Updating known distribution models for forecasting climate change impact on endangered species

To plan endangered species conservation and to design adequate management programmes, it is necessary to predict their distributional response to climate change, especially under the current situation of rapid change. However, these predictions are customarily done by relating de novo the distribution of the species with climatic conditions with no regard of previously available knowledge about the factors affecting the species distribution. We propose to take advantage of known species distribution models, but proceeding to update them with the variables yielded by climatic models before projecting them to the future. To exemplify our proposal, the availability of suitable habitat across Spain for the endangered Bonelli’s Eagle (Aquila fasciata) was modelled by updating a pre-existing model based on current climate and topography to a combination of different general circulation models and Special Report on Emissions Scenarios. Our results suggested that the main threat for this endangered species would not be climate change, since all forecasting models show that its distribution will be maintained and increased in mainland Spain for all the XXI century. We remark on the importance of linking conservation biology with distribution modelling by updating existing models, frequently available for endangered species, considering all the known factors conditioning the species’ distribution, instead of building new models that are based on climate change variables only.Ministerio de Ciencia e Innovación and FEDER (project CGL2009-11316/BOS

What is behind a summary-evaluation decision?

Research in psychology has reported that, among the variety of possibilities for assessment methodologies, summary evaluation offers a particularly adequate context for inferring text comprehension and topic understanding. However, grades obtained in this methodology are hard to quantify objectively. Therefore, we carried out an empirical study to analyze the decisions underlying human summary-grading behavior. The task consisted of expert evaluation of summaries produced in critically relevant contexts of summarization development, and the resulting data were modeled by means of Bayesian networks using an application called Elvira, which allows for graphically observing the predictive power (if any) of the resultant variables. Thus, in this article, we analyzed summary-evaluation decision making in a computational framewor

Targeted plant improvement through genome editing: from laboratory to field

This review illustrates how far we have come since the emergence of GE technologies and how they could be applied to obtain superior and sustainable crop production. The main challenges of today's agriculture are maintaining and raising productivity, reducing its negative impact on the environment, and adapting to climate change. Efficient plant breeding can generate elite varieties that will rapidly replace obsolete ones and address ongoing challenges in an efficient and sustainable manner. Site-specific genome editing in plants is a rapidly evolving field with tangible results. The technology is equipped with a powerful toolbox of molecular scissors to cut DNA at a pre-determined site with different efficiencies for designing an approach that best suits the objectives of each plant breeding strategy. Genome editing (GE) not only revolutionizes plant biology, but provides the means to solve challenges related to plant architecture, food security, nutrient content, adaptation to the environment, resistance to diseases and production of plant-based materials. This review illustrates how far we have come since the emergence of these technologies and how these technologies could be applied to obtain superior, safe and sustainable crop production. Synergies of genome editing with other technological platforms that are gaining significance in plants lead to an exciting new, post-genomic era for plant research and production. In previous months, we have seen what global changes might arise from one new virus, reminding us of what drastic effects such events could have on food production. This demonstrates how important science, technology, and tools are to meet the current time and the future. Plant GE can make a real difference to future sustainable food production to the benefit of both mankind and our environment.European Cooperation in Science and Technology (COST) CA18111info:eu-repo/semantics/publishedVersio

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

The influence of the ligand chelate effect on iron-amine-catalysed Kumada cross-coupling

The application of a variety of iron complexes with chelating amine ligands as pre-catalysts in the representative cross-coupling of 4-tolylmagnesium bromide with cyclohexyl bromide was investigated. The results from this study indicate the the performance of the pre-catalyst is inversely proportional to the strength of the chelate or macrocyclic effect of the amine ligand, as determined by the propensity of the ligand to be displaced from the iron centre by reaction with excess benzyl magnesium chloride. The findings from this study are consistent with a catalytic cycle wherein the chelating amine ligand is not coordinated to the iron centre during turnover.crosscheck: This document is CrossCheck deposited related_data: Supplementary Information copyright_licence: The Royal Society of Chemistry has an exclusive publication licence for this journal copyright_licence: This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) history: Received 9 May 2016; Accepted 15 June 2016; Accepted Manuscript published 16 June 2016; Advance Article published 24 June 2016; Version of Record published 12 October 2016status: publishe

Mixed double planar wire arrays on Michigan's Ltd generator

International audienceDouble Planar Wire Arrays (DPWA), which consist of two parallel rows of wires, have previously demonstrated high radiation efficiency, compact size, and usefulness for various applications in experiments on a University-scale high-impedance Z-pinch generator1. Recently, we successfully performed two experimental campaigns with PWAs on the University of Michigan's low-impedance MAIZE (Linear Transformer Driver (LTD)-driven generator, 0.1ohm, 0.5-1 MA, 100-180 ns) in collaboration with the UM team. The details and the analysis of the results of the first experimental campaign can be found in Ref. [2]. The second experimental campaign was focused on studying the implosion and radiative characteristics of DPWAs using a diagnostic set similar to the first campaign, including: filtered X-ray diodes, X-ray spectrographs and pinhole cameras, and a new four-frame shadowgraphy system with 2-ns, 532 nm frequency doubled Nd:YAG laser. Here we present the results of four, mixed-DPWA shots with the load consisting of one plane with 6 Al wires of 10¿¿m diameter and another plane of 6 stainless steel wires of 5.1 ¿¿m diameter. The rise-time of the current varies between 175 and 225 ns and shadowgraphy images cover the broad span of time from as early as 116 ns to as late as 304 ns. The shadowgraphy images show ablating and imploding mixed DPWAs that are very different from the images of uniform DPWAs. There is a clearly observed asymmetry of implosions of two wire array planes dependent on the material of each plane, (early time images in particular), captured also by X-ray pinhole images. WADM is used for the analysis of shadowgraphy images. X-ray spectra display both K-shell Al and L-shell Fe features analyzed with non-LTE modeling. Advantages of using mixed wire arrays are discussed. [1] V. L. Kantsyrev et al, Phys. Plasmas 15, 030704 (2008). [2] A.S. Safronova, V.L. Kantsyrev, M.E. Weller, V.V. Shlyaptseva, I.K. Shrestha, M. Lorance, M. Schmidt-Petersen, A. Stafford. M. Cooper, A.M. Steiner, D.A. Yager-Elorriaga, S.G. Patel, N.M. Jordan, R.M. Gilgenbach, A.S. Chuvatin, IEEE TPS, Special Issue on Plenary and Invited papers from ICOPS 2015, to be published, April 2016. * This work was supported by NNSA under DOE Cooperative Agreement DE-NA0001984

Double and Single Planar Wire Arrays on University-Scale Low-Impedance LTD Generator

International audiencePlanar wire array (PWA) experiments were performed on Michigan Accelerator for Inductive Z-pinch Experiments, the University of Michigan's low-impedance linear transformer driver (LTD)-driven generator (0.1 &#937;, 0.5-1 MA, and 100-200 ns), for the first time. It was demonstrated that Al wire arrays [both double PWA (DPWA) and single PWA (SPWA)] can be successfully imploded at LTD generator even at the relatively low current of 0.3-0.5 MA. In particular, implosion characteristics and radiative properties of PWAs of different load configurations [for DPWA from Al and stainless steel wires with different wire diameters, interwire gaps, and interplanar gaps (IPGs) and for Al SPWA of different array widths and number of wires] were studied. The major difference from the DPWA experiments on high-impedance Zebra accelerator was in the current rise time that was influenced by the load inductance and was increased up to about 150 ns during the first campaign (and was even longer in the second campaign). The implosion dynamics of DPWAs strongly depends on the critical load parameter, the aspect ratio (the ratio of the array width to IPG) as for Al DPWAs on high-impedance Zebra, but some differences were observed, for low-aspect ratio loads in particular. Analysis of X-ray images and spectroscopy indicates that K-shell Al plasmas from Al PWAs reached the electron temperatures up to more than 450 eV and densities up to 2 x 10²&#8304; cm&#8315;³. Despite the low mass of the loads, opacity effects were observed in the most prominent K-shell Al lines almost in every shot