic diversity among _Coleus sp_ and to identify the best quality for human consumption for its medicinal purpose. The objectives of the present study were to assess molecular variation among _C.amboinicus_, _C.aromaticus_ and _C.forskohlii_. and to determine the level of genetic similarity among them. We performed random amplification of polymorphic DNA (RAPD) analysis on three strains of _Coleus sp_. Random primers were used for the PCR. Electrophoresis on denaturing acrylamide gels improved RAPD reproducibility and increased the band number. The primer OPW 6 and OPW 7 gave reproducible results and the band profiles

Anthroponotic transmission of Cryptosporidium parvum predominates in countries with poorer sanitation - a systematic review and meta-analysis

Background: Globally cryptosporidiosis is one of the commonest causes of mortality in children under 24 months old and may be associated with important longterm health effects. Whilst most strains of Cryptosporidium parvum are zoonotic, C. parvum IIc is almost certainly anthroponotic. The global distribution of this potentially important emerging infection is not clear. Methods: We conducted a systematic review of papers identifying the subtype distribution of C. parvum infections globally. We searched PubMed and Scopus using the following key terms Cryptospor* AND parvum AND (genotyp* OR subtyp* OR gp60). Studies were eligible for inclusion if they had found C. parvum within their human study population and had subtyped some or all of these samples using standard gp60 subtyping. Pooled analyses of the proportion of strains being of the IIc subtype were determined using StatsDirect. Meta-regression analyses were run to determine any association between the relative prevalence of IIc and Gross Domestic Product, proportion of the population with access to improved drinking water and improved sanitation. Results: From an initial 843 studies, 85 were included in further analysis. Cryptosporidium parvum IIc was found in 43 of these 85 studies. Across all studies the pooled estimate of relative prevalence of IIc was 19.0% (95% CI: 12.9–25.9%), but there was substantial heterogeneity. In a meta-regression analysis, the relative proportion of all C. parvum infections being IIc decreased as the percentage of the population with access to improved sanitation increased and was some 3.4 times higher in those studies focussing on HIV-positive indivduals. Conclusions: The anthroponotic C. parvum IIc predominates primarily in lower-income countries with poor sanitation and in HIV-positive individuals. Given the apparent enhanced post-infectious virulence of the other main anthroponotic species of Cryptosporidium (C. hominis), it is important to learn about the impact of this subtype on human health