The link between obesity and allergy: a role of ACP1 genetic polymorphism?

n/

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing iNKT cells (NKT1 cells), suggesting that NKT1 cells may require a lower TCR signal threshold. Zap70 mutant mice develop IL-17-dependent arthritis. In a mouse experimental arthritis model, NKT17 cells are increased as the disease progresses, while NKT1 numbers negatively correlates with disease severity, with this protective effect of NKT1 linked to their IFN-gamma expression. NKT1 cells are also present in the synovial fluid of arthritis patients. Our data therefore suggest that TCR signal strength during thymic differentiation may influence not only IFN-gamma production, but also the protective function of iNKT cells in arthritis

The zCOSMOS redshift survey: how group environment alters global downsizing trends

Context. Groups of galaxies are a common environment, bridging the gap between starforming field galaxies and quiescent cluster galaxies. Within groups secular processes could be at play, contributing to the observed strong decrease of star formation with cosmic time in the global galaxy population. Aims. We took advantage of the wealth of information provided by the first ~10 000 galaxies of the zCOSMOS-bright survey and its group catalogue to study in detail the complex interplay between group environment and galaxy properties. Methods. The classical indicator F_(blue), i.e., the fraction of blue galaxies, proved to be a simple but powerful diagnostic tool. We studied its variation for different luminosity and mass selected galaxy samples, divided as to define groups/field/isolated galaxy subsamples. Results. Using rest-frame evolving B-band volume-limited samples, the groups galaxy population exhibits significant blueing as redshift increases, but maintains a systematic difference (a lower F_(blue)) with respect to the global galaxy population, and an even larger difference with respect to the isolated galaxy population. However moving to mass selected samples it becomes apparent that such differences are largely due to the biased view imposed by the B-band luminosity selection, being driven by the population of lower mass, bright blue galaxies for which we miss the redder, equally low mass, counterparts. By carefully focusing the analysis on narrow mass bins such that mass segregation becomes negligible we find that only for the lowest mass bin explored, i.e., log(M_*/M_☉) ≤ 10.6, does a significant residual difference in color remain as a function of environment, while this difference becomes negligible toward higher masses. Conclusions. Our results indicate that red galaxies of mass log(M_*/M_☉) ≥ 10.8 are already in place at z ~ 1 and do not exhibit any strong environmental dependence, possibly originating from so-called nature or internal mechanisms. In contrast, for lower galaxy masses and redshifts lower than z ~ 1, we observe the emergence in groups of a population of nurture red galaxies: slightly deviating from the trend of the downsizing scenario followed by the global galaxy population, and more so with cosmic time. These galaxies exhibit signatures of group-related secular physical mechanisms directly influencing galaxy evolution. Our analysis implies that these mechanisms begin to significantly influence galaxy evolution after z ~ 1, a redshift corresponding to the emergence of structures in which these mechanisms take place

The 10k zCOSMOS: morphological transformation of galaxies in the group environment since z~1

We study the evolution of galaxies inside and outside of the group environment since z=1 using a large well defined set of groups and galaxies from the zCOSMOS-bright redshift survey in the COSMOS field. The fraction of galaxies with early-type morphologies increases monotonically with M_B luminosity and stellar mass and with cosmic epoch. It is higher in the groups than elsewhere, especially at later epochs. The emerging environmental effect is superposed on a strong global mass-driven evolution, and at z~0.5 and log(M*/Msol)~10.2, the "effect" of group environment is equivalent to (only) about 0.2 dex in stellar mass or 2 Gyr in time. The stellar mass function of galaxies in groups is enriched in massive galaxies. We directly determine the transformation rates from late to early morphologies, and for transformations involving colour and star formation indicators. The transformation rates are systematically about twice as high in the groups as outside, or up to 3-4 times higher correcting for infall and the appearance of new groups. The rates reach values, for masses around the crossing mass 10^10.5 Msol, as high as (0.3-0.7)/Gyr in the groups, implying transformation timescales of 1.4-3 Gyr, compared with less than 0.2/Gyr, i.e. timescales >5 Gyr, outside of groups. All three transformation rates decrease at higher stellar masses, and must decrease also at the lower masses below 10^10 Msol which we cannot well probe. The rates involving colour and star formation are consistently higher than those for morphology, by a factor of about 50%. Our conclusion is that the transformations which drive the evolution of the overall galaxy population since z~1 must occur at a rate 2-4 times higher in groups than outside of them.Comment: 21 pages, 13 figures, submitted to Ap

The zCOSMOS survey: the role of the environment in the evolution of the luminosity function of different galaxy types

Aims. An unbiased and detailed characterization of the galaxy luminosity function (LF) is a basic requirement in many astrophysical issues: it is of particular interest in assessing the role of the environment in the evolution of the LF of different galaxy types. Methods. We studied the evolution in the B band LF to redshift z ~ 1 in the zCOSMOS 10k sample, for which both accurate galaxy classifications (spectrophotometric and morphological) and a detailed description of the local density field are available. Results. The global B band LF exhibits a brightening of ~0.7 mag in M^* from z ~ 0.2 to z ~ 0.9. At low redshifts (z -20), while the bright end is populated mainly by spectrophotometric early types. At higher redshift, spectrophotometric late-type galaxies evolve significantly and, at redshift z ~ 1, the contribution from the various types to the bright end of the LF is comparable. The evolution for spectrophotometric early-type galaxies is in both luminosity and normalization: M* brightens by ~0.6 mag but φ^∗ decreases by a factor ~1.7 between the first and the last redshift bin. A similar behaviour is exhibited by spectrophotometric late-type galaxies, but with an opposite trend for the normalization: a brightening of ~0.5 mag is present in M^*, while φ^∗ increases by a factor ~1.8.
Studying the role of the environment, we find that the global LF of galaxies in overdense regions has always a brighter M^* and a flatter slope. In low density environments, the main contribution to the LF is from blue galaxies, while for high density environments there is an important contribution from red galaxies to the bright end.
The differences between the global LF in the two environments are not due to only a difference in the relative numbers of red and blue galaxies, but also to their relative luminosity distributions: the value of M^* for both types in underdense regions is always fainter than in overdense environments. These results indicate that galaxies of the same type in different environments have different properties.
We also detect a differential evolution in blue galaxies in different environments: the evolution in their LF is similar in underdense and overdense regions between z ~ 0.25 and z ~ 0.55, and is mainly in luminosity. In contrast, between z ~ 0.55 and z ~ 0.85 there is little luminosity evolution but there is significant evolution in φ^∗, that is, however, different between the two environments: in overdense regions φ^∗ increases by a factor ~1.6, while in underdense regions this increase reaches a factor ~2.8. Analyzing the blue galaxy population in more detail, we find that this evolution is driven mainly by the bluest types. Conclusions. The “specular” evolution of late- and early-type galaxies is consistent with a scenario where a part of blue galaxies is transformed in red galaxies with increasing cosmic time, without significant changes in the fraction of intermediate-type galaxies. The bulk of this tranformation in overdense regions probably happened before z ~ 1, while it is still ongoing at lower redshifts in underdense environments

The bimodality of the 10k zCOSMOS-bright galaxies up to z ~ 1: a new statistical and portable classification based on the optical galaxy properties

Our goal is to develop a new and reliable statistical method to classify galaxies from large surveys. We probe the reliability of the method by comparing it with a three-dimensional classification cube, using the same set of spectral, photometric and morphological parameters.We applied two different methods of classification to a sample of galaxies extracted from the zCOSMOS redshift survey, in the redshift range 0.5 < z < 1.3. The first method is the combination of three independent classification schemes, while the second method exploits an entirely new approach based on statistical analyses like Principal Component Analysis (PCA) and Unsupervised Fuzzy Partition (UFP) clustering method. The PCA+UFP method has been applied also to a lower redshift sample (z < 0.5), exploiting the same set of data but the spectral ones, replaced by the equivalent width of H$\alpha$. The comparison between the two methods shows fairly good agreement on the definition on the two main clusters, the early-type and the late-type galaxies ones. Our PCA-UFP method of classification is robust, flexible and capable of identifying the two main populations of galaxies as well as the intermediate population. The intermediate galaxy population shows many of the properties of the green valley galaxies, and constitutes a more coherent and homogeneous population. The fairly large redshift range of the studied sample allows us to behold the downsizing effect: galaxies with masses of the order of $3\cdot 10^{10}$ Msun mainly are found in transition from the late type to the early type group at $z>0.5$, while galaxies with lower masses - of the order of $10^{10}$ Msun - are in transition at later epochs; galaxies with $M <10^{10}$ Msun did not begin their transition yet, while galaxies with very large masses ($M > 5\cdot 10^{10}$ Msun) mostly completed their transition before $z\sim 1$.Comment: 16 pages, 14 figures, accepted for publication in A&

Smoking, haptoglobin and fertility in humans

A prospective study on two samples of consecutive puerperae (total n° 667) from two populations has been carried out in order to investigate the possible effect of smoking habit on relationship between fertility and haptoglobin phenotype

The optical spectra of 24 μm galaxies in the COSMOS field. I. Spitzer MIPS bright sources in the zCOSMOS-bright 10k catalog

We study zCOSMOS-bright optical spectra for 609 Spitzer MIPS 24 μm-selected galaxies with S_(24) μ m > 0.30 mJy and I 10^(11) Lסּ galaxies at 0.6 < z < 0.7 are ~0.6 dex higher than the average ratio of all zCOSMOS galaxies at similar redshifts. Massive star formation and AGNs could simultaneously be present in those galaxies with the highest ionizing fluxes. (5) Roughly 1/3 of the galaxies with metallicity measurements at 0.5 < z < 0.7 lie below the general mass-metallicity relation at the corresponding redshifts. The strengths of the 4000 Å break and the Hδ EW of our galaxies show that secondary bursts of star formation are needed to explain the spectral properties of most IR sources. The LIRG and ULIRG phases occur, on average, between 10^7 and 10^8 yr after the onset of a starburst on top of underlying older stellar populations. These results are valid for galaxies of different IR luminosities at 0.6 < z < 1.0 and seem independent of the mechanisms triggering star formation

The genetics of feto-placental development: A study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants

<p>Abstract</p> <p>Background</p> <p>Acid phosphatase locus 1 and adenosine deaminase locus 1 polymorphisms show cooperative effects on glucose metabolism and immunological functions. The recent observation of cooperation between the two systems on susceptibility to repeated spontaneous miscarriage prompted us to search for possible interactional effects between these genes and the correlation between birth weight and placental weight. Deviation from a balanced development of the feto-placental unit has been found to be associated with perinatal morbidity and mortality and with cardiovascular diseases in adulthood.</p> <p>Methods</p> <p>We examined 400 consecutive newborns from the Caucasian population of Rome. Birth weight, placental weight, and gestational length were registered. Acid phosphatase locus 1 and adenosine deaminase locus 1 phenotypes were determined by starch gel electrophoresis and correlation analysis was performed by SPSS programs. Informed verbal consent to participate in the study was obtained from the mothers.</p> <p>Results</p> <p>Highly significant differences in birth weight-placental weight correlations were observed among acid phosphatase locus 1 phenotypes (p = 0.005). The correlation between birth weight and placental weight was markedly elevated in subjects carrying acid phosphatase locus 1 phenotypes with medium-low F isoform concentration (A, CA and CB phenotypes) compared to those carrying acid phosphatase locus 1 phenotypes with medium-high F isoform concentration (BA and B phenotypes) (p = 0.002). Environmental and developmental variables were found to exert a significant effect on birth weight-placental weight correlation in subjects with medium-high F isoform concentrations, but only a marginal effect was observed in those with medium-low F isoform concentrations. The correlation between birth weight and placental weight is higher among carriers of the adenosine deaminase locus 1 allele*2, which is associated with low activity, than in homozygous adenosine deaminase locus 1 phenotype 1 carriers (p = 0.04). The two systems show a cooperative effect on the correlation between birth weight and placental weight: the highest value is observed in newborns carrying adenosine deaminase locus 1 allele*2 and acid phosphatase locus 1 phenotypes with medium-low F isoform concentration (p = 0.005).</p> <p>Conclusion</p> <p>These data suggest that zygotes with low adenosine deaminase locus 1 activity and low F activity may experience the most favourable intrauterine conditions for a balanced development of the feto-placental unit.</p

The zCOSMOS 10k-sample: the role of galaxy stellar mass in the colour-density relation up to z=1

[Abridged] With the first 10000 spectra of the flux limited zCOSMOS sample (I<=22.5) we study the evolution of environmental effects on galaxy properties since z=1.0, and disentangle the dependence among galaxy colour, stellar mass and local density (3D local density contrast `delta', computed with the 5th nearest neighbour approach). We confirm that within a luminosity-limited sample (M_B=1) galaxies 'f_red' depends on delta at least up to z=1, with red galaxies residing mainly in high densities. This trend weakens for increasing z, and it is mirrored by the behaviour of the fraction of galaxies with D4000A break >=1.4. We also find that up to z=1 the fraction of galaxies with log(EW[OII]) >=1.15 is higher for lower delta, and also this dependence weakens for increasing z. Given the triple dependence among galaxy colours, stellar mass and delta, the colour-delta relation found in the luminosity-selected sample can be due to the broad range of stellar masses. Thus, we fix the stellar mass and we find that in this case the colour-delta relation is flat up to z=1 for galaxies with log(M/M_sun)>=10.7. This means that for these masses the colour-delta relation found in a luminosity-selected sample is the result of the combined colour-mass and mass-delta relations. In contrast, we find that for 0.1<=z<=0.5 and log(M/M_sun)<=10.7 'f_red' depends on delta even at fixed mass. In these mass and z ranges, environment affects directly also galaxy colours. We suggest a scenario in which the colour depends primarily on stellar mass, but for relatively low mass galaxies the local density modulates this dependence. These galaxies formed more recently, in an epoch when evolved structures were already in place, and their longer SFH allowed environment-driven physical processes to operate during longer periods of time.Comment: 19 pages, 12 figures, submitted to A&A, revised version after referee comment