Basic science of osteoarthritis

Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.(undefined

Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at s\sqrt{s} =13 TeV

A search for long-lived particles (LLPs) produced in decays of standard model (SM) Higgs bosons is presented. The data sample consists of 137 fb$^{-1}$ of proton-proton collisions at $\sqrt{s}$=13  TeV, recorded at the LHC in 2016–2018. A novel technique is employed to reconstruct decays of LLPs in the end cap muon detectors. The search is sensitive to a broad range of LLP decay modes and to masses as low as a few GeV. No excess of events above the SM background is observed. The most stringent limits to date on the branching fraction of the Higgs boson to LLPs subsequently decaying to quarks and τ$^{+}$τ$^{-}$ are found for proper decay lengths greater than 6, 20, and 40 m, for LLP masses of 7, 15, and 40 GeV, respectively

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at s =13 TeV

A search for long-lived particles (LLPs) produced in decays of standard model (SM) Higgs bosons is presented. The data sample consists of 137 fb-1 of proton-proton collisions at s=13 TeV, recorded at the LHC in 2016-2018. A novel technique is employed to reconstruct decays of LLPs in the end cap muon detectors. The search is sensitive to a broad range of LLP decay modes and to masses as low as a few GeV. No excess of events above the SM background is observed. The most stringent limits to date on the branching fraction of the Higgs boson to LLPs subsequently decaying to quarks and τ+τ- are found for proper decay lengths greater than 6, 20, and 40 m, for LLP masses of 7, 15, and 40 GeV, respectively

Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis

BACKGROUND: Patients undergoing surgery with perioperative COVID-19 are suggested to have worse outcomes, but whether this is COVID-related or due to selection bias remains unclear. We aimed to compare the postoperative outcomes of patients with and without perioperative COVID-19. METHODS: Patients with perioperative COVID-19 diagnosed within 7 days before or 30 days after surgery between February and July 2020 from 68 US hospitals in COVIDSurg, an international multicenter database, were 1:1 propensity score matched to patients without COVID-19 undergoing similar procedures in the 2012 American College of Surgeons National Surgical Quality Improvement Program database. The matching criteria included demographics (e.g., age, sex), comorbidities (e.g., diabetes, chronic obstructive pulmonary disease, chronic kidney disease), and operation characteristics (e.g., type, urgency, complexity). The primary outcome was 30-day hospital mortality. Secondary outcomes included hospital length of stay and 13 postoperative complications (e.g., pneumonia, renal failure, surgical site infection). RESULTS: A total of 97,936 patients were included, 1,054 with and 96,882 without COVID-19. Prematching, COVID-19 patients more often underwent emergency surgery (76.1% vs. 10.3%, p < 0.001). A total of 843 COVID-19 and 843 non-COVID-19 patients were successfully matched based on demographics, comorbidities, and operative characteristics. Postmatching, COVID-19 patients had a higher mortality (12.0% vs. 8.1%, p = 0.007), longer length of stay (6 [2-15] vs. 5 [1-12] days), and higher rates of acute renal failure (19.3% vs. 3.0%, p < 0.001), sepsis (13.5% vs. 9.0%, p = 0.003), and septic shock (11.8% vs. 6.0%, p < 0.001). They also had higher rates of thromboembolic complications such as deep vein thrombosis (4.4% vs. 1.5%, p < 0.001) and pulmonary embolism (2.5% vs. 0.4%, p < 0.001) but lower rates of bleeding (11.6% vs. 26.1%, p < 0.001). CONCLUSION: Patients undergoing surgery with perioperative COVID-19 have higher rates of 30-day mortality and postoperative complications, especially thromboembolic, compared with similar patients without COVID-19 undergoing similar surgeries. Such information is crucial for the complex surgical decision making and counseling of these patients. (J Trauma Acute Care Surg. 2023;94: 513-524. Copyright (C) 2023 American Association for the Surgery of Trauma.)LEVEL OF EVIDENCE: Prognostic and Epidemiologic; Level IV

Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at s =13 TeV

none2361siA search for long-lived particles (LLPs) produced in decays of standard model (SM) Higgs bosons is presented. The data sample consists of 137 fb-1 of proton-proton collisions at s=13 TeV, recorded at the LHC in 2016-2018. A novel technique is employed to reconstruct decays of LLPs in the end cap muon detectors. The search is sensitive to a broad range of LLP decay modes and to masses as low as a few GeV. No excess of events above the SM background is observed. The most stringent limits to date on the branching fraction of the Higgs boson to LLPs subsequently decaying to quarks and τ+τ- are found for proper decay lengths greater than 6, 20, and 40 m, for LLP masses of 7, 15, and 40 GeV, respectively.noneTumasyan A.; Adam W.; Andrejkovic J.W.; Bergauer T.; Chatterjee S.; Dragicevic M.; Escalante Del Valle A.; Fruhwirth R.; Jeitler M.; Krammer N.; Lechner L.; Liko D.; Mikulec I.; Paulitsch P.; Pitters F.M.; Schieck J.; Schofbeck R.; Schwarz D.; Templ S.; Waltenberger W.; Wulz C.-E.; Chekhovsky V.; Litomin A.; Makarenko V.; Darwish M.R.; De Wolf E.A.; Janssen T.; Kello T.; Lelek A.; Rejeb Sfar H.; Van Mechelen P.; Van Putte S.; Van Remortel N.; Blekman F.; Bols E.S.; D'Hondt J.; Delcourt M.; El Faham H.; Lowette S.; Moortgat S.; Morton A.; Muller D.; Sahasransu A.R.; Tavernier S.; Van Doninck W.; Van Mulders P.; Beghin D.; Bilin B.; Clerbaux B.; De Lentdecker G.; Favart L.; Grebenyuk A.; Kalsi A.K.; Lee K.; Mahdavikhorrami M.; Makarenko I.; Moureaux L.; Petre L.; Popov A.; Postiau N.; Starling E.; Thomas L.; Vanden Bemden M.; Vander Velde C.; Vanlaer P.; Wezenbeek L.; Cornelis T.; Dobur D.; Knolle J.; Lambrecht L.; Mestdach G.; Niedziela M.; Roskas C.; Samalan A.; Skovpen K.; Tytgat M.; Vermassen B.; Vit M.; Benecke A.; Bethani A.; Bruno G.; Bury F.; Caputo C.; David P.; Delaere C.; Donertas I.S.; Giammanco A.; Jaffel K.; Jain S.; Lemaitre V.; Mondal K.; Prisciandaro J.; Taliercio A.; Teklishyn M.; Tran T.T.; Vischia P.; Wertz S.; Alves G.A.; Hensel C.; Moraes A.; Alda Junior W.L.; Alves Gallo Pereira M.; Barroso Ferreira Filho M.; Brandao Malbouisson H.; Carvalho W.; Chinellato J.; Da Costa E.M.; Da Silveira G.G.; De Jesus Damiao D.; Fonseca De Souza S.; Matos Figueiredo D.; Mora Herrera C.; Mota Amarilo K.; Mundim L.; Nogima H.; Rebello Teles P.; Santoro A.; Silva Do Amaral S.M.; Sznajder A.; Thiel M.; Torres Da Silva De Araujo F.; Vilela Pereira A.; Bernardes C.A.; Calligaris L.; Tomei T.R.F.P.; Gregores E.M.; Lemos D.S.; Mercadante P.G.; Novaes S.F.; Padula S.S.; Aleksandrov A.; Antchev G.; Hadjiiska R.; Iaydjiev P.; Misheva M.; Rodozov M.; Shopova M.; Sultanov G.; Dimitrov A.; Ivanov T.; Litov L.; Pavlov B.; Petkov P.; Petrov A.; Cheng T.; Javaid T.; Mittal M.; Yuan L.; Ahmad M.; Bauer G.; Dozen C.; Hu Z.; Martins J.; Wang Y.; Yi K.; Chapon E.; Chen G.M.; Chen H.S.; Chen M.; Iemmi F.; Kapoor A.; Leggat D.; Liao H.; Liu Z.-A.; Milosevic V.; Monti F.; Sharma R.; Tao J.; Thomas-Wilsker J.; Wang J.; Zhang H.; Zhao J.; Agapitos A.; An Y.; Ban Y.; Chen C.; Levin A.; Li Q.; Lyu X.; Mao Y.; Qian S.J.; Wang D.; Wang Q.; Xiao J.; Lu M.; You Z.; Gao X.; Okawa H.; Lin Z.; Xiao M.; Avila C.; Cabrera A.; Florez C.; Fraga J.; Mejia Guisao J.; Ramirez F.; Ruiz Alvarez J.D.; Salazar Gonzalez C.A.; Giljanovic D.; Godinovic N.; Lelas D.; Puljak I.; Antunovic Z.; Kovac M.; Sculac T.; Brigljevic V.; Ferencek D.; Majumder D.; Roguljic M.; Starodumov A.; Susa T.; Attikis A.; Christoforou K.; Erodotou E.; Ioannou A.; Kole G.; Kolosova M.; Konstantinou S.; Mousa J.; Nicolaou C.; Ptochos F.; Razis P.A.; Rykaczewski H.; Saka H.; Finger M.; Finger M.; Kveton A.; Ayala E.; Carrera Jarrin E.; Abdelalim A.A.; Elgammal S.; Mahmoud M.A.; Mohammed Y.; Bhowmik S.; Dewanjee R.K.; Ehataht K.; Kadastik M.; Nandan S.; Nielsen C.; Pata J.; Raidal M.; Tani L.; Veelken C.; Eerola P.; Forthomme L.; Kirschenmann H.; Osterberg K.; Voutilainen M.; Bharthuar S.; Brucken E.; Garcia F.; Havukainen J.; Kim M.S.; Kinnunen R.; Lampen T.; Lassila-Perini K.; Lehti S.; Linden T.; Lotti M.; Martikainen L.; Myllymaki M.; Ott J.; Siikonen H.; Tuominen E.; Tuominiemi J.; Luukka P.; Petrow H.; Tuuva T.; Amendola C.; Besancon M.; Couderc F.; Dejardin M.; Denegri D.; Faure J.L.; Ferri F.; Ganjour S.; Givernaud A.; Gras P.; Hamel De Monchenault G.; Jarry P.; Lenzi B.; Locci E.; Malcles J.; Rander J.; Rosowsky A.; Sahin M.O.; Savoy-Navarro A.; Titov M.; Yu G.B.; Ahuja S.; Beaudette F.; Bonanomi M.; Buchot Perraguin A.; Busson P.; Cappati A.; Charlot C.; Davignon O.; Diab B.; Falmagne G.; Ghosh S.; Granier De Cassagnac R.; Hakimi A.; Kucher I.; Motta J.; Nguyen M.; Ochando C.; Paganini P.; Rembser J.; Salerno R.; Sarkar U.; Sauvan J.B.; Sirois Y.; Tarabini A.; Zabi A.; Zghiche A.; Agram J.-L.; Andrea J.; Apparu D.; Bloch D.; Bourgatte G.; Brom J.-M.; Chabert E.C.; Collard C.; Darej D.; Fontaine J.-C.; Goerlach U.; Grimault C.; Le Bihan A.-C.; Nibigira E.; Van Hove P.; Asilar E.; Beauceron S.; Bernet C.; Boudoul G.; Camen C.; Carle A.; Chanon N.; Contardo D.; Depasse P.; El Mamouni H.; Fay J.; Gascon S.; Gouzevitch M.; Ille B.; Laktineh I.B.; Lattaud H.; Lesauvage A.; Lethuillier M.; Mirabito L.; Perries S.; Shchablo K.; Sordini V.; Torterotot L.; Touquet G.; Vander Donckt M.; Viret S.; Khvedelidze A.; Lomidze I.; Tsamalaidze Z.; Botta V.; Feld L.; Klein K.; Lipinski M.; Meuser D.; Pauls A.; Rowert N.; Schulz J.; Teroerde M.; Dodonova A.; Eliseev D.; Erdmann M.; Fackeldey P.; Fischer B.; Ghosh S.; Hebbeker T.; Hoepfner K.; Ivone F.; Mastrolorenzo L.; Merschmeyer M.; Meyer A.; Mocellin G.; Mondal S.; Mukherjee S.; Noll D.; Novak A.; Pook T.; Pozdnyakov A.; Rath Y.; Reithler H.; Roemer J.; Schmidt A.; Schuler S.C.; Sharma A.; Vigilante L.; Wiedenbeck S.; Zaleski S.; Dziwok C.; Flugge G.; Haj Ahmad W.; Hlushchenko O.; Kress T.; Nowack A.; Pistone C.; Pooth O.; Roy D.; Sert H.; Stahl A.; Ziemons T.; Zotz A.; Aarup Petersen H.; Aldaya Martin M.; Asmuss P.; Baxter S.; Bayatmakou M.; Behnke O.; Bermudez Martinez A.; Bhattacharya S.; Bin Anuar A.A.; Borras K.; Brunner D.; Campbell A.; Cardini A.; Cheng C.; Colombina F.; Consuegra Rodriguez S.; Correia Silva G.; Danilov V.; De Silva M.; Didukh L.; Eckerlin G.; Eckstein D.; Estevez Banos L.I.; Filatov O.; Gallo E.; Geiser A.; Giraldi A.; Grohsjean A.; Guthoff M.; Jafari A.; Jomhari N.Z.; Jung H.; Kasem A.; Kasemann M.; Kaveh H.; Kleinwort C.; Krucker D.; Lange W.; Lidrych J.; Lipka K.; Lohmann W.; Mankel R.; Melzer-Pellmann I.-A.; Mendizabal Morentin M.; Metwally J.; Meyer A.B.; Meyer M.; Mnich J.; Mussgiller A.; Otarid Y.; Perez Adan D.; Pitzl D.; Raspereza A.; Ribeiro Lopes B.; Rubenach J.; Saggio A.; Saibel A.; Savitskyi M.; Scham M.; Scheurer V.; Schutze P.; Schwanenberger C.; Singh A.; Sosa Ricardo R.E.; Stafford D.; Tonon N.; Van De Klundert M.; Walsh R.; Walter D.; Wen Y.; Wichmann K.; Wiens L.; Wissing C.; Wuchterl S.; Aggleton R.; Albrecht S.; Bein S.; Benato L.; Connor P.; De Leo K.; Eich M.; Feindt F.; Frohlich A.; Garbers C.; Garutti E.; Gunnellini P.; Hajheidari M.; Haller J.; Hinzmann A.; Kasieczka G.; Klanner R.; Kogler R.; Kramer T.; Kutzner V.; Lange J.; Lange T.; Lobanov A.; Malara A.; Nigamova A.; Pena Rodriguez K.J.; Rieger O.; Schindler J.; Schleper P.; Schroder M.; Schwandt J.; Sonneveld J.; Stadie H.; Steinbruck G.; Tews A.; Zoi I.; Bechtel J.; Brommer S.; Butz E.; Caspart R.; Chwalek T.; De Boer W.; Dierlamm A.; Droll A.; El Morabit K.; Faltermann N.; Giffels M.; Gosewisch J.O.; Gottmann A.; Hartmann F.; Heidecker C.; Husemann U.; Keicher P.; Koppenhofer R.; Maier S.; Metzler M.; Mitra S.; Muller T.; Neukum M.; Nurnberg A.; Quast G.; Rabbertz K.; Rauser J.; Savoiu D.; Schnepf M.; Seith D.; Shvetsov I.; Simonis H.J.; Ulrich R.; Van Der Linden J.; Von Cube R.F.; Wassmer M.; Weber M.; Wieland S.; Wolf R.; Wozniewski S.; Wunsch S.; Anagnostou G.; Daskalakis G.; Geralis T.; Kyriakis A.; Loukas D.; Stakia A.; Diamantopoulou M.; Karasavvas D.; Karathanasis G.; Kontaxakis P.; Koraka C.K.; Manousakis-Katsikakis A.; Panagiotou A.; Papavergou I.; Saoulidou N.; Theofilatos K.; Tziaferi E.; Vellidis K.; Vourliotis E.; Bakas G.; Kousouris K.; Papakrivopoulos I.; Tsipolitis G.; Zacharopoulou A.; Adamidis K.; Bestintzanos I.; Evangelou I.; Foudas C.; Gianneios P.; Katsoulis P.; Kokkas P.; Manthos N.; Papadopoulos I.; Strologas J.; Csanad M.; Farkas K.; Gadallah M.M.A.; Lokos S.; Major P.; Mandal K.; Mehta A.; Pasztor G.; Radl A.J.; Suranyi O.; Veres G.I.; Bartok M.; Bencze G.; Hajdu C.; Horvath D.; Sikler F.; Veszpremi V.; Vesztergombi G.; Czellar S.; Karancsi J.; Molnar J.; Szillasi Z.; Teyssier D.; Raics P.; Trocsanyi Z.L.; Ujvari B.; Csorgo T.; Nemes F.; Novak T.; Komaragiri J.R.; Kumar D.; Panwar L.; Tiwari P.C.; Bahinipati S.; Kar C.; Mal P.; Mishra T.; Muraleedharan Nair Bindhu V.K.; Nayak A.; Saha P.; Sur N.; Swain S.K.; Vats D.; Bansal S.; Beri S.B.; Bhatnagar V.; Chaudhary G.; Chauhan S.; Dhingra N.; Gupta R.; Kaur A.; Kaur M.; Kaur S.; Kumari P.; Meena M.; Sandeep K.; Singh J.B.; Virdi A.K.; Ahmed A.; Bhardwaj A.; Choudhary B.C.; Gola M.; Keshri S.; Kumar A.; Naimuddin M.; Priyanka P.; Ranjan K.; Shah A.; Bharti M.; Bhattacharya R.; Bhattacharya S.; Bhowmik D.; Dutta S.; Dutta S.; Gomber B.; Maity M.; Palit P.; Rout P.K.; Saha G.; Sahu B.; Sarkar S.; Sharan M.; Singh B.; Thakur S.; Behera P.K.; Behera S.C.; Kalbhor P.; Muhammad A.; Pradhan R.; Pujahari P.R.; Sharma A.; Sikdar A.K.; Dutta D.; Jha V.; Kumar V.; Mishra D.K.; Naskar K.; Netrakanti P.K.; Pant L.M.; Shukla P.; Aziz T.; Dugad S.; Kumar M.; Banerjee S.; Chudasama R.; Guchait M.; Karmakar S.; Kumar S.; Majumder G.; Mazumdar K.; Mukherjee S.; Alpana K.; Dube S.; Kansal B.; Laha A.; Pandey S.; Rane A.; Rastogi A.; Sharma S.; Bakhshiansohi H.; Khazaie E.; Zeinali M.; Chenarani S.; Etesami S.M.; Khakzad M.; Mohammadi Najafabadi M.; Grunewald M.; Abbrescia M.; Aly R.; Aruta C.; Colaleo A.; Creanza D.; De Filippis N.; De Palma M.; Di Florio A.; Di Pilato A.; Elmetenawee W.; Fiore L.; Gelmi A.; Gul M.; Iaselli G.; Ince M.; Lezki S.; Maggi G.; Maggi M.; Margjeka I.; Mastrapasqua V.; Merlin J.A.; My S.; Nuzzo S.; Pellecchia A.; Pompili A.; Pugliese G.; Ramos D.; Ranieri A.; Selvaggi G.; Silvestris L.; Simone F.M.; Venditti R.; Verwilligen P.; Abbiendi G.; Battilana C.; Bonacorsi D.; Borgonovi L.; Brigliadori L.; Campanini R.; Capiluppi P.; Castro A.; Cavallo F.R.; Cuffiani M.; Dallavalle G.M.; Diotalevi T.; Fabbri F.; Fanfani A.; Giacomelli P.; Giommi L.; Grandi C.; Guiducci L.; Lo Meo S.; Lunerti L.; Marcellini S.; Masetti G.; Navarria F.L.; Perrotta A.; Primavera F.; Rossi A.M.; Rovelli T.; Siroli G.P.; Albergo S.; Costa S.; Di Mattia A.; Potenza R.; Tricomi A.; Tuve C.; Barbagli G.; Cassese A.; Ceccarelli R.; Ciulli V.; Civinini C.; D'Alessandro R.; Focardi E.; Latino G.; Lenzi P.; Lizzo M.; Meschini M.; Paoletti S.; Seidita R.; Sguazzoni G.; Viliani L.; Benussi L.; Bianco S.; Piccolo D.; Bozzo M.; Ferro F.; Mulargia R.; Robutti E.; Tosi S.; Benaglia A.; Boldrini G.; Brivio F.; Cetorelli F.; De Guio F.; Dinardo M.E.; Dini P.; Gennai S.; Ghezzi A.; Govoni P.; Guzzi L.; Lucchini M.T.; Malberti M.; Malvezzi S.; Massironi A.; Menasce D.; Moroni L.; Paganoni M.; Pedrini D.; Pinolini B.S.; Ragazzi S.; Redaelli N.; Tabarelli De Fatis T.; Valsecchi D.; Zuolo D.; Buontempo S.; Carnevali F.; Cavallo N.; De Iorio A.; Fabozzi F.; Iorio A.O.M.; Lista L.; Meola S.; Paolucci P.; Rossi B.; Sciacca C.; Azzi P.; Bacchetta N.; Bisello D.; Bortignon P.; Bragagnolo A.; Carlin R.; Checchia P.; Dorigo T.; Dosselli U.; Gasparini F.; Gasparini U.; Grosso G.; Hoh S.Y.; Layer L.; Lusiani E.; Margoni M.; Meneguzzo A.T.; Pazzini J.; Presilla M.; Ronchese P.; Rossin R.; Simonetto F.; Strong G.; Tosi M.; Yarar H.; Zanetti M.; Zotto P.; Zucchetta A.; Zumerle G.; Aime' C.; Braghieri A.; Calzaferri S.; Fiorina D.; Montagna P.; Ratti S.P.; Re V.; Riccardi C.; Salvini P.; Vai I.; Vitulo P.; Asenov P.; Bilei G.M.; Ciangottini D.; Fano L.; Lariccia P.; Magherini M.; Mantovani G.; Mariani V.; Menichelli M.; Moscatelli F.; Piccinelli A.; Rossi A.; Santocchia A.; Spiga D.; Tedeschi T.; Azzurri P.; Bagliesi G.; Bertacchi V.; Bianchini L.; Boccali T.; Bossini E.; Castaldi R.; Ciocci M.A.; D'Amante V.; Dell'Orso R.; Di Domenico M.R.; Donato S.; Giassi A.; Ligabue F.; Manca E.; Mandorli G.; Messineo A.; Palla F.; Parolia S.; Ramirez-Sanchez G.; Rizzi A.; Rolandi G.; Roy Chowdhury S.; Scribano A.; Shafiei N.; Spagnolo P.; Tenchini R.; Tonelli G.; Turini N.; Venturi A.; Verdini P.G.; Barria P.; Campana M.; Cavallari F.; Del Re D.; Di Marco E.; Diemoz M.; Longo E.; Meridiani P.; Organtini G.; Pandolfi F.; Paramatti R.; Quaranta C.; Rahatlou S.; Rovelli C.; Santanastasio F.; Soffi L.; Tramontano R.; Amapane N.; Arcidiacono R.; Argiro S.; Arneodo M.; Bartosik N.; Bellan R.; Bellora A.; Berenguer Antequera J.; Biino C.; Cartiglia N.; Cometti S.; Costa M.; Covarelli R.; Demaria N.; Kiani B.; Legger F.; Mariotti C.; Maselli S.; Migliore E.; Monteil E.; Monteno M.; Obertino M.M.; Ortona G.; Pacher L.; Pastrone N.; Pelliccioni M.; Pinna Angioni G.L.; Ruspa M.; Shchelina K.; Siviero F.; Sola V.; Solano A.; Soldi D.; Staiano A.; Tornago M.; Trocino D.; Vagnerini A.; Belforte S.; Candelise V.; Casarsa M.; Cossutti F.; Da Rold A.; Della Ricca G.; Sorrentino G.; Vazzoler F.; Dogra S.; Huh C.; Kim B.; Kim D.H.; Kim G.N.; Kim J.; Lee J.; Lee S.W.; Moon C.S.; Oh Y.D.; Pak S.I.; Radburn-Smith B.C.; Sekmen S.; Yang Y.C.; Kim H.; Moon D.H.; Francois B.; Kim T.J.; Park J.; Cho S.; Choi S.; Go Y.; Hong B.; Lee K.; Lee K.S.; Lim J.; Park J.; Park S.K.; Yoo J.; Goh J.; Gurtu A.; Kim H.S.; Kim Y.; Almond J.; 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Hoorani H.R.; Khan W.A.; Shah M.A.; Shoaib M.; Waqas M.; Avati V.; Grzanka L.; Malawski M.; Bialkowska H.; Bluj M.; Boimska B.; Gorski M.; Kazana M.; Szleper M.; Zalewski P.; Bunkowski K.; Doroba K.; Kalinowski A.; Konecki M.; Krolikowski J.; Walczak M.; Araujo M.; Bargassa P.; Bastos D.; Boletti A.; Faccioli P.; Gallinaro M.; Hollar J.; Leonardo N.; Niknejad T.; Pisano M.; Seixas J.; Toldaiev O.; Varela J.; Afanasiev S.; Budkouski D.; Golutvin I.; Gorbunov I.; Karjavine V.; Korenkov V.; Lanev A.; Malakhov A.; Matveev V.; Palichik V.; Perelygin V.; Savina M.; Seitova D.; Shalaev V.; Shmatov S.; Shulha S.; Smirnov V.; Teryaev O.; Voytishin N.; Yuldashev B.S.; Zarubin A.; Zhizhin I.; Gavrilov G.; Golovtcov V.; Ivanov Y.; Kim V.; Kuznetsova E.; Murzin V.; Oreshkin V.; Smirnov I.; Sosnov D.; Sulimov V.; Uvarov L.; Volkov S.; Vorobyev A.; Andreev Y.; Dermenev A.; Gninenko S.; Golubev N.; Karneyeu A.; Kirpichnikov D.; Kirsanov M.; Krasnikov N.; Pashenkov A.; Pivovarov G.; Toropin A.; Epshteyn V.; Gavrilov V.; Lychkovskaya N.; Nikitenko A.; Popov V.; Stepennov A.; Toms M.; Vlasov E.; Zhokin A.; Aushev T.; Bychkova O.; Chistov R.; Danilov M.; Oskin A.; Parygin P.; Polikarpov S.; Andreev V.; Azarkin M.; Dremin I.; Kirakosyan M.; Terkulov A.; Belyaev A.; Boos E.; Bunichev V.; Dubinin M.; Dudko L.; Ershov A.; Klyukhin V.; Kodolova O.; Lokhtin I.; Obraztsov S.; Perfilov M.; Petrushanko S.; Savrin V.; Blinov V.; Dimova T.; Kardapoltsev L.; Kozyrev A.; Ovtin I.; Skovpen Y.; Azhgirey I.; Bayshev I.; Elumakhov D.; Kachanov V.; Konstantinov D.; Mandrik P.; Petrov V.; Ryutin R.; Slabospitskii S.; Sobol A.; Troshin S.; Tyurin N.; Uzunian A.; Volkov A.; Babaev A.; Okhotnikov V.; Borshch V.; Ivanchenko V.; Tcherniaev E.; Adzic P.; Dordevic M.; Milenovic P.; Milosevic J.; Aguilar-Benitez M.; Alcaraz Maestre J.; Alvarez Fernandez A.; Bachiller I.; Barrio Luna M.; Bedoya C.F.; Carrillo Montoya C.A.; Cepeda M.; Cerrada M.; Colino N.; De La Cruz B.; Delgado Peris A.; Fernandez Ramos J.P.; Flix J.; Fouz M.C.; Gonzalez Lopez O.; Goy Lopez S.; Hernandez J.M.; Josa M.I.; Leon Holgado J.; Moran D.; Navarro Tobar A.; Perez Dengra C.; Perez-Calero Yzquierdo A.; Puerta Pelayo J.; Redondo I.; Romero L.; Sanchez Navas S.; Urda Gomez L.; Willmott C.; De Troconiz J.F.; Reyes-Almanza R.; Alvarez Gonzalez B.; Cuevas J.; Erice C.; Fernandez Menendez J.; Folgueras S.; Gonzalez Caballero I.; Gonzalez Fernandez J.R.; Palencia Cortezon E.; Ramon Alvarez C.; Rodriguez Bouza V.; Soto Rodriguez A.; Trapote A.; Trevisani N.; Vico Villalba C.; Brochero Cifuentes J.A.; Cabrillo I.J.; Calderon A.; Duarte Campderros J.; Fernandez M.; Fernandez Madrazo C.; Fernandez Manteca P.J.; Garcia Alonso A.; Gomez G.; Martinez Rivero C.; Martinez Ruiz Del Arbol P.; Matorras F.; Matorras-Cuevas P.; Piedra Gomez J.; Prieels C.; Rodrigo T.; Ruiz-Jimeno A.; Scodellaro L.; Vila I.; Vizan Garcia J.M.; Jayananda M.K.; Kailasapathy B.; Sonnadara D.U.J.; Wickramarathna D.D.C.; Dharmaratna W.G.D.; Liyanage K.; Perera N.; Wickramage N.; Aarrestad T.K.; Abbaneo D.; Alimena J.; Auffray E.; Auzinger G.; Baechler J.; Baillon P.; Barney D.; Bendavid J.; Bianco M.; Bocci A.; Camporesi T.; Capeans Garrido M.; Cerminara G.; Chhibra S.S.; Cipriani M.; Cristella L.; D'Enterria D.; Dabrowski A.; David A.; De Roeck A.; Defranchis M.M.; Deile M.; Dobson M.; Dunser M.; Dupont N.; Elliott-Peisert A.; Emriskova N.; Fallavollita F.; Fasanella D.; Florent A.; Franzoni G.; Funk W.; Giani S.; Gigi D.; Gill K.; Glege F.; Gouskos L.; Haranko M.; Hegeman J.; Innocente V.; James T.; Janot P.; Kaspar J.; Kieseler J.; Komm M.; Kratochwil N.; Lange C.; Laurila S.; Lecoq P.; Lintuluoto A.; Long K.; Lourenco C.; Maier B.; Malgeri L.; Mallios S.; Mannelli M.; Marini A.C.; Meijers F.; Mersi S.; Meschi E.; Moortgat F.; Mulders M.; Orfanelli S.; Orsini L.; Pantaleo F.; Pape L.; Perez E.; Peruzzi M.; Petrilli A.; Petrucciani G.; Pfeiffer A.; Pierini M.; Piparo D.; Pitt M.; Qu H.; Quast T.; Rabady D.; Racz A.; Reales Gutierrez G.; Rieger M.; Rovere M.; Sakulin H.; Salfeld-Nebgen J.; Scarfi S.; Schafer C.; Schwick C.; Selvaggi M.; Sharma A.; Silva P.; Snoeys W.; Sphicas P.; Summers S.; Tatar K.; Tavolaro V.R.; Treille D.; Tropea P.; Tsirou A.; Van Onsem G.P.; Wanczyk J.; Wozniak K.A.; Zeuner W.D.; Caminada L.; Ebrahimi A.; Erdmann W.; Horisberger R.; Ingram Q.; Kaestli H.C.; Kotlinski D.; Langenegger U.; Missiroli M.; Noehte L.; Rohe T.; Androsov K.; Backhaus M.; Berger P.; Calandri A.; Chernyavskaya N.; De Cosa A.; Dissertori G.; Dittmar M.; Donega M.; Dorfer C.; Eble F.; Gedia K.; Glessgen F.; Gomez Espinosa T.A.; Grab C.; Hits D.; Lustermann W.; Lyon A.-M.; Manzoni R.A.; Marchese L.; Martin Perez C.; Meinhard M.T.; Nessi-Tedaldi F.; Niedziela J.; Pauss F.; Perovic V.; Pigazzini S.; Ratti M.G.; Reichmann M.; Reissel C.; Reitenspiess T.; Ristic B.; Ruini D.; Sanz Becerra D.A.; Stampf V.; Steggemann J.; Wallny R.; Zhu D.H.; Amsler C.; Bartschi P.; Botta C.; Brzhechko D.; Canelli M.F.; Cormier K.; De Wit A.; Del Burgo R.; Heikkila J.K.; 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Reid I.D.; Teodorescu L.; Zahid S.; Abdullin S.; Brinkerhoff A.; Caraway B.; Dittmann J.; Hatakeyama K.; Kanuganti A.R.; McMaster B.; Pastika N.; Saunders M.; Sawant S.; Sutantawibul C.; Wilson J.; Bartek R.; Dominguez A.; Uniyal R.; Vargas Hernandez A.M.; Bu

Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at root s=13 TeV

A search for long-lived particles (LLPs) produced in decays of standard model (SM) Higgs bosons is presented. The data sample consists of 137 fb(-1) of proton-proton collisions at root s = 13 TeV, recorded at the LHC in 2016-2018. A novel technique is employed to reconstruct decays of LLPs in the end cap muon detectors. The search is sensitive to a broad range of LLP decay modes and to masses as low as a few GeV. No excess of events above the SM background is observed. The most stringent limits to date on the branching fraction of the Higgs boson to LLPs subsequently decaying to quarks and tau(+)tau(-) are found for proper decay lengths greater than 6, 20, and 40 m, for LLP masses of 7, 15, and 40 GeV, respectively.LPH