Low knowledge and awareness of monoclonal gammopathy of undetermined significance (MGUS) among general practitioners

Acknowledgements The authors would like to take this opportunity to thank the organisers of the WONCA Europe 2017 conference and the General Practitioners/Trainee’s for participating in this study. Funding At the time of writing, Dr Charlene McShane was in receipt of a Cancer Research UK Population Science Postdoctoral Research Fellowship (C51094/A18267)Peer reviewedPublisher PD

Patient's perspectives of living with a precancerous condition : monoclonal gammopathy of undetermined significance (MGUS)

Funding for this study was provided by a Cancer Translational Research Group Young Investigator Grant. At the time of the study, Dr Charlene McShane was in receipt of a Cancer Research UK Population Sciences Research Fellowship.Peer reviewedPostprin

(Sub)millimetre interferometric imaging of a sample of COSMOS/AzTEC submillimetre galaxies. II. The spatial extent of the radio-emitting regions

Radio emission at centimetre wavelengths from highly star-forming galaxies, like submillimetre galaxies (SMGs), is dominated by synchrotron radiation arising from supernova activity. Hence, radio continuum imaging has the potential to determine the spatial extent of star formation in these types of galaxies. Using deep, high-resolution (1σ = 2.3 μJy beam-1; 0.75 arcsec) centimetre radio-continuum observations taken by the Karl G. Jansky Very Large Array (VLA)-COSMOS 3 GHz Large Project, we studied the radio-emitting sizes of a flux-limited sample of SMGs in the COSMOS field. The target SMGs were originally discovered in a 1.1 mm continuum survey carried out with the AzTEC bolometer, and followed up with higher resolution interferometric (sub)millimetre continuum observations. Of the 39 SMGs studied here, 3 GHz emission was detected towards 18 of them (~46 ± 11%) with signal-to-noise ratios in the range of S/N = 4.2-37.4. Towards four SMGs (AzTEC2, 5, 8, and 11), we detected two separate 3 GHz sources with projected separations of ~1''&dotbelow;5-6''&dotbelow;6, but they might be physically related in only one or two cases (AzTEC2 and 11). Using two-dimensional elliptical Gaussian fits, we derived a median deconvolved major axis FWHM size of 0''&dotbelow;54±0''&dotbelow;11 for our 18 SMGs detected at 3 GHz. For the 15 SMGs with known redshift we derived a median linear major axis FWHM of 4.2 ± 0.9 kpc. No clear correlation was found between the radio-emitting size and the 3 GHz or submm flux density, or the redshift of the SMG. However, there is a hint of larger radio sizes at z ~ 2.5-5 compared to lower redshifts. The sizes we derived are consistent with previous SMG sizes measured at 1.4 GHz and in mid-J CO emission, but significantly larger than those seen in the (sub)mm continuum emission (typically probing the rest-frame far-infrared with median FWHM sizes of only ~1.5-2.5 kpc). One possible scenario is that SMGs have i) an extended gas component with a low dust temperature, which can be traced by low- to mid-J CO line emission and radio continuum emission; and ii) a warmer, compact starburst region giving rise to the high-excitation line emission of CO, which could dominate the dust continuum size measurements. Because of the rapid cooling of cosmic-ray electrons in dense starburst galaxies (~104-105 yr), the more extended synchrotron radio-emitting size being a result of cosmic-ray diffusion seems unlikely. Instead, if SMGs are driven by galaxy mergers - a process where the galactic magnetic fields can be pulled out to larger spatial scales - the radio synchrotron emission might arise from more extended magnetised interstellar medium around the starburst region

The physical scale of the far-infrared emission in the most luminous submillimetre galaxies II: evidence for merger-driven star formation

We present high-resolution 345 GHz interferometric observations of two extreme luminous (L_{IR}>10^{13} L_sun), submillimetre-selected galaxies (SMGs) in the COSMOS field with the Submillimeter Array (SMA). Both targets were previously detected as unresolved point-sources by the SMA in its compact configuration, also at 345 GHz. These new data, which provide a factor of ~3 improvement in resolution, allow us to measure the physical scale of the far-infrared in the submillimetre directly. The visibility functions of both targets show significant evidence for structure on 0.5-1 arcsec scales, which at z=1.5 translates into a physical scale of 5-8 kpc. Our results are consistent with the angular and physical scales of two comparably luminous objects with high-resolution SMA followup, as well as radio continuum and CO sizes. These relatively compact sizes (<5-10 kpc) argue strongly for merger-driven starbursts, rather than extended gas-rich disks, as the preferred channel for forming SMGs. For the most luminous objects, the derived sizes may also have important physical consequences; under a series of simplifying assumptions, we find that these two objects in particular are forming stars close to or at the Eddington limit for a starburst.Comment: 9 pages, 3 Figures, submitted to MNRA

Measuring space-time variation of the fundamental constants with redshifted submillimetre transitions of neutral carbon

We compare the redshifts of neutral carbon and carbon monoxide in the redshifted sources in which the fine structure transition of neutral carbon, [CI], has been detected, in order to measure space-time variation of the fundamental constants. Comparison with the CO rotational lines measures gives the same combination of constants obtained from the comparison fine structure line of singly ionised carbon, [CII]. However, neutral carbon has the distinct advantage that it may be spatially coincident with the carbon monoxide, whereas [CII] could be located in the diffuse medium between molecular clouds, and so any comparison with CO could be dominated by intrinsic velocity differences. Using [CI], we obtain a mean variation of dF/F = (-3.6 +/- 8.5) x 10^-5, over z = 2.3 - 4.1, for the eight [CI] systems, which degrades to (-1.5+/- 11) x 10^-5, over z = 2.3 - 6.4 when the two [CII] systems are included. That is, zero variation over look-back times of 10.8-12.8 Gyr. However, the latest optical results indicate a spatial variation in alpha, which describes a dipole and we see the same direction in dF/F. This trend is, however, due to a single source for which the [CI] spectrum is of poor quality. This also applies to one of the two [CII] spectra previously used to find a zero variation in alpha^2/mu. Quantifying this, we find an anti-correlation between |dF/F| and the quality of the carbon detection, as measured by the spectral resolution, indicating that the typical values of >50 km/s, used to obtain a detection, are too coarse to reliably measure changes in the constants. From the fluxes of the known z > 1 CO systems, we predict that current instruments are incapable of the sensitivities required to measure changes in the constants through the comparison of CO and carbon lines. We therefore discuss in detail the use of ALMA for such an undertaking ... ABRIDGEDComment: Accepted for publication in Section 3 - Cosmology (including clusters of galaxies) of Astronomy and Astrophysic

Discovery of a Multiply Lensed Submillimeter Galaxy in Early HerMES Herschel/SPIRE Data

We report the discovery of a bright (f(250 μm)>400 mJy), multiply lensed submillimeter galaxy HERMES J105751.1+573027 in Herschel/SPIRE Science Demonstration Phase data from the HerMES project. Interferometric 880 μm Submillimeter Array observations resolve at least four images with a large separation of ~9". A high-resolution adaptive optics K_p image with Keck/NIRC2 clearly shows strong lensing arcs. Follow-up spectroscopy gives a redshift of z = 2.9575, and the lensing model gives a total magnification of μ ~ 11 ± 1. The large image separation allows us to study the multi-wavelength spectral energy distribution (SED) of the lensed source unobscured by the central lensing mass. The far-IR/millimeter-wave SED is well described by a modified blackbody fit with an unusually warm dust temperature, 88 ± 3 K. We derive a lensing-corrected total IR luminosity of (1.43 ± 0.09) × 10^(13) L_☉, implying a star formation rate of ~2500 M_☉ yr^(–1). However, models primarily developed from brighter galaxies selected at longer wavelengths are a poor fit to the full optical-to-millimeter SED. A number of other strongly lensed systems have already been discovered in early Herschel data, and many more are expected as additional data are collected

Deep, ultra-high-resolution radio imaging of submillimetre galaxies using Very Long Baseline Interferometry

We present continent-scale VLBI - obtained with the European VLBI Network (EVN) at a wavelength of 18cm - of six distant, luminous submm-selected galaxies (SMGs). Our images have a synthesized beam width of ~30 milliarcsec FWHM - three orders of magnitude smaller in area than the highest resolution VLA imaging at this wavelength - and are capable of separating radio emission from ultra-compact radio cores (associated with active super-massive black holes - SMBHs) from that due to starburst activity. Despite targeting compact sources - as judged by earlier observations with the VLA and MERLIN - we identify ultra-compact cores in only two of our targets. This suggests that the radio emission from SMGs is produced primarily on larger scales than those probed by the EVN, and therefore is generated by star formation rather than an AGN - a result consistent with other methods used to identify the presence of SMBHs in these systems.Comment: MNRAS, in pres

Step-Indexed Normalization for a Language with General Recursion

The Trellys project has produced several designs for practical dependently typed languages. These languages are broken into two fragments-a_logical_fragment where every term normalizes and which is consistent when interpreted as a logic, and a_programmatic_fragment with general recursion and other convenient but unsound features. In this paper, we present a small example language in this style. Our design allows the programmer to explicitly mention and pass information between the two fragments. We show that this feature substantially complicates the metatheory and present a new technique, combining the traditional Girard-Tait method with step-indexed logical relations, which we use to show normalization for the logical fragment.Comment: In Proceedings MSFP 2012, arXiv:1202.240

On the lack of cold dust in IRAS P09104+4109 and IRAS F15307+3252 -- their spectral energy distributions and implications for finding dusty AGNs at high redshift

We present upper limits on the 850 micron and 450 micron fluxes of the warm hyperluminous (bolometric luminosity L_bol > 10^13 L_sun galaxies IRAS P09104+4109 (z=0.442) and IRAS F15307+3252 (z=0.926), derived from measurements using the SCUBA bolometer array on the James Clerk Maxwell Telescope. Hot luminous infrared sources like these are thought to differ from more normal cold ultraluminous infrared (L_bol > 10^12 L_sun) galaxies in that they derive most of their bolometric luminosities from dusty AGNs as opposed to starbursts. Such hot, dusty AGNs at high redshift are thought to be responsible for much of the mass accretion of the Universe that is in turn responsible for the formation of the supermassive black holes seen in the centres of local galaxies. The galaxy IRAS P09104+4109 is also unusual in that it is a cD galaxy in the center of a substantial cooling-flow cluster, not an isolated interacting galaxy like most ultraluminous infrared galaxies. Previously it was known to have large amounts of hot (T > 50 K) dust from IRAS observations. We now show that the contribution of cold dust to the bolometric luminosity is less than 3 per cent. Most ultraluminous infrared galaxies possess large amounts of cold dust, and it is now known that some cooling flow cluster cD galaxies do as well. Yet this object, which is an extreme example of both, does not have enough cold gas to contribute significantly to the bolometric luminosity. We outline physical reasons why this could have happened. We then provide a discussion of stategies for finding hot dusty AGNs, given the limitations on submillimetre surveys implied by this work.Comment: MNRAS in press, accepted version, minor revision

Submillimeter Follow-up of WISE-Selected Hyperluminous Galaxies

We have used the Caltech Submillimeter Observatory (CSO) to follow-up a sample of WISE-selected, hyperluminous galaxies, so called W1W2-dropout galaxies. This is a rare (~ 1000 all-sky) population of galaxies at high redshift (peaks at z=2-3), that are faint or undetected by WISE at 3.4 and 4.6 um, yet are clearly detected at 12 and 22 um. The optical spectra of most of these galaxies show significant AGN activity. We observed 14 high-redshift (z > 1.7) W1W2-dropout galaxies with SHARC-II at 350 to 850 um, with 9 detections; and observed 18 with Bolocam at 1.1 mm, with five detections. Warm Spitzer follow-up of 25 targets at 3.6 and 4.5 um, as well as optical spectra of 12 targets are also presented in the paper. Combining WISE data with observations from warm Spitzer and CSO, we constructed their mid-IR to millimeter spectral energy distributions (SEDs). These SEDs have a consistent shape, showing significantly higher mid-IR to submm ratios than other galaxy templates, suggesting a hotter dust temperature. We estimate their dust temperatures to be 60-120 K using a single-temperature model. Their infrared luminosities are well over 10^{13} Lsun. These SEDs are not well fitted with existing galaxy templates, suggesting they are a new population with very high luminosity and hot dust. They are likely among the most luminous galaxies in the Universe. We argue that they are extreme cases of luminous, hot dust-obscured galaxies (DOGs), possibly representing a short evolutionary phase during galaxy merging and evolution. A better understanding of their long-wavelength properties needs ALMA as well as Herschel data.Comment: Will be Published on Sep 1, 2012 by Ap